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  1. Book ; Online: Toxin and Immunotoxin Based Therapeutic Approaches

    Bortolotti, Massimo / Polito, Letizia / Bolognesi, Andrea

    2022  

    Keywords Humanities ; Social interaction ; 3D structure ; plant toxin ; primary sequence ; ribosome-inactivating protein ; stenodactylin ; toxic lectin ; fusion proteins ; ricin ; pokeweed antiviral protein ; COVID-19 ; SARS-CoV-2 ; antiviral agent ; ribosome-inactivating proteins ; monoclonal antibody ; immunotoxin ; antibody drug conjugate ; immunoliposome ; drug delivery ; diphtheria toxin ; DT3C ; prostate cancer ; targeted toxins ; epidermal growth factor ; epidermal growth factor receptor ; Pseudomonas Exotoxin A ; patient-derived glioblastoma cell lines ; Chenopodium quinoa wild ; quinoin ; temozolomide ; Glypican-3 ; hepatocellular carcinoma ; humanized YP7 ; new recombinant immunotoxin ; kirkiin ; sugar specificity ; cancer therapy ; n/a
    Size 1 electronic resource (122 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021291682
    ISBN 9783036530642 ; 3036530649
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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    Inter-library loan at ZB MED

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  2. Article: Women's Special Issue Series: Biomedicines.

    Polito, Letizia

    Biomedicines

    2024  Volume 12, Issue 3

    Abstract: Following the invitation ... ...

    Abstract Following the invitation of
    Language English
    Publishing date 2024-02-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12030471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Antibody Based Delivery of Toxins and Other Active Molecules for Cancer Therapy.

    Polito, Letizia

    Biomedicines

    2022  Volume 10, Issue 2

    Abstract: The use of radio- and chemotherapeutic agents in cancer therapy have demonstrated evident antitumor effects, but also limitations (remarkable side-effects due to lack of selectivity for tumor cells, development of drug resistance, and occurrence of ... ...

    Abstract The use of radio- and chemotherapeutic agents in cancer therapy have demonstrated evident antitumor effects, but also limitations (remarkable side-effects due to lack of selectivity for tumor cells, development of drug resistance, and occurrence of secondary malignancies) [...].
    Language English
    Publishing date 2022-01-26
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10020267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Antibody Based Delivery of Toxins and Other Active Molecules for Cancer Therapy

    Letizia Polito

    Biomedicines, Vol 10, Iss 267, p

    2022  Volume 267

    Abstract: The use of radio- and chemotherapeutic agents in cancer therapy have demonstrated evident antitumor effects, but also limitations (remarkable side-effects due to lack of selectivity for tumor cells, development of drug resistance, and occurrence of ... ...

    Abstract The use of radio- and chemotherapeutic agents in cancer therapy have demonstrated evident antitumor effects, but also limitations (remarkable side-effects due to lack of selectivity for tumor cells, development of drug resistance, and occurrence of secondary malignancies) [.]
    Keywords n/a ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  5. Article: Gender Influence on XOR Activities and Related Pathologies: A Narrative Review.

    Bolognesi, Andrea / Bortolotti, Massimo / Battelli, Maria Giulia / Polito, Letizia

    Antioxidants (Basel, Switzerland)

    2024  Volume 13, Issue 2

    Abstract: Taking into account the patient's gender is the first step towards more precise and egalitarian medicine. The gender-related divergences observed in purine catabolism and their pathological consequences are good examples of gender medicine differences. ... ...

    Abstract Taking into account the patient's gender is the first step towards more precise and egalitarian medicine. The gender-related divergences observed in purine catabolism and their pathological consequences are good examples of gender medicine differences. Uric acid is produced by the activity of xanthine oxidoreductase (XOR). The serum levels of both XOR activity and uric acid differ physiologically between the genders, being higher in men than in women. Their higher levels have been associated with gout and hypertension, as well as with vascular, cardiac, renal, and metabolic diseases. The present review analyzes the gender-related differences in these pathological conditions in relation to increases in the serum levels of XOR and/or uric acid and the opportunity for gender-driven pharmacological treatment.
    Language English
    Publishing date 2024-02-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox13020211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Toxin and Immunotoxin Based Therapeutic Approaches.

    Bortolotti, Massimo / Polito, Letizia / Bolognesi, Andrea

    Toxins

    2022  Volume 14, Issue 1

    Abstract: The concept of "magic bullets", i [ ... ]. ...

    Abstract The concept of "magic bullets", i [...].
    MeSH term(s) Humans ; Immunotoxins/therapeutic use ; Toxins, Biological/therapeutic use
    Chemical Substances Immunotoxins ; Toxins, Biological
    Language English
    Publishing date 2022-01-17
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins14010063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Applying the estimand and target trial frameworks to external control analyses using observational data: a case study in the solid tumor setting.

    Polito, Letizia / Liang, Qixing / Pal, Navdeep / Mpofu, Philani / Sawas, Ahmed / Humblet, Olivier / Rufibach, Kaspar / Heinzmann, Dominik

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1223858

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-01-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1223858
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Heterophyllin: A New Adenia Toxic Lectin with Peculiar Biological Properties.

    Bortolotti, Massimo / Biscotti, Francesco / Zanello, Andrea / Polito, Letizia / Bolognesi, Andrea

    Toxins

    2023  Volume 16, Issue 1

    Abstract: Ribosome-inactivating proteins (RIPs) are plant toxins that were identified for their ability to irreversibly damage ribosomes, thereby causing arrest of protein synthesis and induction of cell death. The RIPs purified from Adenia plants are the most ... ...

    Abstract Ribosome-inactivating proteins (RIPs) are plant toxins that were identified for their ability to irreversibly damage ribosomes, thereby causing arrest of protein synthesis and induction of cell death. The RIPs purified from Adenia plants are the most potent ones. Here, we describe a novel toxic lectin from
    MeSH term(s) Humans ; Plant Proteins/metabolism ; Ribosome Inactivating Proteins, Type 2/metabolism ; Ricin/toxicity ; Ricin/metabolism ; Ribosome Inactivating Proteins/toxicity ; Ribosome Inactivating Proteins/metabolism ; Ribosomes/metabolism ; Protein Biosynthesis
    Chemical Substances Plant Proteins ; Ribosome Inactivating Proteins, Type 2 ; Ricin (9009-86-3) ; Ribosome Inactivating Proteins (EC 3.2.2.22)
    Language English
    Publishing date 2023-12-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins16010001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Toxin and Immunotoxin Based Therapeutic Approaches

    Massimo Bortolotti / Letizia Polito / Andrea Bolognesi

    Toxins, Vol 14, Iss 63, p

    2022  Volume 63

    Abstract: The concept of “magic bullets”, i [.] ...

    Abstract The concept of “magic bullets”, i [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article: Editorial: Toxic Plant Proteins as Experimental Drugs for Human Pathologies.

    Polito, Letizia / Bortolotti, Massimo / Iglesias, Rosario / Bolognesi, Andrea

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 689924

    Language English
    Publishing date 2021-04-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.689924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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