LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 9 of total 9

Search options

  1. Article ; Online: Immunotherapy for SARS-CoV-2: potential opportunities.

    Pashaei, Mehrnoosh / Rezaei, Nima

    Expert opinion on biological therapy

    2020  Volume 20, Issue 10, Page(s) 1111–1116

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Immunotherapy ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-12
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2052501-1
    ISSN 1744-7682 ; 1471-2598
    ISSN (online) 1744-7682
    ISSN 1471-2598
    DOI 10.1080/14712598.2020.1807933
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6094: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Immunotherapy for SARS-CoV-2

    Pashaei, Mehrnoosh / Rezaei, Nima

    Expert Opinion on Biological Therapy

    potential opportunities

    2020  Volume 20, Issue 10, Page(s) 1111–1116

    Keywords Clinical Biochemistry ; Pharmacology ; Drug Discovery ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2052501-1
    ISSN 1471-2598
    ISSN 1471-2598
    DOI 10.1080/14712598.2020.1807933
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6094: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Review on Interferon beta

    Fatemeh Hajilou / Pouya Youeseflee / Mehrnoosh Pashaei / Kimiya Bagheri / Bahador Bagheri

    Majallah-i ̒Ilmī-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Simnān, Vol 24, Iss 1, Pp 26-

    from cells to clinical usage

    2022  Volume 37

    Abstract: Introduction: Interferon (IFN) was first introduced by Isaacs and Linddeman in 1957. It referred to a factor that could cause inhibition in the growth of the live influenza virus. Interferons are intracellular proteins that are involved in many cellular ... ...

    Abstract Introduction: Interferon (IFN) was first introduced by Isaacs and Linddeman in 1957. It referred to a factor that could cause inhibition in the growth of the live influenza virus. Interferons are intracellular proteins that are involved in many cellular processes such as growth, proliferation, differentiation, metabolism of the extracellular matrix, apoptosis, and regulating immune responses. There are different intereferones. Amog them, interferons-beta (IFN-β) is a natural cytokine produced by immune cells in response to biological and chemical stimuli. Signal transduction of IFN-β is initiated throughout a heterodimeric receptor complex that is composed of IFNAR1 and IFNAR2; which leads to expression of various proteins via the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway as well as other pathways. In addition to antiviral effects of IFN-β, it has been shown to have therapeutic effects in some autoimmune diseases such as multiple sclerosis, rheumatoid arthritis and lupus. It has recently been shown that the use of IFN-β in combination with other antiviral compounds may be effective in treatment of Covid-19. In this review the various topics about IFN-β are investigated such as signalling pathways, biological functions, therapeutic effects, and side effects of IFN-β therapy.
    Keywords interferon-beta ; signal transduction ; therapeutic uses ; covid-19 ; sars-cov-2 ; autoimmune diseases ; biological functions ; therapeutic effects ; side effects ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610 ; 570
    Language Persian
    Publishing date 2022-01-01T00:00:00Z
    Publisher Semnan Univeristy of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Effect of IL-27 on activity of bone marrow NK cells of patient with B-chronic lymphocytic leukemia in vitro

    Abdolvahid Sadeghnejad / Maral Hemati / Mehrnoosh Pashaei / Zahra Rasouli Nejad / Farahnaz Ghahremanfard / Parviz Kokhaei

    Majallah-i ̒Ilmī-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Simnān, Vol 23, Iss 1, Pp 131-

    2021  Volume 138

    Abstract: Introduction: Functional defect in immune cells is the prominent feature in hematological malignancies that lead to the expansion of tumor cells. Using immunostimulatory cytokines is one of the new therapeutic approaches. This study aimed to investigate ... ...

    Abstract Introduction: Functional defect in immune cells is the prominent feature in hematological malignancies that lead to the expansion of tumor cells. Using immunostimulatory cytokines is one of the new therapeutic approaches. This study aimed to investigate the effect of IL-27 on the activity of bone marrow-NK cells of chronic lymphocytic leukemia (CLL) patients in vitro. Materials and Methods: 10 ml of bone marrow aspirate samples were collected from 5 patients with CLL and isolated monocular cells using Ficoll-Hypaque density gradient. NK cells were then purified by MACS technique. The mononuclear cells were cultured in RPMI with or without recombinant human IL-27 (100ng/ml) for 48 hours. Expression of CD69 was assessed on purified and unpurified NK cells (BMCs) using flow cytometry. Also, purified NK cells were adjacent to the target cells as the K562 cell line in E:T ratios of 2.5:1, 5:1 and 10:1, then the target cell survival was assessed by flow cytometry using Annexin V/7-AAD. Results: The levels of CD69 expression on purified NK cells increased in IL-27 treated group in compared to the control (P=0.05). However, the expression level of CD69 in unpurified NK cells did not significantly increase with IL-27 treatment (P=0.06). Moreover, in the ratio of E/T:10, the NK cell cytotoxicity rate increased significantly (P=0.03), but this difference was not significant in the E:T ratios of 2.5 and 5. Conclusion: IL-27 cytokine increased NK cell function and cytotoxic activity against malignant cells in CLL. The results of this study can be used in clinical trials in the future.
    Keywords chronic lymphocytic leukemia ; interleukin-27 ; nk cells ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610 ; 616
    Language Persian
    Publishing date 2021-01-01T00:00:00Z
    Publisher Semnan Univeristy of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Somatic Mutation in Immunoglobulin Gene Variable Region in Patients with Chronic Lymphocytic Leukemia and Prognostic Impact

    Mehrnoosh Pashaei / Mahdieh Shokrollahi / Parviz Kokhaei

    Basic & Clinical Cancer Research, Vol 8, Iss

    2017  Volume 4

    Abstract: Chronic lymphocyte leukemia (CLL) is the most common leukemia in elderly individuals that is accompanied by the presence of CD5/CD19/CD20/CD23 positive, FMC7 negative and reduced levels of surface membrane Immunoglobuline (IgM & IgD), CD79b on B ... ...

    Abstract Chronic lymphocyte leukemia (CLL) is the most common leukemia in elderly individuals that is accompanied by the presence of CD5/CD19/CD20/CD23 positive, FMC7 negative and reduced levels of surface membrane Immunoglobuline (IgM & IgD), CD79b on B lymphocytes in the blood, bone marrow and lymph nodes. Remarkably, based on the mutational IgVH status, B-CLL cases can be subdivided into two prognostic groups: the first one with presence mutation (≥ 2%) in VH gene and second one with absence mutation (≤ 2%) in VH gene that is the mutation of IgVH status, affected on progression and overall survival of CLL patients. Correspondingly, also the expression level of several markers is correlated with the mutation of IgVH status and prognosis of CLL disease. In this review we focused on relation between mutation IgVH status and CLL prognosis and overall survival and also some cellular markers which may affect CLL clinical status.
    Keywords CLL ; mutation IgVH status ; prognosis factor ; overall survival ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2017-02-01T00:00:00Z
    Publisher Tehran University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Apoptotic effect of berberine via Bcl-2, ROR1, and mir-21 in patients with B-chronic lymphocytic leukemia.

    Mohammadlou, Maryam / Abdollahi, Maryam / Hemati, Maral / Baharlou, Rasoul / Doulabi, Ehsan Manouchehri / Pashaei, Mehrnoosh / Ghahremanfard, Farahnaz / Faranoush, Mohammad / Kokhaei, Parviz

    Phytotherapy research : PTR

    2020  Volume 35, Issue 4, Page(s) 2025–2033

    Abstract: Berberine is a natural isoquinoline alkaloid that has been shown to inhibit the proliferation and induce apoptosis in a wide variety of tumor cells. However, the action mechanism of berberine in CLL cells is unknown. The previous study has shown that ... ...

    Abstract Berberine is a natural isoquinoline alkaloid that has been shown to inhibit the proliferation and induce apoptosis in a wide variety of tumor cells. However, the action mechanism of berberine in CLL cells is unknown. The previous study has shown that berberine leads to reduced viability and elevated levels of apoptosis in PBMCs of CLL patients. CLL cells are characterized by remarkable expression of Bcl-2 and ROR1 which leads to activation and survival and increases disease progression in patients. High-level expression of miR-21 in patients with CLL is associated with a higher risk of death. Here we investigated the anticancer effects of berberine upon peripheral blood mononuclear cells (PBMCs) of CLL patients. To evaluate the expression of anti-apoptotic proteins and ROR1 using flow cytometry and western blot, PBMCs were treated with 25 μM of berberine for 24 hr. The expression levels of mir-21 were evaluated by real-time PCR. Examination of treated cells demonstrated that berberine decreased Bcl-2 and ROR1 levels. Although western blot results did not show any change in Bax as a pro-apoptotic protein, an increased Bax/Bcl-2 ratio indicated that mitochondrial pathway is involved in berberine-induced apoptosis of CLL cells. Interestingly, berberine could reduce the expression of miR-21 in comparison to the untreated group. Our findings describe some of the molecular mechanisms of berberine by decreasing Bcl-2, ROR1, and mir-21 which may be considered as a novel apoptosis inducer in CLL cells.
    MeSH term(s) Apoptosis/drug effects ; Berberine/pharmacology ; Berberine/therapeutic use ; Female ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Male ; MicroRNAs/drug effects ; Middle Aged ; Proto-Oncogene Proteins c-bcl-2/drug effects ; Receptor Tyrosine Kinase-like Orphan Receptors/drug effects
    Chemical Substances BCL2 protein, human ; MIRN21 microRNA, human ; MicroRNAs ; Proto-Oncogene Proteins c-bcl-2 ; Berberine (0I8Y3P32UF) ; ROR1 protein, human (EC 2.7.10.1) ; Receptor Tyrosine Kinase-like Orphan Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2020-11-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.6945
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 3092: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Effect of berberine on cancer cell viability of chronic lymphocytic leukemia patients in in vitro

    Farahnaz Ghahremanfard / Arash Aghabeigi / Ehsan Manouchehri / Mehrnoosh Pashaei / Majid Mirmohammadkhani / Mahdieh Shokrollahi Barough / Fatemeh Pak / Mohammad Faranoush / Parviz Kokhaei

    Majallah-i ̒Ilmī-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Simnān, Vol 19, Iss 3, Pp 634-

    2017  Volume 640

    Abstract: Introduction:Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. CLL generally affects older people by the accumulation and proliferation of B lymphocytes with markers CD19+, CD20+, CD5+ and CD23+ specified. In this way, ... ...

    Abstract Introduction:Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. CLL generally affects older people by the accumulation and proliferation of B lymphocytes with markers CD19+, CD20+, CD5+ and CD23+ specified. In this way, berberine, including natural compounds with isoquinoline alkaloids structure, that has a potential anti-cancer effect. Berberin decreased survival and increased apoptosis of cancer cell lines in in vitro. In this study, the effect of berberine on cell survival and apoptosis in PBMC patients and healthy donors in the presence or absence of berberine and also comparison between bernerine and fludarabine were investigated. Materials and Methods:Peripheral blood mononuclear cells (PBMCs) of 12 patients and 6 healthy donors were isolated by using ficoll technique and PBMC cells seeded into the 96 well culture plate using medium RPMI1640+ AB+ serum with doses ranging from 5 to 200 μM of Berberine. The survival and apoptosis percentage of these cells was measured by MTT and Annexin V/7AAD (Flowcytometery). Results:Our results suggest a reduction in PBMC survival in CLL patients treated with berberine with P<0.05 as compared to patients cells which not treated. Comparing PBMC survival treated with berberine to cells treated with fludarabine showed no significant change (P>0.05). Correspondingly, increasing PBMC apoptosis in patients treated with berberine was observed rather than the cells were not adjacent to berberine (P<0.05) and also compared with PBMC apoptosis treated with fludarabine which shown no significant difference (P >0.05). However, we don’t have this increasing in healthy donors. Conclusion: Berberine leads to reduced viability and elevated levels of apoptosis in PBMCs of CLL Patients. Berberin showed no significant effects on PBMCs of healthy donor viability and apoptosis. Apoptosis induction by berberin is comparable to fludarabine as a standard treatment for CLL patients. Berberine might be a good candidate for clinical trial for CLL ...
    Keywords B-Cell Chronic Lymphocytic Leukemia ; Berberine ; Fludarabine ; Apoptosis ; Annexin 5A ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610
    Language Persian
    Publishing date 2017-06-01T00:00:00Z
    Publisher Semnan Univeristy of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Levels of plasma immunoglobulin E in patients with chronic lymphocytic leukemia and breast cancer

    Mehrnoosh Pashaei / Mehdi Barati / Ehsan Manouchehri Doulabi / Farahnaz Ghahremanfard / Majid Mirmohammadkhani / Fatemeh Pak / Parviz Kokhaei

    Majallah-i ̒Ilmī-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Simnān, Vol 18, Iss 1, Pp 147-

    2016  Volume 152

    Abstract: Introduction: Immunoglobulin E (IgE) is a key player in allergy diseases and immune responses against parasites. Epidemiological studies indicated that there is an inverse association between plasma IgE levels as it been seen in allergic patients and the ...

    Abstract Introduction: Immunoglobulin E (IgE) is a key player in allergy diseases and immune responses against parasites. Epidemiological studies indicated that there is an inverse association between plasma IgE levels as it been seen in allergic patients and the risk of cancer development. The aim of this study was to investigate the plasma IgE levels in breast cancer and patients with chronic lymphocytic leukemia than healthy subjects. Materials and Methods: In this case-control study, twenty patients with CLL also twenty five patients with breast cancer as the cases groups and twenty age-matched healthy subjects as control group were evaluated. Plasma IgE levels in both groups were measured by ELISA. Data from both groups were analyzed and compared by kolmogorov-smirnov test and paired t-test with SPSS version 16. Results: The IgE levels were 9.045±4.261 IU/ml in CLL patients and 37.19±12.21 IU/ml in patients with breast cancer and 40.73±16.18 IU/ml in healthy subjects. Our data showed that plasma IgE levels in CLL patients group were significantly less than controls group (p<0.05), but the difference between patients with breast cancer and controls group was not significant. Conclusion: It seems that there is an inverse correlation between serum IgE levels and the risk of developing CLL. While there is no correlation between the IgE level and the risk of developing breast cancer. IgE levels can be used as a biological marker in chronic lymphocytic leukemia development.
    Keywords Breast Neoplasms ; Chronic lymphocytic leukemia ; Immunoglobulin E ; Enzyme-Linked Immunosorbent Assay ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610 ; 616
    Language Persian
    Publishing date 2016-09-01T00:00:00Z
    Publisher Semnan Univeristy of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top