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Article: Analysis of patients undergoing surgical treatment for primary spontaneous pneumothorax.

Cakmak, M / Durkan, A

2021 Volume 24, Issue 11, Page(s) 1669–1673

Abstract: Background: Primary spontaneous pneumothorax (psp) results from spontaneous rupture of bleb or bulla. Aims: We planned to discuss the etiologic factors, clinical and radiological findings, and treatment results of psp cases.: Materials and methods: ... ...

Abstract	Background: Primary spontaneous pneumothorax (psp) results from spontaneous rupture of bleb or bulla. Aims: We planned to discuss the etiologic factors, clinical and radiological findings, and treatment results of psp cases. Materials and methods: 402 patients were evaluated. Patients were divided into two groups as patients receiving positive results with thoracostomy and patients who received positive results"> thoracotomy/video-assisted thoracoscopic surgery (vats). Groups were compared. Results were evaluated"> using Chi-square or Fishers' exact test. P < 0.05 was considered as significant. Results: Gender difference (P: 1.00) and localization of disease (P: 0.45)were not significant for psp. Smoking and being subtotal or total compared to partial had a substantial effect on the implementation of thoracotomy/vats (P < 0.05). Furthermore, psp was most frequently seen in August and September. Discussion: Risk factors of psp are described as genetic predisposition, being tall, smoking, and autosomal dominant heredity. The main determinant factor in the treatment of psp is the degree of pneumothorax. Conclusion: Psp was frequently observed in smokers. The preferred method for overall psp is tube thoracostomy. Thoracotomy/vats is more commonly performed for subtotal or total psp compared to partial psp.
MeSH term(s)	Chest Tubes ; Humans ; Pneumothorax/etiology ; Pneumothorax/surgery ; Recurrence ; Retrospective Studies ; Thoracic Surgery, Video-Assisted ; Thoracotomy ; Treatment Outcome
Language	English
Publishing date	2021-11-15
Publishing country	India
Document type	Journal Article
ZDB-ID	1458330-6
ISSN	1119-3077
ISSN	1119-3077
DOI	10.4103/njcp.njcp_361_20
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Article ; Online: Biodistribution of radiolabeled alpha-amanitin in mice: An Investigation.

Durkan, Kubra / Ichedef, Cigdem / Baris, Elif / Arici, M Aylin

Toxicon : official journal of the International Society on Toxinology

2024 Volume 241, Page(s) 107661

Abstract: Mushroom poisonings caused by Amanita phalloides are the leading cause of mushroom-related deaths worldwide. Alpha-Amanitin (α-AMA), a toxic substance present in these mushrooms, is responsible for the resulting hepatotoxicity and nephrotoxicity. The ... ...

Abstract	Mushroom poisonings caused by Amanita phalloides are the leading cause of mushroom-related deaths worldwide. Alpha-Amanitin (α-AMA), a toxic substance present in these mushrooms, is responsible for the resulting hepatotoxicity and nephrotoxicity. The objective of our study was to determine the distribution of α-AMA in Balb/c mice by labeling with Iodine-131. Mice were injected with a toxic dose (1.4 mg/kg) of α-AMA labeled with Iodine-131. The mice were sacrificed at the 1st, 2nd, 4th, 8th, 24th, and 48th hours under anesthesia. The organs of the mice were removed, and their biodistribution was assessed in all experiments. The percent injected dose per gram (ID/g %) value for kidney, liver, lung, and heart tissues at 1st hour were 1.59 ± 0.07, 1.25 ± 0.33, 3.67 ± 0.80 and 1.07 ± 0.01 respectively. This study provides insights into the potential long-term effects of α-AMA accumulation in specific organs. Additionally, this study has generated essential data that can be used to demonstrate the impact of antidotes on the biological distribution of α-AMA in future toxicity models.
MeSH term(s)	Animals ; Mice ; Alpha-Amanitin/toxicity ; Tissue Distribution ; Iodine Radioisotopes ; Mushroom Poisoning ; Amanita
Chemical Substances	Alpha-Amanitin ; Iodine-131 ; Iodine Radioisotopes
Language	English
Publishing date	2024-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	204479-1
ISSN	1879-3150 ; 0041-0101
ISSN (online)	1879-3150
ISSN	0041-0101
DOI	10.1016/j.toxicon.2024.107661
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Article ; Online: Children grow upwards, and so does the number line: Evidence from a directional number line paradigm.

Leonard, Sophie J / Roche, Ciara / Durkan, Aoife / Gomides, Mariuche / Santos, Flavia H

Progress in brain research

2023 Volume 279, Page(s) 37–56

Abstract: Technological advancements give researchers the opportunity to explore the internal metric that allows to mentally place numbers in a spatial and ordered way to establish relationships between quantities. In this study, we implement the cMNL, an embodied ...

Abstract	Technological advancements give researchers the opportunity to explore the internal metric that allows to mentally place numbers in a spatial and ordered way to establish relationships between quantities. In this study, we implement the cMNL, an embodied number line paradigm to investigate the configuration of children's number space mappings under multiple conditions. A sample of 185 primary school children aged 8-10years old completed digitally an embodied number line task encompassing directionality and modality as variables. Contrary to the premise of a fixed internal number line moving from left to right in many Western scripts, our results suggest that children's number-space mapping is more robust along a vertical axis. In addition, children's embodied number line estimation differed depending on input modality. The findings provide insight into the variability in children's number line estimation, and the usability of digital assessment in understanding the mechanisms of the developing number-space system.
MeSH term(s)	Child ; Humans ; Child Development ; Spatial Learning ; Mathematics
Language	English
Publishing date	2023-03-21
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1875-7855 ; 0079-6123
ISSN (online)	1875-7855
ISSN	0079-6123
DOI	10.1016/bs.pbr.2023.03.002
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Article ; Online: Desensitisation strategies in high-risk children before kidney transplantation.

Sharma, Ankit / Durkan, Anne M

Pediatric nephrology (Berlin, Germany)

2018 Volume 33, Issue 12, Page(s) 2239–2251

Abstract: Background: Transplantation is the preferred modality for renal replacement therapy in children. With increasing rates of re-transplantation within the paediatric population, there are more sensitised children on waiting lists. One issue with developing ...

Abstract	Background: Transplantation is the preferred modality for renal replacement therapy in children. With increasing rates of re-transplantation within the paediatric population, there are more sensitised children on waiting lists. One issue with developing strategies to treat these children is the number of different definitions of sensitisation. and we would therefore recommend an immunological risk stratification approach. Methods: We discuss methods of sensitisation prevention, assessment and management, including paired exchange programmes and desensitisation protocols. Results: There are limited published evidence-based data for desensitisation in adults and none in children; thus, we present information on the available therapies currently in use. Discussion: Further research is required to investigate strategies which prevent sensitisation in children, including the healthcare utility of incorporating epitope-based matching into organ allocation algorithms. Controlled studies are also needed to establish the most appropriate desensitisation regimen(s).
MeSH term(s)	Allografts/immunology ; Child ; Desensitization, Immunologic/methods ; Donor Selection/methods ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Graft Survival/immunology ; HLA Antigens/immunology ; Histocompatibility Testing ; Humans ; Kidney/immunology ; Kidney Failure, Chronic/immunology ; Kidney Failure, Chronic/surgery ; Kidney Transplantation/adverse effects ; Preoperative Care/methods ; Reoperation/adverse effects ; Risk Assessment
Chemical Substances	HLA Antigens
Language	English
Publishing date	2018-01-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-017-3882-2
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Zs.A 2196: Show issues

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Article ; Online: Incidence and type of restrictive practice use in nursing homes in Ireland.

Dunbar, Paul / McMahon, Martin / Durkan, Ciara / Walsh, Kieran A / Keyes, Laura M

BMC geriatrics

2022 Volume 22, Issue 1, Page(s) 802

Abstract: Background: Use of restrictive practices (RP) in care settings may sometimes be warranted but can also conflict with human rights. Research to date has focused primarily on physical and chemical RP, however other forms are also used. Better ... ...

Abstract	Background: Use of restrictive practices (RP) in care settings may sometimes be warranted but can also conflict with human rights. Research to date has focused primarily on physical and chemical RP, however other forms are also used. Better understanding of practice can inform RP reduction. This study describes the incidence of all types of RP use reported from nursing homes in Ireland. Methods: RP notifications from nursing homes reported in 2020 were extracted from the Database of Statutory Notifications from Social Care in Ireland. The primary outcome measurement was the national incidence of use (frequency of RP/occupancy per 1000 residents) of categories and types of RP. Secondary outcome measurements such as percentage of facilities reporting use and quarterly median incidence of use in these facilities were calculated. Results: Seventy thousand six hundred sixty-three RP uses were notified from 608 facilities (33,219 beds). National incidence of RP use per 1000 residents was, all categories: 2465.1, environmental: 1324.5, physical: 922.5, chemical: 141.1; 'other': 77.0. The most frequently used RPs per category were, environmental: door locks; physical: bedrails; chemical (where drug specified): antipsychotics; 'other': privacy. 90.5% of nursing homes reported using at least one type of RP in the 12-month period. Quarterly incidence of any RP use in these facilities was median 1.642 (IQR: 0.018 to 18.608) per bed. Conclusions: Nursing homes in Ireland regularly use RP; only 9.5% reported no RP use in the 12-month period. A wide variety of types of RP were reported. Environmental and 'other' (largely psychosocial) RP contributed notably to total RP use and warrant attention alongside the traditional focus on physical and chemical RP. Policy implications include the need for more comprehensive RP definitions.
MeSH term(s)	Antipsychotic Agents ; Humans ; Incidence ; Ireland/epidemiology ; Nursing Homes ; Restraint, Physical
Chemical Substances	Antipsychotic Agents
Language	English
Publishing date	2022-10-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-022-03450-4
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Article ; Online: A critical analysis of deficiencies in the quality of information contained in prostate multiparametric MRI requests and reports.

Cullivan, Orla / Roche, Emma / Hegazy, Mohammad / Taha, Mohamed / Durkan, Garrett / O'Malley, Paddy / McCarthy, Peter / Dowling, Catherine M

Irish journal of medical science

2022 Volume 192, Issue 1, Page(s) 27–31

Abstract: Background: Multiparametric magnetic resonance imaging (mpMRI) has been increasingly recognised as an important tool in the diagnosis of prostate cancer. PI-RADSv2 guidelines recommend that important clinical information including prostate-specific ... ...

Abstract	Background: Multiparametric magnetic resonance imaging (mpMRI) has been increasingly recognised as an important tool in the diagnosis of prostate cancer. PI-RADSv2 guidelines recommend that important clinical information including prostate-specific antigen (PSA) levels, examination findings, and biopsy information should be included in mpMRI requests. PIRADS score and PSA density (PSAD) are both independent predictors for the presence of a clinically significant prostate cancer. Aims: This study aims to evaluate the quality of mpMRI requests and reports at our institution in accordance with these parameters. Methods: All prostate mpMRIs performed by radiology services in Galway University Hospital between 1st September 2019 and 1st March 2020 were reviewed. Exclusion criteria were applied. Requests and reports were analysed for the presence of the following parameters: PSA-results, examination findings, biopsy information, PI-RADS score, prostate volume, and PSAD. Results: A total of 586 mpMRIs were performed, and of these, 546 were included. PSA value was provided in 497 (91%) of requests, exam findings in 355 (65%), and biopsy information in 452 (82%). PIRADS score was included in 224 (41%) of reports, prostate volume in 178 (32.6%), and PSAD in 106 (19%). Conclusions: Great variation in the quality of information contained in both requests and reports for prostate mpMRIs exists within our service. We aim to improve this by collaborating with our radiology colleagues to develop a proforma for requesting and reporting of mpMRIs for our radiology systems to ensure important clinical and radiological information is provided in future.
MeSH term(s)	Male ; Humans ; Prostate/diagnostic imaging ; Prostate/pathology ; Prostatic Neoplasms/pathology ; Prostate-Specific Antigen ; Multiparametric Magnetic Resonance Imaging ; Magnetic Resonance Imaging/methods ; Retrospective Studies ; Image-Guided Biopsy/methods
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2022-01-30
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	390895-1
ISSN	1863-4362 ; 0021-1265
ISSN (online)	1863-4362
ISSN	0021-1265
DOI	10.1007/s11845-021-02875-x
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Article ; Online: Preparation of technetium-99m labeled ibuprofen by direct route and technetium-99m tricarbonyl route: a comparison of

Durkan, Kubra / Ichedef, Cigdem / Yurt Kılcar, Ayfer / Arıcı, Mesut / Ucar, Eser

Drug development and industrial pharmacy

2020 Volume 46, Issue 7, Page(s) 1108–1113

Abstract: In the current study, ibuprofen (ibu) which is a non-steroidal anti-inflammatory drug (NSAID) was radiolabeled ... ...

Abstract	In the current study, ibuprofen (ibu) which is a non-steroidal anti-inflammatory drug (NSAID) was radiolabeled with
MeSH term(s)	Animals ; Chromatography, Thin Layer ; Ibuprofen ; Male ; Radiopharmaceuticals/chemistry ; Rats ; Rats, Wistar ; Technetium ; Tissue Distribution
Chemical Substances	Radiopharmaceuticals ; Technetium (7440-26-8) ; Ibuprofen (WK2XYI10QM)
Language	English
Publishing date	2020-06-09
Publishing country	England
Document type	Journal Article
ZDB-ID	751874-2
ISSN	1520-5762 ; 0363-9045
ISSN (online)	1520-5762
ISSN	0363-9045
DOI	10.1080/03639045.2020.1776316
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Article ; Online: Parental understanding of relapsing idiopathic nephrotic syndrome-Where are the knowledge gaps?

Lo Cao, Edward / Amir, Noa / McKay, Ashlene / Durkan, Anne M

Acta paediatrica (Oslo, Norway : 1992)

2019 Volume 109, Issue 7, Page(s) 1465–1472

Abstract: Aim: To assess parental understanding of idiopathic nephrotic syndrome (INS) and its management, to enable targeted education in areas of deficit.: Methods: Families of children with at least one relapse of INS were interviewed, following a template ... ...

Abstract	Aim: To assess parental understanding of idiopathic nephrotic syndrome (INS) and its management, to enable targeted education in areas of deficit. Methods: Families of children with at least one relapse of INS were interviewed, following a template covering key domains of (a) disease understanding, (b) management of INS and (c) access to information. Common trends and responses were identified and notable observations recorded. Results: Twenty-one parents were interviewed. The mean duration of INS was 4.4 years (range 0.5-14.5 years), with a mean of two steroid-sparing agents used. Although 90% parents self-reported that they understood INS, only 29% could appropriately define relapse and 24% name potential complications. The management of INS was generally good, with most parents appropriately testing urine (81%) and managing relapses (90%). Unnecessary dietary restrictions were imposed on 57% during remission. The Internet was searched by 90% of parents for disease and drug information. Further information was desired in paper form (71%), hospital website (81%) and face-to-face workshop (90%), plus educational materials for schools. Conclusion: Parents overestimated their understanding of INS; however, their management was generally well done. Parents desired more information and support in various forms.
MeSH term(s)	Child ; Educational Status ; Humans ; Nephrotic Syndrome/diagnosis ; Nephrotic Syndrome/drug therapy ; Parents ; Recurrence ; Steroids
Chemical Substances	Steroids
Language	English
Publishing date	2019-12-12
Publishing country	Norway
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	203487-6
ISSN	1651-2227 ; 0365-1436 ; 0803-5253
ISSN (online)	1651-2227
ISSN	0365-1436 ; 0803-5253
DOI	10.1111/apa.15111
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Article ; Online: Redox Activation of a Polyaniline-Coated Cantilever: An Electro-Driven Microdevice Parts of this research are supported by The Israel Ministry of Science and the Israel Science Foundation. M. Lahav gratefully acknowledges the support of The Clore Israel Foundation Scholars Programme.

Lahav, Michal / Durkan, Colm / Gabai, Rachel / Katz, Eugenii / Willner, Itamar / Welland, Mark E.

Angewandte Chemie (International ed. in English)

2001 Volume 40, Issue 21, Page(s) 4095–4097

Language	English
Publishing date	2001-11-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
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Article ; Online: Serum OPG/TRAIL ratio predicts the presence of cardiovascular disease in people with type 2 diabetes mellitus.

Forde, H / Davenport, C / Rochfort, K D / Wallace, R G / Durkan, E / Agha, A / Thompson, C J / Tormey, W T / O'Gorman, D J / Cummins, P M / Smith, D

Diabetes research and clinical practice

2022 Volume 189, Page(s) 109936

Abstract: Aims: Cardiovascular disease (CVD) is the leading cause of mortality in type 2 diabetes mellitus (T2DM). Epidemiological studies suggest serum Osteoprotegrin (OPG)/Tumour-necrosis-factor-related-apoptosis-inducing- ligand (TRAIL) ratio may be a useful ... ...

Abstract	Aims: Cardiovascular disease (CVD) is the leading cause of mortality in type 2 diabetes mellitus (T2DM). Epidemiological studies suggest serum Osteoprotegrin (OPG)/Tumour-necrosis-factor-related-apoptosis-inducing- ligand (TRAIL) ratio may be a useful marker of cardiovascular risk. This study aimed to compare serum levels of TRAIL, OPG and OPG/TRAIL ratio in people with T2DM, with and without a history of CVD, and controls; and to determine which of these indices, if any, predict cardiovascular risk. Methods: In this single centre observational study of 133 participants, people with T2DM, with and without a history of a cardiovascular event in the last 5 years, were recruited along with a control cohort without T2DM or CVD. Demographic information and anthropometric measurements were recorded. Blood samples were taken and OPG and TRAIL were measured using ELISA. Results: People with T2DM and CVD had higher OPG/TRAIL ratios compared to controls or those with a new diagnosis of T2DM. After adjustment for potential confounding factors, OPG/TRAIL ratio was significantly associated with the presence of CVD in people with T2DM and an OPG/TRAIL ratio cut-off > 38.6 predicted the presence of CVD in this cohort with a sensitivity of 80% and specificity of 82%. Conclusion: This study suggests that OPG/TRAIL ratio may have a role as a biomarker of CVD in people with T2DM.
MeSH term(s)	Biomarkers ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/etiology ; Diabetes Mellitus, Type 2/complications ; Humans ; Osteoprotegerin ; TNF-Related Apoptosis-Inducing Ligand
Chemical Substances	Biomarkers ; Osteoprotegerin ; TNF-Related Apoptosis-Inducing Ligand
Language	English
Publishing date	2022-06-02
Publishing country	Ireland
Document type	Journal Article ; Observational Study
ZDB-ID	632523-3
ISSN	1872-8227 ; 0168-8227
ISSN (online)	1872-8227
ISSN	0168-8227
DOI	10.1016/j.diabres.2022.109936
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