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  1. Article ; Online: A tale of 2 gasses, 1 regulator, and cholesterol homeostasis.

    Fenton, Nicole M / Brown, Andrew J

    PLoS biology

    2023  Volume 21, Issue 11, Page(s) e3002401

    Abstract: There is a burgeoning appreciation for the wide-ranging effects of carbon dioxide on transcriptional regulation and metabolism. Here, Bolshette and colleagues provide the first link between carbon dioxide and the master transcriptional regulator of ... ...

    Abstract There is a burgeoning appreciation for the wide-ranging effects of carbon dioxide on transcriptional regulation and metabolism. Here, Bolshette and colleagues provide the first link between carbon dioxide and the master transcriptional regulator of cholesterol homeostasis.
    MeSH term(s) Carbon Dioxide/metabolism ; Gene Expression Regulation ; Homeostasis ; Cholesterol/metabolism
    Chemical Substances Carbon Dioxide (142M471B3J) ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2126776-5
    ISSN 1545-7885 ; 1544-9173
    ISSN (online) 1545-7885
    ISSN 1544-9173
    DOI 10.1371/journal.pbio.3002401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Characteristics of papers that affect citations in the Journal of Fish Biology.

    Fenton, M A / Fennell, H L / Kaiser, M J

    Journal of fish biology

    2023  Volume 104, Issue 1, Page(s) 310–314

    Abstract: Identifying the factors that influence the citation of articles helps authors improve the impact and reach of their research. Analysis of publications in the Journal of Fish Biology between 2008 and 2021 revealed that variables such as the number of ... ...

    Abstract Identifying the factors that influence the citation of articles helps authors improve the impact and reach of their research. Analysis of publications in the Journal of Fish Biology between 2008 and 2021 revealed that variables such as the number of keywords, abstract length, number of authors, and page length were associated with higher impact papers. These trends applied to both review and regular papers. These findings suggest that papers that are more informative, have higher numbers of authors, and have more keywords are more likely to be cited. Adoption of some simple "best-practice" behaviors can improve the likelihood that a paper is cited.
    MeSH term(s) Animals ; Journal Impact Factor ; Fishes ; Biology
    Language English
    Publishing date 2023-10-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 410564-3
    ISSN 1095-8649 ; 0022-1112
    ISSN (online) 1095-8649
    ISSN 0022-1112
    DOI 10.1111/jfb.15565
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Characteristics of papers that affect citations in the Journal of Fish Biology

    Fenton, M. A. / Fennell, H. L. / Kaiser, M. J.

    Journal of Fish Biology. 2024 Jan., v. 104, no. 1 p.310-314

    2024  

    Abstract: Identifying the factors that influence the citation of articles helps authors improve the impact and reach of their research. Analysis of publications in the Journal of Fish Biology between 2008 and 2021 revealed that variables such as the number of ... ...

    Abstract Identifying the factors that influence the citation of articles helps authors improve the impact and reach of their research. Analysis of publications in the Journal of Fish Biology between 2008 and 2021 revealed that variables such as the number of keywords, abstract length, number of authors, and page length were associated with higher impact papers. These trends applied to both review and regular papers. These findings suggest that papers that are more informative, have higher numbers of authors, and have more keywords are more likely to be cited. Adoption of some simple “best‐practice” behaviors can improve the likelihood that a paper is cited.
    Keywords Biological Sciences ; behavior ; fish ; journals ; paper
    Language English
    Dates of publication 2024-01
    Size p. 310-314.
    Publishing place Blackwell Publishing Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 410564-3
    ISSN 1095-8649 ; 0022-1112
    ISSN (online) 1095-8649
    ISSN 0022-1112
    DOI 10.1111/jfb.15565
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Impact of overdose on health plan disenrollment among patients prescribed long-term opioids: Retrospective cohort study.

    Fenton, Joshua J / Magnan, Elizabeth M / Tancredi, Daniel J / Tseregounis, Iraklis Erik / Agnoli, Alicia L

    Drug and alcohol dependence

    2024  Volume 258, Page(s) 111277

    Abstract: Context: Health plan disenrollment may disrupt chronic or preventive care for patients prescribed long-term opioid therapy (LTOT).: Purpose: To assess whether overdose events in patients prescribed LTOT are associated with subsequent health plan ... ...

    Abstract Context: Health plan disenrollment may disrupt chronic or preventive care for patients prescribed long-term opioid therapy (LTOT).
    Purpose: To assess whether overdose events in patients prescribed LTOT are associated with subsequent health plan disenrollment.
    Design: Retrospective cohort study.
    Setting and dataset: Data from the Optum Labs Data Warehouse which includes de-identified medical and pharmacy claims and enrollment records for commercial and Medicare Advantage enrollees. The database contains longitudinal health information on patients, representing a mixture of ages and geographical regions across the United States.
    Patients: Adults prescribed stable opioid therapy (≥10 morphine milligram equivalents/day) for a 6-month baseline period prior to an index opioid prescription from January 1, 2018 to December 31, 2018.
    Main measures: Health plan disenrollment during follow-up.
    Results: The cohort comprised 404,151 patients who were followed up after 800,250 baseline periods of stable opioid dosing. During a mean follow-up of 9.1 months, unadjusted disenrollment rates among primary commercial beneficiaries and Medicare Advantage enrollees were 37.2 and 13.9 per 100 person-years, respectively. Incident overdoses were associated with subsequent health plan disenrollment with a statistically significantly stronger association among primary commercial insurance beneficiaries [adjusted incidence rate ratio (aIRR) 1.48 (95% CI: 1.33-1.64)] as compared to Medicare Advantage enrollees [aIRR 1.15 (95% CI: 1.07-1.23)].
    Conclusions: Among patients prescribed long-term opioids, overdose events were strongly associated with subsequent health plan disenrollment, especially among primary commercial insurance beneficiaries. These findings raise concerns about the social consequences of overdose, including potential health insurance loss, which may limit patient access to care at a time of heightened vulnerability.
    Language English
    Publishing date 2024-03-30
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 519918-9
    ISSN 1879-0046 ; 0376-8716
    ISSN (online) 1879-0046
    ISSN 0376-8716
    DOI 10.1016/j.drugalcdep.2024.111277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reconstructing cardiac electrical excitations from optical mapping recordings.

    Marcotte, C D / Hoffman, M J / Fenton, F H / Cherry, E M

    Chaos (Woodbury, N.Y.)

    2023  Volume 33, Issue 9

    Abstract: The reconstruction of electrical excitation patterns through the unobserved depth of the tissue is essential to realizing the potential of computational models in cardiac medicine. We have utilized experimental optical-mapping recordings of cardiac ... ...

    Abstract The reconstruction of electrical excitation patterns through the unobserved depth of the tissue is essential to realizing the potential of computational models in cardiac medicine. We have utilized experimental optical-mapping recordings of cardiac electrical excitation on the epicardial and endocardial surfaces of a canine ventricle as observations directing a local ensemble transform Kalman filter data assimilation scheme. We demonstrate that the inclusion of explicit information about the stimulation protocol can marginally improve the confidence of the ensemble reconstruction and the reliability of the assimilation over time. Likewise, we consider the efficacy of stochastic modeling additions to the assimilation scheme in the context of experimentally derived observation sets. Approximation error is addressed at both the observation and modeling stages through the uncertainty of observations and the specification of the model used in the assimilation ensemble. We find that perturbative modifications to the observations have marginal to deleterious effects on the accuracy and robustness of the state reconstruction. Furthermore, we find that incorporating additional information from the observations into the model itself (in the case of stimulus and stochastic currents) has a marginal improvement on the reconstruction accuracy over a fully autonomous model, while complicating the model itself and thus introducing potential for new types of model errors. That the inclusion of explicit modeling information has negligible to negative effects on the reconstruction implies the need for new avenues for optimization of data assimilation schemes applied to cardiac electrical excitation.
    MeSH term(s) Animals ; Dogs ; Reproducibility of Results ; Heart ; Heart Ventricles ; Endocardium ; Electricity
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1472677-4
    ISSN 1089-7682 ; 1054-1500
    ISSN (online) 1089-7682
    ISSN 1054-1500
    DOI 10.1063/5.0156314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Presentation and management of delayed aortic endograft infection.

    Li, Ben / Hennessey, Hooman / Fenton, John / Qadura, Mohammad

    BMJ case reports

    2023  Volume 16, Issue 3

    Abstract: A man in his 60s who underwent endovascular aneurysm repair (EVAR) for abdominal aortic aneurysm 4 years ago presents with 1 week of abdominal pain, fever and leucocytosis. CT angiogram demonstrated an enlarged aneurysm sac with intraluminal gas and ... ...

    Abstract A man in his 60s who underwent endovascular aneurysm repair (EVAR) for abdominal aortic aneurysm 4 years ago presents with 1 week of abdominal pain, fever and leucocytosis. CT angiogram demonstrated an enlarged aneurysm sac with intraluminal gas and periaortic stranding consistent with infected EVAR. He was clinically unfit for an open surgical intervention due to his significant cardiac comorbidities, including hypertension, dyslipidaemia, type 2 diabetes, recent coronary artery bypass grafting and congestive heart failure secondary to ischaemic cardiomyopathy with an ejection fraction of 30%. Therefore, due to this significant surgical risk, he was treated with percutaneous drainage for the aortic collection and lifelong antibiotics. The patient is well 8 months following presentation with no signs of ongoing endograft infection, residual aneurysm sac enlargement, endoleak or haemodynamic instability.
    MeSH term(s) Male ; Humans ; Aortic Aneurysm, Abdominal/surgery ; Blood Vessel Prosthesis Implantation ; Treatment Outcome ; Diabetes Mellitus, Type 2/surgery ; Risk Factors ; Reoperation ; Endovascular Procedures ; Endoleak ; Retrospective Studies
    Language English
    Publishing date 2023-03-10
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-252924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Urinary Prostaglandin E2 Excretion and the Risk of Cardiovascular and Kidney Disease.

    Geurts, Frank / Chaker, Layal / van der Burgh, Anna C / Cronin-Fenton, Deirdre / Fenton, Robert A / Hoorn, Ewout J

    Journal of the American Heart Association

    2024  Volume 13, Issue 4, Page(s) e032835

    Abstract: ... min per 1.73 m: Conclusions: Urinary PGE2 and PGEM excretions are novel markers for the presence ...

    Abstract Background: Inhibition of prostaglandin synthesis by nonsteroidal anti-inflammatory drugs is associated with cardiovascular mortality and kidney disease. This study hypothesizes that urinary prostaglandin E2 (PGE2) and PGE2 metabolite (PGEM) excretions are markers of cardiovascular and kidney health, because they reflect both systemic and kidney-derived PGE2 production.
    Methods and results: PGE2 and PGEM were measured in spot urine samples from 2291 participants (≥55 years old) of the population-based Rotterdam Study. Urinary PGE2 and PGEM excretions were analyzed using linear regression analyses to identify cross-sectional associations with cardiovascular risk factors and baseline estimated glomerular filtration rate (eGFR). Longitudinal associations with cardiovascular mortality and kidney outcomes (eGFR <60 or <45 mL/min per 1.73 m
    Conclusions: Urinary PGE2 and PGEM excretions are novel markers for the presence and progression of cardiovascular and kidney disease. Future studies should address whether these associations are causal and can be targeted to improve cardiovascular and kidney outcomes.
    MeSH term(s) Humans ; Middle Aged ; Dinoprostone ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cross-Sectional Studies ; Kidney Diseases/diagnosis ; Kidney Diseases/epidemiology ; Kidney Diseases/complications ; Kidney ; Glomerular Filtration Rate/physiology ; Albuminuria/urine ; Risk Factors
    Chemical Substances Dinoprostone (K7Q1JQR04M)
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.032835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Reconstructing Cardiac Electrical Excitations from Optical Mapping Recordings.

    Marcotte, Christopher D / Hoffman, Matthew J / Fenton, Flavio H / Cherry, Elizabeth M

    ArXiv

    2023  

    Abstract: The reconstruction of electrical excitation patterns through the unobserved depth of the tissue is essential to realizing the potential of computational models in cardiac medicine. We have utilized experimental optical-mapping recordings of cardiac ... ...

    Abstract The reconstruction of electrical excitation patterns through the unobserved depth of the tissue is essential to realizing the potential of computational models in cardiac medicine. We have utilized experimental optical-mapping recordings of cardiac electrical excitation on the epicardial and endocardial surfaces of a canine ventricle as observations directing a local ensemble transform Kalman Filter (LETKF) data assimilation scheme. We demonstrate that the inclusion of explicit information about the stimulation protocol can marginally improve the confidence of the ensemble reconstruction and the reliability of the assimilation over time. Likewise, we consider the efficacy of stochastic modeling additions to the assimilation scheme in the context of experimentally derived observation sets. Approximation error is addressed at both the observation and modeling stages, through the uncertainty of observations and the specification of the model used in the assimilation ensemble. We find that perturbative modifications to the observations have marginal to deleterious effects on the accuracy and robustness of the state reconstruction. Further, we find that incorporating additional information from the observations into the model itself (in the case of stimulus and stochastic currents) has a marginal improvement on the reconstruction accuracy over a fully autonomous model, while complicating the model itself and thus introducing potential for new types of model error. That the inclusion of explicit modeling information has negligible to negative effects on the reconstruction implies the need for new avenues for optimization of data assimilation schemes applied to cardiac electrical excitation.
    Language English
    Publishing date 2023-09-05
    Publishing country United States
    Document type Preprint
    ISSN 2331-8422
    ISSN (online) 2331-8422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A tale of 2 gasses, 1 regulator, and cholesterol homeostasis.

    Nicole M Fenton / Andrew J Brown

    PLoS Biology, Vol 21, Iss 11, p e

    2023  Volume 3002401

    Abstract: There is a burgeoning appreciation for the wide-ranging effects of carbon dioxide on transcriptional regulation and metabolism. Here, Bolshette and colleagues provide the first link between carbon dioxide and the master transcriptional regulator of ... ...

    Abstract There is a burgeoning appreciation for the wide-ranging effects of carbon dioxide on transcriptional regulation and metabolism. Here, Bolshette and colleagues provide the first link between carbon dioxide and the master transcriptional regulator of cholesterol homeostasis.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Older Canadians' Perceptions of the Safety, Effectiveness and Accessibility of Cannabis for Medicinal Purposes: A Cross-Sectional Analysis.

    Bolt, Jennifer / Movold, Jacob / Behm, Megan / Williamson, Jill / Fenton, Melanie / Jakobi, Jennifer M

    Drugs & aging

    2024  Volume 41, Issue 4, Page(s) 329–337

    Abstract: Background and objective: Cannabis use is increasing among older adults, with use primarily for medicinal purposes. Much of the evidence on perceptions of cannabis is derived from younger populations and current users of cannabis. The purpose of this ... ...

    Abstract Background and objective: Cannabis use is increasing among older adults, with use primarily for medicinal purposes. Much of the evidence on perceptions of cannabis is derived from younger populations and current users of cannabis. The purpose of this study was to describe community-dwelling older Canadians' perceptions of cannabis effectiveness, safety and accessibility for medicinal purposes and to identify factors influencing cannabis perceptions.
    Methods: An online survey of older adults' perceptions, knowledge and experiences with cannabis was completed between February and September 2022. The survey was open to English-speaking and French-speaking Canadians aged 50 years and older regardless of their cannabis use history.
    Results: A total of 1615 Canadians completed the survey. Respondents identified primarily as men (49.7%) or women (48.5%) of Caucasian decent. The majority of participants viewed cannabis as a reasonable alternative (65.8%) and an effective (70.5%) treatment modality for symptom management in older adults. Few respondents (16.4%) felt that older adults compared to younger adults were at a higher risk of side effects and 34.5% felt that cannabis is safe to use with most medicines. Cannabis perceptions were influenced by gender, cannabis use history (prior use vs current use) and reasons for cannabis use (recreational purposes vs medicinal purposes vs both purposes).
    Conclusions: Older Canadians have a positive view of the role of cannabis in symptom management. The perceptions of cannabis safety and effectiveness were influenced by gender, cannabis use history and reasons for cannabis use. Healthcare professionals should leverage these perceptions when discussing cannabis with their older patient populations.
    MeSH term(s) Aged ; Female ; Humans ; Male ; Middle Aged ; Canada ; Cannabis ; Cross-Sectional Studies ; Medical Marijuana/adverse effects ; Medical Marijuana/therapeutic use ; North American People
    Chemical Substances Medical Marijuana
    Language English
    Publishing date 2024-03-19
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 1075770-3
    ISSN 1179-1969 ; 1170-229X
    ISSN (online) 1179-1969
    ISSN 1170-229X
    DOI 10.1007/s40266-024-01109-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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