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  1. Article ; Online: Kidney transplantation from deceased donors with vaccine-induced thrombosis and thrombocytopenia (VITT): Definitely feasible and safe?

    Picciotto, Daniela / Bussalino, Elisabetta / Paoletti, Ernesto

    Transplant infectious disease : an official journal of the Transplantation Society

    2022  , Page(s) e13921

    Language English
    Publishing date 2022-08-04
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.13921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5100: Show issues Location:
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  2. Article: Kidney Transplantation in a Patient Affected by Sickle Cell Trait: A Case Report and State-of-the-Art Review.

    Picciotto, Daniela / Bussalino, Elisabetta / Viazzi, Francesca / Paoletti, Ernesto / Esposito, Pasquale

    Cureus

    2023  Volume 15, Issue 1, Page(s) e33400

    Abstract: Chronic kidney disease (CKD) is a common feature of sickle cell disease (SCD). The awareness of the clinical presentation and renal involvement in patients affected by hemoglobinopathies is greatly needed. Patient management is particularly complex, ... ...

    Abstract Chronic kidney disease (CKD) is a common feature of sickle cell disease (SCD). The awareness of the clinical presentation and renal involvement in patients affected by hemoglobinopathies is greatly needed. Patient management is particularly complex, especially with kidney transplantation. We, therefore, report the case of a 56-year-old patient affected by sickle cell trait who underwent kidney transplantation. This case will underline all the various challenges the nephrologist must face in this clinical setting and their management.
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.33400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Roxadustat for renal patients with hyporesponsiveness to ESAs: a new opportunity?

    Paoletti, Ernesto / Bussalino, Elisabetta / Ravera, Maura

    Internal and emergency medicine

    2021  Volume 16, Issue 8, Page(s) 2041–2042

    MeSH term(s) Glycine/analogs & derivatives ; Humans ; Isoquinolines
    Chemical Substances Isoquinolines ; Glycine (TE7660XO1C) ; roxadustat (X3O30D9YMX)
    Language English
    Publishing date 2021-06-20
    Publishing country Italy
    Document type Journal Article ; Comment
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-021-02794-w
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    Zs.A 6673: Show issues Location:
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  4. Article ; Online: Practical patient care appraisals with use of new potassium binders in heart failure and chronic kidney diseases.

    Senni, Michele / Sciatti, Edoardo / Bussalino, Elisabetta / D'Elia, Emilia / Ravera, Maura / Paoletti, Ernesto

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2023  Volume 24, Issue 11, Page(s) 781–789

    Abstract: Hyperkalaemia is a life-threatening condition leading to significant morbidity and mortality. It is common in heart failure and in chronic kidney disease (CKD) patients due to the diseases themselves, which often coexist, the high co-presence of diabetes, ...

    Abstract Hyperkalaemia is a life-threatening condition leading to significant morbidity and mortality. It is common in heart failure and in chronic kidney disease (CKD) patients due to the diseases themselves, which often coexist, the high co-presence of diabetes, the fluctuations in renal function, and the use of some drugs [i.e. renin-angiotensin-aldosterone system (RAAS) inhibitors]. Hyperkalaemia limits their administration or uptitration, thus impacting on mortality. New K + binders, namely patiromer and sodium zirconium cyclosilicate (ZS-9), are an intriguing option to manage hyperkalaemia in heart failure and/or CKD patients, both to reduce its fatal effects and to let clinicians uptitrate RAAS inhibition. Even if their real impact on strong outcomes is still to be determined, we hereby provide a practical approach to favour their use in routine clinical practice in order to gain the correct confidence and provide an additive tool to heart failure and CKD patients' wellbeing. New trials are welcome to fill the gap in knowledge.
    MeSH term(s) Humans ; Hyperkalemia/chemically induced ; Hyperkalemia/drug therapy ; Hyperkalemia/complications ; Potassium/pharmacology ; Renin-Angiotensin System ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/drug therapy ; Heart Failure/drug therapy ; Heart Failure/complications
    Chemical Substances Potassium (RWP5GA015D)
    Language English
    Publishing date 2023-08-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/JCM.0000000000001555
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5210: Show issues Location:
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    Zs.MO 559: Show issues

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  5. Article ; Online: Metabolomics for contrast-induced nephropathy risk prediction?

    Bussalino, Elisabetta / Ravera, Maura / Paoletti, Ernesto

    Internal and emergency medicine

    2019  Volume 15, Issue 1, Page(s) 21–22

    MeSH term(s) Contrast Media ; Humans ; Magnetic Resonance Imaging ; Metabolomics
    Chemical Substances Contrast Media
    Language English
    Publishing date 2019-08-07
    Publishing country Italy
    Document type Journal Article ; Comment
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-019-02168-3
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  6. Article ; Online: Non-Haemodynamic Mechanisms Underlying Hypertension-Associated Damage in Target Kidney Components.

    Russo, Elisa / Bussalino, Elisabetta / Macciò, Lucia / Verzola, Daniela / Saio, Michela / Esposito, Pasquale / Leoncini, Giovanna / Pontremoli, Roberto / Viazzi, Francesca

    International journal of molecular sciences

    2023  Volume 24, Issue 11

    Abstract: Arterial hypertension (AH) is a global challenge that greatly impacts cardiovascular morbidity and mortality worldwide. AH is a major risk factor for the development and progression of kidney disease. Several antihypertensive treatment options are ... ...

    Abstract Arterial hypertension (AH) is a global challenge that greatly impacts cardiovascular morbidity and mortality worldwide. AH is a major risk factor for the development and progression of kidney disease. Several antihypertensive treatment options are already available to counteract the progression of kidney disease. Despite the implementation of the clinical use of renin-angiotensin aldosterone system (RAAS) inhibitors, gliflozins, endothelin receptor antagonists, and their combination, the kidney damage associated with AH is far from being resolved. Fortunately, recent studies on the molecular mechanisms of AH-induced kidney damage have identified novel potential therapeutic targets. Several pathophysiologic pathways have been shown to play a key role in AH-induced kidney damage, including inappropriate tissue activation of the RAAS and immunity system, leading to oxidative stress and inflammation. Moreover, the intracellular effects of increased uric acid and cell phenotype transition showed their link with changes in kidney structure in the early phase of AH. Emerging therapies targeting novel disease mechanisms could provide powerful approaches for hypertensive nephropathy management in the future. In this review, we would like to focus on the interactions of pathways linking the molecular consequences of AH to kidney damage, suggesting how old and new therapies could aim to protect the kidney.
    MeSH term(s) Humans ; Hypertension ; Kidney/metabolism ; Renin-Angiotensin System ; Antihypertensive Agents/pharmacology ; Antihypertensive Agents/therapeutic use ; Antihypertensive Agents/metabolism ; Hypertension, Renal/metabolism
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2023-05-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24119422
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  7. Article ; Online: Changes over time in ambulatory blood pressure and cardiac parameters predict cardiovascular outcome of patients with CKD and low cardiovascular morbidity.

    Paoletti, Ernesto / Bussalino, Elisabetta / Minutolo, Roberto / Vettoretti, Simone / De Nicola, Luca / Messa, Piergiorgio / Ravera, Maura

    Journal of nephrology

    2022  Volume 35, Issue 8, Page(s) 2147–2149

    MeSH term(s) Humans ; Blood Pressure Monitoring, Ambulatory ; Blood Pressure/physiology ; Hypertension/complications ; Hypertension/diagnosis ; Hypertension/epidemiology ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diagnosis ; Cardiovascular System ; Disease Progression
    Language English
    Publishing date 2022-05-31
    Publishing country Italy
    Document type Letter
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-022-01355-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3369: Show issues Location:
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  8. Article ; Online: Immunosuppressive therapy maintenance in a kidney transplant recipient with SARS-CoV-2 pneumonia: A case report.

    Bussalino, Elisabetta / De Maria, Andrea / Russo, Rodolfo / Paoletti, Ernesto

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2020  Volume 20, Issue 7, Page(s) 1922–1924

    Abstract: The role of systemic inflammation is proving crucial in determining unfavorable outcome in SARS-CoV-2-infected patients. Limited data are available regarding immunosuppression management in kidney transplant recipients (KTRs) with SARS-CoV-2 pneumonia. ... ...

    Abstract The role of systemic inflammation is proving crucial in determining unfavorable outcome in SARS-CoV-2-infected patients. Limited data are available regarding immunosuppression management in kidney transplant recipients (KTRs) with SARS-CoV-2 pneumonia. We report a case of a 32-year-old KTR who developed SARS-CoV-2 infection and fully recovered in 15 days while maintaining standard immunosuppressive therapy.
    MeSH term(s) Adult ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/therapy ; Humans ; Immunosuppression Therapy ; Immunosuppressive Agents/administration & dosage ; Inflammation ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/surgery ; Kidney Transplantation ; Male ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; Transplant Recipients ; Treatment Outcome
    Chemical Substances Immunosuppressive Agents
    Keywords covid19
    Language English
    Publishing date 2020-05-08
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/ajt.15920
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    Zs.A 5542: Show issues Location:
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  9. Article ; Online: A new CHA2DS2VASC score integrated with estimated glomerular filtration rate, left ventricular hypertrophy, and pulse pressure is highly effective in predicting adverse cardiovascular outcome in chronic kidney disease.

    Bussalino, Elisabetta / Ravera, Maura / Minutolo, Roberto / Vettoretti, Simone / Di Lullo, Luca / Fusaro, Maria / De Nicola, Luca / Paoletti, Ernesto

    European journal of preventive cardiology

    2022  Volume 29, Issue 8, Page(s) e275–e278

    MeSH term(s) Blood Pressure ; Glomerular Filtration Rate ; Humans ; Hypertrophy, Left Ventricular/diagnosis ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology ; Ventricular Remodeling
    Language English
    Publishing date 2022-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1093/eurjpc/zwac039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4686: Show issues Location:
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  10. Article ; Online: SGLT2is and Renal Protection: From Biological Mechanisms to Real-World Clinical Benefits.

    Leoncini, Giovanna / Russo, Elisa / Bussalino, Elisabetta / Barnini, Cecilia / Viazzi, Francesca / Pontremoli, Roberto

    International journal of molecular sciences

    2021  Volume 22, Issue 9

    Abstract: In recent years, following the publication of results from several RCTs, first on cardiovascular and more recently on renal outcomes, SGLT2is have become the standard of care to prevent diabetic kidney disease and slow its progression. This narrative ... ...

    Abstract In recent years, following the publication of results from several RCTs, first on cardiovascular and more recently on renal outcomes, SGLT2is have become the standard of care to prevent diabetic kidney disease and slow its progression. This narrative review focuses on biological mechanisms, both renal and extrarenal, underlying kidney protection with SGLT2is. Furthermore, data from cardiovascular as well as renal outcome trials, mostly conducted in diabetic patients, are presented and discussed to provide an overview of current uses as well as the future therapeutic potential of these drugs.
    MeSH term(s) Animals ; Diabetes Mellitus, Type 2/complications ; Diabetic Nephropathies/drug therapy ; Diabetic Nephropathies/etiology ; Diabetic Nephropathies/pathology ; Glomerular Filtration Rate ; Humans ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2021-04-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22094441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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