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Article ; Online: Amanda Boyd-Respect local knowledge, communication, and traditions.

Burger, Joanna / Greenberg, Michael / Lowrie, Karen / Boyd, Amanda

Risk analysis : an official publication of the Society for Risk Analysis

2023 Volume 42, Issue 11, Page(s) 2515–2519

MeSH term(s)	Respect ; Communication
Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Editorial ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	778660-8
ISSN	1539-6924 ; 0272-4332
ISSN (online)	1539-6924
ISSN	0272-4332
DOI	10.1111/risa.14042
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Article ; Online: Preparing occupational therapy students for practice in rural areas: a scoping review protocol.

Hayes, Karen / Dos Santos, Vagner / Boyd, Nerida / Connelly, Bronwyn / Lustig, Kim

BMJ open

2024 Volume 14, Issue 2, Page(s) e075886

Abstract: Introduction: Despite greater needs in rural areas, occupational therapists are maldistributed to urban spaces which limits service access and health outcomes for rural people and communities. Preparation of students for rural practice may improve rural ...

Abstract	Introduction: Despite greater needs in rural areas, occupational therapists are maldistributed to urban spaces which limits service access and health outcomes for rural people and communities. Preparation of students for rural practice may improve rural workforce recruitment and retention; however, the range and scope of preparation strategies employed by education providers are unclear. This scoping review aims to understand and describe the range of strategies education services use to prepare occupational therapy students for rural practice across the globe. Methods and analysis: The study will include all publications about strategies used to prepare occupational therapy students for future rural practice, prior to enrolment, during the programme or on graduation. Ethics and dissemination: This study will not involve human/animal subjects and does not require ethics approval. Results will be disseminated to relevant groups in peer-reviewed journal(s) and at relevant occupational therapy, higher education and/or rural health conferences. Results will also be translated and shared in blogs/social media to support access for non-research audiences and shared with other regional universities to influence curriculum design.
MeSH term(s)	Humans ; Occupational Therapy ; Occupational Therapists ; Students ; Research Design ; Systematic Reviews as Topic
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-075886
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Article ; Online: Therapeutic Outcomes of Non-Infectious Scleritis Treated with Tumor Necrosis Factor-Alpha Inhibitors.

Brown, Jaime E / Thomas, Akshay S / Armbrust, Karen R / Boyd, Kelly / Berkenstock, Meghan / Kopplin, Laura J

Ocular immunology and inflammation

2023 , Page(s) 1–7

Abstract: Purpose: We determine the efficacy of tumor necrosis factor-α (TNF) inhibitors in establishing scleritis quiescence.: Methods: We conducted a multicenter retrospective chart review of patients with non-infectious scleritis treated with a TNF ... ...

Abstract	Purpose: We determine the efficacy of tumor necrosis factor-α (TNF) inhibitors in establishing scleritis quiescence. Methods: We conducted a multicenter retrospective chart review of patients with non-infectious scleritis treated with a TNF inhibitor for at least 6 months. The primary endpoint was scleritis quiescence at 6 months. Secondary endpoints included scleritis quiescence at 12 months, TNF inhibitor effects on concurrent doses of systemic corticosteroids and visual acuity outcomes at 6 and 12 months. Results: At 6 months, 82.2% (37/45) of subjects obtained scleritis quiescence with TNF inhibition. At 12 months, 76.2% (32/42) of subjects remained quiescent. Baseline daily corticosteroid use (21.5 ± 21.6 mg) decreased to 5.4 ± 8.3 mg by 6 months ( Conclusions: TNF inhibitors are an effective scleritis therapy with significant systemic corticosteroid sparing effect.
Language	English
Publishing date	2023-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.1080/09273948.2023.2191712
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Article ; Online: The diversity of neutrophil inclusion bodies in fulminant sepsis.

Boyd, Karen / Tauro, Sudhir

British journal of haematology

2018 Volume 182, Issue 3, Page(s) 317

MeSH term(s)	Adenocarcinoma/surgery ; Aged ; Colonic Neoplasms/surgery ; Humans ; Inclusion Bodies/pathology ; Male ; Neutrophils/pathology ; Postoperative Complications/blood ; Shock, Septic/blood
Language	English
Publishing date	2018-05-24
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.15218
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Article ; Online: Commentary on South Africa’s syndemic of undernutrition, obesity, and climate change

Agnes Erzse / Adam Balusik / Petronell Kruger / Evelyn Thsehla / Boyd Swinburn / Karen Hofman

South African Journal of Science, Vol 119, Iss 3/

2023 Volume 4

Keywords	syndemic ; food environment ; climate change ; nutrition ; Science ; Q ; Science (General) ; Q1-390 ; Social Sciences ; H ; Social sciences (General) ; H1-99
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Academy of Science of South Africa
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Barriers to attendance at a tertiary hospital's perinatal mortality meeting.

Burke, Barbara / Boyd, Sophie / McNamara, Karen / O'Donoghue, Keelin

Irish journal of medical science

2022 Volume 192, Issue 3, Page(s) 1265–1270

Abstract: Background: Perinatal mortality multi-disciplinary team meetings (PM-MDTMs) offer a forum for multi-disciplinary discussion of poor perinatal outcomes. They ensure a thorough understanding of individual cases and present an important learning ... ...

Abstract	Background: Perinatal mortality multi-disciplinary team meetings (PM-MDTMs) offer a forum for multi-disciplinary discussion of poor perinatal outcomes. They ensure a thorough understanding of individual cases and present an important learning opportunity for healthcare professionals (HCPs). Attendance at PM-MDTMs in this tertiary maternity hospital has been low. Aims: We aimed to identify barriers which may be targeted to improve attendance and engagement. Methods: An anonymous questionnaire was developed, and all HCPs invited to participate. Demographic data on respondents was collected, as was knowledge of PM-MDTMs, their purpose and relevance to clinical practice, and barriers to attendance at meetings. A total of 78 responses were obtained and analysed. Results: Self-reported understanding of the purpose and format PM-MDTMs was high (84.6% (66/78) and 65.4% (51/78), respectively), while only 50% (39/78) of respondents provided an accurate description of either. Only 50% (39/78) reported having attended a meeting in the hospital, of whom 61.5% (24/39) described the correct meeting. Of these, 37.5% (9/24) reported attending regularly and 70.8% (17/24) found the meeting relevant to their clinical practice. Of the 33.33% (26/78) who reported attending a PM-MDTM in another hospital, 73.1% (19/26) accurately described the meeting, 63.1% (12/19) of these attended regularly, and 100% (19/19) found it relevant. Three main qualitative themes emerged as barriers to attendance and were areas for suggested improvements: workload and staffing levels, meeting logistics, and lack of communication and education regarding PM-MDTMs. Conclusions: Communication regarding PM-MDTMs and their learning opportunities needs to improve. Lack of engagement is likely compounded by high workloads and staffing levels, but these issues should be surmountable.
MeSH term(s)	Female ; Humans ; Pregnancy ; Health Personnel ; Hospitals, Maternity/organization & administration ; Perinatal Mortality ; Physician Engagement/organization & administration ; Tertiary Care Centers/organization & administration ; Workload ; Infant, Newborn
Language	English
Publishing date	2022-09-02
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	390895-1
ISSN	1863-4362 ; 0021-1265
ISSN (online)	1863-4362
ISSN	0021-1265
DOI	10.1007/s11845-022-03137-0
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Article ; Online: Mediators of measurement-based care implementation in community mental health settings: results from a mixed-methods evaluation.

Lewis, Cara C / Boyd, Meredith R / Marti, C Nathan / Albright, Karen

Implementation science : IS

2022 Volume 17, Issue 1, Page(s) 71

Abstract: Background: Tailored implementation approaches are touted as superior to standardized ones with the reasoning that tailored approaches afford opportunities to select strategies to resolve determinants of the local context. However, results from ... ...

Abstract	Background: Tailored implementation approaches are touted as superior to standardized ones with the reasoning that tailored approaches afford opportunities to select strategies to resolve determinants of the local context. However, results from implementation trials on this topic are equivocal. Therefore, it is important to explore relevant contextual factors that function as determinants to evaluate if they are improved by tailoring and subsequently associated with changes in implementation outcomes (i.e., via statistical mediation) to better understand how tailoring achieves (or does not achieve) its effects. The present study examined the association between a tailored and standardized implementation approach, contextual factors that might mediate change, and a target implementation outcome in an initiative to implement measurement-based care (specifically the clinical integration of the Patient Health Questionnaire [PHQ-9] for depression) in a community mental health organization. Methods: Using a cluster randomized control design, twelve community-based mental health clinics were assigned to a tailored or standardized implementation group. Clinicians completed a self-report battery assessing contextual factors that served as candidate mediators informed by the Framework for Dissemination at three time points: baseline, 5 months after active implementation support, and 10 months after sustainment monitoring. A subset of clinicians also participated in focus groups at 5 months. The routine use of the PHQ-9 (implementation outcome) was monitored during the 10-month sustainment period. Multi-level mediation analyses assessed the association between the implementation group and contextual factors and the association between contextual factors and PHQ-9 completion. Quantitative results were then elaborated by analyzing qualitative data from exemplar sites. Results: Although tailored clinics outperformed standard clinics in terms of PHQ-9 completion at the end of active implementation, these group differences disappeared post sustainment monitoring. Perhaps related to this, no significant mediators emerged from our quantitative analyses. Exploratory qualitative analyses of focus group content emphasized the importance of support from colleagues, supervisors, and leadership when implementing clinical innovations in practice. Conclusions: Although rates of PHQ-9 completion improved across the study, their sustained levels were roughly equivalent across groups and low overall. No mediators were established using quantitative methods; however, several partial quantitative pathways, as well as themes from the qualitative data, reveal fruitful areas for future research. Trial registration: Standardized versus tailored implementation of measurement-based care for depression. Clinicaltrials: gov NCT02266134, first posted on October 16, 2014.
MeSH term(s)	Humans ; Focus Groups ; Leadership ; Mental Health
Language	English
Publishing date	2022-10-21
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	2225822-X
ISSN	1748-5908 ; 1748-5908
ISSN (online)	1748-5908
ISSN	1748-5908
DOI	10.1186/s13012-022-01244-1
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Article: Almanac: Retrieval-Augmented Language Models for Clinical Medicine.

Zakka, Cyril / Chaurasia, Akash / Shad, Rohan / Dalal, Alex R / Kim, Jennifer L / Moor, Michael / Alexander, Kevin / Ashley, Euan / Boyd, Jack / Boyd, Kathleen / Hirsch, Karen / Langlotz, Curt / Nelson, Joanna / Hiesinger, William

Research square

2023

Abstract: Large-language models have recently demonstrated impressive zero-shot capabilities in a variety of natural language tasks such as summarization, dialogue generation, and question-answering. Despite many promising applications in clinical medicine, ... ...

Abstract	Large-language models have recently demonstrated impressive zero-shot capabilities in a variety of natural language tasks such as summarization, dialogue generation, and question-answering. Despite many promising applications in clinical medicine, adoption of these models in real-world settings has been largely limited by their tendency to generate incorrect and sometimes even toxic statements. In this study, we develop Almanac, a large language model framework augmented with retrieval capabilities for medical guideline and treatment recommendations. Performance on a novel dataset of clinical scenarios (
Language	English
Publishing date	2023-05-02
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-2883198/v1
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Article ; Online: Immunosuppression in hematological cancer patients with Covid-19 -Uncomplicated infections but delayed viral clearance?

Boyd, Karen / Parcell, Benjamin / Tauro, Sudhir

Leukemia research

2020 Volume 96, Page(s) 106407

MeSH term(s)	Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Asymptomatic Diseases ; Betacoronavirus/drug effects ; Betacoronavirus/growth & development ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Female ; Humans ; Hypertension/complications ; Hypertension/drug therapy ; Hypertension/immunology ; Hypertension/virology ; Immunosuppressive Agents/therapeutic use ; Leukemia/complications ; Leukemia/drug therapy ; Leukemia/immunology ; Leukemia/virology ; Lymphocyte Count ; Male ; Myelodysplastic Syndromes/complications ; Myelodysplastic Syndromes/drug therapy ; Myelodysplastic Syndromes/immunology ; Myelodysplastic Syndromes/virology ; Obesity/complications ; Obesity/drug therapy ; Obesity/immunology ; Obesity/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Time Factors ; Viral Load/drug effects
Chemical Substances	Immunosuppressive Agents
Keywords	covid19
Language	English
Publishing date	2020-06-30
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	752396-8
ISSN	1873-5835 ; 0145-2126
ISSN (online)	1873-5835
ISSN	0145-2126
DOI	10.1016/j.leukres.2020.106407
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Article ; Online: Whole transcriptome screening for novel genes involved in meiosis and fertility in Drosophila melanogaster.

Sun, Siqi / Defosse, Tyler / Boyd, Ayla / Sop, Joel / Verderose, Faith / Surray, Diya / Aziz, Mark / Howland, Margaret / Wu, Siwen / Changela, Neha / Jang, Janet / Schindler, Karen / Xing, Jinchuan / McKim, Kim S

Scientific reports

2024 Volume 14, Issue 1, Page(s) 3602

Abstract: Reproductive success requires the development of viable oocytes and the accurate segregation of chromosomes during meiosis. Failure to segregate chromosomes properly can lead to infertility, miscarriages, or developmental disorders. A variety of factors ... ...

Abstract	Reproductive success requires the development of viable oocytes and the accurate segregation of chromosomes during meiosis. Failure to segregate chromosomes properly can lead to infertility, miscarriages, or developmental disorders. A variety of factors contribute to accurate chromosome segregation and oocyte development, such as spindle assembly and sister chromatid cohesion. However, many proteins required for meiosis remain unknown. In this study, we aimed to develop a screening pipeline for identifying novel meiotic and fertility genes using the genome of Drosophila melanogaster. To accomplish this goal, genes upregulated within meiotically active tissues were identified. More than 240 genes with no known function were silenced using RNA interference (RNAi) and the effects on meiosis and fertility were assessed. We identified 94 genes that when silenced caused infertility and/or high levels of chromosomal nondisjunction. The vast majority of these genes have human and mouse homologs that are also poorly studied. Through this screening process, we identified novel genes that are crucial for meiosis and oocyte development but have not been extensively studied in human or model organisms. Understanding the function of these genes will be an important step towards the understanding of their biological significance during reproduction.
MeSH term(s)	Humans ; Animals ; Mice ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Transcriptome ; Cell Cycle Proteins/metabolism ; Chromosomal Proteins, Non-Histone/metabolism ; Meiosis/genetics ; Chromosome Segregation ; Fertility/genetics ; Infertility/metabolism ; Oocytes/metabolism
Chemical Substances	Drosophila Proteins ; Cell Cycle Proteins ; Chromosomal Proteins, Non-Histone
Language	English
Publishing date	2024-02-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53346-z
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