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  1. Article ; Online: What every intensivist should know about..Patient safety huddles in the ICU.

    Hoyler, Margo / Niederman, Michael S / Girardi, Natalia Ivascu

    Journal of critical care

    2024  , Page(s) 154788

    Abstract: Patient safety huddles are brief, multidisciplinary conversations that focus on a specific topic or event. Huddles have been shown to improve communication among healthcare providers in a variety of settings, including the intensive care unit (ICU). This ...

    Abstract Patient safety huddles are brief, multidisciplinary conversations that focus on a specific topic or event. Huddles have been shown to improve communication among healthcare providers in a variety of settings, including the intensive care unit (ICU). This paper presents key features of patient safety huddles and describes the ways in which huddle techniques may be particularly relevant to the practice of critical care.
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2024.154788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2152: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: A rare presentation of cutaneous T-cell lymphoma mimicking morphea.

    Yu, Beverly / Kim, Sa Rang / Roy, Simon F / Girardi, Michael

    JAAD case reports

    2023  Volume 33, Page(s) 59–61

    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2023.01.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A case of bullous lesions in cutaneous T-cell lymphoma.

    Xu, Suzanne / Weiss, Emma / Singh, Katelyn / Damsky, William / Girardi, Michael

    JAAD case reports

    2023  Volume 35, Page(s) 90–93

    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2023.02.026
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  4. Article ; Online: Comment on "Diagnostic testing of eczematous dermatitis with incomplete response to dupilumab".

    Cohen, Jeffrey M / Damsky, William / Girardi, Michael

    Journal of the American Academy of Dermatology

    2022  Volume 87, Issue 6, Page(s) e241–e242

    MeSH term(s) Humans ; Mycosis Fungoides ; Sezary Syndrome ; Eczema/diagnosis ; Eczema/drug therapy ; Skin Neoplasms ; Diagnostic Techniques and Procedures
    Chemical Substances dupilumab (420K487FSG)
    Language English
    Publishing date 2022-08-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2022.05.069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1540: Show issues Location:
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  5. Article ; Online: Treatment at high-volume facilities is associated with improved overall survival for patients with cutaneous B-cell lymphoma.

    Cheraghlou, Shayan / Ugwu, Nelson / Girardi, Michael

    Journal of the American Academy of Dermatology

    2022  Volume 88, Issue 1, Page(s) 203–205

    MeSH term(s) Humans ; Skin Neoplasms/therapy ; Hospitals, High-Volume ; Bone Neoplasms ; Lymphoma, B-Cell/therapy ; Retrospective Studies ; Survival Rate
    Language English
    Publishing date 2022-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2022.04.032
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    Zs.A 1540: Show issues Location:
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  6. Article ; Online: Nanoparticles as a Therapeutic Delivery System for Skin Cancer Prevention and Treatment.

    Chang, Jungsoo / Yu, Beverly / Saltzman, W Mark / Girardi, Michael

    JID innovations : skin science from molecules to population health

    2023  Volume 3, Issue 4, Page(s) 100197

    Abstract: The use of nanoparticles (NPs) as a therapeutic delivery system has expanded markedly over the past decade, particularly regarding applications targeting the skin. The delivery of NP-based therapeutics to the skin requires special consideration owing to ... ...

    Abstract The use of nanoparticles (NPs) as a therapeutic delivery system has expanded markedly over the past decade, particularly regarding applications targeting the skin. The delivery of NP-based therapeutics to the skin requires special consideration owing to its role as both a physical and immunologic barrier, and specific technologies must not only take into consideration the target but also the pathway of delivery. The unique challenge this poses has been met with the development of a wide panel of NP-based technologies meant to precisely address these considerations. In this review article, we describe the application of NP-based technologies for drug delivery targeting the skin, summarize the types of NPs, and discuss the current landscape of NPs for skin cancer prevention and skin cancer treatment as well as future directions within these applications.
    Language English
    Publishing date 2023-03-16
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2667-0267
    ISSN (online) 2667-0267
    DOI 10.1016/j.xjidi.2023.100197
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  7. Article ; Online: Insights Into the Molecular and Cellular Underpinnings of Cutaneous T Cell Lymphoma.

    Yumeen, Sara / Girardi, Michael

    The Yale journal of biology and medicine

    2020  Volume 93, Issue 1, Page(s) 111–121

    Abstract: Cutaneous T cell lymphoma (CTCL) is a rare malignancy of skin-homing T lymphocytes. Advances in whole exome sequencing have identified a vast number of both single nucleotide variants (SNVs) and genomic copy number alterations (GCNAs) as driver mutations ...

    Abstract Cutaneous T cell lymphoma (CTCL) is a rare malignancy of skin-homing T lymphocytes. Advances in whole exome sequencing have identified a vast number of both single nucleotide variants (SNVs) and genomic copy number alterations (GCNAs) as driver mutations present in CTCL cells. These alterations cluster within several key pathways - T cell/NF-κB/JAK-STAT activation, cell cycle dysregulation/apoptosis, and DNA structural dysregulation affecting gene expression - allowing the maintenance of a population of proliferating, activated malignant T lymphocytes. While much of the clinical spectrum, genetic alterations, and oncogenic behavior of CTCL have been elucidated, little is known about the etiology that underlies CTCL malignant transformation and progression. Herein, we review the epidemiology, clinical presentation, and pathophysiology of CTCL to provide a perspective on CTCL pathogenesis. We outline a series of alterations by which mature, activated T lymphocytes are endowed with apoptosis resistance and cutaneous persistence. Subsequent genomic alterations including the loss of chromosomal structural controls further promote proliferation and constitutive T cell activation. CTCL cells are both malignant cells and highly functional T cells that can have major cutaneous and immunologic effects on the patient, including the suppression of cell-mediated immunity that facilitates malignant cell expansion. A deeper understanding of the molecular and cellular underpinnings of CTCL can help guide clinical management as well as inform prognosis and therapeutic discovery.
    MeSH term(s) Gene Expression ; Genetic Association Studies ; Humans ; Lymphoma, T-Cell, Cutaneous/genetics ; Lymphoma, T-Cell, Cutaneous/metabolism ; Lymphoma, T-Cell, Cutaneous/pathology ; Signal Transduction ; Skin Neoplasms/genetics ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology
    Language English
    Publishing date 2020-03-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 200515-3
    ISSN 1551-4056 ; 0044-0086
    ISSN (online) 1551-4056
    ISSN 0044-0086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.197: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: FISH Panel for Leukemic Cutaneous T-Cell Lymphoma: Extended Patient Cohort Correlation with Blood Involvement and Clinical Outcomes.

    Avery, Jonathan / Kim, Sa Rang / Cheng, Wei / Foss, Francine / Girardi, Michael

    JID innovations : skin science from molecules to population health

    2023  Volume 3, Issue 5, Page(s) 100212

    Abstract: The genomic basis of cutaneous T-cell lymphoma has been characterized by gene copy number alterations and genomic sequencing, but there are few clinical tests that are being widely used to inform the diagnosis and prognosis of leukemic cutaneous T-cell ... ...

    Abstract The genomic basis of cutaneous T-cell lymphoma has been characterized by gene copy number alterations and genomic sequencing, but there are few clinical tests that are being widely used to inform the diagnosis and prognosis of leukemic cutaneous T-cell lymphoma that may arise as a progression from mycosis fungoides or de novo as Sézary syndrome. An 11-gene FISH panel of
    Language English
    Publishing date 2023-06-14
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2667-0267
    ISSN (online) 2667-0267
    DOI 10.1016/j.xjidi.2023.100212
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  9. Article ; Online: Proteasome Inhibitors Interact Synergistically with BCL2, Histone Deacetylase, BET, and Jak Inhibitors against Cutaneous T-Cell Lymphoma Cells.

    Xu, Suzanne / Ren, Jingjing / Lewis, Julia M / Carlson, Kacie R / Girardi, Michael

    The Journal of investigative dermatology

    2023  Volume 143, Issue 7, Page(s) 1322–1325.e3

    MeSH term(s) Humans ; Proteasome Inhibitors/pharmacology ; Proteasome Inhibitors/therapeutic use ; Janus Kinase Inhibitors/therapeutic use ; Histone Deacetylases ; Lymphoma, T-Cell, Cutaneous/drug therapy ; Lymphoma, T-Cell, Cutaneous/pathology ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/therapeutic use ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology ; Proto-Oncogene Proteins c-bcl-2 ; Cell Line, Tumor ; Antineoplastic Agents/therapeutic use
    Chemical Substances Proteasome Inhibitors ; Janus Kinase Inhibitors ; Histone Deacetylases (EC 3.5.1.98) ; Histone Deacetylase Inhibitors ; Proto-Oncogene Proteins c-bcl-2 ; Antineoplastic Agents ; BCL2 protein, human
    Language English
    Publishing date 2023-01-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2022.12.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui VI Zs.124: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Generation and optimization of off-the-shelf immunotherapeutics targeting TCR-Vβ2+ T cell malignancy.

    Ren, Jingjing / Liao, Xiaofeng / Lewis, Julia M / Chang, Jungsoo / Qu, Rihao / Carlson, Kacie R / Foss, Francine / Girardi, Michael

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 519

    Abstract: Current treatments for T cell malignancies encounter issues of disease relapse and off-target toxicity. Using T cell receptor (TCR)Vβ2 as a model, here we demonstrate the rapid generation of an off-the-shelf allogeneic chimeric antigen receptor (CAR)-T ... ...

    Abstract Current treatments for T cell malignancies encounter issues of disease relapse and off-target toxicity. Using T cell receptor (TCR)Vβ2 as a model, here we demonstrate the rapid generation of an off-the-shelf allogeneic chimeric antigen receptor (CAR)-T platform targeting the clone-specific TCR Vβ chain for malignant T cell killing while limiting normal cell destruction. Healthy donor T cells undergo CRISPR-induced TRAC, B2M and CIITA knockout to eliminate T cell-dependent graft-versus-host and host-versus-graft reactivity. Second generation 4-1BB/CD3zeta CAR containing high affinity humanized anti-Vβ scFv is expressed efficiently on donor T cells via both lentivirus and adeno-associated virus transduction with limited detectable pre-existing immunoreactivity. Our optimized CAR-T cells demonstrate specific and persistent killing of Vβ2+ Jurkat cells and Vβ2+ patient derived malignant T cells, in vitro and in vivo, without affecting normal T cells. In parallel, we generate humanized anti-Vβ2 antibody with enhanced antibody-dependent cellular cytotoxicity (ADCC) by Fc-engineering for NK cell ADCC therapy.
    MeSH term(s) Humans ; Receptors, Antigen, T-Cell/genetics ; Jurkat Cells ; Immunotherapy, Adoptive ; Receptors, Chimeric Antigen/genetics ; Clone Cells
    Chemical Substances Receptors, Antigen, T-Cell ; Receptors, Chimeric Antigen
    Language English
    Publishing date 2024-01-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-44786-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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