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  1. Article ; Online: Treatment of Graves' ophthalmopathy.

    Alijotas-Reig, Jaume

    Medicina clinica

    2021  Volume 158, Issue 2, Page(s) 93

    Title translation Tratamiento de la oftalmopatía de Graves.
    MeSH term(s) Graves Disease ; Graves Ophthalmopathy/diagnosis ; Humans
    Language Spanish
    Publishing date 2021-06-16
    Publishing country Spain
    Document type Letter ; Comment
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2021.03.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Does incomplete obstetric antiphospholipid syndrome really exist?

    Alijotas-Reig, Jaume

    Medicina clinica

    2021  Volume 156, Issue 10, Page(s) 515–519

    MeSH term(s) Antibodies, Antiphospholipid ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Female ; Humans ; Pregnancy ; Pregnancy Complications/diagnosis
    Chemical Substances Antibodies, Antiphospholipid
    Language Spanish
    Publishing date 2021-02-22
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2020.12.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Correspondence on '2023 ACR/EULAR antiphospholipid syndrome classification criteria'.

    Miro-Mur, Francesc A / Alijotas-Reig, Jaume / Anunciacion-Llunell, Ariadna / Marques-Soares, Joana / Esteve-Valverde, Enrique / Pardos-Gea, Jose

    Annals of the rheumatic diseases

    2024  Volume 83, Issue 3, Page(s) e2

    MeSH term(s) Humans ; Antiphospholipid Syndrome/diagnosis ; Antibodies, Antiphospholipid ; Sjogren's Syndrome ; Rheumatology
    Chemical Substances Antibodies, Antiphospholipid
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Letter
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/ard-2023-225042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Acquired thrombotic thrombocytopenic purpura and pregnancy: More light than shade but controversies remain.

    Alijotas-Reig, Jaume

    Thrombosis research

    2017  Volume 156, Page(s) 195–197

    MeSH term(s) ADAM Proteins ; Female ; Humans ; Light ; Plasma Exchange ; Pregnancy ; Pregnancy Complications, Hematologic ; Purpura, Thrombotic Thrombocytopenic
    Chemical Substances ADAM Proteins (EC 3.4.24.-)
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2017.07.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Thrombosis and Hyperinflammation in COVID-19 Acute Phase Are Related to Anti-Phosphatidylserine and Anti-Phosphatidylinositol Antibody Positivity.

    Alijotas-Reig, Jaume / Anunciación-Llunell, Ariadna / Morales-Pérez, Stephanie / Trapé, Jaume / Esteve-Valverde, Enrique / Miro-Mur, Francesc

    Biomedicines

    2023  Volume 11, Issue 8

    Abstract: Antiphospholipid antibodies (APLA) are strongly associated with thrombosis seen in patients with antiphospholipid syndrome. In COVID-19, thrombosis has been observed as one of the main comorbidities. In patients hospitalised for COVID-19, we want to ... ...

    Abstract Antiphospholipid antibodies (APLA) are strongly associated with thrombosis seen in patients with antiphospholipid syndrome. In COVID-19, thrombosis has been observed as one of the main comorbidities. In patients hospitalised for COVID-19, we want to check whether APLA positivity is associated with COVID-19-related thrombosis, inflammation, severity of disease, or long COVID-19. We enrolled 92 hospitalised patients with COVID-19 between March and April 2020 who were tested for 18 different APLAs (IgG and IgM) with a single line-immunoassay test. A total of 30 healthy blood donors were used to set the cut-off for each APLA positivity. Of the 92 COVID-19 inpatients, 30 (32.61%; 95% CI [23.41-43.29]) tested positive for APLA, of whom 10 (33.3%; 95% CI [17.94-52.86]) had more than one APLA positivity. Anti-phosphatidylserine IgM positivity was described in 5.4% of inpatients (
    Language English
    Publishing date 2023-08-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11082301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Pituitary-Adrenal Axis and Peripheral Immune Cell Profile in Long COVID.

    Alijotas-Reig, Jaume / Anunciacion-Llunell, Ariadna / Esteve-Valverde, Enrique / Morales-Pérez, Stephanie / Rivero-Santana, Sergio / Trapé, Jaume / González-García, Laura / Ruiz, Domingo / Marques-Soares, Joana / Miro-Mur, Francesc

    Biomedicines

    2024  Volume 12, Issue 3

    Abstract: In Long COVID, dysfunction in the pituitary-adrenal axis and alterations in immune cells and inflammatory status are warned against. We performed a prospective study in a cohort of 42 patients who suffered COVID-19 at least 6 months before attending the ... ...

    Abstract In Long COVID, dysfunction in the pituitary-adrenal axis and alterations in immune cells and inflammatory status are warned against. We performed a prospective study in a cohort of 42 patients who suffered COVID-19 at least 6 months before attending the Long COVID unit at Althaia Hospital. Based on Post-COVID Functional Status, 29 patients were diagnosed with Long COVID, while 13 were deemed as recovered. The hormones of the pituitary-adrenal axis, adrenocorticotropin stimulation test, and immune cell profiles and inflammatory markers were examined. Patients with Long COVID had significantly lower EuroQol and higher mMRC scores compared to the recovered individuals. Their symptoms included fatigue, myalgia, arthralgia, persistent coughing, a persistent sore throat, dyspnoea, a lack of concentration, and anxiety. We observed the physiological levels of cortisol and adrenocorticotropin in individuals with or without Long COVID. The results of the adrenocorticotropin stimulation test were similar between both groups. The absolute number of neutrophils was lower in the Long COVID patients compared to recovered individuals (
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12030581
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  7. Article ; Online: Risk of adverse pregnancy outcomes prior to the onset of an autoimmune rheumatic disease: a systematic review.

    Muñoz, Candido Muñoz / Goulden, Bethan / Ahmed, Kawser / Alijotas-Reig, Jaume / Giles, Ian

    Rheumatology (Oxford, England)

    2022  Volume 62, Issue 2, Page(s) 497–511

    Abstract: Objectives: An increased risk of adverse maternal and foetal pregnancy complications (including pre-eclampsia, intrauterine growth restriction, and small for gestational age) is well described in women with autoimmune rheumatic disease (ARD) compared ... ...

    Abstract Objectives: An increased risk of adverse maternal and foetal pregnancy complications (including pre-eclampsia, intrauterine growth restriction, and small for gestational age) is well described in women with autoimmune rheumatic disease (ARD) compared with the general population (GenPop). It is less clear, however, whether this risk of adverse pregnancy outcome (APO) also exists in women with 'preclinical ARD' (pre-ARD) before they are diagnosed with an ARD many years post-partum. Therefore, we have undertaken a systematic review of the available evidence on APO in patients who subsequently were diagnosed with a rheumatic disease to identify whether there is an increased risk in pre-ARD.
    Methods: The present study was reported in accordance with the guidance of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standard. A systematic literature review was performed using the online PubMed database. Pre-SLE and pre-RA patients were defined as those who, over the subsequent years, developed SLE or RA according to international classification criteria.
    Results: A total of 176 articles were screened, and 27 original articles were selected for final analysis. Pre-RA was the most studied group, with 15 studies and a total of >1600 pregnancies, and pre-SLE was the second-most studied pre-ARD in pregnancy, with 14 studies and a total of >1000 pregnancies. We found that patients who subsequently developed SLE had an increased burden of poor pregnancy outcomes compared with pregnant women from the GenPop, but fewer APOs compared with pregnancies of women with SLE. In contrast, a similar rate of APOs was found when pre-RA pregnancies were compared with GenPop pregnancies.
    Conclusion: Our findings of an increased risk of APO in certain pre-ARDs highlights the relevance of taking an obstetric history during the first rheumatology appointment and the need for novel screening strategies for the prediction of APOs. Further research is required to elucidate the immune basis of APOs in preclinical and clinical ARD.
    MeSH term(s) Pregnancy ; Humans ; Female ; Pregnancy Outcome/epidemiology ; Pregnancy Complications/epidemiology ; Pregnancy Complications/etiology ; Pre-Eclampsia ; Autoimmune Diseases/complications ; Fetal Growth Retardation ; Rheumatic Diseases/complications ; Lupus Erythematosus, Systemic/complications ; Retrospective Studies
    Language English
    Publishing date 2022-08-15
    Publishing country England
    Document type Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keac417
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  8. Article ; Online: Antiphospholipid antibodies in women with recurrent embryo implantation failure: A systematic review and meta-analysis.

    Jarne-Borràs, Marina / Miró-Mur, Francesc / Anunciación-Llunell, Ariadna / Alijotas-Reig, Jaume

    Autoimmunity reviews

    2022  Volume 21, Issue 6, Page(s) 103101

    Abstract: Objective: Antiphospholipid antibodies (aPL) are related to poor pregnancy outcomes, but their effect on embryo implantation is unclear. We aimed to assess the prevalence of different aPL in women with recurrent implantation failure (RIF).: Methods: ... ...

    Abstract Objective: Antiphospholipid antibodies (aPL) are related to poor pregnancy outcomes, but their effect on embryo implantation is unclear. We aimed to assess the prevalence of different aPL in women with recurrent implantation failure (RIF).
    Methods: We searched studies in PubMed (MEDLINE), Scopus and Cochrane Library. Quality of studies was scored by the Newcastle-Ottawa Scale and risk of bias assessment by items described in RevMan5 software. Statistical analyses were made using random-effects model and presented as pooled Odds Ratio (OR), 95% confidence interval (CI). Heterogeneity was assessed by I
    Results: This systematic review and meta-analysis included 17 studies and showed a high degree of variability in aPL positivity in RIF. In the latter, the risk of bias assessment suggested unclear bias on study performance with a median sample size and interquartile range for RIF patients and fertile women of 96 (57-417) and 100 (60.5-202.5), respectively. Among the criteria aPL, IgG anticardiolipin autoantibodies (OR 5.02, 95% CI [1.95, 12.93]) were associated with RIF. Within the non-criteria aPL, anti-β2 glycoprotein I-IgA (OR 64.8, 95% CI [9.74, 431.0]), and antiphosphatidylglycerol-IgG and IgM (OR 10.74, 95% CI [5.25, 22.0]; OR 4.26, 95% CI [1.76,10.31]; respectively) were associated with RIF, too.
    Conclusions: Anticardiolipin-IgG is a prevalent autoantibody in women with RIF. Three other non-criteria aPL, aβ2GP I-IgA, aPG-IgG and aPG-IgM also present a positive rate in RIF. Overall, these results advise about testing them as indicators of RIF risk in women seeking IVF treatment.
    MeSH term(s) Antibodies, Anticardiolipin ; Antibodies, Antiphospholipid ; Antiphospholipid Syndrome ; Embryo Implantation ; Female ; Humans ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; Pregnancy
    Chemical Substances Antibodies, Anticardiolipin ; Antibodies, Antiphospholipid ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M
    Language English
    Publishing date 2022-04-20
    Publishing country Netherlands
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2022.103101
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  9. Article ; Online: Inflammatory immune-mediated adverse reactions induced by COVID-19 vaccines in previously injected patients with soft tissue fillers: A case series of 20 patients.

    Alijotas-Reig, Jaume / García-GImenez, Victor / Velthuis, Peter J / Niessen, Frank B / Decates, Tom S

    Journal of cosmetic dermatology

    2022  Volume 21, Issue 8, Page(s) 3181–3187

    Abstract: Background: Adverse events (AE) after COVID-19 vaccines, particularly, but not solely, with those messenger RNA (mRNA)-based vaccines, have rarely been reported in patients previously treated with dermal fillers (DF).: Objective: To evaluate the ... ...

    Abstract Background: Adverse events (AE) after COVID-19 vaccines, particularly, but not solely, with those messenger RNA (mRNA)-based vaccines, have rarely been reported in patients previously treated with dermal fillers (DF).
    Objective: To evaluate the morphology, clinical characteristics, the timing of presentation, and outcomes of inflammatory AE appeared in patients injected with DF, after anti-COVID-19 vaccination.
    Methods: Descriptive study of a case series of 20 consecutive patients collected after the occurrence of AE in previously filled areas post COVID-19 vaccination.
    Results: From January 2021 to July 2021, we analyzed 20 AE reactions triggered by COVID-19 vaccines in the previously mentioned cohort. They were vaccinated with Pfizer/Biontech (11; 55%), Moderna (5; 25%), Astra-Zeneca (3; 15%), and Sputnik (1; 5%). The most common manifestations were oedema/swelling, angioedema, erythema, skin induration, and granuloma. Less common reactions included myalgia and lymphadenopathy. In 13/20 (65%) cases, the AE appeared after the first dose of vaccine. These inflammatory AE appeared more rapidly after the second dose than after the first one. In 13/20 (65%) cases, the symptomatology subsided with anti-inflammatory/antihistaminic drugs, while spontaneously in 3/20 (15%). The manifestations are ongoing.in the remaining four cases (20%).
    Conclusion: Although probably rare, both RNA-based and adenovirus-based anti-COVID-19 vaccines can cause inflammatory bouts in patients previously treated with DF. In these cases, caution should be paid on subsequent vaccine doses, considering a tailored risk/benefit for any case before next vaccination.
    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Dermal Fillers/adverse effects ; Humans ; Inflammation/etiology ; Injections/adverse effects ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Dermal Fillers ; Vaccines
    Language English
    Publishing date 2022-06-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.15117
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  10. Article ; Online: Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex.

    Kandhaya-Pillai, Renuka / Miro-Mur, Francesc / Alijotas-Reig, Jaume / Tchkonia, Tamar / Schwartz, Simo / Kirkland, James L / Oshima, Junko

    Aging

    2023  Volume 15, Issue 10, Page(s) 4012–4034

    Abstract: Cellular senescence is a dynamic stress response process that contributes to aging. From initiation to maintenance, senescent cells continuously undergo complex molecular changes and develop an altered transcriptome. Understanding how the molecular ... ...

    Abstract Cellular senescence is a dynamic stress response process that contributes to aging. From initiation to maintenance, senescent cells continuously undergo complex molecular changes and develop an altered transcriptome. Understanding how the molecular architecture of these cells evolve to sustain their non-proliferative state will open new therapeutic avenues to alleviate or delay the consequences of aging. Seeking to understand these molecular changes, we studied the transcriptomic profiles of endothelial replication-induced senescence and senescence induced by the inflammatory cytokine, TNF-α. We previously reported gene expressional pattern, pathways, and the mechanisms associated with upregulated genes during TNF-α induced senescence. Here, we extend our work and find downregulated gene signatures of both replicative and TNF-α senescence were highly overlapped, involving the decreased expression of several genes associated with cell cycle regulation, DNA replication, recombination, repair, chromatin structure, cellular assembly, and organization. We identified multiple targets of p53/p16-RB-E2F-DREAM that are essential for proliferation, mitotic progression, resolving DNA damage, maintaining chromatin integrity, and DNA synthesis that were repressed in senescent cells. We show that repression of multiple target genes in the p53/p16-RB-E2F-DREAM pathway collectively contributes to the stability of the senescent arrest. Our findings show that the regulatory connection between DREAM and cellular senescence may play a potential role in the aging process.
    MeSH term(s) Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Chromatin ; Cellular Senescence/genetics ; DNA Repair/genetics
    Chemical Substances Tumor Suppressor Protein p53 ; Tumor Necrosis Factor-alpha ; Chromatin
    Language English
    Publishing date 2023-05-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.204743
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