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  1. Article ; Online: Chronic lymphoproliferative disorder of NK cells with TNFAIP3 and DNMT3A mutations.

    Bulterys, Philip L / Silva, Oscar

    Blood

    2021  Volume 137, Issue 24, Page(s) 3460

    MeSH term(s) Aged, 80 and over ; Chronic Disease ; DNA Methyltransferase 3A/genetics ; DNA Methyltransferase 3A/metabolism ; Female ; Humans ; Killer Cells, Natural/metabolism ; Killer Cells, Natural/pathology ; Lymphoproliferative Disorders/genetics ; Lymphoproliferative Disorders/metabolism ; Lymphoproliferative Disorders/pathology ; Mutation ; Tumor Necrosis Factor alpha-Induced Protein 3/genetics ; Tumor Necrosis Factor alpha-Induced Protein 3/metabolism
    Chemical Substances DNMT3A protein, human ; DNA Methyltransferase 3A (EC 2.1.1.37) ; TNFAIP3 protein, human (EC 3.4.19.12) ; Tumor Necrosis Factor alpha-Induced Protein 3 (EC 3.4.19.12)
    Language English
    Publishing date 2021-06-17
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021011812
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  2. Article ; Online: Postpandemic Effects of COVID-19 Shelter-in-Place Orders on the Gastrointestinal Pathogen Landscape.

    Bulterys, Philip L / Leung, Nicole Y / Saleem, Atif / Budvytiene, Indre / Pinsky, Benjamin A / Banaei, Niaz

    Journal of clinical microbiology

    2023  Volume 61, Issue 8, Page(s) e0038523

    MeSH term(s) Humans ; COVID-19 ; Emergency Shelter ; SARS-CoV-2 ; Quarantine
    Language English
    Publishing date 2023-07-19
    Publishing country United States
    Document type Letter
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.00385-23
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    Zs.A 1188: Show issues Location:
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  3. Article: Inflammatory pseudotumor-like follicular dendritic cell tumor of the spleen: a case report and approach to differential diagnosis.

    Nguyen, Andrew / Negrete, Lindsey M / Bulterys, Philip L / Shen, Luyao

    Radiology case reports

    2021  Volume 16, Issue 11, Page(s) 3213–3216

    Abstract: We present a case of an inflammatory pseudotumor-like follicular dendritic cell tumor of the spleen. The patient is a 44-year-old woman, without significant underlying history, who presented with nonspecific abdominal pain for a few months. Both a ... ...

    Abstract We present a case of an inflammatory pseudotumor-like follicular dendritic cell tumor of the spleen. The patient is a 44-year-old woman, without significant underlying history, who presented with nonspecific abdominal pain for a few months. Both a contrast enhanced computed tomography and magnetic resonance imaging revealed a new 2.5 cm enhancing splenic lesion, which demonstrated hypermetabolic activity on subsequent positron emission tomography and computed tomography scan. Since the lesion was new compared to more remote imaging and hypermetabolic, a splenectomy was performed.  Pathology confirmed the diagnosis and demonstrated positivity for Epstein-Barr Virus .
    Language English
    Publishing date 2021-08-26
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2021.07.078
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  4. Article ; Online: Predictors of COVID-19 incidence, mortality, and epidemic growth rate at the country level

    Leung, Nicole Y. / Bulterys, Michelle A. / Bulterys, Philip L.

    Abstract: Background. The burden of the coronavirus disease 2019 (COVID-19) pandemic has been geographically disproportionate. Certain weather factors and population characteristics are thought to drive transmission, but studies examining these factors are limited. ...

    Abstract Background. The burden of the coronavirus disease 2019 (COVID-19) pandemic has been geographically disproportionate. Certain weather factors and population characteristics are thought to drive transmission, but studies examining these factors are limited. We aimed to identify weather, sociodemographic, and geographic drivers of COVID-19 at the global scale using a comprehensive collection of country/territory-level data, and to use discovered associations to estimate the timing of community transmission. Methods. We examined COVID-19 cases and deaths reported up to May 2, 2020 across 205 countries and territories in relation to weather data collected from capital cities for the eight weeks prior to and four weeks after the date of the first reported case, as well as country/territory-level population, geographic, and planetary data. We performed univariable and multivariable regression modeling and odds ratio analyses to investigate associations with COVID-19 cases, deaths, and epidemic growth rate. We also conducted maximum likelihood analysis to estimate the timing of initial community spread. Findings. Lower temperature (p<0.0001), lower humidity (p=0.006), higher altitude (p=0.0080), higher percentage of urban population (p<0.0001), increased air travelers (p=0.00019), and higher prevalence of obesity (p<0.0001) were strong independent predictors of national COVID-19 incidence, mortality, and epidemic growth rate. Temperature at 5-7 weeks before the first reported case best predicted epidemic growth, suggesting that significant community transmission was occurring on average 1-2 months prior to detection. Interpretation. The results of this ecologic analysis demonstrate that global COVID-19 burden and timing of country-level epidemic growth can be predicted by weather and population factors. In particular, we find that cool, dry, and higher altitude environments, as well as more urban and obese populations, may be conducive to more rapid epidemic spread. Funding sources: None.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    Note WHO #Covidence: #20101097
    DOI 10.1101/2020.05.15.20101097
    Database COVID19

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  5. Article ; Online: Predictors of COVID-19 incidence, mortality, and epidemic growth rate at the country level

    Leung, Nicole Y. / Bulterys, Michelle A. / Bulterys, Philip L.

    medRxiv

    Abstract: Background. The burden of the coronavirus disease 2019 (COVID-19) pandemic has been geographically disproportionate. Certain weather factors and population characteristics are thought to drive transmission, but studies examining these factors are limited. ...

    Abstract Background. The burden of the coronavirus disease 2019 (COVID-19) pandemic has been geographically disproportionate. Certain weather factors and population characteristics are thought to drive transmission, but studies examining these factors are limited. We aimed to identify weather, sociodemographic, and geographic drivers of COVID-19 at the global scale using a comprehensive collection of country/territory-level data, and to use discovered associations to estimate the timing of community transmission. Methods. We examined COVID-19 cases and deaths reported up to May 2, 2020 across 205 countries and territories in relation to weather data collected from capital cities for the eight weeks prior to and four weeks after the date of the first reported case, as well as country/territory-level population, geographic, and planetary data. We performed univariable and multivariable regression modeling and odds ratio analyses to investigate associations with COVID-19 cases, deaths, and epidemic growth rate. We also conducted maximum likelihood analysis to estimate the timing of initial community spread. Findings. Lower temperature (p<0.0001), lower humidity (p=0.006), higher altitude (p=0.0080), higher percentage of urban population (p<0.0001), increased air travelers (p=0.00019), and higher prevalence of obesity (p<0.0001) were strong independent predictors of national COVID-19 incidence, mortality, and epidemic growth rate. Temperature at 5-7 weeks before the first reported case best predicted epidemic growth, suggesting that significant community transmission was occurring on average 1-2 months prior to detection. Interpretation. The results of this ecologic analysis demonstrate that global COVID-19 burden and timing of country-level epidemic growth can be predicted by weather and population factors. In particular, we find that cool, dry, and higher altitude environments, as well as more urban and obese populations, may be conducive to more rapid epidemic spread. Funding sources: None.
    Keywords covid19
    Language English
    Publishing date 2020-05-19
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.05.15.20101097
    Database COVID19

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  6. Article ; Online: Impact of COVID-19 Shelter-in-Place Order on Transmission of Gastrointestinal Pathogens in Northern California.

    Bulterys, Philip L / Leung, Nicole Y / Saleem, Atif / Budvytiene, Indre / Banaei, Niaz

    Journal of clinical microbiology

    2021  Volume 59, Issue 7, Page(s) e0044921

    MeSH term(s) COVID-19 ; California ; Emergency Shelter ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-06-18
    Publishing country United States
    Document type Letter
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.00449-21
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    Zs.A 1188: Show issues Location:
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  7. Article ; Online: Inflammatory pseudotumor-like follicular dendritic cell tumor of the spleen

    Andrew Nguyen / Lindsey M. Negrete / Philip L. Bulterys / Luyao Shen

    Radiology Case Reports, Vol 16, Iss 11, Pp 3213-

    a case report and approach to differential diagnosis

    2021  Volume 3216

    Abstract: We present a case of an inflammatory pseudotumor-like follicular dendritic cell tumor of the spleen. The patient is a 44-year-old woman, without significant underlying history, who presented with nonspecific abdominal pain for a few months. Both a ... ...

    Abstract We present a case of an inflammatory pseudotumor-like follicular dendritic cell tumor of the spleen. The patient is a 44-year-old woman, without significant underlying history, who presented with nonspecific abdominal pain for a few months. Both a contrast enhanced computed tomography and magnetic resonance imaging revealed a new 2.5 cm enhancing splenic lesion, which demonstrated hypermetabolic activity on subsequent positron emission tomography and computed tomography scan. Since the lesion was new compared to more remote imaging and hypermetabolic, a splenectomy was performed. Pathology confirmed the diagnosis and demonstrated positivity for Epstein-Barr Virus .
    Keywords Follicular dendritic cell tumor ; Epstein-Barr Virus ; Splenic mass ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Trimmed central venous catheters do not increase endothelial injury in an ovine model.

    Wang, Hanjay / Williams, Kiah M / Elde, Stefan / Bulterys, Philip L / Thakore, Akshara D / Lucian, Haley J / Farry, Justin M / Mullis, Danielle M / Zhu, Yuanjia / Paulsen, Michael J / Woo, Y Joseph

    The journal of vascular access

    2023  , Page(s) 11297298231153716

    Abstract: Introduction: Central venous catheters (CVCs) are often trimmed during heart transplantation and pediatric cardiac surgery. However, the risk of endothelial injury caused by the cut tip of the CVC has not been evaluated. We hypothesized that there is no ...

    Abstract Introduction: Central venous catheters (CVCs) are often trimmed during heart transplantation and pediatric cardiac surgery. However, the risk of endothelial injury caused by the cut tip of the CVC has not been evaluated. We hypothesized that there is no difference in the degree of endothelial injury associated with trimmed CVCs versus standard untrimmed CVCs.
    Methods: In four adult male sheep, the left external jugular vein was exposed in three segments, one designated for an untouched control group, one for the trimmed CVC group, and one for the untrimmed CVC group. Trimmed and untrimmed CVC tips were rotated circumferentially within their respective segments to abrade the lumen of the vein. The vein samples were explanted, and two representative sections from each sample were analyzed using hematoxylin and eosin (H&E) staining, as well as with immunohistochemistry against CD31, von Willebrand factor (vWF), endothelial nitric oxide synthase (eNOS), and caveolin. Higher immunohistochemical stain distributions and intensities are associated with normal health and function of the venous endothelium. Data are presented as counts with percentages or as means with standard error.
    Results: H&E staining revealed no evidence of endothelial injury in 6/8 (75%) samples from the untouched control group, and no injury in 4/8 (50%) samples from both the trimmed and untrimmed CVC groups (
    Conclusion: Trimmed CVCs do not increase endothelial injury compared to standard untrimmed CVCs.
    Language English
    Publishing date 2023-02-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2252820-9
    ISSN 1724-6032 ; 1129-7298
    ISSN (online) 1724-6032
    ISSN 1129-7298
    DOI 10.1177/11297298231153716
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    Zs.A 6414: Show issues Location:
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  9. Article ; Online: Diagnosis of Dengue in a returning traveler from Pakistan suspected of COVID-19, California, USA.

    Bulterys, Philip L / Solis, Daniel / Verghese, Michelle / Huang, Chunhong / Sibai, Mamdouh / Costales, Cristina / Sahoo, Malaya K / Pinsky, Benjamin A

    Diagnostic microbiology and infectious disease

    2021  Volume 101, Issue 4, Page(s) 115517

    Abstract: Dengue and COVID-19 cocirculation presents a diagnostic conundrum for physicians evaluating patients with acute febrile illnesses, both in endemic regions and among returning travelers. We present a case of a returning traveler from Pakistan who, ... ...

    Abstract Dengue and COVID-19 cocirculation presents a diagnostic conundrum for physicians evaluating patients with acute febrile illnesses, both in endemic regions and among returning travelers. We present a case of a returning traveler from Pakistan who, following repeated negative SARS-CoV-2 tests, was found to have a Dengue virus serotype 2 infection.
    MeSH term(s) Adult ; COVID-19/diagnosis ; COVID-19/epidemiology ; California/epidemiology ; Dengue/diagnosis ; Dengue/epidemiology ; Dengue Virus/classification ; Dengue Virus/genetics ; Female ; Genome, Viral ; Humans ; Pakistan/epidemiology ; Phylogeny ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Serogroup ; Travel
    Language English
    Publishing date 2021-08-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 604920-5
    ISSN 1879-0070 ; 0732-8893
    ISSN (online) 1879-0070
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2021.115517
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  10. Article ; Online: Impact of COVID-19 shelter-in-place order on transmission of gastrointestinal pathogens in Northern California

    Bulterys, Philip L. / Leung, Nicole Y / Saleem, Atif / Budvytiene, Indre / Banaei, Niaz

    medRxiv

    Abstract: Society-wide cessation of human interaction outside the household due to the COVID-19 shelter-in-place created a unique opportunity in modern history to reexamine the transmission of communicable gastrointestinal pathogens. We conducted a quasi- ... ...

    Abstract Society-wide cessation of human interaction outside the household due to the COVID-19 shelter-in-place created a unique opportunity in modern history to reexamine the transmission of communicable gastrointestinal pathogens. We conducted a quasi-experimental study from January 1, 2018 to Sept 30, 2020 to investigate the effect of California9s COVID-19 shelter-in-place order on the community transmission of viral, bacterial, and parasitic gastrointestinal pathogens detected with the FilmArray GI Panel (BioFire Diagnostics, Salt Lake City, UT). The incidence of viral causes of gastroenteritis, enteroaggregative/enteropathogenic/enterotoxigenic Escherichia coli, Shigella, and Cyclospora cayetanensis decreased sharply after shelter-in place took effect, whilst Salmonella, Campylobacter, shiga toxin-producing E. coli (O157 and non-O157) and other bacterial and parasitic causes of gastroenteritis were largely unaffected. Findings suggest community spread of viral gastroenteritis, pathogenic E. coli (except for shiga toxin-producing E. coli), Shigella, and Cyclospora are more susceptible to changes associated with shelter-in-place than other gastrointestinal pathogens.
    Keywords covid19
    Language English
    Publishing date 2021-01-15
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.01.12.21249708
    Database COVID19

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