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  1. Article ; Online: C

    Yang, Jeehyun / Smith, Mica C / Prendergast, Matthew B / Chu, Te-Chun / Green, William H

    Physical chemistry chemical physics : PCCP

    2021  Volume 23, Issue 26, Page(s) 14325–14339

    Abstract: The formation of polycyclic aromatic hydrocarbons (PAHs) during combustion has a substantial impact on environmental pollution and public health. The hydrogen-abstraction-acetylene-addition (HACA) mechanism is expected to be a significant source of ... ...

    Abstract The formation of polycyclic aromatic hydrocarbons (PAHs) during combustion has a substantial impact on environmental pollution and public health. The hydrogen-abstraction-acetylene-addition (HACA) mechanism is expected to be a significant source of larger PAHs containing more than two rings. In this study, the reactions of 1-naphthalenyl and 2-naphthalenyl radicals with acetylene (C2H2) are investigated using VUV photoionization time-of-flight mass spectrometry at 500 to 800 K, 15 to 50 torr, and reaction times up to 10 ms. Our experimental conditions allow us to probe the Bittner-Howard and modified Frenklach HACA routes, but not routes that require multiple radicals to drive the chemistry. The kinetic measurements are compared to a temperature-dependent kinetic model constructed using quantum chemistry calculations and accounting for chemical-activation and fall-off effects. We measure significant quantities of C14H10 (likely phenanthrene and anthracene), as well as 2-ethynylnaphthalene (C12H8), from the reaction of the 2-naphthalenyl radical with C2H2; these results are consistent with the predictions of the kinetic model and the HACA mechanism, but contradict a previous experimental study that indicated no C14H10 formation in the 2-naphthalenyl + C2H2 reaction. In the 1-naphthalenyl radical + C2H2 reaction system, the primary product measured is C12H8, consistent with the predicted formation of acenaphthylene via HACA. The present work provides direct experimental evidence that single-radical HACA can be an important mechanism for the formation of PAHs larger than naphthalene, validating a common assumption in combustion models.
    Language English
    Publishing date 2021-06-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d1cp01565f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: C

    Stein, Rebekah A / Sheldon, Nathan D / Smith, Selena Y

    The New phytologist

    2020  Volume 229, Issue 5, Page(s) 2576–2585

    Abstract: Plant carbon isotope discrimination is complex, and could be driven by climate, evolution and/or edaphic factors. We tested the climate drivers of carbon isotope discrimination in modern and historical plant chemistry, and focus in particular on the ... ...

    Abstract Plant carbon isotope discrimination is complex, and could be driven by climate, evolution and/or edaphic factors. We tested the climate drivers of carbon isotope discrimination in modern and historical plant chemistry, and focus in particular on the relationship between rising [CO
    MeSH term(s) Atmosphere ; Carbon Dioxide ; Carbon Isotopes/analysis ; Phylogeny ; Plants
    Chemical Substances Carbon Isotopes ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2020-11-22
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 208885-x
    ISSN 1469-8137 ; 0028-646X
    ISSN (online) 1469-8137
    ISSN 0028-646X
    DOI 10.1111/nph.17030
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    In stock of ZB MED Bonn / Germany

    Z 868: Show issues

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  3. Article ; Online: Access to C(sp

    Chhabra, Arzoo / Reich, Sabrina / Shannon, Timothy M / Maleczka, Robert E / Smith, Milton R

    RSC advances

    2024  Volume 14, Issue 15, Page(s) 10590–10607

    Abstract: This paper presents a simple and cost-effective hydrogenation method for synthesizing a myriad of cycloalkanes and saturated heterocycles bearing boryl or silyl substituents. The catalyst used are heterogeneous, readily available, bench stable, and ... ...

    Abstract This paper presents a simple and cost-effective hydrogenation method for synthesizing a myriad of cycloalkanes and saturated heterocycles bearing boryl or silyl substituents. The catalyst used are heterogeneous, readily available, bench stable, and recyclable. Also demonstrated is the application of the method to compounds that possess both boryl and silyl groups. When combined with Ir-catalyzed sp
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d4ra00491d
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  4. Article ; Online: Mapping the global distribution of C

    Luo, Xiangzhong / Zhou, Haoran / Satriawan, Tin W / Tian, Jiaqi / Zhao, Ruiying / Keenan, Trevor F / Griffith, Daniel M / Sitch, Stephen / Smith, Nicholas G / Still, Christopher J

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1219

    Abstract: Plants with the C ...

    Abstract Plants with the C
    MeSH term(s) Carbon Dioxide/metabolism ; Photosynthesis/physiology ; Poaceae/metabolism ; Plants/metabolism ; Zea mays/metabolism
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45606-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Direct Formation of C-C, C-N, and C-O Bonds in Dihydroquinazolines via Hypervalent Iodine(III)-Mediated sp

    Carlson, Haley M / Smith, Sydney R / Mosey, R Adam

    The Journal of organic chemistry

    2024  Volume 89, Issue 2, Page(s) 1160–1174

    Abstract: ... of C-C, C-N, and C-O bonds in dihydroquinazolines has been developed. This one-pot method allows ...

    Abstract A hypervalent iodine(III)-mediated cross-dehydrogenative coupling reaction for the direct formation of C-C, C-N, and C-O bonds in dihydroquinazolines has been developed. This one-pot method allows for the synthesis of C4-disubstituted dihydroquinazolines as well as C4-spirolactam, spirolactone, and spiroindene dihydroquinazolines in moderate to high yields.
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c02334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Visible-Light/Nickel-Catalyzed Carboxylation of C(sp

    Smith, Gavin C / Zhang, Drason H / Zhang, Wanli / Soliven, Abigail H / Wuest, William M

    The Journal of organic chemistry

    2023  Volume 88, Issue 13, Page(s) 9565–9568

    Abstract: ... While many C(sp ...

    Abstract A new visible-light-driven method for the carboxylation of (hetero)aryl/vinyl bromides has been developed using catalytic 4CzIPN, nickel, phenyl triflimide, and sodium formate as a carboxylation agent. Interestingly, we found catalytic phenyl triflimide plays an essential role in promoting the reaction. While many C(sp
    MeSH term(s) Nickel ; Bromides ; Formates ; Catalysis
    Chemical Substances Nickel (7OV03QG267) ; triflimide ; Bromides ; formic acid (0YIW783RG1) ; Formates
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c00895
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: The Epigenetic Role of Vitamin C in Neurodevelopment.

    Coker, Sharna J / Smith-Díaz, Carlos C / Dyson, Rebecca M / Vissers, Margreet C M / Berry, Mary J

    International journal of molecular sciences

    2022  Volume 23, Issue 3

    Abstract: ... been found to require vitamin C as a cofactor. These enzymes include the ten-eleven translocation ... methylcytosine dioxygenases (TETs) and the Jumonji C domain-containing histone lysine demethylases that catalyse ... of pluripotency and development. The dependence of these enzymes on vitamin C for optimal catalytic activity ...

    Abstract The maternal diet during pregnancy is a key determinant of offspring health. Early studies have linked poor maternal nutrition during gestation with a propensity for the development of chronic conditions in offspring. These conditions include cardiovascular disease, type 2 diabetes and even compromised mental health. While multiple factors may contribute to these outcomes, disturbed epigenetic programming during early development is one potential biological mechanism. The epigenome is programmed primarily in utero, and during this time, the developing fetus is highly susceptible to environmental factors such as nutritional insults. During neurodevelopment, epigenetic programming coordinates the formation of primitive central nervous system structures, neurogenesis, and neuroplasticity. Dysregulated epigenetic programming has been implicated in the aetiology of several neurodevelopmental disorders such as Tatton-Brown-Rahman syndrome. Accordingly, there is great interest in determining how maternal nutrient availability in pregnancy might affect the epigenetic status of offspring, and how such influences may present phenotypically. In recent years, a number of epigenetic enzymes that are active during embryonic development have been found to require vitamin C as a cofactor. These enzymes include the ten-eleven translocation methylcytosine dioxygenases (TETs) and the Jumonji C domain-containing histone lysine demethylases that catalyse the oxidative removal of methyl groups on cytosines and histone lysine residues, respectively. These enzymes are integral to epigenetic regulation and have fundamental roles in cellular differentiation, the maintenance of pluripotency and development. The dependence of these enzymes on vitamin C for optimal catalytic activity illustrates a potentially critical contribution of the nutrient during mammalian development. These insights also highlight a potential risk associated with vitamin C insufficiency during pregnancy. The link between vitamin C insufficiency and development is particularly apparent in the context of neurodevelopment and high vitamin C concentrations in the brain are indicative of important functional requirements in this organ. Accordingly, this review considers the evidence for the potential impact of maternal vitamin C status on neurodevelopmental epigenetics.
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Ascorbic Acid/pharmacology ; Ascorbic Acid Deficiency/complications ; Ascorbic Acid Deficiency/genetics ; Ascorbic Acid Deficiency/pathology ; Epigenesis, Genetic ; Female ; Gene Expression Regulation, Developmental ; Humans ; Maternal Nutritional Physiological Phenomena ; Neurodevelopmental Disorders/etiology ; Neurodevelopmental Disorders/pathology ; Neurodevelopmental Disorders/prevention & control ; Neurogenesis ; Pregnancy
    Chemical Substances Antioxidants ; Ascorbic Acid (PQ6CK8PD0R)
    Language English
    Publishing date 2022-01-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23031208
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  8. Article ; Online: The Effectiveness of Ultraviolet-C (UV-C) Irradiation on the Viability of Airborne

    Nguyen, Thi Tham / He, Congrong / Carter, Robyn / Ballard, Emma L / Smith, Kim / Groth, Robert / Jaatinen, Esa / Kidd, Timothy J / Nguyen, Thuy-Khanh / Stockwell, Rebecca E / Tay, George / Johnson, Graham R / Bell, Scott C / Knibbs, Luke D

    International journal of environmental research and public health

    2022  Volume 19, Issue 20

    Abstract: Pseudomonas ... ...

    Abstract Pseudomonas aeruginosa
    MeSH term(s) Humans ; Pseudomonas aeruginosa ; Disinfection/methods ; Respiratory Aerosols and Droplets ; Ultraviolet Rays ; Cystic Fibrosis/microbiology
    Language English
    Publishing date 2022-10-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192013706
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  9. Article ; Online: Cardiac allograft vasculopathy in heart transplant recipients from hepatitis C viremic donors.

    Kadosh, Bernard S / Birs, Antoinette S / Flattery, Erin / Stachel, Maxine / Hong, Kimberly N / Xia, Yuhe / Gidea, Claudia / Aslam, Saima / Razzouk, Louai / Saraon, Tajinderpal / Goldberg, Randal / Rao, Shaline / Pretorius, Victor / Moazami, Nader / Smith, Deane E / Adler, Eric D / Reyentovich, Alex

    Clinical transplantation

    2024  Volume 38, Issue 4, Page(s) e15294

    Abstract: Background: Recent studies suggest the transplantation of Hepatitis C (HCV) hearts from viremic ...

    Abstract Background: Recent studies suggest the transplantation of Hepatitis C (HCV) hearts from viremic donors is associated with comparable 1 year survival to nonviremic donors. Though HCV viremia is a known risk factor for accelerated atherosclerosis, data on cardiac allograft vasculopathy (CAV) outcomes are limited. We compared the incidence of CAV in heart transplant recipients from HCV viremic donors (nucleic acid amplification test positive; NAT+) compared to non-HCV infected donors (NAT-).
    Methods: We retrospectively reviewed annual coronary angiograms with intravascular ultrasound from April 2017 to August 2020 at two large cardiac transplant centers. CAV was graded according to ISHLT guidelines. Maximal intimal thickness (MIT) ≥ 0.5 mm was considered significant for subclinical disease.
    Results: Among 270 heart transplant recipients (mean age 54; 77% male), 62 patients were transplanted from NAT+ donors. CAV ≥ grade 1 was present in 8.8% of the NAT+ versus 16.8% of the NAT- group at 1 year, 20% versus 28.8% at 2 years, and 33.3% versus 41.5% at 3 years. After adjusting for donor age, donor smoking history, recipient BMI, recipient, hypertension, and recipient diabetes, NAT+ status did not confer increased risk of CAV (HR.80; 95% CI.45-1.40, p = 0.43) or subclinical IVUS disease (HR.87; 95% CI.58-1.30, p = 0.49). Additionally, there was no difference in the presence of rapidly progressive lesions on IVUS.
    Conclusion: Our data show that NAT+ donors conferred no increased risk for early CAV or subclinical IVUS disease following transplantation in a cohort of heart transplant patients who were treated for HCV, suggesting the short-term safety of this strategy to maximize the pool of available donor hearts.
    MeSH term(s) Humans ; Male ; Middle Aged ; Female ; Tissue Donors ; Retrospective Studies ; Heart Transplantation/adverse effects ; Viremia/epidemiology ; Viremia/etiology ; Follow-Up Studies ; Hepatitis C/etiology ; Hepacivirus ; Allografts ; Transplant Recipients
    Language English
    Publishing date 2024-03-28
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.15294
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2204: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Strategies for Nucleophilic C(sp

    Leibler, Isabelle Nathalie-Marie / Gandhi, Shivaani S / Tekle-Smith, Makeda A / Doyle, Abigail G

    Journal of the American Chemical Society

    2023  Volume 145, Issue 18, Page(s) 9928–9950

    Abstract: ... methodologies. Despite the long and rich history of C(sp ...

    Abstract This Perspective surveys the progress and current limitations of nucleophilic fluorination methodologies. Despite the long and rich history of C(sp
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c01824
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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
    Z 7.3: Show issues

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