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Article ; Online: Rate of pathological complete response in early HER2 breast cancer.

Bodet, Marie-Lucile / Rouzier, Roman / Héquet, Delphine

2022 Volume 109, Issue 6, Page(s) 722–723

MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Female ; Humans ; Neoadjuvant Therapy ; Receptor, ErbB-2 ; Trastuzumab/therapeutic use ; Treatment Outcome
Chemical Substances	Receptor, ErbB-2 (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK)
Language	English
Publishing date	2022-05-11
Publishing country	France
Document type	Letter
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2022.02.016
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Article ; Online: Impact of catch-up human papillomavirus vaccination on cervical conization rate in a real-life population in France.

Eliès, Antoine / Bonneau, Claire / Houzard, Sophie / Rouzier, Roman / Héquet, Delphine

PloS one

2022 Volume 17, Issue 3, Page(s) e0264821

Abstract: Objective: To evaluate the impact of catch-up human papillomavirus (HPV) vaccination on conization rates in France in a large population-based study.: Methods: We conducted a retrospective real-life cohort study on data collected prospectively by ... ...

Abstract	Objective: To evaluate the impact of catch-up human papillomavirus (HPV) vaccination on conization rates in France in a large population-based study. Methods: We conducted a retrospective real-life cohort study on data collected prospectively by French National Health Insurance. Echantillon généralistes des bénéficiaires (EGB) is a database composed of demographic and health care utilization data for a 1/97th sample of the French population. We extracted data about all women born between 1983 and 1991, corresponding to the catch-up population (vaccination after 14 years old) at the time of implementation of HPV vaccination. The primary outcome was the occurrence of conization (all types of procedures) compared between vaccinated and non-vaccinated women. Results: The cohort consisted of 42,452 women. Vaccination coverage (at least one dose) was low (9.8%, n = 4,129), but increased with time from vaccine implementation, from 0% in the 1983 cohort to 31% in the 1991 cohort. The conization rate was 1% for the overall population. The risk of conization for women between the ages of 19 and 30 years was reduced in the vaccinated group with a Hazard Ratio (HR) of 0.59 (95% CI[0.39-0.90]; p = 0.043). Conclusions: With a 10-year follow-up, catch-up HPV vaccination is associated with risk reduction of conization between the ages of 19 and 30.
MeSH term(s)	Adolescent ; Adult ; Alphapapillomavirus ; Cohort Studies ; Conization ; Female ; Humans ; Male ; Papillomavirus Infections ; Papillomavirus Vaccines ; Retrospective Studies ; Uterine Cervical Neoplasms ; Vaccination ; Young Adult
Chemical Substances	Papillomavirus Vaccines
Language	English
Publishing date	2022-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0264821
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Article ; Online: Regional spread of an atypical ESBL-producing

Martischang, Romain / Seth-Smith, Helena / Verschuuren, Tess D / Héquet, Delphine / Gaïa, Nadia / François, Patrice / Fluit, Ad C / Kluytmans, Jan A J W / Seiffert, Salome N / Tacconelli, Evelina / Cherkaoui, Abdessalam / Harbarth, Stephan / Egli, Adrian / Kohler, Philipp

Antimicrobial agents and chemotherapy

2024 Volume 68, Issue 2, Page(s) e0092523

Abstract: We describe the inter-regional spread of a novel ESBL- ... ...

Abstract	We describe the inter-regional spread of a novel ESBL-producing
MeSH term(s)	Humans ; Escherichia coli Infections/epidemiology ; Switzerland ; Escherichia coli/genetics ; Escherichia coli Proteins/genetics ; Anti-Bacterial Agents ; beta-Lactamases ; Molecular Epidemiology
Chemical Substances	Escherichia coli Proteins ; Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/aac.00925-23
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Article ; Online: Impact of catch-up human papillomavirus vaccination on cervical conization rate in a real-life population in France

Antoine Eliès / Claire Bonneau / Sophie Houzard / Roman Rouzier / Delphine Héquet

PLoS ONE, Vol 17, Iss

2022 Volume 3

Abstract: Objective To evaluate the impact of catch-up human papillomavirus (HPV) vaccination on conization rates in France in a large population-based study. Methods We conducted a retrospective real-life cohort study on data collected prospectively by French ... ...

Abstract	Objective To evaluate the impact of catch-up human papillomavirus (HPV) vaccination on conization rates in France in a large population-based study. Methods We conducted a retrospective real-life cohort study on data collected prospectively by French National Health Insurance. Echantillon généralistes des bénéficiaires (EGB) is a database composed of demographic and health care utilization data for a 1/97th sample of the French population. We extracted data about all women born between 1983 and 1991, corresponding to the catch-up population (vaccination after 14 years old) at the time of implementation of HPV vaccination. The primary outcome was the occurrence of conization (all types of procedures) compared between vaccinated and non-vaccinated women. Results The cohort consisted of 42,452 women. Vaccination coverage (at least one dose) was low (9.8%, n = 4,129), but increased with time from vaccine implementation, from 0% in the 1983 cohort to 31% in the 1991 cohort. The conization rate was 1% for the overall population. The risk of conization for women between the ages of 19 and 30 years was reduced in the vaccinated group with a Hazard Ratio (HR) of 0.59 (95% CI[0.39–0.90]; p = 0.043). Conclusions With a 10-year follow-up, catch-up HPV vaccination is associated with risk reduction of conization between the ages of 19 and 30.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article ; Online: Impact of catch-up human papillomavirus vaccination on cervical conization rate in a real-life population in France.

Antoine Eliès / Claire Bonneau / Sophie Houzard / Roman Rouzier / Delphine Héquet

PLoS ONE, Vol 17, Iss 3, p e

2022 Volume 0264821

Abstract	Objective To evaluate the impact of catch-up human papillomavirus (HPV) vaccination on conization rates in France in a large population-based study. Methods We conducted a retrospective real-life cohort study on data collected prospectively by French National Health Insurance. Echantillon généralistes des bénéficiaires (EGB) is a database composed of demographic and health care utilization data for a 1/97th sample of the French population. We extracted data about all women born between 1983 and 1991, corresponding to the catch-up population (vaccination after 14 years old) at the time of implementation of HPV vaccination. The primary outcome was the occurrence of conization (all types of procedures) compared between vaccinated and non-vaccinated women. Results The cohort consisted of 42,452 women. Vaccination coverage (at least one dose) was low (9.8%, n = 4,129), but increased with time from vaccine implementation, from 0% in the 1983 cohort to 31% in the 1991 cohort. The conization rate was 1% for the overall population. The risk of conization for women between the ages of 19 and 30 years was reduced in the vaccinated group with a Hazard Ratio (HR) of 0.59 (95% CI[0.39-0.90]; p = 0.043). Conclusions With a 10-year follow-up, catch-up HPV vaccination is associated with risk reduction of conization between the ages of 19 and 30.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bouffées de chaleur et cancer du sein avec récepteurs hormonaux positifs : mécanismes et prise en charge.

Cavadias, Iphigénie / Rouzier, Roman / Lerebours, Florence / Héquet, Delphine

Bulletin du cancer

2020 Volume 107, Issue 11, Page(s) 1171–1185

Abstract: Breast cancer is the most frequently diagnosed cancer in women and the first cause of cancer death in France. Among the different subtypes of breast cancer, the predominant form is characterized by positive hormone receptors (more than 70% of breast ... ...

Title translation	Hot flushes and breast cancer with positive hormone receptors: Mechanisms and management.
Abstract	Breast cancer is the most frequently diagnosed cancer in women and the first cause of cancer death in France. Among the different subtypes of breast cancer, the predominant form is characterized by positive hormone receptors (more than 70% of breast cancers). Hormone therapy thus plays a key role in the strategy of management of these cancers both in adjuvant and metastatic situations. The two types of adjuvant hormone therapy used are selective estrogen receptor modulators and aromatase inhibitors. Fulvestrant, an anti-estrogen, is used alone or in combination with other molecules in metastatic situations. Hot flashes are one of the symptoms most frequently reported by patients under hormone therapy. Hormone replacement therapy, which is currently the most effective treatment for hot flashes, is contraindicated in patients with a personal history of breast cancer. Various therapeutic classes of drugs have been tested in this indication but without real efficacy in the various studies carried out to date, and moreover associated with non-negligible side effects. The recent discovery of the implication of the kisspeptin system located at the hypothalamic level in the mechanism of genesis of hot flashes opens the way to possible new symptomatic treatments for hot flashes. Neurokinin 3 receptor antagonists have shown encouraging preliminary results in postmenopausal cancer-free patients and could be considered in patients in hormonal therapy for breast cancer. Broader additional studies are needed to confirm these initial results.
MeSH term(s)	Antineoplastic Agents, Hormonal/therapeutic use ; Aromatase Inhibitors/therapeutic use ; Breast Neoplasms/chemistry ; Breast Neoplasms/drug therapy ; Contraindications, Drug ; Estrogen Replacement Therapy/adverse effects ; Female ; Fulvestrant/therapeutic use ; Hot Flashes/etiology ; Humans ; Kisspeptins/physiology ; Ovary/drug effects ; Ovary/surgery ; Receptors, Neurokinin-3/antagonists & inhibitors ; Selective Estrogen Receptor Modulators/administration & dosage ; Selective Estrogen Receptor Modulators/therapeutic use ; Tamoxifen/administration & dosage ; Tamoxifen/therapeutic use
Chemical Substances	Antineoplastic Agents, Hormonal ; Aromatase Inhibitors ; KISS1 protein, human ; Kisspeptins ; Receptors, Neurokinin-3 ; Selective Estrogen Receptor Modulators ; Tamoxifen (094ZI81Y45) ; Fulvestrant (22X328QOC4)
Language	French
Publishing date	2020-09-25
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2020.07.005
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Article ; Online: Financement à l’épisode de soins : évaluation du coût d’une chirurgie première pour cancer du sein précoce.

Majou, Doriane / Mekarnia, Yanis / Martin, Barbara / Rouzier, Roman / Héquet, Delphine

Bulletin du cancer

2021 Volume 108, Issue 12, Page(s) 1091–1100

Abstract: Introduction: Episode-based bundled payment model is actually opposing to fee-for-service model, intending to incentivize coordinated care. The aims of these study were to determine episode-based costs for surgery in early breast cancer patients and to ... ...

Title translation	Episode-based bundled payment model: evaluation of medical costs for early operable breast cancer.
Abstract	Introduction: Episode-based bundled payment model is actually opposing to fee-for-service model, intending to incentivize coordinated care. The aims of these study were to determine episode-based costs for surgery in early breast cancer patients and to propose a payment model. Methods: OPTISOINS01 was a multicenter prospective study including early breast cancer patients from diagnosis to one-year follow up. Direct medical costs, quality and patient reported outcomes were collected. Results: Data from 604 patients were analyzed. Episode-based costs for surgery were higher in case of: planned radical surgery (OR=9,47 ; IC95 % [3,49-28,01]; P<0,001), hospitalization during more than one night (OR=6,73; IC95% [2,59-17,46]; P<0,001), home hospitalization (OR=11,07 ; IC95 % [3,01-173][3,01-54][3,01-543][3,01-54,33]; P<0,001) and re-hospitalization (OR=25,71 ; IC95 % [9,24-89,17; P<0,001). The average cost was 5 268 € [2 947-18 461] when a lumpectomy was planned and 7408 € [4 222-22 565] in case of radical mastectomy. Bootstrap method was applied for internal validation of the cost model showing the reliability of the model with an area under the curve of 0,83 (95 % CI [0,80-0,86]). Care quality and patient reported outcomes were not related to the costs. Discussion: This is the first report of episode-based costs for breast cancer surgery. An external validation will be necessary to validate our payment model.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Area Under Curve ; Breast Neoplasms/economics ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Direct Service Costs ; Fee-for-Service Plans/economics ; Female ; Home Care Services/economics ; Hospitalization/economics ; Humans ; Mastectomy, Radical/economics ; Mastectomy, Segmental/economics ; Middle Aged ; Patient Readmission/economics ; Patient Reported Outcome Measures ; Prospective Studies ; Quality of Health Care ; Reimbursement Mechanisms/economics ; Reproducibility of Results
Language	French
Publishing date	2021-10-14
Publishing country	France
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2021.07.006
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Article ; Online: COVID-19 burden and influencing factors in Swiss long-term-care facilities: a cross-sectional analysis of a multicentre observational cohort.

Scanferla, Giulia / Héquet, Delphine / Graf, Nicole / Münzer, Thomas / Kessler, Simone / Kohler, Philipp / Nussbaumer, Andres / Petignat, Christiane / Schlegel, Matthias / Flury, Domenica

Swiss medical weekly

2023 Volume 153, Page(s) 40052

Abstract: Objectives: To describe the burden of COVID-19 in Swiss long-term care facilities in 2020, to identify its influencing factors, and to assess vaccination rates among residents and healthcare workers at the end of the vaccine campaign in Switzerland in ... ...

Abstract	Objectives: To describe the burden of COVID-19 in Swiss long-term care facilities in 2020, to identify its influencing factors, and to assess vaccination rates among residents and healthcare workers at the end of the vaccine campaign in Switzerland in May 2021. Design: Cross-sectional survey. Setting and participants: Long-term care facilities from two Swiss cantons (St. Gallen / Eastern Switzerland and Vaud / Western Switzerland). Methods: We collected numbers of COVID-19 cases and related deaths and all-cause mortality for 2020, potential risk factors at the institutional level (e.g. size, infection prevention and control measures, and resident characteristics), and vaccination rates among residents and healthcare workers. Univariate and multivariate analyses were used to identify factors associated with resident mortality in 2020. Results: We enrolled 59 long-term care facilities with a median of 46 (interquartile range [IQR]: 33-69) occupied beds. In 2020, the median COVID-19 incidence was 40.2 (IQR: 0-108.6) per 100 occupied beds, with higher rates in VD (49.9%) than in SG (32.5%; p = 0.037). Overall, 22.7% of COVID-19 cases died, of which 24.8% were COVID-19-related deaths. In the univariate analysis, higher resident mortality was associated with COVID-19 rates among residents (p < 0.001) and healthcare workers (p = 0.002) and age (p = 0.013). Lower resident mortality was associated with the proportion of single rooms (p = 0.012), isolation of residents with COVID-19 in single rooms (p = 0.003), symptom screening of healthcare workers (p = 0.031), limiting the number of visits per day (p = 0.004), and pre-scheduling visits (p = 0.037). In the multivariate analysis, higher resident mortality was only associated with age (p = 0.03) and the COVID-19 rate among residents (p = 0.013). Among 2936 residents, 2042 (69.9%) received ≥1 dose of the COVID-19 vaccine before 31 May 2021. Vaccine uptake among healthcare workers was 33.8%. Conclusion and implications: COVID-19 burden was high but also highly variable in Swiss long-term care facilities. severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among healthcare workers was a modifiable factor associated with increased resident mortality. Symptom screening of healthcare workers appeared to be an effective preventive strategy and should be included in routine infection prevention and control measures. Promoting COVID-19 vaccine uptake among healthcare workers should be a priority in Swiss long-term care facilities.
MeSH term(s)	Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; Cross-Sectional Studies ; SARS-CoV-2 ; COVID-19 Vaccines ; Switzerland/epidemiology
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-03-31
Publishing country	Switzerland
Document type	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	2036179-8
ISSN	1424-3997 ; 1424-7860
ISSN (online)	1424-3997
ISSN	1424-7860
DOI	10.57187/smw.2023.40052
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Article ; Online: Utilisation des réseaux sociaux en oncologie.

Mottais-Cosnefroy, Victoria / Allouche, Dan / Zerbib, Elie / Hequet, Delphine / Bonneau, Claire / Rouzier, Roman

Bulletin du cancer

2022 Volume 109, Issue 3, Page(s) 382–383

Title translation	Use of social networks in oncology.
MeSH term(s)	Humans ; Medical Oncology ; Social Networking
Language	French
Publishing date	2022-02-11
Publishing country	France
Document type	Letter
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2021.12.015
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Article ; Online: Impact de la pandémie de COVID-19 sur la prise en charge du cancer du sein : retour d’expérience d’un centre de lutte contre le cancer.

Tran, Mélanie / Brouard, Nora / Hequet, Delphine / Rouzier, Roman / Donval, Lou

Bulletin du cancer

2022 Volume 109, Issue 12, Page(s) 1236–1244

Abstract: Introduction: The COVID-19 pandemic had a profound impact on health-care systems and reduced access to care. This study assays the mid-term effects of the COVID-19 pandemic on breast cancer management over a 2-year-period in a single French ... ...

Title translation	Impact of the COVID-19 pandemic on breast cancer management: Experience of a French Comprehensive Cancer Center.
Abstract	Introduction: The COVID-19 pandemic had a profound impact on health-care systems and reduced access to care. This study assays the mid-term effects of the COVID-19 pandemic on breast cancer management over a 2-year-period in a single French Comprehensive Cancer Center. Methods: We performed, in a French comprehensive cancer center, an observational study including all patients with newly diagnosed breast cancer between 2019 and 2021. We collected the number of first consultations for breast cancer, the number of breast and axillary surgeries, pTNM and ypTNM cancer staging, the therapeutic sequence (surgery or neoadjuvant chemotherapy as a primary treatment), patients' age and their place of residence. Results: In total, 14,772 patients had a first consultation for breast cancer. Among these 9058 breast and axillary surgeries were performed, 1798 patients had neoadjuvant chemotherapy as a primary treatment. During the first COVID-19 lockdown ( March17, 2020-May 10, 2020), we observed a reduction in the number of first consultations for breast cancer and breast cancer surgeries giving respectively a 42.3% and 27% rate of change. Subsequently, we observed a resumption of consultations and surgeries with a slight increase in early 2021 compared to 2019. In addition, we did not find any difference in terms of therapeutic sequence, pTNM and ypTNM stages, age at diagnosis or place of residence between the reference year 2019 and the years 2020 and 2021. Conclusion: Our study shows a decrease in activity during the first lockdown of 2020, then a resumption of activity. These reassuring results only concern patients with breast cancer, and are specific to our institution, whose oncology activity was preserved during the COVID-19 pandemic.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/epidemiology ; Breast Neoplasms/surgery ; COVID-19/epidemiology ; Pandemics ; Communicable Disease Control ; Breast
Language	French
Publishing date	2022-09-27
Publishing country	France
Document type	Observational Study ; English Abstract ; Journal Article
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2022.09.004
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