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  1. Article ; Online: T-bet

    Keller, Baerbel / Warnatz, Klaus

    Current opinion in immunology

    2023  Volume 82, Page(s) 102300

    Abstract: After many years of a niche research in a few laboratories of the world, T- ... ...

    Abstract After many years of a niche research in a few laboratories of the world, T-bet
    MeSH term(s) Humans ; Receptors, Antigen, B-Cell/metabolism ; B-Lymphocytes ; Cell Differentiation ; Gene Expression Regulation ; Communicable Diseases
    Chemical Substances Receptors, Antigen, B-Cell
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2023.102300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2773: Show issues Location:
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  2. Article ; Online: "Are you gonna go my way?"-Decisions at the Tfh-B cell interface.

    Tangye, Stuart G / Warnatz, Klaus

    Immunity

    2022  Volume 55, Issue 3, Page(s) 377–379

    Abstract: The generation of memory B cells and plasma cells is complex and involves inputs from the microenvironment, notably from T follicular helper cells. In last month's issue of Immunity, Yeh et al. and Song et al. refine our understanding of the B cell ... ...

    Abstract The generation of memory B cells and plasma cells is complex and involves inputs from the microenvironment, notably from T follicular helper cells. In last month's issue of Immunity, Yeh et al. and Song et al. refine our understanding of the B cell intrinsic and extrinsic requirements to generate effective humoral immunity in response to foreign antigens.
    MeSH term(s) B-Lymphocytes/immunology ; Germinal Center/immunology ; Immunity, Humoral/immunology ; Programmed Cell Death 1 Receptor ; Receptors, CXCR5 ; T Follicular Helper Cells ; T-Lymphocytes, Helper-Inducer/immunology
    Chemical Substances Programmed Cell Death 1 Receptor ; Receptors, CXCR5
    Language English
    Publishing date 2022-02-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2022.02.002
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    Zs.A 4227: Show issues Location:
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  3. Article ; Online: Editorial: Updates on the pathogenesis of common variable immunodeficiency (CVID).

    Martelius, Timi / Seppänen, Mikko R J / Warnatz, Klaus

    Frontiers in immunology

    2023  Volume 13, Page(s) 1130418

    MeSH term(s) Humans ; Common Variable Immunodeficiency
    Language English
    Publishing date 2023-01-10
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1130418
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  4. Article ; Online: Hypogammaglobulinemia and immune dysregulation-not just 2 sides of a coin.

    Uzel, Gulbu / Keller, Baerbel / Warnatz, Klaus

    The Journal of allergy and clinical immunology

    2023  Volume 153, Issue 1, Page(s) 90–92

    MeSH term(s) Humans ; Agammaglobulinemia
    Language English
    Publishing date 2023-11-18
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2023.11.005
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  5. Article ; Online: Grundlagen der Diagnostik primärer Immunstörungen („inborn errors of immunity“).

    Geier, Christoph B / Voll, Reinhard E / Warnatz, Klaus

    Zeitschrift fur Rheumatologie

    2023  Volume 82, Issue 4, Page(s) 285–297

    Abstract: Inborn errors of immunity (IEI) are a heterogeneous group of nearly 500 diseases characterized by a congenital dysfunction of the immune system. The vast majority of IEIs are rare diseases but all IEIs share a cumulative prevalence of 1:1200-1:2000. In ... ...

    Title translation Principles of the diagnostics of inborn errors of immunity.
    Abstract Inborn errors of immunity (IEI) are a heterogeneous group of nearly 500 diseases characterized by a congenital dysfunction of the immune system. The vast majority of IEIs are rare diseases but all IEIs share a cumulative prevalence of 1:1200-1:2000. In addition to a pathological susceptibility to infections, IEIs can also present with lymphoproliferative, autoimmune or autoinflammatory manifestations. There is often an overlap with classical rheumatic and inflammatory disease patterns. Therefore, a basic knowledge of the clinical presentation and the diagnostics of IEIs is also relevant for the practicing rheumatologist.
    MeSH term(s) Humans ; Rare Diseases ; Rheumatologists
    Language German
    Publishing date 2023-04-20
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 124985-x
    ISSN 1435-1250 ; 0340-1855 ; 0301-6382
    ISSN (online) 1435-1250
    ISSN 0340-1855 ; 0301-6382
    DOI 10.1007/s00393-023-01351-4
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  6. Article ; Online: Interstitial lung disease in primary immunodeficiency: towards a brighter future.

    Hurst, John R / Warnatz, Klaus

    The European respiratory journal

    2020  Volume 55, Issue 4

    MeSH term(s) Cognition ; Common Variable Immunodeficiency ; Humans ; Lung/diagnostic imaging ; Lung Diseases, Interstitial/diagnosis
    Language English
    Publishing date 2020-04-03
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00089-2020
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    Zs.MO 292: Show issues

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  7. Book ; Thesis: Charakterisierung einer übertragbaren enzymatischen Resistenz gegen Cephalosporine der dritten Generation

    Warnatz, Klaus

    SHV Aachen

    1993  

    Author's details vorgelegt von Klaus Warnatz
    Language German
    Size 92 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Aachen, Techn. Hochsch., Diss., 1993
    HBZ-ID HT004517943
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    93 D 3337 order for loan Magazin

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  8. Article ; Online: Editorial: Interstitial Lung Disease in Primary Immunodeficiencies.

    Fevang, Børre / Warnatz, Klaus / Hurst, John R

    Frontiers in immunology

    2021  Volume 12, Page(s) 699126

    MeSH term(s) Humans ; Lung Diseases, Interstitial/etiology ; Lung Diseases, Interstitial/immunology ; Lung Diseases, Interstitial/pathology ; Primary Immunodeficiency Diseases/complications ; Primary Immunodeficiency Diseases/immunology ; Primary Immunodeficiency Diseases/pathology
    Language English
    Publishing date 2021-07-08
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.699126
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  9. Article ; Online: GVHD, IBD, and primary immunodeficiencies: The gut as a target of immunopathology resulting from impaired immunity.

    Zeiser, Robert / Warnatz, Klaus / Rosshart, Stephan / Sagar / Tanriver, Yakup

    European journal of immunology

    2022  Volume 52, Issue 9, Page(s) 1406–1418

    Abstract: The intestinal tract is the largest immunological organ in the body and has a central function of regulating local immune responses, as the intestinal epithelial barrier is a location where the immune system interacts with the gut microbiome including ... ...

    Abstract The intestinal tract is the largest immunological organ in the body and has a central function of regulating local immune responses, as the intestinal epithelial barrier is a location where the immune system interacts with the gut microbiome including bacteria, fungi, and viruses. Impaired immunity in the intestinal tract can lead to immunopathology, which manifests in different diseases such as inflammatory bowel disease or intestinal graft-versus-host disease. A disturbed communication between epithelial cells, immune cells, and microbiome will shape pathogenic immune responses to antigens, which need to be counterbalanced by tolerogenic mechanisms and repair mechanisms. Here, we review how impaired intestinal immune function leads to immunopathology with a specific focus on innate immune cells, the role of the microbiome, and the resulting clinical manifestations including intestinal graft-versus-host disease, inflammatory bowel disease, and enteropathy in primary immunodeficiency.
    MeSH term(s) Epithelial Cells/pathology ; Gastrointestinal Microbiome ; Graft vs Host Disease/pathology ; Humans ; Immunity, Innate ; Inflammatory Bowel Diseases ; Intestinal Mucosa ; Microbiota
    Language English
    Publishing date 2022-04-13
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202149530
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  10. Article ; Online: A Toolkit for Monitoring Immunoglobulin G Levels from Dried Blood Spots of Patients with Primary Immunodeficiencies.

    Haberstroh, Hanna / Hirsch, Aleksandra / Goldacker, Sigune / Zessack, Norbert / Warnatz, Klaus / Grimbacher, Bodo / Salzer, Ulrich

    Journal of clinical immunology

    2023  Volume 43, Issue 6, Page(s) 1185–1192

    Abstract: Purpose: This study assessed whether measuring immunoglobulin G (IgG) from dried blood spots (DBSs) using nephelometry is a suitable remote monitoring method for patients with primary immunodeficiencies (PID).: Methods: Patients receiving ... ...

    Abstract Purpose: This study assessed whether measuring immunoglobulin G (IgG) from dried blood spots (DBSs) using nephelometry is a suitable remote monitoring method for patients with primary immunodeficiencies (PID).
    Methods: Patients receiving immunoglobulin replacement therapy for PID were included in this non-interventional single-arm study (DRKS-ID: DRKS00020522) conducted in Germany from December 4, 2019, to December 22, 2020. Three blood samples, two capillary DBSs (one mail-transferred and the other direct-transferred to the laboratory), and one intravenous were collected from each patient. IgG levels were determined using nephelometry. IgG levels were summarized descriptively, and significant differences were assessed using Wilcoxon matched-pairs signed-rank tests. Correlation and agreement between IgG levels were assessed using Spearman correlation and Bland-Altman analyses, respectively.
    Results: Among 135 included patients, IgG levels measured from DBS samples were lower than those measured in serum (p < 0.0001). There was no significant difference between IgG levels in direct- and mail-transferred DBS samples. There was a high degree of correlation between IgG levels in serum samples and DBS samples (r = 0.94-0.95). Although there was a bias for higher levels of IgG in serum than in DBS samples, most samples were within the 95% interval of agreement. There was a high degree of correlation between IgG levels measured in direct- and mail-transferred DBS samples (r = 0.96) with no bias based on the shipment process and most samples within the 95% interval of agreement.
    Conclusion: Monitoring IgG levels from DBS samples is a suitable alternative to the standard method, and results are not substantially affected by mailing DBS cards.
    MeSH term(s) Humans ; Dried Blood Spot Testing/methods ; Immunoglobulin G ; Serum ; Germany
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2023-03-21
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-023-01464-0
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