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  1. Article: LRRC25 expression during physiological aging and in mouse models of Alzheimer's disease and iPSC-derived neurons.

    Devadoss, Dinesh / Akkaoui, Juliet / Nair, Madhavan / Lakshmana, Madepalli K

    Frontiers in molecular neuroscience

    2024  Volume 17, Page(s) 1365752

    Abstract: The leucine-rich repeat-containing protein 25 (LRRC25) is relatively a novel protein with no information on its role in neuronal or brain function. A recent study suggested LRRC25 is a potential risk factor for Alzheimer's disease (AD). As a first step ... ...

    Abstract The leucine-rich repeat-containing protein 25 (LRRC25) is relatively a novel protein with no information on its role in neuronal or brain function. A recent study suggested LRRC25 is a potential risk factor for Alzheimer's disease (AD). As a first step to understanding LRRC25's role in the brain and AD, we found LRRC25 is expressed in both cell membranes and cytoplasm in a punctuate appearance in astrocytes, microglia, and neurons in cell lines as well as mouse brain. We also found that LRRC25 expression is both age- and brain region-dependent and that 1-day-old (1D) pups expressed the least amount of LRRC25 protein compared to adult ages. In the APΔE9 mice, immunoblot quantified LRRC25 protein levels were increased by 166% (**
    Language English
    Publishing date 2024-02-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2024.1365752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Corrigendum to "E-cigarette synthetic cooling agent WS-23 and nicotine aerosols differentially modulate airway epithelial cell responses" [Toxicol. Rep. 9 (2022) 1823-1830].

    Manevski, Marko / Yogeswaran, Shaiesh / Rahman, Irfan / Devadoss, Dinesh / Chand, Hitendra S

    Toxicology reports

    2023  Volume 11, Page(s) 259–260

    Abstract: This corrects the article DOI: 10.1016/j.toxrep.2022.09.010.]. ...

    Abstract [This corrects the article DOI: 10.1016/j.toxrep.2022.09.010.].
    Language English
    Publishing date 2023-09-19
    Publishing country Ireland
    Document type Published Erratum
    ZDB-ID 2805786-7
    ISSN 2214-7500 ; 2214-7500
    ISSN (online) 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2023.09.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: E-cigarette synthetic cooling agent WS-23 and nicotine aerosols differentially modulate airway epithelial cell responses.

    Manevski, Marko / Yogeswaran, Shaiesh / Rahman, Irfan / Devadoss, Dinesh / Chand, Hitendra S

    Toxicology reports

    2022  Volume 9, Page(s) 1823–1830

    Abstract: Electronic cigarette (e-cig) aerosol exposures are strongly associated with pulmonary dysfunctions, and the airway epithelial cells (AECs) of respiratory passages play a pivotal role in understanding this association. However, not much is known about the ...

    Abstract Electronic cigarette (e-cig) aerosol exposures are strongly associated with pulmonary dysfunctions, and the airway epithelial cells (AECs) of respiratory passages play a pivotal role in understanding this association. However, not much is known about the effect of synthetic cooling agents such as WS-23 on AECs. WS-23 is a synthetic menthol-like cooling agent widely used to enhance the appeal of e-cigs and to suppress the harshness and bitterness of other e-cig constituents. Using primary human AECs, we compared the effects of aerosolized WS-23 with propylene glycol/vegetable glycerin (PG/VG) vehicle control and nicotine aerosol exposures. AECs treated with 3 % WS-23 aerosols showed a significant increase in viable cell numbers compared to PG/VG-vehicle aerosol exposed cells and cell growth was comparable following 2.5 % nicotine aerosol exposure. AEC inflammatory factors, IL-6 and ICAM-1 levels were significantly suppressed by WS-23 aerosols compared to PG/VG-controls. When differentiated AECs were challenged with WS-23 aerosols, there was a significant increase in secretory mucin MUC5AC expression with no discernible change in airway inflammatory SCGB1A1 expression. Compared to PG/VG-controls, WS-23 or nicotine aerosols presented with increased MUC5AC expression, but there was no synergistic effect of WS-23 + nicotine combination exposure. Thus, WS-23 and nicotine aerosols modulate the AEC responses and induce goblet cell hyperplasia, which could impact the airway physiology and susceptibility to respiratory diseases.
    Language English
    Publishing date 2022-09-20
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2805786-7
    ISSN 2214-7500 ; 2214-7500
    ISSN (online) 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2022.09.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Novel Alzheimer risk factor IQ motif containing protein K is abundantly expressed in the brain and is markedly increased in patients with Alzheimer's disease.

    Wang, Hongjie / Devadoss, Dinesh / Nair, Madhavan / Chand, Hitendra S / Lakshmana, Madepalli K

    Frontiers in cellular neuroscience

    2022  Volume 16, Page(s) 954071

    Abstract: Alzheimer's disease (AD) is complex and highly heterogeneous. Less than 10% of AD cases are early-onset (EOAD) caused by autosomal dominantly inherited mutations in amyloid precursor protein (APP), presenilin 1 (PS1), or presenilin 2 (PS2), each of which ...

    Abstract Alzheimer's disease (AD) is complex and highly heterogeneous. Less than 10% of AD cases are early-onset (EOAD) caused by autosomal dominantly inherited mutations in amyloid precursor protein (APP), presenilin 1 (PS1), or presenilin 2 (PS2), each of which can increase Aβ generation and, thus, amyloid plaques. The remaining 90% of cases of AD are late-onset (LOAD) or sporadic. Intense research efforts have led to identification of many genes that increase the risk of AD. An IQ motif containing protein K (IQCK) was recently identified by several investigators as an Alzheimer's disease risk gene. However, how IQCK increases AD risk is completely unknown. Since IQCK is a novel gene, there is limited information on its physiological characterization. To understand its role in AD, it is first important to determine its subcellular localization, whether and where it is expressed in the brain, and what type of brain cells express the IQCK protein. Therefore, in this study, we show by immunocytochemical (ICC) staining that IQCK is expressed in both the nucleus and the cytoplasm of SH-SY5Y neuroblastoma cells as well as HeLa cells but not in either HMC3 microglial or CHO cells. By immunohistochemistry (IHC), we also show that IQCK is expressed in both mouse and human neurons, including neuronal processes
    Language English
    Publishing date 2022-07-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2022.954071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Indoor-air purification by photoelectrochemical oxidation mitigates allergic airway responses to aerosolized cat dander in a murine model.

    Devadoss, Dinesh / Surbaugh, Kerri / Manevski, Marko / Wickramaratne, Chatura / Chaput, Dale / Chung, Arianne / de Leon, Francisco / Chand, Hitendra S / Dhau, Jaspreet S

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 10980

    Abstract: Portable air purifiers help improve indoor air quality by neutralizing allergens, including animal dander proteins. However, there are limited in-vivo models to assess the efficacy of these devices. Here, we developed a novel animal model of experimental ...

    Abstract Portable air purifiers help improve indoor air quality by neutralizing allergens, including animal dander proteins. However, there are limited in-vivo models to assess the efficacy of these devices. Here, we developed a novel animal model of experimental asthma using aerosolized cat dander extract (CDE) exposure and compared the efficacy of select air purification technologies. Mice were exposed to CDE aerosols for 6 weeks in separate custom-built whole-body exposure chambers equipped with either a photoelectrochemical oxidative (PECO) Molekule filtration device (PFD) or a HEPA-assisted air filtration device (HFD) along with positive (a device with no filtration capability) and negative controls. Compared to the positive control group, the CDE-induced airway resistance, and plasma IgE and IL-13 levels were significantly reduced in both air purifier groups. However, PFD mice showed a better attenuation of lung tissue mucous hyperplasia and eosinophilia than HFD and positive control mice, indicating a better efficacy in managing CDE-induced allergic responses. Cat dander protein destruction was evaluated by LCMS proteomic analysis, which revealed the degradation of 2731 unique peptides on PECO media in 1 h. Thus, allergen protein destruction on filtration media enhances air purifier efficacy that could provide relief from allergy responses compared to traditional HEPA-based filtration alone.
    MeSH term(s) Mice ; Animals ; Disease Models, Animal ; Dander/metabolism ; Proteomics ; Hypersensitivity/metabolism ; Asthma ; Allergens ; Air Pollution, Indoor
    Chemical Substances Allergens
    Language English
    Publishing date 2023-07-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-38155-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: SARS-CoV-2 Infection in the Central and Peripheral Nervous System-Associated Morbidities and Their Potential Mechanism.

    Karuppan, Mohan Kumar Muthu / Devadoss, Dinesh / Nair, Madhavan / Chand, Hitendra S / Lakshmana, Madepalli K

    Molecular neurobiology

    2021  Volume 58, Issue 6, Page(s) 2465–2480

    Abstract: The recent outbreak of SARS-CoV-2 infections that causes coronavirus-induced disease of 2019 (COVID-19) is the defining and unprecedented global health crisis of our time in both the scale and magnitude. Although the respiratory tract is the primary ... ...

    Abstract The recent outbreak of SARS-CoV-2 infections that causes coronavirus-induced disease of 2019 (COVID-19) is the defining and unprecedented global health crisis of our time in both the scale and magnitude. Although the respiratory tract is the primary target of SARS-CoV-2, accumulating evidence suggests that the virus may also invade both the central nervous system (CNS) and the peripheral nervous system (PNS) leading to numerous neurological issues including some serious complications such as seizures, encephalitis, and loss of consciousness. Here, we present a comprehensive review of the currently known role of SARS-CoV-2 and identify all the neurological problems reported among the COVID-19 case reports throughout the world. The virus might gain entry into the CNS either through the trans-synaptic route via the olfactory neurons or through the damaged endothelium in the brain microvasculature using the ACE2 receptor potentiated by neuropilin-1 (NRP-1). The most critical of all symptoms appear to be the spontaneous loss of breathing in some COVID-19 patients. This might be indicative of a dysfunction within the cardiopulmonary regulatory centers in the brainstem. These pioneering studies, thus, lay a strong foundation for more in-depth basic and clinical research required to confirm the role of SARS-CoV-2 infection in neurodegeneration of critical brain regulatory centers.
    MeSH term(s) Adult ; Age Factors ; Angiotensin-Converting Enzyme 2/metabolism ; Brain/virology ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/physiopathology ; Cardiovascular Diseases/epidemiology ; Central Nervous System Diseases/diagnostic imaging ; Central Nervous System Diseases/etiology ; Central Nervous System Diseases/physiopathology ; Child ; Comorbidity ; Diabetes Mellitus/epidemiology ; Endothelial Cells/pathology ; Female ; Humans ; Kidney Diseases/etiology ; Liver Diseases/etiology ; Male ; Nerve Tissue Proteins/metabolism ; Neuroimaging ; Neuropilin-1/physiology ; Obesity/epidemiology ; Organ Specificity ; Peripheral Nervous System Diseases/etiology ; Peripheral Nervous System Diseases/physiopathology ; Receptors, Virus/metabolism ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/metabolism
    Chemical Substances NRP1 protein, human ; Nerve Tissue Proteins ; Receptors, Virus ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Neuropilin-1 (144713-63-3) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2021-01-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-020-02245-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2411: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: E-cigarette synthetic cooling agent WS-23 and nicotine aerosols differentially modulate airway epithelial cell responses

    Manevski, Marko / Yogeswaran, Shaiesh / Rahman, Irfan / Devadoss, Dinesh / Chand, Hitendra S.

    Toxicology Reports. 2022, v. 9 p.1823-1830

    2022  

    Abstract: Electronic cigarette (e-cig) aerosol exposures are strongly associated with pulmonary dysfunctions, and the airway epithelial cells (AECs) of respiratory passages play a pivotal role in understanding this association. However, not much is known about the ...

    Abstract Electronic cigarette (e-cig) aerosol exposures are strongly associated with pulmonary dysfunctions, and the airway epithelial cells (AECs) of respiratory passages play a pivotal role in understanding this association. However, not much is known about the effect of synthetic cooling agents such as WS-23 on AECs. WS-23 is a synthetic menthol-like cooling agent widely used to enhance the appeal of e-cigs and to suppress the harshness and bitterness of other e-cig constituents. Using primary human AECs, we compared the effects of aerosolized WS-23 with propylene glycol/vegetable glycerin (PG/VG) vehicle control and nicotine aerosol exposures. AECs treated with 3 % WS-23 aerosols showed a significant increase in viable cell numbers compared to PG/VG-vehicle aerosol exposed cells and cell growth was comparable following 2.5 % nicotine aerosol exposure. AEC inflammatory factors, IL-6 and ICAM-1 levels were significantly suppressed by WS-23 aerosols compared to PG/VG-controls. When differentiated AECs were challenged with WS-23 aerosols, there was a significant increase in secretory mucin MUC5AC expression with no discernible change in airway inflammatory SCGB1A1 expression. Compared to PG/VG-controls, WS-23 or nicotine aerosols presented with increased MUC5AC expression, but there was no synergistic effect of WS-23 + nicotine combination exposure. Thus, WS-23 and nicotine aerosols modulate the AEC responses and induce goblet cell hyperplasia, which could impact the airway physiology and susceptibility to respiratory diseases.
    Keywords aerosols ; bitterness ; cell growth ; cell viability ; electronic equipment ; epithelial cells ; epithelium ; glycerol ; humans ; hyperplasia ; intercellular adhesion molecule-1 ; interleukin-6 ; mucins ; nicotine ; physiology ; propylene glycol ; synergism ; toxicology ; vegetables ; Airway epithelial cells ; E-cigarette ; WS-23 ; Synthetic cooling agent ; Mucin ; MUC5AC ; ICAM-1
    Language English
    Size p. 1823-1830.
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2805786-7
    ISSN 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2022.09.010
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Targeting inflammation: a potential approach for the treatment of depression.

    Bhatt, Shvetank / Devadoss, Thangaraj / Jha, Niraj Kumar / Baidya, Moushumi / Gupta, Gaurav / Chellappan, Dinesh Kumar / Singh, Sachin Kumar / Dua, Kamal

    Metabolic brain disease

    2022  Volume 38, Issue 1, Page(s) 45–59

    Abstract: Major depressive disorder (MDD) or Depression is one of the serious neuropsychiatric disorders affecting over 280 million people worldwide. It is 4th important cause of disability, poor quality of life, and economic burden. Women are more affected with ... ...

    Abstract Major depressive disorder (MDD) or Depression is one of the serious neuropsychiatric disorders affecting over 280 million people worldwide. It is 4th important cause of disability, poor quality of life, and economic burden. Women are more affected with the depression as compared to men and severe depression can lead to suicide. Most of the antidepressants predominantly work through the modulation on the availability of monoaminergic neurotransmitter (NTs) levels in the synapse. Current antidepressants have limited efficacy and tolerability. Moreover, treatment resistant depression (TRD) is one of the main causes for failure of standard marketed antidepressants. Recently, inflammation has also emerged as a crucial factor in pathological progression of depression. Proinflammatory cytokine levels are increased in depressive patients. Antidepressant treatment may attenuate depression via modulation of pathways of inflammation, transformation in structure of brain, and synaptic plasticity. Hence, targeting inflammation may be emerged as an effective approach for the treatment of depression. The present review article will focus on the preclinical and clinical studies that targets inflammation. In addition, it also concentrates on the therapeutic approaches' that targets depression via influence on the inflammatory signaling pathways. Graphical abstract demonstrate the role of various factors in the progression and neuroinflammation, oxidative stress. It also exhibits the association of neuroinflammation, oxidative stress with depression.
    MeSH term(s) Male ; Humans ; Female ; Depressive Disorder, Major/drug therapy ; Depressive Disorder, Major/metabolism ; Depression/drug therapy ; Neuroinflammatory Diseases ; Quality of Life ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Inflammation/drug therapy ; Inflammation/metabolism
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2022-10-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632824-6
    ISSN 1573-7365 ; 0885-7490
    ISSN (online) 1573-7365
    ISSN 0885-7490
    DOI 10.1007/s11011-022-01095-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2155: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Corrigendum: Increased expression of

    Manevski, Marko / Devadoss, Dinesh / Long, Christopher / Singh, Shashi P / Nasser, Mohd Wasim / Borchert, Glen M / Nair, Madhavan N / Rahman, Irfan / Sopori, Mohan / Chand, Hitendra S

    Frontiers in immunology

    2022  Volume 13, Page(s) 988069

    Abstract: This corrects the article DOI: 10.3389/fimmu.2022.803362.]. ...

    Abstract [This corrects the article DOI: 10.3389/fimmu.2022.803362.].
    Language English
    Publishing date 2022-08-08
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.988069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Physiological Oxygen Tension Enhances Competence and Functional Properties of Murine Cardiac Mesenchymal Cells.

    Bolli, Robi Ar / Dasari, Chandrashekhar / Arshia, Asma / Devadoss, Dinesh / Guo, Yiru / Ashraf, Usman / Li, Qianhong

    Stem cell reviews and reports

    2021  Volume 17, Issue 3, Page(s) 900–910

    Abstract: Cardiac mesenchymal cells (CMCs), a newly-discovered and promising type of progenitor cells, are effective in improving cardiac function in rodents after myocardial infarction. Stem/progenitor cells are usually cultured at atmospheric ... ...

    Abstract Cardiac mesenchymal cells (CMCs), a newly-discovered and promising type of progenitor cells, are effective in improving cardiac function in rodents after myocardial infarction. Stem/progenitor cells are usually cultured at atmospheric O
    MeSH term(s) Animals ; Heart ; Mice ; Oxygen ; Stem Cells ; Telomerase/genetics ; Vascular Malformations
    Chemical Substances Telomerase (EC 2.7.7.49) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2021-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2495577-2
    ISSN 2629-3277 ; 1558-6804 ; 1550-8943
    ISSN (online) 2629-3277 ; 1558-6804
    ISSN 1550-8943
    DOI 10.1007/s12015-020-10106-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6198: Show issues Location:
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