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  1. Article: "Klinische Studien haben bei den Fortschritten für Melanompatienten eine ganz entscheidende Rolle gespielt". Interview mit D. Schadendorf

    Schadendorf, D.

    Diskurs

    2020  Volume -, Issue 2, Page(s) 22

    Language German
    Document type Article
    ZDB-ID 2948038-3
    ISSN 2626-8957
    Database Current Contents Medicine

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  2. Book: Dabrafenib und Trametinib

    Schadendorf, Dirk

    Kombinationstherapie bei erwachsenen Patienten mit einer BRAF-V600-Mutation

    (Drug report ; 13. Jahrgang, Heft 4 (März 2019))

    2019  

    Author's details Herausgeber Prof. Dirk Schadendorf, Prof. Frank Giesinger, Dr. Markus Tiemann
    Series title Drug report ; 13. Jahrgang, Heft 4 (März 2019)
    Collection
    Language German
    Size 23 Seiten, Illustrationen, Diagramme, 27 cm
    Publisher Thieme
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT020105486
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Adjuvant Therapy of Nivolumab Combined With Ipilimumab Versus Nivolumab Alone in Patients With Resected Stage IIIB-D or Stage IV Melanoma (CheckMate 915).

    Weber, Jeffrey S / Schadendorf, Dirk / Del Vecchio, Michele / Larkin, James / Atkinson, Victoria / Schenker, Michael / Pigozzo, Jacopo / Gogas, Helen / Dalle, Stéphane / Meyer, Nicolas / Ascierto, Paolo A / Sandhu, Shahneen / Eigentler, Thomas / Gutzmer, Ralf / Hassel, Jessica C / Robert, Caroline / Carlino, Matteo S / Di Giacomo, Anna Maria / Butler, Marcus O /
    Muñoz-Couselo, Eva / Brown, Michael P / Rutkowski, Piotr / Haydon, Andrew / Grob, Jean-Jacques / Schachter, Jacob / Queirolo, Paola / de la Cruz-Merino, Luis / van der Westhuizen, Andre / Menzies, Alexander M / Re, Sandra / Bas, Tuba / de Pril, Veerle / Braverman, Julia / Tenney, Daniel J / Tang, Hao / Long, Georgina V

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2022  Volume 41, Issue 3, Page(s) 517–527

    Abstract: ... alone in patients with resected stage IIIB-D or IV melanoma.: Patients and methods ... nivolumab 480 mg once every 4 weeks in patients with stage IIIB-D or stage IV melanoma. Nivolumab showed ...

    Abstract Purpose: Ipilimumab and nivolumab have each shown treatment benefit for high-risk resected melanoma. The phase III CheckMate 915 trial evaluated adjuvant nivolumab plus ipilimumab versus nivolumab alone in patients with resected stage IIIB-D or IV melanoma.
    Patients and methods: In this randomized, double-blind, phase III trial, 1,833 patients received nivolumab 240 mg once every 2 weeks plus ipilimumab 1 mg/kg once every 6 weeks (916 patients) or nivolumab 480 mg once every 4 weeks (917 patients) for ≤ 1 year. After random assignment, patients were stratified by tumor programmed death ligand 1 (PD-L1) expression and stage. Dual primary end points were recurrence-free survival (RFS) in randomly assigned patients and in the tumor PD-L1 expression-level < 1% subgroup.
    Results: At a minimum follow-up of approximately 23.7 months, there was no significant difference between treatment groups for RFS in the all-randomly assigned patient population (hazard ratio, 0.92; 95% CI, 0.77 to 1.09;
    Conclusion: Nivolumab 240 mg once every 2 weeks plus ipilimumab 1 mg/kg once every 6 weeks did not improve RFS versus nivolumab 480 mg once every 4 weeks in patients with stage IIIB-D or stage IV melanoma. Nivolumab showed efficacy consistent with previous adjuvant studies in a population resembling current practice using American Joint Committee on Cancer eighth edition, reaffirming nivolumab as a standard of care for melanoma adjuvant treatment.
    MeSH term(s) Humans ; Adjuvants, Immunologic/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; B7-H1 Antigen/therapeutic use ; Double-Blind Method ; Ipilimumab/therapeutic use ; Melanoma/drug therapy ; Melanoma/surgery ; Neoplasm Staging ; Nivolumab/therapeutic use ; Skin Neoplasms/drug therapy ; Skin Neoplasms/surgery
    Chemical Substances Adjuvants, Immunologic ; B7-H1 Antigen ; Ipilimumab ; Nivolumab (31YO63LBSN)
    Language English
    Publishing date 2022-09-26
    Publishing country United States
    Document type Clinical Trial, Phase III ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.00533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Fortgeschrittenes Melanom

    Schadendorf, Dirk

    Einsatz der zielgerichteten Kombination Cobimetinib/Vemurafenib sowie Wirksamkeit bei Patienten mit erhöhter LDH

    (Aktuelle Dermatologie : Drug report ; [45, 12], Beilage (Dezember 2019))

    2019  

    Author's details Herausgeber Prof. Dirk Schadendorf
    Series title Aktuelle Dermatologie : Drug report ; [45, 12], Beilage (Dezember 2019)
    Aktuelle Dermatologie
    Aktuelle Dermatologie
    Collection Aktuelle Dermatologie
    Aktuelle Dermatologie
    Language German
    Size 11 Seiten, Illustrationen, Diagramme
    Publisher Thieme
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT020361374
    Database Catalogue ZB MED Medicine, Health

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  5. Book: Hautklinik

    Schadendorf, Dirk

    Universitätsklinikum Essen

    2018  

    Author's details Herausgeber: Univ.-Prof.Dr.med. Dirk Schadendorf
    Keywords Klinik für Dermatologie
    Language German
    Size 68 Seiten, Illustrationen
    Publisher Universitätsklinikum Essen
    Publishing place Essen
    Publishing country Germany
    Document type Book
    HBZ-ID HT019709558
    Database Catalogue ZB MED Medicine, Health

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  6. Article: derm dialog. Interview mit D. Schadendorf

    Schadendorf, D.

    Derm

    2013  Volume 19, Issue 4, Page(s) 329

    Language German
    Document type Article
    ZDB-ID 1315453-9
    ISSN 0949-7633
    Database Current Contents Medicine

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  7. Book: Fortgeschrittenes Melanom als Herausforderung

    Schadendorf, Dirk

    zielgerichtete Kombinationstherapie verbessert das Überleben

    (Drug report ; 12. Jahrgang, Heft 8 (Juni 2018))

    2018  

    Author's details Herausgeber Prof. Dr. med. Dirk Schadendorf
    Series title Drug report ; 12. Jahrgang, Heft 8 (Juni 2018)
    Collection
    Language German
    Size 15 Seiten, Illustrationen, Diagramme
    Publisher Thieme
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT019932715
    Database Catalogue ZB MED Medicine, Health

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  8. Book ; Thesis: Advanced melanoma - optimizing therapeutic strategies through real-world data analysis

    Knispel, Sarah / Schadendorf, Dirk

    2021  

    Institution Universität Duisburg-Essen
    Author's details vorgelegt von Dr. med. Sarah Knispel ; 1. Gutachter/in: Herr Univ.-Prof. Dr. D. Schadendorf, 2. Gutachter/in: Herr Prof. Dr. med. A. Hauschild
    Language English
    Size 67 Seiten, Illustrationen
    Publishing place Duisburg ; Essen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Duisburg-Essen, 2021
    HBZ-ID HT021734812
    Database Catalogue ZB MED Medicine, Health

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  9. Book: Venenzentrum - Klinik für Dermatologie

    Schadendorf, Dirk

    2016  

    Institution Universitätsklinikum Essen
    Author's details Universitätsklinikum Essen, Medizinische Fakultät der Universität Duisburg-Essen ; Herausgeber: Univ.-Prof.Dr.med. Dirk Schadendorf
    Keywords Klinik für Dermatologie ; Venenkrankheit
    Subject Vene ; Venenkrankheiten
    Language German
    Size 56 Seiten, Illustrationen
    Publisher IPV-Informations-Presse-Verlag
    Publishing place Langenfeld
    Publishing country Germany
    Document type Book
    HBZ-ID HT019161492
    Database Catalogue ZB MED Medicine, Health

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  10. Book: Dabrafenib in Kombination mit Trametinib

    Schadendorf, Dirk

    erste zugelassene Kombinationstherapie beim erwachsenen Patienten mit nicht-resezierbarem oder metastasiertem Melanom mit BRAF-V600-Mutation

    (Thieme Drug Report ; 2016,1)

    2016  

    Author's details Herausgeber Prof. Dr. Dirk Schadendorf
    Series title Thieme Drug Report ; 2016,1
    Thieme drug report
    Collection Thieme drug report
    Language German
    Size 11 Seiten, Illustrationen
    Publisher Thieme
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT018929782
    Database Catalogue ZB MED Medicine, Health

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