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  1. Article ; Online: Can artificial intelligence (AI) replace oral food challenge?

    Tang, Sindy K Y / Castaño, Nicolas / Nadeau, Kari C / Galli, Stephen J

    The Journal of allergy and clinical immunology

    2024  Volume 153, Issue 3, Page(s) 666–668

    MeSH term(s) Humans ; Artificial Intelligence ; Allergens ; Basophils ; Food ; Food Hypersensitivity/diagnosis
    Chemical Substances Allergens
    Language English
    Publishing date 2024-01-21
    Publishing country United States
    Document type Editorial
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2024.01.008
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  2. Article ; Online: The TWEAK/Fn14 axis in anaphylactic shock.

    Galli, Stephen J

    The Journal of allergy and clinical immunology

    2020  Volume 145, Issue 2, Page(s) 491–493

    MeSH term(s) Anaphylaxis ; Apoptosis ; Fibroblast Growth Factors ; Histamine ; Humans ; Platelet Activating Factor
    Chemical Substances Platelet Activating Factor ; Fibroblast Growth Factors (62031-54-3) ; Histamine (820484N8I3)
    Language English
    Publishing date 2020-02-05
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2019.11.044
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  3. Article ; Online: Complexities in analyzing human basophil responses to autoantibodies to IgE or FcεRI.

    Galli, Stephen J

    The Journal of allergy and clinical immunology

    2019  Volume 143, Issue 3, Page(s) 932–934

    MeSH term(s) Autoantibodies ; Basophils ; Humans ; Immunoglobulin E ; Receptors, IgE ; Syk Kinase
    Chemical Substances Autoantibodies ; Receptors, IgE ; Immunoglobulin E (37341-29-0) ; Syk Kinase (EC 2.7.10.2)
    Language English
    Publishing date 2019-01-14
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2018.12.998
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  4. Article ; Online: Mast cells: a novel therapeutic avenue for cardiovascular diseases?

    Poto, Remo / Marone, Gianni / Galli, Stephen J / Varricchi, Gilda

    Cardiovascular research

    2024  

    Abstract: Mast cells are tissue-resident immune cells strategically located in different compartments of the normal human heart (the myocardium, pericardium, aortic valve and close to nerves) as well as in atherosclerotic plaques. Cardiac mast cells produce a ... ...

    Abstract Mast cells are tissue-resident immune cells strategically located in different compartments of the normal human heart (the myocardium, pericardium, aortic valve and close to nerves) as well as in atherosclerotic plaques. Cardiac mast cells produce a broad spectrum of vasoactive and proinflammatory mediators, which have potential roles in inflammation, angiogenesis, lymphangiogenesis, tissue remodeling and fibrosis. Mast cells release preformed mediators (e.g., histamine, tryptase, chymase) and de novo synthesized mediators [e.g., cysteinyl leukotriene C4 (LTC4) and prostaglandin D2 (PGD2)], as well as cytokines and chemokines, which can activate different resident immune cells (e.g., macrophages) and structural cells (e.g., fibroblasts, endothelial cells) in the human heart and aorta. The transcriptional profiles of various mast cell populations highlight their potential heterogeneity and distinct gene and proteome expression. Mast cell plasticity and/or heterogeneity enable these cells the potential for performing different, even opposite, functions in response to changing tissue contexts. Human cardiac mast cells display significant differences compared to mast cells isolated from other organs. These characteristics make cardiac mast cells intriguing, given their dichotomous potential roles of inducing or protecting against cardiovascular diseases. Identification of cardiac mast cell subpopulations represents a prerequisite for understanding their potential multifaceted roles in health and disease. Several new drugs specifically targeting human mast cell activation are under development or in clinical trials. Mast cells and/or their subpopulations can potentially represent novel therapeutic targets for cardiovascular disorders.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvae066
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  5. Article ; Online: Recruiting CD33 on mast cells to inhibit IgE-mediated mast cell-dependent anaphylaxis.

    Galli, Stephen J

    The Journal of clinical investigation

    2019  Volume 129, Issue 3, Page(s) 955–957

    Abstract: IgE-mediated activation of mast cells is a hallmark of an anaphylactic reaction to allergen. In this issue of the JCI, Duan et al. describe an approach for suppressing IgE-dependent mast cell activation, thereby suppressing anaphylaxis. Specifically, the ...

    Abstract IgE-mediated activation of mast cells is a hallmark of an anaphylactic reaction to allergen. In this issue of the JCI, Duan et al. describe an approach for suppressing IgE-dependent mast cell activation, thereby suppressing anaphylaxis. Specifically, the authors show that delivery of liposomes containing both the specific antigen recognized by the mast cell-bound IgE and a high-affinity glycan ligand of the inhibitory receptor CD33 (CD33L) to targeted mast cells inhibits antigen-induced, FcεRI-dependent spleen tyrosine kinase (Syk) phosphorylation and downstream protein tyrosine kinase (PTK) phosphorylation, Ca++ flux, and β-hexosaminidase release (i.e., degranulation). However, this strategy only worked if both the antigen (reactive with the mast cell-bound IgE) and CD33L were on the same liposome. This approach promises to rapidly reduce IgE-dependent mast cell activation in response to challenge with offending allergens.
    MeSH term(s) Allergens ; Anaphylaxis ; Cell Degranulation ; Humans ; Immunoglobulin E ; Mast Cells/immunology ; Receptors, IgE ; Sialic Acid Binding Ig-like Lectin 3 ; Syk Kinase
    Chemical Substances Allergens ; CD33 protein, human ; Receptors, IgE ; Sialic Acid Binding Ig-like Lectin 3 ; Immunoglobulin E (37341-29-0) ; Syk Kinase (EC 2.7.10.2)
    Language English
    Publishing date 2019-02-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI127100
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  6. Article ; Online: Mary Hewitt Loveless, MD: The origin of venom immunotherapy.

    Galli, Stephen J

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2018  Volume 121, Issue 3, Page(s) 268–271

    MeSH term(s) Anaphylaxis/pathology ; Anaphylaxis/prevention & control ; Antibodies, Blocking/therapeutic use ; Bee Venoms/administration & dosage ; Desensitization, Immunologic/methods ; History, 20th Century ; Humans ; Insect Bites and Stings/pathology ; Insect Bites and Stings/therapy ; Rhinitis, Allergic, Seasonal/therapy ; Wasp Venoms/administration & dosage
    Chemical Substances Antibodies, Blocking ; Bee Venoms ; Wasp Venoms
    Language English
    Publishing date 2018-06-28
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2018.06.020
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  7. Article ; Online: Reply.

    Galli, Stephen J

    The Journal of allergy and clinical immunology

    2017  Volume 139, Issue 6, Page(s) 2029–2031

    MeSH term(s) Biomarkers ; Desensitization, Immunologic ; Immunoglobulin E
    Chemical Substances Biomarkers ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2017-04-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2016.12.988
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  8. Article ; Online: Mast Cells and KIT as Potential Therapeutic Targets in Severe Asthma.

    Galli, Stephen J

    The New England journal of medicine

    2017  Volume 376, Issue 20, Page(s) 1983–1984

    MeSH term(s) Asthma/drug therapy ; Humans ; Mast Cells ; Proto-Oncogene Proteins c-kit
    Chemical Substances Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
    Language English
    Publishing date 2017--18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe1702653
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  9. Article ; Online: Omalizumab in "non-IgE-mediated" diseases.

    Chinthrajah, R Sharon / Galli, Stephen J

    The Journal of allergy and clinical immunology

    2020  Volume 147, Issue 4, Page(s) 1207–1208

    MeSH term(s) Animals ; Asthma/drug therapy ; Asthma/etiology ; Chronic Urticaria/drug therapy ; Cytokines/metabolism ; Disease Progression ; Humans ; Immunoglobulin E/immunology ; Mastocytosis/drug therapy ; Omalizumab/therapeutic use ; Pemphigoid, Bullous/drug therapy ; Receptors, IgE/metabolism ; Virus Diseases/complications ; Virus Diseases/drug therapy
    Chemical Substances Cytokines ; Receptors, IgE ; Omalizumab (2P471X1Z11) ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2020-11-05
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2020.10.033
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  10. Article ; Online: Letter by Varricchi et al Regarding Article, "Role of IgE-FcεR1 in Pathological Cardiac Remodeling and Dysfunction".

    Varricchi, Gilda / Rengo, Giuseppe / Galli, Stephen J

    Circulation

    2021  Volume 144, Issue 13, Page(s) e214–e215

    MeSH term(s) Heart ; Humans ; Immunoglobulin E ; Ventricular Remodeling
    Chemical Substances Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2021-09-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.121.055167
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