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  1. Article ; Online: Emerging Potential of Plant Virus Nanoparticles (PVNPs) in Anticancer Immunotherapies.

    Shahgolzari, Mehdi / Fiering, Steven

    Journal of cancer immunology

    2022  Volume 4, Issue 1, Page(s) 22–29

    Abstract: Cancer immunotherapies using plant virus nanoparticles (PVNPs) have achieved considerable success in preclinical studies. PVNP based nanoplatforms can be endogenous immune adjuvants and act as nanocarriers that stabilize and deliver cancer antigens and ... ...

    Abstract Cancer immunotherapies using plant virus nanoparticles (PVNPs) have achieved considerable success in preclinical studies. PVNP based nanoplatforms can be endogenous immune adjuvants and act as nanocarriers that stabilize and deliver cancer antigens and exogenous immune adjuvants. Although they do not infect mammalian cells, PVNPs are viruses and they are variably recognized by pathogen pattern recognition receptors (PRR), activate innate immune cells including antigen-presenting cells (APCs), and increase the expression of costimulatory molecules. Novel immunotherapy strategies use them as
    Language English
    Publishing date 2022-05-24
    Publishing country United States
    Document type Journal Article
    ISSN 2689-968X
    ISSN (online) 2689-968X
    DOI 10.33696/cancerimmunol.4.061
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  2. Article ; Online: Combining

    Kalami, Arman / Shahgolzari, Mehdi / Khosroushahi, Ahmad Yari / Fiering, Steven

    Immunotherapy

    2023  Volume 15, Issue 5, Page(s) 367–381

    Abstract: Immunization approaches are designed to stimulate the immune system and eliminate the tumor. Studies indicate that cancer immunization combined with certain chemotherapeutics and immunostimulatory agents can improve outcomes. Chemotherapeutics-based ... ...

    Abstract Immunization approaches are designed to stimulate the immune system and eliminate the tumor. Studies indicate that cancer immunization combined with certain chemotherapeutics and immunostimulatory agents can improve outcomes. Chemotherapeutics-based immunogenic cell death makes the tumor more recognizable by the immune system.
    MeSH term(s) Humans ; Neoplasms/therapy ; Vaccination ; Immunization ; Apoptosis ; Adjuvants, Immunologic/therapeutic use ; Tumor Microenvironment
    Chemical Substances Adjuvants, Immunologic
    Language English
    Publishing date 2023-02-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2495964-9
    ISSN 1750-7448 ; 1750-743X
    ISSN (online) 1750-7448
    ISSN 1750-743X
    DOI 10.2217/imt-2022-0137
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  3. Article ; Online: Green Synthesis of Near-Infrared Copper-Doped Carbon Dots from

    Najaflu, Meysam / Shahgolzari, Mehdi / Bani, Farhad / Khosroushahi, Ahmad Yari

    ACS omega

    2022  Volume 7, Issue 38, Page(s) 34573–34582

    Abstract: Heteroatom-doped carbon dots (CDs) with optical absorbance in the near-infrared (NIR) region can provide an opportunity for selective cancer photothermal therapy (PTT). Here, an eco-friendly, simple, cost-efficient, and one-step hydrothermal method was ... ...

    Abstract Heteroatom-doped carbon dots (CDs) with optical absorbance in the near-infrared (NIR) region can provide an opportunity for selective cancer photothermal therapy (PTT). Here, an eco-friendly, simple, cost-efficient, and one-step hydrothermal method was developed to synthesize copper-doped CDs (Cu-doped CDs). The
    Language English
    Publishing date 2022-09-13
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c04484
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  4. Article: Plant Virus Nanoparticles Combat Cancer.

    Shahgolzari, Mehdi / Venkataraman, Srividhya / Osano, Anne / Akpa, Paul Achile / Hefferon, Kathleen

    Vaccines

    2023  Volume 11, Issue 8

    Abstract: Plant virus nanoparticles (PVNPs) have garnered considerable interest as a promising nanotechnology approach to combat cancer. Owing to their biocompatibility, stability, and adjustable surface functionality, PVNPs hold tremendous potential for both ... ...

    Abstract Plant virus nanoparticles (PVNPs) have garnered considerable interest as a promising nanotechnology approach to combat cancer. Owing to their biocompatibility, stability, and adjustable surface functionality, PVNPs hold tremendous potential for both therapeutic and imaging applications. The versatility of PVNPs is evident from their ability to be tailored to transport a range of therapeutic agents, including chemotherapy drugs, siRNA, and immunomodulators, thereby facilitating targeted delivery to the tumor microenvironment (TME). Furthermore, PVNPs may be customized with targeting ligands to selectively bind to cancer cell receptors, reducing off-target effects. Additionally, PVNPs possess immunogenic properties and can be engineered to exhibit tumor-associated antigens, thereby stimulating anti-tumor immune responses. In conclusion, the potential of PVNPs as a versatile platform for fighting cancer is immense, and further research is required to fully explore their potential and translate them into clinical applications.
    Language English
    Publishing date 2023-07-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11081278
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  5. Article ; Online: Development of a novel multi‑epitope vaccine against the pathogenic human polyomavirus V6/7 using reverse vaccinology.

    Salahlou, Reza / Farajnia, Safar / Bargahi, Nasrin / Bakhtiyari, Nasim / Elmi, Faranak / Shahgolzari, Mehdi / Fiering, Steven / Venkataraman, Srividhya

    BMC infectious diseases

    2024  Volume 24, Issue 1, Page(s) 177

    Abstract: Background: Human polyomaviruses contribute to human oncogenesis through persistent infections, but currently there is no effective preventive measure against the malignancies caused by this virus. Therefore, the development of a safe and effective ... ...

    Abstract Background: Human polyomaviruses contribute to human oncogenesis through persistent infections, but currently there is no effective preventive measure against the malignancies caused by this virus. Therefore, the development of a safe and effective vaccine against HPyV is of high priority.
    Methods: First, the proteomes of 2 polyomavirus species (HPyV6 and HPyV7) were downloaded from the NCBI database for the selection of the target proteins. The epitope identification process focused on selecting proteins that were crucial, associated with virulence, present on the surface, antigenic, non-toxic, and non-homologous with the human proteome. Then, the immunoinformatic methods were used to identify cytotoxic T-lymphocyte (CTL), helper T-lymphocyte (HTL), and B-cell epitopes from the target antigens, which could be used to create epitope-based vaccine. The physicochemical features of the designed vaccine were predicted through various online servers. The binding pattern and stability between the vaccine candidate and Toll-like receptors were analyzed through molecular docking and molecular dynamics (MD) simulation, while the immunogenicity of the designed vaccines was assessed using immune simulation.
    Results: Online tools were utilized to forecast the most optimal epitope from the immunogenic targets, including LTAg, VP1, and VP1 antigens of HPyV6 and HPyV7. A multi-epitope vaccine was developed by combining 10 CTL, 7 HTL, and 6 LBL epitopes with suitable linkers and adjuvant. The vaccine displayed 98.35% of the world's population coverage. The 3D model of the vaccine structure revealed that the majority of residues (87.7%) were located in favored regions of the Ramachandran plot. The evaluation of molecular docking and MD simulation revealed that the constructed vaccine exhibits a strong binding (-1414.0 kcal/mol) towards the host's TLR4. Moreover, the vaccine-TLR complexes remained stable throughout the dynamic conditions present in the natural environment. The immune simulation results demonstrated that the vaccine design had the capacity to elicit robust immune responses in the host.
    Conclusion: The multi-parametric analysis revealed that the designed vaccine is capable of inducing sustained immunity against the selected polyomaviruses, although further in-vivo investigations are needed to verify its effectiveness.
    MeSH term(s) Humans ; Molecular Docking Simulation ; Vaccinology ; Epitopes, T-Lymphocyte ; Vaccines ; Polyomavirus/genetics ; Computational Biology/methods
    Chemical Substances Epitopes, T-Lymphocyte ; Vaccines
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-024-09046-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Multifunctional plant virus nanoparticles in the next generation of cancer immunotherapies.

    Shahgolzari, Mehdi / Dianat-Moghadam, Hassan / Fiering, Steven

    Seminars in cancer biology

    2021  Volume 86, Issue Pt 2, Page(s) 1076–1085

    Abstract: Plant virus nanoparticles (PVNPs) have inherent immune stimulatory ability, and have been investigated as immune adjuvants to stimulate an anti-tumor immune response. The combination of immune stimulation, nanoparticle structure and the ability to ... ...

    Abstract Plant virus nanoparticles (PVNPs) have inherent immune stimulatory ability, and have been investigated as immune adjuvants to stimulate an anti-tumor immune response. The combination of immune stimulation, nanoparticle structure and the ability to deliver other therapeutic molecules provides a flexible platform for cancer immunotherapy. Researching multifunctional PVNPs and their modification will generate novel reagents for cancer immunotherapy. Here we review the properties of PVNPs, and their potential for clinical utilization to activate anti-tumor innate and lymphoid immune responses. PVNPs have potential utility for cancer immunotherapy as vaccine adjuvant, and delivery systems for other reagents as mono immunotherapy or combined with other immunotherapies. This review outlines the potential and challenges in developing PVNPs as cancer immunotherapy reagents.
    MeSH term(s) Humans ; Immunotherapy ; Neoplasms/therapy ; Nanoparticles/chemistry ; Plant Viruses ; Immunologic Factors ; Cancer Vaccines/therapeutic use
    Chemical Substances Immunologic Factors ; Cancer Vaccines
    Language English
    Publishing date 2021-08-08
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1016/j.semcancer.2021.07.018
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2922: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Multifunctional plant virus nanoparticles: An emerging strategy for therapy of cancer.

    Azizi, Mehdi / Shahgolzari, Mehdi / Fathi-Karkan, Sonia / Ghasemi, Maryam / Samadian, Hadi

    Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

    2022  Volume 15, Issue 6, Page(s) e1872

    Abstract: Cancer therapy requires sophisticated treatment strategies to obtain the highest success. Nanotechnology is enabling, revolutionizing, and multidisciplinary concepts to improve conventional cancer treatment modalities. Nanomaterials have a central role ... ...

    Abstract Cancer therapy requires sophisticated treatment strategies to obtain the highest success. Nanotechnology is enabling, revolutionizing, and multidisciplinary concepts to improve conventional cancer treatment modalities. Nanomaterials have a central role in this scenario, explaining why various nanomaterials are currently being developed for cancer therapy. Viral nanoparticles (VNPs) have shown promising performance in cancer therapy due to their unique features. VNPs possess morphological homogeneity, ease of functionalization, biocompatibility, biodegradability, water solubility, and high absorption efficiency that are beneficial for cancer therapy applications. In the current review paper, we highlight state-of-the-art properties and potentials of plant viruses, strategies for multifunctional plant VNPs formulations, potential applications and challenges in VNPs-based cancer therapy, and finally practical solutions to bring potential cancer therapy one step closer to real applications. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Biology-Inspired Nanomaterials > Protein and Virus-Based Structures.
    MeSH term(s) Humans ; Plant Viruses ; Nanotechnology ; Nanomedicine ; Nanostructures ; Nanoparticles/therapeutic use ; Nanoparticles/chemistry ; Neoplasms/drug therapy
    Language English
    Publishing date 2022-11-30
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2502698-7
    ISSN 1939-0041 ; 1939-5116
    ISSN (online) 1939-0041
    ISSN 1939-5116
    DOI 10.1002/wnan.1872
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    Zs.A 6781: Show issues Location:
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  8. Article: Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors.

    Shahgolzari, Mehdi / Dianat-Moghadam, Hassan / Yavari, Afagh / Fiering, Steven N / Hefferon, Kathleen

    Vaccines

    2022  Volume 10, Issue 9

    Abstract: Breast cancer treatment using plant-virus-based nanoparticles (PVNPs) has achieved considerable success in preclinical studies. PVNP-based breast cancer therapies include non-targeted and targeted nanoplatforms for delivery of anticancer therapeutic ... ...

    Abstract Breast cancer treatment using plant-virus-based nanoparticles (PVNPs) has achieved considerable success in preclinical studies. PVNP-based breast cancer therapies include non-targeted and targeted nanoplatforms for delivery of anticancer therapeutic chemo and immune agents and cancer vaccines for activation of local and systemic antitumor immunity. Interestingly, PVNP platforms combined with other tumor immunotherapeutic options and other modalities of oncotherapy can improve tumor efficacy treatment. These applications can be achieved by encapsulation of a wide range of active ingredients and conjugating ligands for targeting immune and tumor cells. This review presents the current breast cancer treatments based on PVNP platforms.
    Language English
    Publishing date 2022-08-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10091431
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  9. Article: Crosslinking strategies for biomimetic hydrogels in bone tissue engineering.

    Dibazar, Zahra Ebrahimvand / Zarei, Mahdi / Mohammadikhah, Meysam / Oudah, Shamam Kareem / Elyasi, Milad / Kokabi, Hadi / Shahgolzari, Mehdi / Asl, Leila Delnabi / Azizy, Mahdi

    Biophysical reviews

    2023  Volume 15, Issue 6, Page(s) 2027–2040

    Abstract: Bone tissue engineering has become a popular area of study for making biomimetic hydrogels to treat bone diseases. In this work, we looked at biocompatible hydrogels that can be injected into bone defects that require the smallest possible surgery. ... ...

    Abstract Bone tissue engineering has become a popular area of study for making biomimetic hydrogels to treat bone diseases. In this work, we looked at biocompatible hydrogels that can be injected into bone defects that require the smallest possible surgery. Mineral ions can be attached to polymer chains to make useful hydrogels that help bones heal faster. These ions are very important for the balance of the body. In the chemically-triggered sector, advanced hydrogels cross-linked by different molecular agents have many advantages, such as being selective, able to form gels, and having mechanical properties that can be modified. In addition, different photo-initiators can be used to make photo cross linkable hydrogels react quickly and moderately under certain light bands. Enzyme-triggered hydrogels are another type of hydrogel that can be used to repair bone tissue because they are biocompatible and gel quickly. We also look at some of the important factors mentioned above that could change how well bone tissue engineering works as a therapy. Finally, this review summarizes the problems that still need to be solved to make clinically relevant hydrogels.
    Language English
    Publishing date 2023-09-25
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2486483-3
    ISSN 1867-2469 ; 1867-2450
    ISSN (online) 1867-2469
    ISSN 1867-2450
    DOI 10.1007/s12551-023-01141-x
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  10. Article ; Online: Probiotic immunonutrition impacts on colon cancer immunotherapy and prevention.

    Nami, Yousef / Hejazi, Salva / Geranmayeh, Mohammad Hossein / Shahgolzari, Mehdi / Yari Khosroushahi, Ahmad

    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)

    2022  Volume 32, Issue 1, Page(s) 30–47

    Abstract: The important role of the immune system in treating cancer has attracted the attention of researchers to the emergence of oncology research. Immunotherapy has shown that the immune system is important in the fight against cancer. The challenge has led ... ...

    Abstract The important role of the immune system in treating cancer has attracted the attention of researchers to the emergence of oncology research. Immunotherapy has shown that the immune system is important in the fight against cancer. The challenge has led researchers to analyze the impact of immunotherapy on improving the status of the immune system, modifying the resulting safety response, reducing toxicity, and improving the results. This study aimed to discuss the potential mechanisms of probiotics in preventing colon cancer. The mechanisms include the change in intestinal microbiota, the metabolic activity of microbiota, the binding and degradation of the carcinogenic compounds present in the lumen of the intestine, the production of compounds with anticancer activity, immune system modification, intestinal dysfunction, changes in host physiology, and inhibition of cell proliferation and induction of apoptosis in cancerous cells. By contrast, very few reports have shown the harmful effects of oral probiotic supplements. According to available evidence, further studies on probiotics are needed, especially in identifying bacterial species with anticancer potential, studying the survival of the strains after passing the digestive tract, reviewing potential side effects in people with a weak immune system, and ultimately consuming and repeating its use. This study emphasizes that the nutritional formula can modulate inflammatory and immune responses in cancer patients. This effect reduces acute toxicity, although the pathways and measurement of this immune response are unclear. Nutrition safety is an emerging field in oncology, and further research is required.
    MeSH term(s) Humans ; Immunonutrition Diet ; Probiotics/therapeutic use ; Colonic Neoplasms/prevention & control ; Gastrointestinal Diseases
    Language English
    Publishing date 2022-09-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1137033-6
    ISSN 1473-5709 ; 0959-8278
    ISSN (online) 1473-5709
    ISSN 0959-8278
    DOI 10.1097/CEJ.0000000000000738
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    Zs.A 3621: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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