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  1. Article: Editorial: Synovial tissue biopsy research.

    Veale, Douglas J / Firestein, Gary S / Wechalekar, Mihir D / Najm, Aurélie

    Frontiers in medicine

    2022  Volume 9, Page(s) 1004029

    Language English
    Publishing date 2022-10-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.1004029
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  2. Article ; Online: The relationship between symptoms of obsessive compulsive disorder and depression during therapy: A random intercept cross-lagged panel model.

    Simkin, Vicky / Hodsoll, John / Veale, David

    Journal of behavior therapy and experimental psychiatry

    2022  Volume 76, Page(s) 101748

    Abstract: Background and objectives: We know little about how symptoms of obsessive-compulsive disorder and depression interact during psychological therapy. Although some previous research suggests that reductions in the severity of depression are driven by ... ...

    Abstract Background and objectives: We know little about how symptoms of obsessive-compulsive disorder and depression interact during psychological therapy. Although some previous research suggests that reductions in the severity of depression are driven by reductions in OCD, support for this conclusion is limited due to the exclusion of individuals with severe depression and limitations of the statistical approaches used.
    Methods: This study re-examined the interaction between symptoms of OCD and depression during therapy in a sample of 137 adults with a primary diagnosis of OCD and a full range of depression severity. All participants received a 12 to 16-week specialist residential treatment. Participants completed the Florida Obsessive Compulsive Inventory and Patient Health Questionnaire for depression weekly. The relationship between severity of OCD and depression was examined using a random intercept cross-lagged panel model.
    Results: Both cross-lagged paths were significant, with prior levels of OCD influencing subsequent levels of depression, and prior levels of depression influencing subsequent levels of OCD.
    Limitations: The present study was conducted in a residential setting, meaning the findings may not generalise to outpatient settings characterised by less severe OCD and depression.
    Conclusions: Contrary to previous findings, which suggest that the influence of OCD on depression is far greater than the reverse, our findings suggest that OCD and depression influence each other equally. As improvements in mood can help to improve symptoms of OCD, it appears important to target depression concurrently during treatment for OCD. This would be a new treatment target for improvement outcomes in OCD.
    MeSH term(s) Adult ; Depression/psychology ; Depressive Disorder ; Humans ; Obsessive-Compulsive Disorder/complications ; Obsessive-Compulsive Disorder/diagnosis ; Obsessive-Compulsive Disorder/therapy
    Language English
    Publishing date 2022-06-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 280250-8
    ISSN 1873-7943 ; 0005-7916
    ISSN (online) 1873-7943
    ISSN 0005-7916
    DOI 10.1016/j.jbtep.2022.101748
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  3. Article: Treating and healing a leg ulcer in a diabetic patient in Wyke Regis Leg Club.

    Spencer-Veale, Demelza / Timmons, John / Hampton, Sylvie

    British journal of community nursing

    2020  Volume 25, Issue 3, Page(s) S30–S31

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Diabetes Complications/nursing ; Female ; Humans ; Leg Ulcer/nursing ; Male ; Middle Aged ; Nursing Care/standards ; Organizational Case Studies ; Practice Guidelines as Topic ; United Kingdom ; Wound Healing/physiology
    Language English
    Publishing date 2020-03-11
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2146386-4
    ISSN 1462-4753
    ISSN 1462-4753
    DOI 10.12968/bjcn.2020.25.Sup3.S30
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  4. Article ; Online: The wellbeing and health needs of a cohort of transgender young people accessing specialist medical gender-affirming healthcare in Auckland.

    Oliphant, Jeannie / Barnett, Daniel / Veale, Jaimie / Denny, Simon / Farrant, Bridget

    The New Zealand medical journal

    2021  Volume 134, Issue 1541, Page(s) 33–44

    Abstract: Introduction: Increasing numbers of young people are seeking gender-affirming healthcare in Aotearoa New Zealand, and although international studies report health and wellbeing benefits of early medical intervention, we have no published reports on the ... ...

    Abstract Introduction: Increasing numbers of young people are seeking gender-affirming healthcare in Aotearoa New Zealand, and although international studies report health and wellbeing benefits of early medical intervention, we have no published reports on the impact of health services in this country.
    Methods: Transgender young people accessing a specialist service providing medical gender-affirming healthcare were invited to take part in a survey about their health and wellbeing.
    Results: High or very high psychological distress levels were reported by 74% of respondents, with 39% being unable to access mental health support when needed.
    Discussion: Although the proportion of transgender young people with high or very high levels of psychological distress was five times greater (74%) than for the general population of young people (14.5%) in Aotearoa New Zealand, it was not as large as the proportion found for transgender young people in a community study (86%) in which an unmet need for hormones was reported by 29%. This highlights the need for clear referral pathways to access specialist gender-affirming healthcare services in order to reduce disparities in mental health outcomes.
    MeSH term(s) Adolescent ; Attitude to Health ; Body Dissatisfaction ; Body Image ; Clinical Competence ; Female ; Health Services Accessibility ; Health Services for Transgender Persons ; Health Status ; Humans ; Male ; Mental Health ; Needs Assessment ; New Zealand/epidemiology ; Physician-Patient Relations ; Primary Health Care ; Psychological Distress ; Self-Injurious Behavior/epidemiology ; Sex Reassignment Procedures/statistics & numerical data ; Social Discrimination ; Suicidal Ideation ; Suicide, Attempted/statistics & numerical data ; Surveys and Questionnaires ; Transgender Persons ; Voice ; Young Adult
    Language English
    Publishing date 2021-09-03
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 390590-1
    ISSN 1175-8716 ; 0028-8446 ; 0110-7704
    ISSN (online) 1175-8716
    ISSN 0028-8446 ; 0110-7704
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  5. Article: The distribution of offshore benthic molluscs provides new insight into South Africa's marine biogeography

    Heyns-Veale, E.R. / Bernard, A.T.F. / Midgley, J.M. / Herbert, D.G.

    Ocean & coastal management. 2022 Feb. 15, v. 217

    2022  

    Abstract: South African marine biogeography has received a great deal of attention in the past. However, offshore biogeographic breaks are based on abiotic variables or specialist opinion rather than data-driven approaches. Here we investigate biogeographic breaks ...

    Abstract South African marine biogeography has received a great deal of attention in the past. However, offshore biogeographic breaks are based on abiotic variables or specialist opinion rather than data-driven approaches. Here we investigate biogeographic breaks based on the distribution of offshore marine benthic molluscs collected during the Natal Museum Dredging Programme (1981–1997) along the coast of South Africa, between the South East Atlantic and South West Indian Oceans. Spatially constrained (depth, latitude and longitude) cluster analyses were applied to three resemblance measures; the Jaccard coefficient, popular in biogeographic studies, and gamma+ and theta+ coefficients, where taxonomic relatedness is considered when comparing sites. We used these resemblances to 1) find the most consistent biogeographic breaks and 2) compare the results of different measures to better understand the patterns and possible processes involved in the biogeographical classification. Although there were differences in the overall results from the three resemblance measures, they produced comparable findings at depths shallower than 80 m. Our data-driven approach indicated that the biogeographic break between the warm-temperate and sub-tropical assemblages was 140 km north of the current inshore break. The break between the sub-tropical and tropical mollusc assemblages agreed more closely with the present Ecoregions. Compared to Jaccard, where relatedness is not considered, gamma+ and theta+ results revealed a more substantial depth effect, and samples collected in the same depth range were more closely related and shared a more recent evolutionary history than geographically close samples from different depths. Furthermore, assemblages found deeper than ∼80 m demonstrated greater diversity in terms of relatedness, an essential consideration in marine spatial planning and consequent designation of protected areas. This study reveals the importance of including in-situ data and interspecies relationships in future marine spatial planning to ensure that these evolutionary rich animal communities are considered adequately.
    Keywords biogeography ; coastal zone management ; coasts ; geographical distribution ; latitude ; longitude ; molluscs ; museums ; South Africa
    Language English
    Dates of publication 2022-0215
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 0964-5691
    DOI 10.1016/j.ocecoaman.2021.106001
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Effectiveness of pulmonary rehabilitation in COVID-19 respiratory failure patients post-ICU.

    Al Chikhanie, Y / Veale, D / Schoeffler, M / Pépin, J L / Verges, S / Hérengt, F

    Respiratory physiology & neurobiology

    2021  Volume 287, Page(s) 103639

    Abstract: Introduction: Some COVID-19 patients develop respiratory failure requiring admission to intensive care unit (ICU). We aim to evaluate the effects of pulmonary rehabilitation (PR) post-ICU in COVID-19 patients.: Methods: Twenty-one COVID-19 patients ... ...

    Abstract Introduction: Some COVID-19 patients develop respiratory failure requiring admission to intensive care unit (ICU). We aim to evaluate the effects of pulmonary rehabilitation (PR) post-ICU in COVID-19 patients.
    Methods: Twenty-one COVID-19 patients were evaluated pre- and post-PR and compared retrospectively to a non-COVID-19 group of 21 patients rehabilitated after ICU admission due to respiratory failure.
    Results: PR induced greater 6-min walking distance improvement in COVID-19 patients (+205 ± 121 m) than in other respiratory failure patients post-ICU (+93 ± 66 m). The sooner PR was performed post-ICU, the better patients recovered.
    Conclusions: PR induced large functional improvements in COVID-19 patients post-ICU although significant physical and psychosocial impairments remained post-PR.
    MeSH term(s) Aged ; Aged, 80 and over ; Breathing Exercises ; COVID-19/complications ; COVID-19/rehabilitation ; Critical Care ; Exercise Therapy ; Female ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Recovery of Function ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/rehabilitation ; Retrospective Studies ; Treatment Outcome ; Walk Test
    Language English
    Publishing date 2021-02-12
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2077867-3
    ISSN 1878-1519 ; 1569-9048
    ISSN (online) 1878-1519
    ISSN 1569-9048
    DOI 10.1016/j.resp.2021.103639
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    Zs.A 519: Show issues Location:
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  7. Article ; Online: Therapeutic Effects of Mesenchymal/Stromal Stem Cells and Their Derived Extracellular Vesicles in Rheumatoid Arthritis.

    Tsiapalis, Dimitrios / Floudas, Achilleas / Tertel, Tobias / Boerger, Verena / Giebel, Bernd / Veale, Douglas J / Fearon, Ursula / O'Driscoll, Lorraine

    Stem cells translational medicine

    2023  Volume 12, Issue 12, Page(s) 849–862

    Abstract: Currently available therapies for rheumatoid arthritis (RA) are inadequate to alleviate the inflammation and reduce joint damage. While the immune-regulatory effect of human mesenchymal/stromal stem cells (MSCs) extracellular vesicles (EVs) has been ... ...

    Abstract Currently available therapies for rheumatoid arthritis (RA) are inadequate to alleviate the inflammation and reduce joint damage. While the immune-regulatory effect of human mesenchymal/stromal stem cells (MSCs) extracellular vesicles (EVs) has been tested in many inflammation-related diseases, little is known regarding their effect on patients with RA. Thus, we assessed the effect of human MSCs and MSC-EVs (from naïve or IFN-β-primed MSCs) on CD4+ T cells from patients with RA. Moreover, we investigated the effect of MSC-EVs on RA patients-derived synovial fibroblasts (FLS). MSC-EVs were prepared using a PEG precipitation followed by ultracentrifugation-based protocol. Applied to RA CD4+ T cells, EVs from IFN-β-primed MSCs, suppressed the expression of more key RA-associated cytokines (IL-4, GM-CSF IFN-γ, IL-2, TNF-α), and decreased CD4+ T-cell polyfunctionality than MSCs or EVs from naïve MSCs. MSCs mediated a slight decrease in the frequency of T-regulatory cells, while MSC-EVs rescued the frequency of T-regulatory cells. MSCs significantly inhibited CD4+ T-cell proliferation (P < .05), while no inhibition was observed in response to EV preparations. EVs from IFN-β-primed MSCs inhibited (P < .01) RA FLS migration and downregulated (P < .05) RA FLS surface markers CD34 and HLA-DR. Collectively, we demonstrated the immune-modulatory function of MSCs and their derived EVs in RA CD4+ T cells, which could be further enhanced by priming MSCs with IFN-β. Moreover, EVs from IFN-β-primed MSCs more efficiently inhibit RA FLS migration, and expression of RA FLS-related surface markers, suggesting these EVs as a potent therapy for RA.
    MeSH term(s) Humans ; Extracellular Vesicles/metabolism ; Arthritis, Rheumatoid/therapy ; Cytokines/metabolism ; Inflammation/metabolism ; Stem Cells/metabolism
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-11-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2642270-0
    ISSN 2157-6580 ; 2157-6580
    ISSN (online) 2157-6580
    ISSN 2157-6580
    DOI 10.1093/stcltm/szad065
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  8. Article: Out-patient triple chronotherapy for the rapid treatment and maintenance of response in depression: Feasibility and pilot randomised controlled trial - ADDENDUM.

    Veale, David / Serfaty, Marc / Humpston, Clara / Papageorgiou, Adriana / Markham, Sarah / Hodsoll, John / Young, Allan H

    BJPsych open

    2023  Volume 9, Issue 6, Page(s) e203

    Language English
    Publishing date 2023-11-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2829557-2
    ISSN 2056-4724
    ISSN 2056-4724
    DOI 10.1192/bjo.2023.566
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  9. Article ; Online: "I teach them. I have no choice": experiences of primary care among transgender people in Aotearoa New Zealand.

    Tan, Kyle K H / Carroll, Rona / Treharne, Gareth J / Byrne, Jack L / Veale, Jaimie F

    The New Zealand medical journal

    2022  Volume 135, Issue 1559, Page(s) 59–72

    Abstract: ... participants had greater risk of feeling no confidence in their GPs (Mdifference=0.22; Cohen's d=0.39 ...

    Abstract Aim: This study aims to report primary care experiences among transgender people in Aotearoa New Zealand based on quantitative and qualitative data from a nationwide community-based survey of transgender people.
    Methods: Subsamples with a usual general practitioner were employed from the 2018 Counting Ourselves Survey (n=871) and the 2018/19 New Zealand Health Survey to assess inequities between these samples in primary care experiences and barriers. Guided by Andersen's Behavioural Model of healthcare access, we conducted a content analysis on comments from Counting Ourselves participants (n=153) to identify themes about issues of concern for transgender people when accessing primary care.
    Results: Transgender participants had greater risk of feeling no confidence in their GPs (Mdifference=0.22; Cohen's d=0.39), reporting barriers accessing primary care due to cost (38.4% vs 17.4%; RR=2.21), and transport issues (13.5% vs 3.0%; RR=4.58) compared to the general population. Content analysis uncovered how transgender people's primary care experiences are shaped by healthcare environments, predisposing characteristics, and enabling resources.
    Conclusion: Our findings indicate ways to ensure primary care services are inclusive so that all transgender people feel welcome. This requires all primary healthcare professionals to demonstrate core trans-specific cultural safety when providing healthcare to transgender patients.
    MeSH term(s) Health Services Accessibility ; Humans ; New Zealand ; Primary Health Care ; Transgender Persons ; Transsexualism
    Language English
    Publishing date 2022-08-05
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 390590-1
    ISSN 1175-8716 ; 0028-8446 ; 0110-7704
    ISSN (online) 1175-8716
    ISSN 0028-8446 ; 0110-7704
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  10. Article ; Online: The Kidney-Transplant Waiting List and the Opioid Crisis.

    Maghen, Ariella / Mone, Thomas D / Veale, Jeffrey

    The New England journal of medicine

    2019  Volume 380, Issue 23, Page(s) 2273–2274

    MeSH term(s) Donor Selection ; Humans ; Kidney Transplantation/trends ; Opioid-Related Disorders/mortality ; Tissue Donors/supply & distribution ; United States ; Waiting Lists
    Language English
    Publishing date 2019-06-04
    Publishing country United States
    Document type Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1817188
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