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  1. Article: Deutscher Krebskongress - Interview mit Stephan Grupp, Philadelphia: "Die Stärken der CAR-T-Zellen: Erkennung von Krebszellen, starke Proliferation und Persistenz"

    Grupp, Stephan

    Trillium-Krebsmedizin

    2016  Volume 25, Issue 2, Page(s) 128

    Language German
    Document type Article
    ZDB-ID 2768536-6
    ISSN 2198-9818
    Database Current Contents Medicine

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    Zs.A 6564: Show issues Location:
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  2. Article ; Online: Defibrotide prophylaxis for prevention of sinusoidal obstruction syndrome - Authors' reply.

    Grupp, Stephan A

    The Lancet. Haematology

    2023  Volume 10, Issue 7, Page(s) e488–e489

    MeSH term(s) Humans ; Hepatic Veno-Occlusive Disease/drug therapy ; Hepatic Veno-Occlusive Disease/prevention & control ; Polydeoxyribonucleotides/therapeutic use ; Hematopoietic Stem Cell Transplantation/adverse effects
    Chemical Substances defibrotide (438HCF2X0M) ; Polydeoxyribonucleotides
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Letter ; Comment
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(23)00176-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Driving two chimeric antigen receptors (CARs) in a row to reduce antigen escape in B-cell acute lymphocytic leukaemia.

    Myers, Regina M / Grupp, Stephan A

    The Lancet. Oncology

    2023  Volume 24, Issue 11, Page(s) 1163–1164

    MeSH term(s) Humans ; Receptors, Chimeric Antigen/genetics ; Antigenic Drift and Shift ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/therapy ; Immunotherapy, Adoptive ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Receptors, Antigen, T-Cell
    Chemical Substances Receptors, Chimeric Antigen ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2023-10-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(23)00517-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reply to W.H. Tong et al.

    Laetsch, Theodore W / Tiwari, Ranjan / Grupp, Stephan A

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 13, Page(s) 2451–2453

    Language English
    Publishing date 2023-03-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.00187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Corrigendum to "Advances in T-cell therapy for ALL" [Best Pract Res Clin Haematol 27 (2014) 222-228].

    Grupp, Stephan A

    Best practice & research. Clinical haematology

    2016  Volume 29, Issue 1, Page(s) 133

    Language English
    Publishing date 2016
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2048027-1
    ISSN 1532-1924 ; 1521-6926
    ISSN (online) 1532-1924
    ISSN 1521-6926
    DOI 10.1016/j.beha.2016.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Will allogeneic CAR T cells for CD19

    DiNofia, Amanda M / Grupp, Stephan A

    Nature reviews. Clinical oncology

    2021  Volume 18, Issue 4, Page(s) 195–196

    MeSH term(s) Adult ; Antigens, CD19 ; B-Lymphocytes/immunology ; Child ; Hematopoietic Stem Cell Transplantation ; Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Receptors, Antigen, T-Cell ; Receptors, Chimeric Antigen/genetics ; T-Lymphocytes/immunology
    Chemical Substances Antigens, CD19 ; Receptors, Antigen, T-Cell ; Receptors, Chimeric Antigen
    Language English
    Publishing date 2021-02-19
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/s41571-021-00485-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Chimeric Antigen Receptor T Cell Manufacturing on an Automated Cell Processor.

    Machietto, Rene / Giacobbe, Nicholas / Perazzelli, Jessica / Hofmann, Ted J / Barz Leahy, Allison / Grupp, Stephan A / Wang, Yongping / Kadauke, Stephan

    Journal of visualized experiments : JoVE

    2023  , Issue 198

    Abstract: Chimeric antigen receptor (CAR)-T cells represent a promising immunotherapeutic approach for the treatment of various malignant and non-malignant diseases. CAR-T cells are genetically modified T cells that express a chimeric protein that recognizes and ... ...

    Abstract Chimeric antigen receptor (CAR)-T cells represent a promising immunotherapeutic approach for the treatment of various malignant and non-malignant diseases. CAR-T cells are genetically modified T cells that express a chimeric protein that recognizes and binds to a cell surface target, resulting in the killing of the target cell. Traditional CAR-T cell manufacturing methods are labor-intensive, expensive, and may carry the risk of contamination. The CliniMACS Prodigy, an automated cell processor, allows for manufacturing cell therapy products at a clinical scale in a closed system, minimizing the risk of contamination. Processing occurs semi-automatically under the control of a computer and thus minimizes human involvement in the process, which saves time and reduces variability and errors. This manuscript and video describes the T cell transduction (TCT) process for manufacturing CAR-T cells using this processor. The TCT process involves CD4+/CD8+ T cell enrichment, activation, transduction with a viral vector, expansion, and harvest. Using the Activity Matrix, a functionality that allows ordering and timing of these steps, the TCT process can be customized extensively. We provide a walk-through of CAR-T cell manufacturing in compliance with current Good Manufacturing Practice (cGMP) and discuss required release testing and preclinical experiments that will support an Investigational New Drug (IND) application. We demonstrate the feasibility and discuss the advantages and disadvantages of using a semi-automatic process for clinical CAR-T cell manufacturing. Finally, we describe an ongoing investigator-initiated clinical trial that targets pediatric B-cell malignancies [NCT05480449] as an example of how this manufacturing process can be applied in a clinical setting.
    MeSH term(s) Child ; Humans ; Receptors, Chimeric Antigen/genetics ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; Cell Membrane ; B-Lymphocytes
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2023-08-18
    Publishing country United States
    Document type Journal Article ; Video-Audio Media ; Research Support, Non-U.S. Gov't
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/65488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Thesis: Tierexperimentelle Untersuchung Pharmakodynamischer Effekte auf die Modulation inflammatorischer Prozesse durch die Lokalanästhetika Bupivacain und Ropivacain am Ganztiermodell

    Grupp, Stephan

    2004  

    Author's details vorgelegt von Stephan Grupp
    Language German
    Size 57 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2004
    HBZ-ID HT014121695
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2004 E 1708 order for loan Magazin

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  9. Article ; Online: Prevention of veno-occlusive disease/sinusoidal obstruction syndrome: a never-ending story and no easy answer.

    Corbacioglu, Selim / Grupp, Stephan A / Richardson, Paul Gerard / Duarte, Rafael / Pagliuca, Antonio / Ruutu, Tapani / Mahadeo, Kris / Carreras, Enric

    Bone marrow transplantation

    2023  Volume 58, Issue 8, Page(s) 839–841

    MeSH term(s) Humans ; Hepatic Veno-Occlusive Disease/etiology ; Hepatic Veno-Occlusive Disease/prevention & control ; Vascular Diseases ; Hematopoietic Stem Cell Transplantation
    Language English
    Publishing date 2023-05-25
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-023-02007-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  10. Article ; Online: Refining megatherapy, improving outcome in neuroblastoma.

    Bagatell, Rochelle / Grupp, Stephan A

    The Lancet. Oncology

    2017  Volume 18, Issue 4, Page(s) 423–424

    MeSH term(s) Disease-Free Survival ; Humans ; Infant ; Neuroblastoma
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(17)30069-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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