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  1. Article: Immunopathogenesis of SARS-CoV-2-induced pneumonia: lessons from influenza virus infection.

    Miyazawa, Masaaki

    Inflammation and regeneration

    2020  Volume 40, Page(s) 39

    Abstract: Factors determining the progression of frequently mild or asymptomatic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection into life-threatening pneumonia remain poorly understood. Viral and host factors involved in the development of ... ...

    Abstract Factors determining the progression of frequently mild or asymptomatic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection into life-threatening pneumonia remain poorly understood. Viral and host factors involved in the development of diffuse alveolar damage have been extensively studied in influenza virus infection. Influenza is a self-limited upper respiratory tract infection that causes acute and severe systemic symptoms and its spread to the lungs is limited by CD4
    Keywords covid19
    Language English
    Publishing date 2020-10-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2051471-2
    ISSN 1880-9693 ; 0389-4290
    ISSN 1880-9693 ; 0389-4290
    DOI 10.1186/s41232-020-00148-1
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  2. Article ; Online: Immunopathogenesis of SARS-CoV-2-induced pneumonia

    Masaaki Miyazawa

    Inflammation and Regeneration, Vol 40, Iss 1, Pp 1-

    lessons from influenza virus infection

    2020  Volume 13

    Abstract: Abstract Factors determining the progression of frequently mild or asymptomatic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection into life-threatening pneumonia remain poorly understood. Viral and host factors involved in the ... ...

    Abstract Abstract Factors determining the progression of frequently mild or asymptomatic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection into life-threatening pneumonia remain poorly understood. Viral and host factors involved in the development of diffuse alveolar damage have been extensively studied in influenza virus infection. Influenza is a self-limited upper respiratory tract infection that causes acute and severe systemic symptoms and its spread to the lungs is limited by CD4+ T-cell responses. A vicious cycle of CCL2- and CXCL2-mediated inflammatory monocyte and neutrophil infiltration and activation and resultant massive production of effector molecules including tumor necrosis factor (TNF)-α, nitric oxide, and TNF-related apoptosis-inducing ligand are involved in the pathogenesis of progressive tissue injury. SARS-CoV-2 directly infects alveolar epithelial cells and macrophages and induces foci of pulmonary lesions even in asymptomatic individuals. Mechanisms of tissue injury in SARS-CoV-2-induced pneumonia share some aspects with influenza virus infection, but IL-1β seems to play more important roles along with CCL2 and impaired type I interferon signaling might be associated with delayed virus clearance and disease severity. Further, data indicate that preexisting memory CD8+ T cells may play important roles in limiting viral spread in the lungs and prevent progression from mild to severe or critical pneumonia. However, it is also possible that T-cell responses are involved in alveolar interstitial inflammation and perhaps endothelial cell injury, the latter of which is characteristic of SARS-CoV-2-induced pathology.
    Keywords SARS-CoV-2 ; Influenza virus ; Pneumonia ; Tissue injury ; Cytokines ; Chemokines ; Pathology ; RB1-214 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
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  3. Article ; Online: Integrating mathematical approaches (IMAS): Novel methodology for predicting dermal absorption rates of chemicals under finite dose conditions.

    Kunita, Ryoki / Nishijima, Takafumi / Todo, Hiroaki / Miyazawa, Masaaki

    The Journal of toxicological sciences

    2024  Volume 49, Issue 5, Page(s) 219–230

    Abstract: Quantitative structure permeation relationship (QSPR) models have gained prominence in recent years owing to their capacity to elucidate the influence of physicochemical properties on the dermal absorption of chemicals. These models facilitate the ... ...

    Abstract Quantitative structure permeation relationship (QSPR) models have gained prominence in recent years owing to their capacity to elucidate the influence of physicochemical properties on the dermal absorption of chemicals. These models facilitate the prediction of permeation coefficient (Kp) values, indicating the skin permeability of a chemical under infinite dose conditions. Conversely, obtaining dermal absorption rates (DAs) under finite dose conditions, which are crucial for skin product safety evaluation, remains a challenge when relying solely on Kp predictions from QSPR models. One proposed resolution involves using Kroes' methodology, categorizing DAs based on Kp values; however, refinement becomes necessary owing to discreteness in the obtained values. We previously developed a mathematical model using Kp values obtained from in vitro dermal absorption tests to predict DAs. The present study introduces a new methodology, Integrating Mathematical Approaches (IMAS), which combines QSPR models and our mathematical model to predict DAs for risk assessments without conducting in vitro dermal absorption tests. Regarding 40 chemicals (76.1 ≤ MW ≤ 220; -1.4 ≤ Log K
    MeSH term(s) Skin Absorption ; Quantitative Structure-Activity Relationship ; Risk Assessment ; Permeability ; Skin/metabolism ; Humans ; Models, Theoretical ; Solubility ; Hydrophobic and Hydrophilic Interactions ; Animals ; Models, Biological
    Language English
    Publishing date 2024-05-02
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 770623-6
    ISSN 1880-3989 ; 0388-1350
    ISSN (online) 1880-3989
    ISSN 0388-1350
    DOI 10.2131/jts.49.219
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  4. Article ; Online: Importance of tenosynovitis in preventing the progression through rheumatoid arthritis continuum.

    Izumiyama, Tomomasa / Miyazawa, Masaaki

    Modern rheumatology

    2022  Volume 33, Issue 5, Page(s) 868–874

    Abstract: Rheumatoid arthritis (RA) has long been characterized by synovitis and bone erosions typically developing symmetrically in small joints. However, recent advances in imaging modalities have indicated frequent association of tenosynovitis with RA, and some ...

    Abstract Rheumatoid arthritis (RA) has long been characterized by synovitis and bone erosions typically developing symmetrically in small joints. However, recent advances in imaging modalities have indicated frequent association of tenosynovitis with RA, and some consider tenosynovitis to be not just a complication but a major trait of RA. Furthermore, as there are cases with tenosynovitis preceding the clinical detection of inflammatory arthritis in predisposed individuals, tenosynovitis may constitute an important biomarker in defining the pre-RA phase of disease development. Tenosynovitis itself must be treated as it causes functional impairment and physical as well as socioeconomic burden, and its treatment may result in effective prevention of RA development at a pre-arthritic stage. Thus, further efforts need to be taken in detecting and treating tenosynovitis in the pre-RA stage, which can be facilitated by ultrasonography and magnetic resonance imaging.
    MeSH term(s) Humans ; Tenosynovitis/complications ; Tenosynovitis/diagnostic imaging ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/diagnostic imaging ; Synovitis/complications ; Synovitis/diagnostic imaging ; Biomarkers ; Magnetic Resonance Imaging/methods
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-09-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2078157-X
    ISSN 1439-7609 ; 1439-7595
    ISSN (online) 1439-7609
    ISSN 1439-7595
    DOI 10.1093/mr/roac109
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  5. Article ; Online: Author Correction: CTLA-4 suppresses hapten-induced contact hypersensitivity in atopic dermatitis model mice.

    Tetsu, Hiroe / Nakayama, Kanako / Nishijo, Taku / Yuki, Takuo / Miyazawa, Masaaki

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 10552

    Language English
    Publishing date 2023-06-29
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-37446-w
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  6. Article: Immunopathogenesis of SARS-CoV-2-induced pneumonia: lessons from influenza virus infection

    Miyazawa, Masaaki

    Inflammation and Regeneration

    Abstract: Factors determining the progression of frequently mild or asymptomatic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection into life-threatening pneumonia remain poorly understood Viral and host factors involved in the development of ... ...

    Abstract Factors determining the progression of frequently mild or asymptomatic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection into life-threatening pneumonia remain poorly understood Viral and host factors involved in the development of diffuse alveolar damage have been extensively studied in influenza virus infection Influenza is a self-limited upper respiratory tract infection that causes acute and severe systemic symptoms and its spread to the lungs is limited by CD4 + T-cell responses A vicious cycle of CCL2- and CXCL2-mediated inflammatory monocyte and neutrophil infiltration and activation and resultant massive production of effector molecules including tumor necrosis factor (TNF)-α, nitric oxide, and TNF-related apoptosis-inducing ligand are involved in the pathogenesis of progressive tissue injury SARS-CoV-2 directly infects alveolar epithelial cells and macrophages and induces foci of pulmonary lesions even in asymptomatic individuals Mechanisms of tissue injury in SARS-CoV-2-induced pneumonia share some aspects with influenza virus infection, but IL-1β seems to play more important roles along with CCL2 and impaired type I interferon signaling might be associated with delayed virus clearance and disease severity Further, data indicate that preexisting memory CD8 + T cells may play important roles in limiting viral spread in the lungs and prevent progression from mild to severe or critical pneumonia However, it is also possible that T-cell responses are involved in alveolar interstitial inflammation and perhaps endothelial cell injury, the latter of which is characteristic of SARS-CoV-2-induced pathology
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #845231
    Database COVID19

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  7. Article ; Online: Evaluating the applicability of the Ames test for cosmetic packaging assessment by comparing carcinogenic risk levels of migrants from plastics with biological detection limits.

    Kunita, Ryoki / Kawamoto, Taisuke / Nishijima, Takafumi / Miyazawa, Masaaki

    Regulatory toxicology and pharmacology : RTP

    2023  Volume 139, Page(s) 105363

    Abstract: Risk assessments for cosmetic packaging are required according to the EU Cosmetics Regulation (EC) No. 1223/2009, however, the assessment method is well-established for food packaging but limited for cosmetic packaging. In food packaging assessments, ... ...

    Abstract Risk assessments for cosmetic packaging are required according to the EU Cosmetics Regulation (EC) No. 1223/2009, however, the assessment method is well-established for food packaging but limited for cosmetic packaging. In food packaging assessments, Cramer class III TTC (90 μg/day) is applied as the threshold for systemic toxicity when the Ames test including the process of sample concentration steps provides the negative results. However, the human health risks of mutagenic and carcinogenic migrants at exposure levels where the Ames test with the concentrated samples cannot detect are unclear. In the present study, to confirm the applicability of the Ames test for cosmetic packaging assessments, the toxicological data on 37 candidate migrants with Ames test-positive results was collected. For these migrants, the carcinogenic risk levels through cosmetics use were compared to the detection levels of the Ames test for concentrated samples. Regarding at least 32 migrants, the case study showed the negative result from the Ames test incorporating the sample concentration process would indicate negligible mutagenic and carcinogenic risks of packaging extracts. Therefore, application of the Ames test to cosmetic packaging assessments would be helpful to ensure the safety for mutagenicity and carcinogenicity as well as use Cramer-TTC for systemic toxicity.
    MeSH term(s) Humans ; Carcinogens/toxicity ; Plastics/toxicity ; Limit of Detection ; Transients and Migrants ; Cosmetics/toxicity ; Mutagens/toxicity ; Mutagens/analysis ; Risk Assessment
    Chemical Substances Carcinogens ; Plastics ; Cosmetics ; Mutagens
    Language English
    Publishing date 2023-02-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604672-1
    ISSN 1096-0295 ; 0273-2300
    ISSN (online) 1096-0295
    ISSN 0273-2300
    DOI 10.1016/j.yrtph.2023.105363
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  8. Article ; Online: Author Correction

    Hiroe Tetsu / Kanako Nakayama / Taku Nishijo / Takuo Yuki / Masaaki Miyazawa

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    CTLA-4 suppresses hapten-induced contact hypersensitivity in atopic dermatitis model mice

    2023  Volume 1

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
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  9. Article ; Online: CTLA-4 suppresses hapten-induced contact hypersensitivity in atopic dermatitis model mice.

    Tetsu, Hiroe / Nakayama, Kanako / Nishijo, Taku / Yuki, Takuo / Miyazawa, Masaaki

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 7936

    Abstract: Atopic dermatitis (AD) patients with skin barrier dysfunction are considered to be at a higher risk of allergic contact dermatitis (ACD), although previous studies showed that attenuated ACD responses to strong sensitizers in AD patients compared to ... ...

    Abstract Atopic dermatitis (AD) patients with skin barrier dysfunction are considered to be at a higher risk of allergic contact dermatitis (ACD), although previous studies showed that attenuated ACD responses to strong sensitizers in AD patients compared to healthy controls. However, the mechanisms of ACD response attenuation in AD patients are unclear. Therefore, using the contact hypersensitivity (CHS) mouse model, this study explored the differences in CHS responses to hapten sensitization between NC/Nga mice with or without AD induction (i.e., non-AD and AD mice, respectively). In this study, ear swelling and hapten-specific T cell proliferation were significantly lower in AD than in non-AD mice. Moreover, we examined the T cells expressing cytotoxic T lymphocyte antigen-4 (CTLA-4), which is known to suppress T cell activation, and found a higher frequency of CTLA-4
    MeSH term(s) Mice ; Animals ; Dermatitis, Atopic/chemically induced ; CTLA-4 Antigen ; Dermatitis, Allergic Contact ; Haptens ; T-Lymphocytes, Regulatory
    Chemical Substances CTLA-4 Antigen ; Haptens
    Language English
    Publishing date 2023-05-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-35139-y
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  10. Article ; Online: Tolerogenic phenotype of dendritic cells is induced after hapten sensitization followed by attenuated contact hypersensitivity response in atopic dermatitis model NC/Nga mice.

    Nakayama, Kanako / Tetsu, Hiroe / Nishijo, Taku / Yuki, Takuo / Miyazawa, Masaaki

    Biochemical and biophysical research communications

    2023  Volume 678, Page(s) 24–32

    Abstract: Allergic contact dermatitis (ACD) and atopic dermatitis (AD) are common inflammatory diseases. We previously reported attenuated contact hypersensitivity (CHS) responses in AD model mice using 2,4-dinitrofluorobenzene, reflecting clinical experiments. ... ...

    Abstract Allergic contact dermatitis (ACD) and atopic dermatitis (AD) are common inflammatory diseases. We previously reported attenuated contact hypersensitivity (CHS) responses in AD model mice using 2,4-dinitrofluorobenzene, reflecting clinical experiments. However, previous studies have not addressed the commonality of findings across haptens and mechanisms focused on dendritic cells (DCs). Thus, this study evaluated CHS responses to fluorescein isothiocyanate (FITC) and DC migration and maturation in the sensitization phase of CHS in AD. CHS responses to FITC were compared between NC/Nga mice without and with AD induction (non-AD and AD mice, respectively). T-cell responses and DC migration and maturation after FITC-induced sensitization were examined in the draining lymph nodes of non-AD and AD mice. AD mice demonstrated reduced CHS responses to FITC under decreased T-cell proliferation following sensitization and interferon-γ production by hapten-specific T cells compared with non-AD mice. In addition, the number of FITC
    MeSH term(s) Mice ; Animals ; Dermatitis, Atopic ; Fluorescein-5-isothiocyanate ; Phenotype ; Fluorescein ; Haptens ; Dermatitis, Contact ; Dendritic Cells
    Chemical Substances Fluorescein-5-isothiocyanate (I223NX31W9) ; isothiocyanic acid (3129-90-6) ; Fluorescein (TPY09G7XIR) ; Haptens
    Language English
    Publishing date 2023-08-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2023.08.042
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