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Article ; Online: Corrigendum to "Silencing adenosine A2a receptor enhances dendritic cell-based cancer immunotherapy" [Nanomedicine Nanotechnol Biol Med 29 (2020) 102240].

Masjedi, Ali / Ahmadi, Armin / Ghanee, Sepideh / Malakotikhah, Farinaz / Afjadi, Mohsen Nabi / Irandoust, Mahzad / Kiani, Fariba Karoon / Asl, Sima Heydarzadeh / Atyabi, Fatemeh / Hassannia, Hadi / Hojjat-Farsangi, Mohammad / Namdar, Afshin / Ghalamfarsa, Ghasem / Jadidi-Niaragh, Farhad

Nanomedicine : nanotechnology, biology, and medicine

2023 Volume 51, Page(s) 102690

Language	English
Publishing date	2023-05-09
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2183417-9
ISSN	1549-9642 ; 1549-9634
ISSN (online)	1549-9642
ISSN	1549-9634
DOI	10.1016/j.nano.2023.102690
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Immunopharmacological perspective on zinc in SARS-CoV-2 infection.

Asl, Sima Heydarzadeh / Nikfarjam, Sepideh / Majidi Zolbanin, Naime / Nassiri, Reza / Jafari, Reza

International immunopharmacology

2021 Volume 96, Page(s) 107630

Abstract: The novel SARS-CoV-2 which was first reported in China is the cause of infection known as COVID-19. In comparison with other coronaviruses such as SARS-CoV and MERS, the mortality rate of SARS-CoV-2 is lower but the transmissibility is higher. Immune ... ...

Abstract	The novel SARS-CoV-2 which was first reported in China is the cause of infection known as COVID-19. In comparison with other coronaviruses such as SARS-CoV and MERS, the mortality rate of SARS-CoV-2 is lower but the transmissibility is higher. Immune dysregulation is the most common feature of the immunopathogenesis of COVID-19 that leads to hyperinflammation. Micronutrients such as zinc are essential for normal immune function. According to the assessment of WHO, approximately one-third of the world's society suffer from zinc deficiency. Low plasma levels of zinc are associated with abnormal immune system functions such as impaired chemotaxis of polymorphonuclear cells (PMNs) and phagocytosis, dysregulated intracellular killing, overexpression of the inflammatory cytokines, lymphopenia, decreased antibody production, and sensitivity to microbes especially viral respiratory infections. Zinc exerts numerous direct and indirect effects against a wide variety of viral species particularly RNA viruses. The use of zinc and a combination of zinc-pyrithione at low concentrations impede SARS-CoV replication in vitro. Accordingly, zinc can inhibit the elongation step of RNA transcription. Furthermore, zinc might improve antiviral immunity by up-regulation of IFNα through JAK/STAT1 signaling pathway in leukocytes. On the other hand, zinc supplementation might ameliorate tissue damage caused by mechanical ventilation in critical COVID-19 patients. Finally, zinc might be used in combination with antiviral medications for the management of COVID-19 patients. In the current review article, we review and discuss the immunobiological roles and antiviral properties as well as the therapeutic application of zinc in SARS-CoV-2 and related coronaviruses infections.
MeSH term(s)	COVID-19/pathology ; Humans ; SARS-CoV-2/drug effects ; Virus Replication/drug effects ; Zinc/metabolism ; Zinc/pharmacology
Chemical Substances	Zinc (J41CSQ7QDS)
Language	English
Publishing date	2021-04-01
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2021.107630
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Inhibition of CD73 using folate targeted nanoparticles carrying anti-CD73 siRNA potentiates anticancer efficacy of Dinaciclib.

Hallaj, Shahin / Heydarzadeh Asl, Sima / Alian, Fatemeh / Farshid, Sajjad / Eshaghi, Farzaneh Sadat / Namdar, Afshin / Atyabi, Fatemeh / Masjedi, Ali / Hallaj, Tooba / Ghorbani, Anahita / Ghalamfarsa, Ghasem / Sojoodi, Mozhdeh / Jadidi-Niaragh, Farhad

Life sciences

2020 Volume 259, Page(s) 118150

Abstract: Conventional therapeutic methods against cancer, including chemotherapy, radiotherapy, surgery, and combination therapy, have exhibited different toxicity levels due to their unspecific mechanism of action. To overcome the challenges facing conventional ... ...

Abstract	Conventional therapeutic methods against cancer, including chemotherapy, radiotherapy, surgery, and combination therapy, have exhibited different toxicity levels due to their unspecific mechanism of action. To overcome the challenges facing conventional cancer therapies, newly developed methods are being investigated. Significant levels of specificity, remarkable accumulation at the tumor site, limited side effects, and minimal off-target effects enable the newly synthesized nanoparticles (NPs) to become the preferred drug delivery method in anticancer therapeutic approaches. According to the literature, CD73 has a pivotal role in cancer progression and resistance to chemotherapy and radiotherapy. Therefore, CD73 has attracted considerable attention among scientists to target this molecule. Accordingly, FDA approved CDK inhibitors such as Dinaciclib that blocks CDK1, 2, 5, and 9, and exhibits significant anticancer activity. So in this study, we intended to simultaneously suppress CD73 and CDKs in cancer cells by using the folic acid (FA)-conjugated chitosan-lactate (CL) NPs loaded with anti-CD73 siRNA and Dinaciclib to control tumor progression and metastasis. The results showed that NPs could effectively transfect cancer cells in a FA receptor-dependent manner leading to suppression of proliferation, survival, migration, and metastatic potential. Moreover, the treatment of tumor-bearing mice with this combination strategy robustly inhibited tumor growth and enhanced survival time in mice. These findings imply the high potential of FA-CL NPs loaded with anti-CD73 siRNA and Dinaciclib for use in cancer treatment shortly.
MeSH term(s)	5'-Nucleotidase/antagonists & inhibitors ; 5'-Nucleotidase/drug effects ; Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Cell Line, Tumor ; Combined Modality Therapy ; Cyclin-Dependent Kinases/drug effects ; Disease Progression ; Drug Delivery Systems ; Drug Synergism ; Folic Acid ; Humans ; Mice ; Nanoparticles ; Neoplasm Metastasis/drug therapy ; Neoplasms, Experimental/drug therapy ; Pyridinium Compounds/pharmacology ; RNA, Small Interfering/administration & dosage ; RNA, Small Interfering/pharmacology ; Tumor Stem Cell Assay
Chemical Substances	Antineoplastic Agents ; Bridged Bicyclo Compounds, Heterocyclic ; Pyridinium Compounds ; RNA, Small Interfering ; dinaciclib (4V8ECV0NBQ) ; Folic Acid (935E97BOY8) ; Cyclin-Dependent Kinases (EC 2.7.11.22) ; 5'-Nucleotidase (EC 3.1.3.5)
Keywords	covid19
Language	English
Publishing date	2020-07-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2020.118150
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Article ; Online: Silencing adenosine A2a receptor enhances dendritic cell-based cancer immunotherapy.

Masjedi, Ali / Ahmadi, Armin / Ghani, Sepideh / Malakotikhah, Farinaz / Nabi Afjadi, Mohsen / Irandoust, Mahzad / Karoon Kiani, Fariba / Heydarzadeh Asl, Sima / Atyabi, Fatemeh / Hassannia, Hadi / Hojjat-Farsangi, Mohammad / Namdar, Afshin / Ghalamfarsa, Ghasem / Jadidi-Niaragh, Farhad

Nanomedicine : nanotechnology, biology, and medicine

2020 Volume 29, Page(s) 102240

Abstract: Overexpression of adenosine in the tumor region leads to suppression of various immune cells, particularly T cells through ligation with adenosine 2a receptor (A2aR). In this study, we intended to increase the efficacy of tumor lysate-loaded DC vaccine ... ...

Abstract	Overexpression of adenosine in the tumor region leads to suppression of various immune cells, particularly T cells through ligation with adenosine 2a receptor (A2aR). In this study, we intended to increase the efficacy of tumor lysate-loaded DC vaccine by silencing the expression of A2aR on T cells through the application of A2aR-specific siRNA-loaded PEG-chitosan-lactate (PCL) nanoparticles (NPs) in the 4T1 breast tumor-bearing mice. Combination therapy by DC vaccine and siRNA-loaded NPs markedly induced tumor regression and increased survival time of mice. These ameliorative effects were partly via downregulation of immunosuppressive cells, increased function of cytotoxic T lymphocytes, and induction of immune-stimulatory cytokines. Moreover, combination therapy could markedly suppress angiogenesis and metastasis processes. These results imply the efficacy of novel combination therapy for the treatment of breast cancer by using A2aR siRNA-loaded NPs and DC vaccine which can be translated into the initial phase of clinical trials in the near future.
MeSH term(s)	Adenosine A2 Receptor Antagonists/chemistry ; Adenosine A2 Receptor Antagonists/pharmacology ; Animals ; Breast Neoplasms/genetics ; Breast Neoplasms/immunology ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/immunology ; Cancer Vaccines/pharmacology ; Cell Line, Tumor ; Chitosan/chemistry ; Chitosan/pharmacology ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Disease Models, Animal ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Immunotherapy ; Lactic Acid/chemistry ; Lactic Acid/pharmacology ; Mammary Neoplasms, Animal/genetics ; Mammary Neoplasms, Animal/pathology ; Mammary Neoplasms, Animal/therapy ; Mice ; Nanoparticles/chemistry ; Polyethylene Glycols/chemistry ; Polyethylene Glycols/pharmacology ; RNA, Small Interfering/genetics ; RNA, Small Interfering/pharmacology ; Receptor, Adenosine A2A/genetics ; T-Lymphocytes, Cytotoxic/drug effects ; T-Lymphocytes, Cytotoxic/immunology
Chemical Substances	Adenosine A2 Receptor Antagonists ; Cancer Vaccines ; RNA, Small Interfering ; Receptor, Adenosine A2A ; Lactic Acid (33X04XA5AT) ; Polyethylene Glycols (3WJQ0SDW1A) ; Chitosan (9012-76-4)
Language	English
Publishing date	2020-06-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2183417-9
ISSN	1549-9642 ; 1549-9634
ISSN (online)	1549-9642
ISSN	1549-9634
DOI	10.1016/j.nano.2020.102240
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Blockade of HIF-1α and STAT3 by hyaluronate-conjugated TAT-chitosan-SPION nanoparticles loaded with siRNA molecules prevents tumor growth.

Budi, Hendrik Setia / Izadi, Sepideh / Timoshin, Anton / Asl, Sima Heydarzadeh / Beyzai, Behzad / Ghaderpour, Amir / Alian, Fatemeh / Eshaghi, Farzaneh Sadat / Mousavi, Seyedeh Mahboubeh / Rafiee, Behnam / Nikkhoo, Afshin / Ahmadi, Armin / Hassannia, Hadi / Ahmadi, Majid / Sojoodi, Mozhdeh / Jadidi-Niaragh, Farhad

Nanomedicine : nanotechnology, biology, and medicine

2021 Volume 34, Page(s) 102373

Abstract: HIF-1α and STAT3 are two of the critical factors in the growth, proliferation, and metastasis of cancer cells and play a crucial role in inhibiting anti-cancer immune responses. Therefore, we used superparamagnetic iron oxide (SPION) nanoparticles (NPs) ... ...

Abstract	HIF-1α and STAT3 are two of the critical factors in the growth, proliferation, and metastasis of cancer cells and play a crucial role in inhibiting anti-cancer immune responses. Therefore, we used superparamagnetic iron oxide (SPION) nanoparticles (NPs) coated with thiolated chitosan (ChT) and trimethyl chitosan (TMC) and functionalized with hyaluronate (H) and TAT peptide for delivery of siRNA molecules against STAT3 and HIF-1α to cancer cells both in vivo and in vitro. The results indicated that tumor cell transfection with siRNA-encapsulated NPs robustly inhibited proliferation and migration and induced apoptosis in tumor cells. Furthermore, simultaneous silencing of HIF-1α and STAT3 significantly repressed cancer development in two different tumor types (4T1 breast cancer and CT26 colon cancer) which were associated with upregulation of cytotoxic T lymphocytes and IFN-γ secretion. The findings suggest inhibiting the HIF-1α/STAT3 axis by SPION-TMC-ChT-TAT-H NPs as an effective way to treat cancer.
MeSH term(s)	Animals ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation ; Chitosan/chemistry ; Colonic Neoplasms/pathology ; Female ; Humans ; Hyaluronic Acid/chemistry ; Hypoxia-Inducible Factor 1, alpha Subunit/antagonists & inhibitors ; Magnetic Iron Oxide Nanoparticles/administration & dosage ; Magnetic Iron Oxide Nanoparticles/chemistry ; Mice ; Mice, Inbred BALB C ; RNA, Small Interfering/administration & dosage ; STAT3 Transcription Factor/antagonists & inhibitors
Chemical Substances	HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; RNA, Small Interfering ; STAT3 Transcription Factor ; STAT3 protein, human ; Hyaluronic Acid (9004-61-9) ; Chitosan (9012-76-4)
Language	English
Publishing date	2021-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2183417-9
ISSN	1549-9642 ; 1549-9634
ISSN (online)	1549-9642
ISSN	1549-9634
DOI	10.1016/j.nano.2021.102373
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Inhibition of CD73 using folate targeted nanoparticles carrying anti-CD73 siRNA potentiates anticancer efficacy of Dinaciclib

Life sciences. 2020 Oct. 15, v. 259

2020

Abstract	Conventional therapeutic methods against cancer, including chemotherapy, radiotherapy, surgery, and combination therapy, have exhibited different toxicity levels due to their unspecific mechanism of action. To overcome the challenges facing conventional cancer therapies, newly developed methods are being investigated. Significant levels of specificity, remarkable accumulation at the tumor site, limited side effects, and minimal off-target effects enable the newly synthesized nanoparticles (NPs) to become the preferred drug delivery method in anticancer therapeutic approaches. According to the literature, CD73 has a pivotal role in cancer progression and resistance to chemotherapy and radiotherapy. Therefore, CD73 has attracted considerable attention among scientists to target this molecule. Accordingly, FDA approved CDK inhibitors such as Dinaciclib that blocks CDK1, 2, 5, and 9, and exhibits significant anticancer activity. So in this study, we intended to simultaneously suppress CD73 and CDKs in cancer cells by using the folic acid (FA)-conjugated chitosan-lactate (CL) NPs loaded with anti-CD73 siRNA and Dinaciclib to control tumor progression and metastasis. The results showed that NPs could effectively transfect cancer cells in a FA receptor-dependent manner leading to suppression of proliferation, survival, migration, and metastatic potential. Moreover, the treatment of tumor-bearing mice with this combination strategy robustly inhibited tumor growth and enhanced survival time in mice. These findings imply the high potential of FA-CL NPs loaded with anti-CD73 siRNA and Dinaciclib for use in cancer treatment shortly.
Keywords	antineoplastic activity ; cancer therapy ; drug delivery systems ; drug therapy ; folic acid ; mechanism of action ; metastasis ; neoplasm progression ; neoplasms ; radiotherapy ; surgery ; toxicity
Language	English
Dates of publication	2020-1015
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-light
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2020.118150
Database	NAL-Catalogue (AGRICOLA)

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Article: Inhibition of CD73 using folate targeted nanoparticles carrying anti-CD73 siRNA potentiates anticancer efficacy of Dinaciclib

Hallaj, Shahin / Asl, Sima Heydarzadeh / Alian, Fatemeh / Farshid, Sajjad / Eshaghi, Farzaneh Sadat / Namdar, Afshin / Atyabi, Fatemeh / Masjedi, Ali / Hallaj, Tooba / Ghorbani, Anahita / Ghalamfarsa, Ghasem / Sojoodi, Mozhdeh / Jadidi-Niaragh, Farhad

Life Sci

Abstract	Conventional therapeutic methods against cancer, including chemotherapy, radiotherapy, surgery, and combination therapy, have exhibited different toxicity levels due to their unspecific mechanism of action. To overcome the challenges facing conventional cancer therapies, newly developed methods are being investigated. Significant levels of specificity, remarkable accumulation at the tumor site, limited side effects, and minimal off-target effects enable the newly synthesized nanoparticles (NPs) to become the preferred drug delivery method in anticancer therapeutic approaches. According to the literature, CD73 has a pivotal role in cancer progression and resistance to chemotherapy and radiotherapy. Therefore, CD73 has attracted considerable attention among scientists to target this molecule. Accordingly, FDA approved CDK inhibitors such as Dinaciclib that blocks CDK1, 2, 5, and 9, and exhibits significant anticancer activity. So in this study, we intended to simultaneously suppress CD73 and CDKs in cancer cells by using the folic acid (FA)-conjugated chitosan-lactate (CL) NPs loaded with anti-CD73 siRNA and Dinaciclib to control tumor progression and metastasis. The results showed that NPs could effectively transfect cancer cells in a FA receptor-dependent manner leading to suppression of proliferation, survival, migration, and metastatic potential. Moreover, the treatment of tumor-bearing mice with this combination strategy robustly inhibited tumor growth and enhanced survival time in mice. These findings imply the high potential of FA-CL NPs loaded with anti-CD73 siRNA and Dinaciclib for use in cancer treatment shortly.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32726663
Database	COVID19

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Article ; Online: Inhibition of HIF-1α/EP4 axis by hyaluronate-trimethyl chitosan-SPION nanoparticles markedly suppresses the growth and development of cancer cells.

Karpisheh, Vahid / Fakkari Afjadi, Javad / Nabi Afjadi, Mohsen / Haeri, Melika Sadat / Abdpoor Sough, Tayebeh Sadat / Heydarzadeh Asl, Sim / Edalati, Mehdi / Atyabi, Fatemeh / Masjedi, Ali / Hajizadeh, Farnaz / Izadi, Sepideh / Mirzazadeh Tekie, Farnaz Sadat / Hajiramezanali, Maliheh / Sojoodi, Mozhdeh / Jadidi-Niaragh, Farhad

International journal of biological macromolecules

2020 Volume 167, Page(s) 1006–1019

Abstract: Increased expression of Hypoxia-inducible factor-1α (HIF-1α) in the tumor microenvironment, mainly due to tumor growth, plays a major role in the growth of cancer. Tumor cells induce the expression of cyclooxygenase 2 (COX2) and its product, ... ...

Abstract	Increased expression of Hypoxia-inducible factor-1α (HIF-1α) in the tumor microenvironment, mainly due to tumor growth, plays a major role in the growth of cancer. Tumor cells induce the expression of cyclooxygenase 2 (COX2) and its product, prostaglandin E2 (PGE2), through overexpression of HIF-1α. It has been shown that ligation of PGE2 with its receptor, EP4, robustly promotes cancer progression. HIF-1α/COX2/PGE2/EP4 signaling pathways appear to play an important role in tumor growth. Therefore, we decided to block the expansion of cancer cells by blocking the initiator (HIF-1α) and end (EP4) of this pathway. In this study, we used hyaluronate (HA), and trimethyl chitosan (TMC) recoated superparamagnetic iron oxide nanoparticles (SPIONs) loaded with HIF-1α-silencing siRNA and the EP4 antagonist (E7046) to treat cancer cells and assessed the effect of combination therapy on cancer progression. The results showed that optimum physicochemical characteristics of NPs (size 126.9 nm, zeta potential 27 mV, PDI < 0.2) and linkage of HA with CD44 molecules overexpressed on cancer cells could deliver siRNAs to cancer cells and significantly suppress the HIF-1α in them. Combination therapy of cancer cells by using HIF-1α siRNA-loaded SPION-TMC-HA NPs and E7046 also prevent proliferation, migration, invasion, angiogenesis, and colony formation of the cancer cells, remarkably.
MeSH term(s)	Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chemical Phenomena ; Chemistry Techniques, Synthetic ; Chitosan/chemistry ; Dinoprostone/chemistry ; Disease Models, Animal ; Humans ; Hyaluronic Acid/chemistry ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Magnetic Iron Oxide Nanoparticles/chemistry ; Magnetite Nanoparticles/chemistry ; Mice ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; RNA, Small Interfering/genetics ; Receptors, Prostaglandin E, EP4 Subtype/metabolism ; Signal Transduction/drug effects ; Spectrum Analysis
Chemical Substances	Antineoplastic Agents ; Hypoxia-Inducible Factor 1, alpha Subunit ; Magnetite Nanoparticles ; N-trimethyl chitosan chloride ; RNA, Small Interfering ; Receptors, Prostaglandin E, EP4 Subtype ; Hyaluronic Acid (9004-61-9) ; Chitosan (9012-76-4) ; Dinoprostone (K7Q1JQR04M)
Language	English
Publishing date	2020-11-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2020.11.056
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Article: Inhibition of HIF-1α/EP4 axis by hyaluronate-trimethyl chitosan-SPION nanoparticles markedly suppresses the growth and development of cancer cells

International journal of biological macromolecules. 2021 Jan. 15, v. 167

2021

Abstract	Increased expression of Hypoxia-inducible factor-1α (HIF-1α) in the tumor microenvironment, mainly due to tumor growth, plays a major role in the growth of cancer. Tumor cells induce the expression of cyclooxygenase 2 (COX2) and its product, prostaglandin E2 (PGE2), through overexpression of HIF-1α. It has been shown that ligation of PGE2 with its receptor, EP4, robustly promotes cancer progression. HIF-1α/COX2/PGE2/EP4 signaling pathways appear to play an important role in tumor growth. Therefore, we decided to block the expansion of cancer cells by blocking the initiator (HIF-1α) and end (EP4) of this pathway. In this study, we used hyaluronate (HA), and trimethyl chitosan (TMC) recoated superparamagnetic iron oxide nanoparticles (SPIONs) loaded with HIF-1α-silencing siRNA and the EP4 antagonist (E7046) to treat cancer cells and assessed the effect of combination therapy on cancer progression. The results showed that optimum physicochemical characteristics of NPs (size 126.9 nm, zeta potential 27 mV, PDI < 0.2) and linkage of HA with CD44 molecules overexpressed on cancer cells could deliver siRNAs to cancer cells and significantly suppress the HIF-1α in them. Combination therapy of cancer cells by using HIF-1α siRNA-loaded SPION-TMC-HA NPs and E7046 also prevent proliferation, migration, invasion, angiogenesis, and colony formation of the cancer cells, remarkably.
Keywords	angiogenesis ; antagonists ; chitosan ; growth and development ; hyaluronic acid ; iron oxides ; neoplasm progression ; neoplasms ; prostaglandin synthase ; prostaglandins ; therapeutics ; zeta potential
Language	English
Dates of publication	2021-0115
Size	p. 1006-1019.
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2020.11.056
Database	NAL-Catalogue (AGRICOLA)

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