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Article ; Online: The NASPGHAN Master Educator Award: Alan Leichtner, MD.

Mallon, Daniel

Journal of pediatric gastroenterology and nutrition

2020 Volume 70, Issue 4, Page(s) 409

MeSH term(s)	Awards and Prizes ; Gastroenterology ; Humans
Language	English
Publishing date	2020-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0000000000002638
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Article ; Online: Relevance, quick hits, and vibe: Features of meaningful teaching and learning during trainee consult interactions.

Rutsky, Jessica / Schumacher, Daniel / Mallon, Daniel

Journal of hospital medicine

2023 Volume 19, Issue 1, Page(s) 24–30

Abstract: Background: Consults are increasingly frequent in inpatient pediatric services. Consult interactions between trainees provide a rich opportunity for teaching and learning. What constitutes meaningful teaching interactions with trainees has not been ... ...

Abstract	Background: Consults are increasingly frequent in inpatient pediatric services. Consult interactions between trainees provide a rich opportunity for teaching and learning. What constitutes meaningful teaching interactions with trainees has not been described. Objective: Explore how consulting fellows and residents define "meaningful teaching interactions" associated with inpatient consult interactions. Methods: Four focus groups were conducted with 21 pediatric trainees (11 subspecialty fellows and 10 residents) at one institution. Transcriptions were analyzed using thematic analysis to inductively create categories and themes. Results: Five factors define meaningful teaching interactions: (1) Relevance; (2) Quick Hits; (3) Vibe; (4) Face-to-face Interactions; and (5) Timing and Busyness. Meaningful content was described as relevant to current or future patient care. Residents valued content that would enable them to explain the reasoning behind recommendations and think through the next steps. Trainees highlighted brief clinical pearls as superior to longer teaching sessions. The "vibe" between resident and fellow was described as a prerequisite to meaningful teaching and included aspects of interest, receptivity, tone, and attitude. Face-to-face interactions were preferred by many trainees, from initial consults to seeing patients or co-rounding. Timing and workload reflected discordant schedules, including time of day and week, but setting a planned time for teaching was beneficial. Conclusion: Relevant, bite-sized educational content combined with a good vibe and optimal timing creates a context in which consult fellows can foster meaningful teaching opportunities for residents.
MeSH term(s)	Humans ; Child ; Internship and Residency ; Education, Medical, Graduate ; Learning ; Focus Groups ; Referral and Consultation ; Teaching
Language	English
Publishing date	2023-12-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2233783-0
ISSN	1553-5606 ; 1553-5592
ISSN (online)	1553-5606
ISSN	1553-5592
DOI	10.1002/jhm.13256
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Zs.MO 542: Show issues

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Article ; Online: COVID-19 and Pediatric Gastroenterology.

Taylor, Richard / Mallon, Daniel

Pediatric clinics of North America

2021 Volume 68, Issue 6, Page(s) 1157–1169

Abstract: Pediatric gastroenterologists took on a variety of challenges during the coronavirus disease 2019 pandemic, including learning about a new disease and how to recognize and manage it, prevent its spread among their patients and health professions ... ...

Abstract	Pediatric gastroenterologists took on a variety of challenges during the coronavirus disease 2019 pandemic, including learning about a new disease and how to recognize and manage it, prevent its spread among their patients and health professions colleagues, and make decisions about managing patients with chronic gastrointestinal and liver problems in light of the threat. They adapted their practice to accommodate drastically decreased numbers of in-person visits, adopting telehealth technologies, and instituting new protocols to perform endoscopies safely. The workforce pipeline was also affected by the impact of the pandemic on trainee education, clinical experience, research, and job searches.
MeSH term(s)	COVID-19/epidemiology ; Child ; Child Welfare/statistics & numerical data ; Gastroenterology/organization & administration ; Health Equity/statistics & numerical data ; Health Services Accessibility/organization & administration ; Health Status Disparities ; Healthcare Disparities/statistics & numerical data ; Humans ; Social Determinants of Health ; Socioeconomic Factors ; United States
Language	English
Publishing date	2021-07-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	215711-1
ISSN	1557-8240 ; 0031-3955
ISSN (online)	1557-8240
ISSN	0031-3955
DOI	10.1016/j.pcl.2021.07.003
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Article ; Online: Usefulness of remote pulmonary arterial pressure monitoring in patients with advanced heart failure listed for HT.

Couto-Mallón, David / Enríquez-Vázquez, Daniel / Calviño-Santos, Ramón / Velasco-García de Sierra, Carlos / Rodríguez-Vázquez, José Manuel / Crespo-Leiro, María G

Revista espanola de cardiologia (English ed.)

2024

Language	Spanish
Publishing date	2024-02-19
Publishing country	Spain
Document type	Case Reports
ZDB-ID	2592481-3
ISSN	1885-5857 ; 1885-5857
ISSN (online)	1885-5857
ISSN	1885-5857
DOI	10.1016/j.rec.2023.12.014
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Article ; Online: Serologic Evaluation of Celiac Disease for Patients Younger Than 2 Years of Age.

Mallon, Daniel / Hajjat, Temara M

The Journal of pediatrics

2020 Volume 224, Page(s) 16–17

MeSH term(s)	Celiac Disease/diagnosis ; Celiac Disease/epidemiology ; Child ; Child, Preschool ; Gliadin ; Humans ; Immunoglobulin A ; Transglutaminases
Chemical Substances	Immunoglobulin A ; Gliadin (9007-90-3) ; Transglutaminases (EC 2.3.2.13)
Language	English
Publishing date	2020-05-21
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2020.05.023
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Article ; Online: The South Australian Emergency Department Admission Blood Psychoactive Testing (EDABPT) program: first results.

Alfred, Sam / Stockham, Peter / Partridge, Emma / Ward, Alastair / Green, Hannah / Mallon, Jake / Kostakis, Chris / Camilleri, Andrew / Haustead, Daniel

The Medical journal of Australia

2023 Volume 218, Issue 8, Page(s) 376–377

MeSH term(s)	Humans ; South Australia ; Australia ; Drug Overdose ; Psychotropic Drugs/adverse effects ; Emergency Service, Hospital
Chemical Substances	Psychotropic Drugs
Language	English
Publishing date	2023-03-28
Publishing country	Australia
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	186082-3
ISSN	1326-5377 ; 0025-729X
ISSN (online)	1326-5377
ISSN	0025-729X
DOI	10.5694/mja2.51907
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Article ; Online: Prolonged Impact of COVID-19 on Job Prospects and Training for Pediatric Gastroenterology Fellows in North America.

Sanchez, Raul E / Grossman, Arielle / Irastorza, Laura E / Mallon, Daniel / Lee, Christine K

JPGN reports

2022 Volume 3, Issue 4, Page(s) e261

Abstract: As the COVID-19 pandemic persisted into the 2020 to 2021 academic year, there was a continued effect on graduate medical education trainees and graduating trainee job attainment. Our survey aims to investigate how the pandemic has continued to affect job ...

Abstract	As the COVID-19 pandemic persisted into the 2020 to 2021 academic year, there was a continued effect on graduate medical education trainees and graduating trainee job attainment. Our survey aims to investigate how the pandemic has continued to affect job search and attainment for pediatric gastroenterology fellows as well as to re-evaluate the pandemic's impact on pediatric gastroenterology fellow educational experiences. Methods: An anonymous survey was distributed to all North American pediatric gastroenterology fellows from May to June 2021. Survey questions included topics related to job search and fellowship training and were tailored to respondent year of training. Results: Of 453 pediatric gastroenterology fellows in the 2020 to 2021 academic year, 158 fellows (35%) responded to the survey. Of graduating fellow respondents with job contracts, 74% reported willingness to make compromises in their job search, 76% reported accepting academic positions that were primary clinical, and 42% estimated staying at their accepted job for less than 5 years. When asked about the impact of COVID-19 on various aspects of fellowship education, a negative impact was reported in the following areas: 76% in research, 94% in clinical experience, 73% in procedural skills, and 84% in didactics. Conclusion: The COVID-19 pandemic continues to make a significant impact on pediatric gastroenterology fellowship education and the job attainment process. Regarding accepted job positions, we found substantial willingness to compromise, a shorter duration to stay at the job than expected, and minimal research focus. This raises concern regarding job preparedness and satisfaction as fellows complete their medical training.
Language	English
Publishing date	2022-09-30
Publishing country	United States
Document type	Journal Article
ISSN	2691-171X
ISSN (online)	2691-171X
DOI	10.1097/PG9.0000000000000261
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Article ; Online: Randomized Controlled Trial of Interactive Spaced Education to Support Constipation Management by Pediatric Primary Care Providers.

Mallon, Daniel / Fei, Lin / Farrell, Michael / Anderson, Jeffrey B / Klein, Melissa

Journal of pediatric gastroenterology and nutrition

2022 Volume 74, Issue 5, Page(s) 568–574

Abstract: Introduction: Integrating continuing medical education and quality improvement (QI) initiatives is challenging. We aimed to compare one method, Interactive Spaced Education (ISE/QI), with standard (sTD/Qi) education embedded within a constipation ... ...

Abstract	Introduction: Integrating continuing medical education and quality improvement (QI) initiatives is challenging. We aimed to compare one method, Interactive Spaced Education (ISE/QI), with standard (sTD/Qi) education embedded within a constipation management Qi initiative. Methods: We conducted a randomized, controlled study to compare ISE/QI and STD/QI education. Pediatric primary care providers (PCPs) were recruited from a network of local private practices. The QI initiative was implemented with all providers before education interventions. ISE/QI participants received questions by email weekly, provided answers, received feedback, and repeated questions over a 4-month period. The STD/QI group received a Power Point with the same educational content. Pre- and post-surveys evaluated usability, self-assessed confidence, and practice changes while quizzes evaluated knowledge. Process control charts tracked subsequent visits to gastroenterology (GI). Results: Of the 212 eligible PCPs, 101 (48%) enrolled, with 49 PCPs in the ISE/QI arm and 52 in STD/QI education arm. Quiz scores improved in the ISE/QI arm with a strong effect size (Cohen d 1.76). Mean increase in confidence managing difficult cases was higher in the ISE/QI group (1.84 vs 1.21, P = 0.030). ISE/QI participants were more likely to rate the activity better than most online education (odds ratio [OR] 18.1, P < 0.0001) and incorporate practice changes (OR 3.35, P = 0.0152). Visits to GI decreased among the entire population, but the effect on GI visits within each education arm was mixed. Conclusions: ISE/QI improved knowledge and confidence managing difficult cases. ISE/QI participants reported higher likelihood to change practice, but no differences were seen in GI referrals.
MeSH term(s)	Humans ; Constipation/therapy ; Education, Medical, Continuing/methods ; Pediatrics/education ; Pediatrics/methods ; Pediatrics/organization & administration ; Practice Management, Medical ; Primary Health Care/methods ; Primary Health Care/organization & administration ; Quality Improvement
Language	English
Publishing date	2022-03-06
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0000000000003405
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Zs.A 1728: Show issues

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Article ; Online: Characteristics of analytically confirmed gamma-hydroxybutyrate (GHB) positive patients in the emergency department: presentation, poly-drug use, disposition and impact on intensive care resource utilisation.

Stockham, Peter / Partridge, Emma / Alfred, Sam / Boyle, Laura / Camilleri, Andrew / Green, Hannah / Haustead, Daniel / Humphries, Melissa / Kostakis, Chris / Mallon, Jake

Clinical toxicology (Philadelphia, Pa.)

2023 Volume 61, Issue 4, Page(s) 241–247

Abstract: Background: Gamma-hydroxybutyrate is a potent central nervous system depressant with a narrow recreational dose window and analytical detection time. We describe data relating to intoxicated patients presenting to emergency departments across ... ...

Abstract	Background: Gamma-hydroxybutyrate is a potent central nervous system depressant with a narrow recreational dose window and analytical detection time. We describe data relating to intoxicated patients presenting to emergency departments across metropolitan Adelaide who tested positive for gamma-hydroxybutyrate. This work was part of the Emergency Department Admission Blood Psychoactive Testing study. Methods: Over a 15-month period, patients presenting to four metropolitan emergency departments with symptoms of drug intoxication were enrolled in the study. The methodology involved the collection of demographic and clinical data and a de-identified blood sample which underwent comprehensive toxicological analysis. Gamma-hydroxybutyrate was determined using an acid-catalysed cyclisation followed by liquid-liquid extraction and gas chromatography-mass spectrometry. Data relating to samples positive for gamma-hydroxybutyrate were examined. Results and discussion: A total of 1120 patients were enrolled between March 2019 and May 2020, 309 of whom were positive for gamma-hydroxybutyrate (27.6%). Of these, 256 (83%) were also positive for metamfetamine (methamphetamine). The most common clinical observation in gamma-hydroxybutyrate-positive patients was central nervous system depression (89%). There was a significant relationship between gamma-hydroxybutyrate status and sex; although males outnumbered females in absolute terms, a higher proportion of females (32%) tested positive for gamma-hydroxybutyrate than males (25%, Conclusions: Gamma-hydroxybutyrate is commonly detected in illicit drug-related emergency department presentations and is detected disproportionately in the patient cohort who require intensive care unit level care.
MeSH term(s)	Male ; Female ; Humans ; Sodium Oxybate ; Substance-Related Disorders ; Illicit Drugs ; Critical Care ; Emergency Service, Hospital
Chemical Substances	Sodium Oxybate (7G33012534) ; Illicit Drugs
Language	English
Publishing date	2023-05-01
Publishing country	England
Document type	Journal Article
ZDB-ID	204476-6
ISSN	1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
ISSN (online)	1556-9519
ISSN	0009-9309 ; 0731-3810 ; 1556-3650
DOI	10.1080/15563650.2023.2178933
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Article: Phase separation of polyubiquitinated proteins in UBQLN2 condensates controls substrate fate.

Valentino, Isabella M / Llivicota-Guaman, Jeniffer G / Dao, Thuy P / Mulvey, Erin O / Lehman, Andrew M / Galagedera, Sarasi K K / Mallon, Erica L / Castañeda, Carlos A / Kraut, Daniel A

bioRxiv : the preprint server for biology

2024

Abstract: Ubiquitination is one of the most common post-translational modifications in eukaryotic cells. Depending on the architecture of polyubiquitin chains, substrate proteins can meet different cellular fates, but our understanding of how chain linkage ... ...

Abstract	Ubiquitination is one of the most common post-translational modifications in eukaryotic cells. Depending on the architecture of polyubiquitin chains, substrate proteins can meet different cellular fates, but our understanding of how chain linkage controls protein fate remains limited. UBL-UBA shuttle proteins, such as UBQLN2, bind to ubiquitinated proteins and to the proteasome or other protein quality control machinery elements and play a role in substrate fate determination. Under physiological conditions, UBQLN2 forms biomolecular condensates through phase separation, a physicochemical phenomenon in which multivalent interactions drive the formation of a macromolecule-rich dense phase. Ubiquitin and polyubiquitin chains modulate UBQLN2's phase separation in a linkage-dependent manner, suggesting a possible link to substrate fate determination, but polyubiquitinated substrates have not been examined directly. Using sedimentation assays and microscopy we show that polyubiquitinated substrates induce UBQLN2 phase separation and incorporate into the resulting condensates. This substrate effect is strongest with K63-linked substrates, intermediate with mixed-linkage substrates, and weakest with K48-linked substrates. Proteasomes can be recruited to these condensates, but proteasome activity towards K63-linked and mixed linkage substrates is inhibited in condensates. Substrates are also protected from deubiquitinases by UBQLN2-induced phase separation. Our results imply that phase separation can act as a regulatory switch that controls the fate of ubiquitinated substrates in a chain-linkage dependent manner, thus serving as an interpreter of the ubiquitin code.
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.03.15.585243
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