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  1. Article ; Online: A

    Liu, Dany / Sica, Maria Sole / Mao, Jiwei / Chao, Lucy Fang-I / Siewers, Verena

    ACS synthetic biology

    2022  Volume 11, Issue 10, Page(s) 3228–3238

    Abstract: In vivo biosensors that can convert metabolite concentrations into measurable output signals are valuable tools for high-throughput screening and dynamic pathway control in the field of metabolic engineering. Here, we present a novel biosensor ... ...

    Abstract In vivo biosensors that can convert metabolite concentrations into measurable output signals are valuable tools for high-throughput screening and dynamic pathway control in the field of metabolic engineering. Here, we present a novel biosensor in
    MeSH term(s) Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Malonyl Coenzyme A/metabolism ; Flavanones ; Biosensing Techniques
    Chemical Substances naringenin (HN5425SBF2) ; Malonyl Coenzyme A (524-14-1) ; Flavanones
    Language English
    Publishing date 2022-09-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2161-5063
    ISSN (online) 2161-5063
    DOI 10.1021/acssynbio.2c00111
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  2. Article ; Online: Specialization determines outcomes in inflammation and cancer.

    Sica, Antonio / Lazzeri, Massimo

    Nature immunology

    2023  Volume 24, Issue 9, Page(s) 1399–1401

    MeSH term(s) Humans ; Neoplasms ; Inflammation
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-023-01592-0
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    Zs.A 5294: Show issues Location:
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    Zs.MG 42: Show issues

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  3. Article: Two cases of unilateral limbal Vernal keratoconjunctivitis in the same family: first case report.

    Michieletto, Paola / Sica, Attilio / Barbi, Egidio / Pensiero, Stefano

    Frontiers in pediatrics

    2023  Volume 11, Page(s) 1237760

    Abstract: This case report describes two cases of unilateral limbal Vernal keratoconjunctivitis (VKC) in the same family. To our knowledge, these are the first two reported cases of unilateral limbal VKC. VKC is a chronic inflammatory disease that typically ... ...

    Abstract This case report describes two cases of unilateral limbal Vernal keratoconjunctivitis (VKC) in the same family. To our knowledge, these are the first two reported cases of unilateral limbal VKC. VKC is a chronic inflammatory disease that typically affects both eyes, with unilateral cases being rare and previously only reported in the tarsal form. Our first case involved a 12-year-old girl with a history of allergic asthma, who had been experiencing conjunctivitis in her right eye since the age of 7. Upon examination, she was diagnosed with unilateral limbal VKC and treated with 1% cyclosporine eye drops with a significant improvement observed at the one and three-month follow-ups. Her 7-year-old brother was also examined and found to have unilateral limbal VKC in his right eye, although it was milder and not associated with allergic pathogenesis. Therefore, in this case, a treatment with hydrocortisone eye drops was started leading to an immediate reduction of the itching. In both cases an IgE-mediated mechanism is less likely because of the monolateral eye involvement, the complete absence of nasal symptoms, the lack of correlation between symptoms and any pollen season, and the negative prick skin test in one of the two siblings. Both cases suggest that unilateral VKC may occur even in the limbal form and that genetic mechanisms may contribute to the inflammatory reaction in VKC. This report highlights the need for further studies to explain the occurrence of unilateral VKC cases and reminds clinicians to consider the possibility of unilateral limbal VKC in pediatric patients.
    Language English
    Publishing date 2023-10-02
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2023.1237760
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  4. Article ; Online: Awareness through relationships in individuals undergoing rehabilitation following acquired brain injury.

    McCabe, Corinne / Sica, Andrea / Fortune, Donal G

    Neuropsychological rehabilitation

    2023  , Page(s) 1–29

    Abstract: Aim: This cross-sectional study investigated the association between self-awareness and quality of therapeutic relationships following acquired brain injury (ABI) while controlling for the potential impact of cognitive problems. It also aimed to ... ...

    Abstract Aim: This cross-sectional study investigated the association between self-awareness and quality of therapeutic relationships following acquired brain injury (ABI) while controlling for the potential impact of cognitive problems. It also aimed to investigate attachment as a potential moderator.
    Method: 83 adults with ABI were recruited alongside a key member of their community neurorehabilitation team. The Scale to Assess Therapeutic Relationships (STAR) was used to measure therapeutic relationship quality and attachment was measured using the Experiences in Close Relationships - Relationship Structure (ECR-RS) questionnaire. Awareness was measured using the Patient Competency Rating Scale (PCRS) and the Mayo-Portland Adaptability Inventory (MPAI-4) provided a measure of cognitive problems. The MPAI-4 also provided an additional measure of awareness.
    Results: A significant association between self-awareness and therapeutic relationships was found in some regression models such that higher-quality relationships were associated with better awareness, after controlling for the impact of cognitive problems. Neither childhood parental attachment nor participants' attachment towards their rehabilitation staff were moderators.
    Conclusion: The observed associations between awareness in clients and therapeutic relationships with rehabilitation staff may have importance for rehabilitation in this context. Results highlight the value of continuing to prioritize the therapeutic relational environment in ABI rehabilitation and research.
    Language English
    Publishing date 2023-10-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1080508-4
    ISSN 1464-0694 ; 0960-2011
    ISSN (online) 1464-0694
    ISSN 0960-2011
    DOI 10.1080/09602011.2023.2273578
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    Zs.A 3276: Show issues Location:
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  5. Article ; Online: Editorial.

    Sica, Antonio

    Current opinion in pharmacology

    2017  Volume 35, Page(s) vii–ix

    MeSH term(s) Antineoplastic Agents/immunology ; Humans ; Immunosuppression/methods ; Myeloid Cells/immunology ; Neoplasms/immunology ; Neoplasms/therapy ; Tumor Microenvironment/immunology
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2017-11-05
    Publishing country England
    Document type Editorial
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2017.11.002
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    Zs.A 5608: Show issues Location:
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  6. Book: Calcium channel blockers: monotherapy and dual therapy considerations in the treatment of hypertension

    Sica, Domenic A.

    (American journal of cardiovascular drugs ; 7, Suppl. 1)

    2007  

    Author's details guest ed. Domenic A. Sica
    Series title American journal of cardiovascular drugs ; 7, Suppl. 1
    Collection
    Language English
    Size 29 S. : graph. Darst.
    Publisher Adis International
    Publishing place Auckland
    Publishing country New Zealand
    Document type Book
    HBZ-ID HT015185530
    Database Catalogue ZB MED Medicine, Health

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    Zs A 5487 -7,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  7. Article: Should the BCRA1/2-mutations healthy carriers be valid candidates for hematopoietic stem cell donation?

    Fresa, Alberto / Sica, Simona

    Hereditary cancer in clinical practice

    2021  Volume 19, Issue 1, Page(s) 22

    Abstract: It's still not clear whether the mutational status of BRCA-mutated healthy hematopoietic stem cells (HSCs) donors could have an impact on the engraftment. Comparing the studies present in literature, we focused on the correlation between BRCA mutations ... ...

    Abstract It's still not clear whether the mutational status of BRCA-mutated healthy hematopoietic stem cells (HSCs) donors could have an impact on the engraftment. Comparing the studies present in literature, we focused on the correlation between BRCA mutations and the development of hematological malignancies and Fanconi anemia (FA); then, we explored HSCs types, frequencies, and functions in the presence of BRCA mutations, as well as the reconstitution of hematopoiesis after chemotherapy and radiation treatments. The role of BRCA mutations in the FA showed a possible involvement in the onset of the disease; the mutation carriers, indeed, did not show any sign of the typical phenotype of the FA. BRCA mutational status can be considered as a risk factor for hematological malignancies, but only for secondary malignancies and/or in the presence of bone marrow stress factors. Currently we don't know if a conditioning regimen could be compensated by BRCA mutated HSCs, even if murine models tried to show the possible differences between fully mutated, haploinsufficient and normal HSCs. Thus, given the downregulating effect of the mutations on hematopoiesis, it could be questionable to use the HSCs of a BRCA-mutated donor in the presence of another available donor with the same compatibility.
    Language English
    Publishing date 2021-04-01
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 2252512-9
    ISSN 1897-4287 ; 1731-2302
    ISSN (online) 1897-4287
    ISSN 1731-2302
    DOI 10.1186/s13053-021-00179-w
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    Zs.A 6407: Show issues Location:
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  8. Book: Design of a novel controlled release formulation of carvedilol: pharmacology and clinical aspects

    Sica, Domenic A.

    (The American journal of cardiology ; 98,7A = Suppl.)

    2006  

    Title variant Design of a novel controlled-release formulation of carvedilol: pharmacology and clinical aspects
    Author's details guest. ed.: Domenic A. Sica
    Series title The American journal of cardiology ; 98,7A = Suppl.
    Collection
    Language English
    Size 69L S. : graph. Darst.
    Publisher Elsevier
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT014887099
    Database Catalogue ZB MED Medicine, Health

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    Ui IV Zs 73 -98,7A- verfügbar in Königswinter Königswinter

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  9. Article ; Online: Cisplatin Binding to Human Serum Transferrin: A Crystallographic Study.

    Troisi, Romualdo / Galardo, Francesco / Ferraro, Giarita / Sica, Filomena / Merlino, Antonello

    Inorganic chemistry

    2023  Volume 62, Issue 2, Page(s) 675–678

    Abstract: The molecular mechanism of how human serum transferrin (hTF) recognizes cisplatin at the atomic level is still unclear. Here, we report the molecular structure of the adduct formed upon the reaction of hTF with cisplatin. Pt binds the side chain of ... ...

    Abstract The molecular mechanism of how human serum transferrin (hTF) recognizes cisplatin at the atomic level is still unclear. Here, we report the molecular structure of the adduct formed upon the reaction of hTF with cisplatin. Pt binds the side chain of Met256 (at the N-lobe), without altering the protein overall conformation.
    MeSH term(s) Humans ; Cisplatin/metabolism ; Transferrin/chemistry ; Iron/chemistry ; Protein Conformation ; Protein Binding ; Receptors, Transferrin/chemistry ; Receptors, Transferrin/metabolism
    Chemical Substances Cisplatin (Q20Q21Q62J) ; Transferrin ; Iron (E1UOL152H7) ; Receptors, Transferrin
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.2c04206
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  10. Article ; Online: Self-awareness and quality of relationships after acquired brain injury: Systematic review without meta-analysis (SWiM).

    McCabe, Corinne / Sica, Andrea / Doody, Niamh / Fortune, Donal G

    Neuropsychological rehabilitation

    2023  Volume 34, Issue 3, Page(s) 335–361

    Abstract: Background: Relational aspects of self-awareness following Acquired Brain Injury (ABI) are increasingly being recognized. However, research underpinning the nature of the association between self-awareness and quality of relationships has yet to be ... ...

    Abstract Background: Relational aspects of self-awareness following Acquired Brain Injury (ABI) are increasingly being recognized. However, research underpinning the nature of the association between self-awareness and quality of relationships has yet to be synthesized.
    Method: Searches, which were completed between February 2022 and February 2023, consisted of combining terms related to ABI, self-awareness, and quality of relationships. Data were analyzed using the Synthesis Without Meta-Analysis (SWiM) approach.
    Results: Associations between self-awareness and relationship quality across eight studies identified for this review differed in direction and significance. A more consistent pattern emerged, however, when studies assessing the quality of specific types of relationships i.e., spousal (
    Conclusion: Results are discussed with consideration given to measures assessing the quality of specific relationships. In particular, such measures may tap into important patterns of interaction between two individuals, such as those related to attunement or communication, which may be valuable preconditions for improving awareness.
    MeSH term(s) Humans ; Brain Injuries/complications
    Language English
    Publishing date 2023-03-12
    Publishing country England
    Document type Systematic Review
    ZDB-ID 1080508-4
    ISSN 1464-0694 ; 0960-2011
    ISSN (online) 1464-0694
    ISSN 0960-2011
    DOI 10.1080/09602011.2023.2186437
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