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  1. Artikel ; Online: Valgus-impacted subcapital neck of femur fractures: a systematic review, meta-analysis with cost analysis of fixation

    Vidakovic, Herv / Kieser, David / Hooper, Gary / Frampton, Chris / Wyatt, Michael

    Hip international : the journal of clinical and experimental research on hip pathology and therapy

    2023  Band 34, Heft 2, Seite(n) 260–269

    Abstract: Background: The management of the valgus-impacted neck of femur fracture (AO/OTA 31-B1) remains contentious. The objective of this study was to determine whether operative intervention is cost-effective.: Methods: We conducted a systematic review ... ...

    Abstract Background: The management of the valgus-impacted neck of femur fracture (AO/OTA 31-B1) remains contentious. The objective of this study was to determine whether operative intervention is cost-effective.
    Methods: We conducted a systematic review using electronic databases (Medline, Embase, Cochrane, Ebsco, Scholar) identifying studies published in the English language concerning valgus-impacted neck of femur fractures until June 2022. Additional studies were identified through hand searches of major orthopaedic journals, and bibliographies of major orthopaedic textbooks. MeSH terms (hip fracture and femoral neck fracture) and keywords (undisplaced, valgus-impacted, valgus, subcapital, Garden) connected by the Boolean operators "AND" and "OR" were used to identify studies. 2 reviewers independently extracted the data using standardised forms and recording spreadsheet. Methodological validity prior to inclusion in the review using standardized critical appraisal instruments from the Joanna Briggs Institute Meta-analysis of Statistics Assessment and Review Instrument. Meta-analysis was undertaken. Outcome measures were rate of displacement, avascular necrosis, non-union, mortality and requirement of further operative intervention. A cost utility analysis was then conducted to compare the 2 groups on the basis of the cost of initial treatment and the potential requirement of secondary intervention to hemiarthroplasty.
    Results: 47 studies met the inclusion criteria. Meta-analysis data demonstrated a significant difference in the displacement rate of 22.8% and 2.8% between the nonoperative and internal fixation groups respectively (
    Conclusions: This meta-analysis of the existing literature concludes that whilst nonoperative management is possible for valgus impacted neck of femur fractures, it is associated with higher complication rates and greater expense than management by internal fixation.
    Mesh-Begriff(e) Humans ; Arthroplasty, Replacement, Hip ; Femoral Neck Fractures/surgery ; Femoral Neck Fractures/complications ; Fracture Fixation, Internal/methods ; Osteonecrosis/surgery ; Costs and Cost Analysis ; Femur/surgery ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2023-11-21
    Erscheinungsland United States
    Dokumenttyp Systematic Review ; Meta-Analysis ; Journal Article
    ZDB-ID 1162513-2
    ISSN 1724-6067 ; 1120-7000
    ISSN (online) 1724-6067
    ISSN 1120-7000
    DOI 10.1177/11207000231210240
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Ballistic gelatin calibration standardisation.

    Pullen, Amy / Kieser, D C / Hooper, G

    BMJ military health

    2020  Band 168, Heft 2, Seite(n) 124–127

    Abstract: Introduction: A review of ballistic gelatin calibration standards has highlighted that data used from studies with different calibrations methods may not be able to be compared. Calibration of ballistic gelatin did not occur until the mid-1980s when ... ...

    Abstract Introduction: A review of ballistic gelatin calibration standards has highlighted that data used from studies with different calibrations methods may not be able to be compared. Calibration of ballistic gelatin did not occur until the mid-1980s when Fackler recognised the deficiencies of uncalibrated gelatin. He determined that the calibration standard should be 85±5 mm of ball bearing penetration for a 180 m/s impact velocity. This study looks to improve on and optimise current ballistic gelatin calibration standards METHODS: Nine 0.177 cal (4.5 mm) spheres were fired using a Daisy Powerline air rifle at velocities between 134 m/s and 224 m/s at 25 gelatin blocks (n=225). Velocities were measured using an
    Results: The R-squared regression model showed that all batches had a close fit to the regression line. Using the R-squared regression model, the equation y=0.584x - 20.02 (where x is the velocity) returned a DoP of 84.918 mm for a 180 m/s impact and therefore needed minimal adjustment to align with Fackler's 85 mm DoP. The equation can be adjusted to y=0.584x - 20.12 to return a DoP of 85 mm for 180 m/s.
    Conclusions: We propose that the calibration standard of ballistic gelatin with 4.5 mm spheres is DoP=0.584x - 20.12 where DoP is the depth of penetration (mm) and x is the impact velocity (m/s), The measured DoP should be within 5% of the calculated DoP.
    Mesh-Begriff(e) Calibration ; Gelatin ; Humans ; Male
    Chemische Substanzen Gelatin (9000-70-8)
    Sprache Englisch
    Erscheinungsdatum 2020-03-12
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 3011686-7
    ISSN 2633-3775 ; 2633-3767
    ISSN (online) 2633-3775
    ISSN 2633-3767
    DOI 10.1136/bmjmilitary-2020-001430
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: The intra-muscular course and distribution of the anterior interosseous nerve within pronator quadratus: An anatomical study.

    Trowbridge, S / Sagmeister, M L / Lewis, T L / Vidakovic, H / Hammer, N / Kieser, D C

    Journal of clinical orthopaedics and trauma

    2022  Band 28, Seite(n) 101868

    Abstract: Background: The anterior interosseous nerve (AIN) is a terminal motor branch of the median nerve innervating the following three muscles from proximal to distal: Flexor pollicis longus (FPL), the radial half of flexor digitorum profundus (FDP), and the ... ...

    Abstract Background: The anterior interosseous nerve (AIN) is a terminal motor branch of the median nerve innervating the following three muscles from proximal to distal: Flexor pollicis longus (FPL), the radial half of flexor digitorum profundus (FDP), and the pronator quadratus (PQ). The aim of this study was to define the course of the AIN within the PQ to aid surgeons performing distal radial procedures.
    Methods: Ten embalmed cadaveric forearms were dissected to identify the path of the AIN within PQ. An en-bloc excision of the PQ with its supplying AIN and vasculature was performed to identify a safe zone where PQ can be elevated without damaging AIN. A scoping literature search was performed to identify other studies reporting the path of AIN through PQ.
    Results: The mean distance from the radial border of the radius perpendicular to the point at which the AIN enters the PQ was 22.3 mm (range 21-24 mm). The mean distance from the distal wrist crease to the AIN entering PQ was 74.3 mm (range 59-84 mm). The mean number of nerve branches to PQ was 5.2 (range 3-8). In all specimens, the AIN was found to lie on the radial side of the anterior interosseous artery (AIA).
    Conclusions: The AIN courses on the deep surface of the PQ in a longitudinal proximal to distal direction. A 'safe zone' was identified within 20 mm of the radial border of the distal radius, which may be utilised by surgeons in a muscle-splitting approach to the distal radius.
    Sprache Englisch
    Erscheinungsdatum 2022-04-12
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 2596956-0
    ISSN 2213-3445 ; 0976-5662
    ISSN (online) 2213-3445
    ISSN 0976-5662
    DOI 10.1016/j.jcot.2022.101868
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Benchmarking total knee replacement constructs using noninferiority analysis: the New Zealand joint registry study.

    Wyatt, M C / Frampton, C F / Whitehouse, M R / Deere, K C / Sayers, A / Kieser, D

    BMC musculoskeletal disorders

    2021  Band 22, Heft 1, Seite(n) 721

    Abstract: Background: The aim of this study was to compare the relative performance of total knee replacement constructs and discern if there is variability in performance in currently commonly used prostheses in the New Zealand Joint Registry (NZJR) using a ... ...

    Abstract Background: The aim of this study was to compare the relative performance of total knee replacement constructs and discern if there is variability in performance in currently commonly used prostheses in the New Zealand Joint Registry (NZJR) using a noninferiority analysis.
    Methods: All patients who underwent a primary total knee replacement (TKR) registered in the NZJR between 1st January 1999 to June 2020 were identified. Using a noninferiority analysis, the performance of total knee replacement prostheses were compared with the best performing contemporary construct. Construct all-cause revision rate was estimated using the 1-Kaplan Meier survival function method to estimate net failure. The difference in all-cause revision rates between the contemporary benchmark and all other constructs was tested.
    Results: In total 110 183 TKR were recorded and 25 constructs (102 717 procedures) had > 500 procedures at risk at 3 years post-primary of which 5 were inferior by at least 20 % relative risk of which, one was inferior by at least 100 % relative risk. 14 constructs were identified with > 500 procedures at risk at 10 years with 5 inferior by at least 20 %, of which 2 were inferior by > 100 % relative risk.
    Conclusions: We discerned that there is great variability in construct performance and at all time points, greater than 25 % of constructs are inferior to the best performing construct by at least 20 %. These results can help inform patients, clinicians and health care funders when considering TKR surgery.
    Mesh-Begriff(e) Arthroplasty, Replacement, Knee/adverse effects ; Artificial Limbs ; Benchmarking ; Humans ; New Zealand/epidemiology ; Prosthesis Failure ; Registries ; Reoperation
    Sprache Englisch
    Erscheinungsdatum 2021-08-23
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2041355-5
    ISSN 1471-2474 ; 1471-2474
    ISSN (online) 1471-2474
    ISSN 1471-2474
    DOI 10.1186/s12891-021-04606-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: A Positive Quadriceps Active Test, without the Quadriceps Being Active.

    Kieser, D C / Savage, E / Sharplin, P

    Case reports in orthopedics

    2019  Band 2019, Seite(n) 6135632

    Abstract: Case: A 55-year-old male with a chronic isolated grade 3 PCL injury who demonstrates a positive quadriceps active test without activating his quadriceps musculature.: Conclusion: Gravity and hamstring contraction posteriorly translate the tibia into ... ...

    Abstract Case: A 55-year-old male with a chronic isolated grade 3 PCL injury who demonstrates a positive quadriceps active test without activating his quadriceps musculature.
    Conclusion: Gravity and hamstring contraction posteriorly translate the tibia into a subluxed position. Subsequent gastrocnemius contraction with the knee flexed causes an anterior tibial translation by virtue of the mass enlargement of the gastrocnemius muscular bulk, the string of a bow effect, and the anterior origin of the gastrocnemius in relation to the posterior border of the subluxed tibia aided by the normal posterior tibial slope.
    Sprache Englisch
    Erscheinungsdatum 2019-12-27
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 2684648-2
    ISSN 2090-6757 ; 2090-6749
    ISSN (online) 2090-6757
    ISSN 2090-6749
    DOI 10.1155/2019/6135632
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Teleconsultation in the Management of Elective Orthopedic and Spinal Conditions During the COVID-19 Pandemic: Prospective Cohort Study of Patient Experiences.

    Melian, Christina / Frampton, Christopher / Wyatt, Michael Charles / Kieser, David

    JMIR formative research

    2021  Band 5, Heft 6, Seite(n) e28140

    Abstract: Background: The global adoption of teleconsultation has been expedited as a result of the COVID-19 pandemic. By allowing remote communication, teleconsultation may help limit the spread of the virus while maintaining the crucial patient-provider ... ...

    Abstract Background: The global adoption of teleconsultation has been expedited as a result of the COVID-19 pandemic. By allowing remote communication, teleconsultation may help limit the spread of the virus while maintaining the crucial patient-provider relationship.
    Objective: The aim of this study is to evaluate the value of teleconsultation compared to in-person visits in the management of elective orthopedic and spinal procedures.
    Methods: This was a prospective observational cohort study of 853 patients receiving orthopedic and spinal care at a private outpatient clinic in New Zealand. Patients were randomly divided into two groups: (1) patients receiving telephone consultation remotely, and (2) patients receiving in-person office consultations at the outpatient clinic. All patients received telephone consultations for 4 weeks during the mandated COVID-19 lockdown, followed by 4 weeks of telephone or in-person consultation. Patient preference, satisfaction, and duration of visit were recorded. Comparisons of patient preference between groups, visit type, sex, and location were performed using chi-square tests; similarly, satisfaction scores and visit durations were compared using a general linear model.
    Results: We report that 91% (353/388) of patients in the telephone group preferred teleconsultation over in-person office visits during the COVID-19 lockdown (P<.001). A combined-group analysis showed that 55.3% (446/807) of all patients preferred teleconsultation compared to 31.2% (252/807) who preferred in-person office visits (P<.001). Patients in the telephone group reported significantly higher satisfaction scores (mean 9.95, SD 0.04, 95% CI 9.87-10.03) compared to patients in the in-person group (mean 9.53, SE 0.04, 95% CI 9.45-9.62; P<.001). Additionally, in-person consultations were significantly longer in duration compared to telephone consultations, with a mean visit time of 6.70 (SE 0.18) minutes, 95% CI 6.32-7.02, compared to 5.10 (SE 0.17) minutes, 95% CI 4.73-5.42 (P<.001).
    Conclusions: Patients who use telephone consultations are more likely to prefer it over traditional, in-person visits in the future. This increased preference, coupled with higher patient satisfaction scores and shorter duration of visits, suggests that teleconsultation has a role in orthopedic surgery, which may even extend beyond the COVID-19 pandemic.
    Sprache Englisch
    Erscheinungsdatum 2021-06-15
    Erscheinungsland Canada
    Dokumenttyp Journal Article
    ISSN 2561-326X
    ISSN (online) 2561-326X
    DOI 10.2196/28140
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: The 45-year evolution of the Mathys RM monoblock cups: have the paradigm shifts been worthwhile?

    Foxall-Smith, Michael / Wyatt, Michael C / Frampton, Christopher / Kieser, David / Hooper, Gary

    Hip international : the journal of clinical and experimental research on hip pathology and therapy

    2022  Band 33, Heft 2, Seite(n) 193–202

    Abstract: Introduction: The Robert Mathys (RM) monoblock uncemented cup is a design less commonly used in primary total hip replacement. It's purported advantages over modular cemented cups are: (1) its modulus of elasticity approximating bone, thus mimicking ... ...

    Abstract Introduction: The Robert Mathys (RM) monoblock uncemented cup is a design less commonly used in primary total hip replacement. It's purported advantages over modular cemented cups are: (1) its modulus of elasticity approximating bone, thus mimicking load transmission and the biomechanical behaviour of the cup to better match stresses on the acetabulum, leading to bone-preservation; and (2) as a 1-piece cup there is absence of a mobile interface between a liner and shell, preventing backside wear. Since its inception in 1983 there have been 3 major design changes: the RM Classic, the RM Pressfit, and the RM Vitamys with the most modern polyethylene (vitamin E).
    Methods: In a retrospective cohort study of the New Zealand Joint Registry, all designs of RM acetabular cup were reviewed. Data were included from1998 to 2018. All-cause revision rates, reasons for revision and the Oxford Hip Score (OHS) were assessed.
    Results: In total 13,272 acetabular cups were included. The all-cause revision rates did not differ between the designs. Revision rates for aseptic loosening in the RM Vitamys were lower, but the follow-up was shorter and more larger heads were used. There was no difference in the OHS.
    Conclusion: All implant designs were safe. The use of larger heads led to a decrease in revisions due to dislocation. It has to be waited out whether the RM Vitamys performs superior in the long-term due to the highly cross-linked polyethylene.
    Mesh-Begriff(e) Humans ; Arthroplasty, Replacement, Hip ; Hip Prosthesis ; Retrospective Studies ; Prosthesis Failure ; Prosthesis Design ; Acetabulum/surgery ; Polyethylene ; Reoperation ; Follow-Up Studies
    Chemische Substanzen Polyethylene (9002-88-4)
    Sprache Englisch
    Erscheinungsdatum 2022-04-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1162513-2
    ISSN 1724-6067 ; 1120-7000
    ISSN (online) 1724-6067
    ISSN 1120-7000
    DOI 10.1177/11207000211067507
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Clinical associations of fetal heart rate accelerations as derived from transabdominal fetal electrocardiograms.

    Odendaal, H J / Kieser, E / Crockart, I C / Brink, L T / Du Plessis, C / Nel, D G

    European journal of obstetrics, gynecology, and reproductive biology

    2022  Band 279, Seite(n) 5–11

    Abstract: Objective: To determine the value of quantifying accelerations of the fetal heart rate (FHR), as collected non-invasively during pregnancy, as a proxy for fetal movements.: Study design: The study consists of a prospective collection of research ... ...

    Abstract Objective: To determine the value of quantifying accelerations of the fetal heart rate (FHR), as collected non-invasively during pregnancy, as a proxy for fetal movements.
    Study design: The study consists of a prospective collection of research material with retrospective analyses of the collected fetal electrocardiograms (ECGs), done in a homogeneous population in a low socioeconomic residential area of Cape Town, South Africa, as part of the Safe Passage Study. Recruitment and follow-up were done from August 2007 to August 2016. Maternal and fetal ECGs were collected non-invasively at various gestational ages, for approximately 30-60 min at a time in 4418 pregnant women. After processing of the signal, the number and duration of accelerations and the area under the acceleration curve of the FHR were calculated and compared with the pulsatility index (PI) of the uterine, umbilical, and middle cerebral arteries, common medical conditions, tobacco, alcohol, marijuana, and methamphetamine use and z-scores of the birthweight (BWZS).
    Results: Of the total, 2777, 691, and 3879 women were at gestational ages of 20-24, 28-32 and 34-38 weeks respectively. At 20-24 weeks duration of accelerations was significantly longer in women who used marijuana (p = 0.014) or methamphetamine (p < 0.001) when compared to nonusers. At 28-32 weeks the duration of accelerations was significantly shorter in hypertensive women (p = 0.003) and significantly longer in women who used methamphetamine (p = 0.015). At 34-38 weeks the number of accelerations were significantly less in women who had hypertension ((p = 0.01) or stillbirths (p = 0.028) and the duration significantly shorter in hypertensive women (p = 0.007) and significantly longer in women who used marjuana (p = 0.003) or methamphetamine (p = 0.028). The acceleration area was significantly smaller (p = 0.02) in women who has stillbirths. Duration of accelerations was significantly longer in users of nicotine and alcohol when compared with that of abstainers. Birthweight z-score correlated significantly with number of accelerations (p < 0.01) and the acceleration area (<0.01). There was a significant negative correlation between the number of accelerations (p < 0.01) and acceleration area (p < 0.01) and the PI of the uterine artery at 34-38 weeks.
    Conclusions: Calculation of the acceleration parameters of the FHR during pregnancy may provide useful information for evaluating fetal development.
    Mesh-Begriff(e) Female ; Pregnancy ; Humans ; Infant ; Male ; Heart Rate, Fetal/physiology ; Birth Weight ; Stillbirth ; Retrospective Studies ; Prospective Studies ; South Africa ; Gestational Age ; Electrocardiography ; Acceleration ; Methamphetamine ; Heart Rate
    Chemische Substanzen Methamphetamine (44RAL3456C)
    Sprache Englisch
    Erscheinungsdatum 2022-10-08
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2022.10.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Senior Club-Level Rugby Union Player's Positional Movement Performance Using Individualized Velocity Thresholds and Accelerometer-Derived Impacts in Matches.

    Takamori, Sohei / Hamlin, Michael J / Kieser, David C / King, Doug / Hume, Patria / Yamazaki, Tetsuya / Hachiya, Masashi / Olsen, Peter D

    Journal of strength and conditioning research

    2022  Band 36, Heft 3, Seite(n) 710–716

    Abstract: Abstract: Takamori, S, Hamlin, MJ, Kieser, DC, King, D, Hume, P, Yamazaki, T, Hachiya, M, and ...

    Abstract Abstract: Takamori, S, Hamlin, MJ, Kieser, DC, King, D, Hume, P, Yamazaki, T, Hachiya, M, and Olsen, PD. Senior club-level rugby union player's positional movement performance using individualized velocity thresholds and accelerometer-derived impacts in matches. J Strength Cond Res 36(3): 710-716, 2022-Game demands of professional rugby union players have been well documented; however, there is minimal game demand information using individualized velocity thresholds and collision loads, particularly for amateurs. This study investigated movement patterns of 20 male amateur rugby players during 16 senior premier division one matches using global positioning system (GPS) devices sampling at 10 Hz. Derived GPS variables included distances, velocities, sprinting, and impacts. Data files from 86 player games (≥60 minutes of play per game) were categorized into broad (forwards and backs) and specific (front row, second row, back row, half back, inside back, and outside back) positional groups for analysis. It was most likely that backs covered more distance in the high-speed running (>60% maximal velocity) zone (502 ± 157 m) compared with forwards (238 ± 147 m) (100/0/0%, chances of positive/trivial/negative differences, effect size [ES] = 1.3), performed more striding (backs 1,116 ± 240, forwards 954 ± 240 m, 96/4/0%, ES = 0.5), and sprinting (backs 121 ± 58, forwards 90 ± 65 m, 93/7/0%, ES = 0.5). However, forwards had higher collision loads (35 ± 12 arbitrary units) compared with backs (20 ± 6, 99.9/0.1/0%, ES = 1.3) with back row forwards completing the highest collision load of any playing position (40 ± 13). Our example match movement performance and impact information is valuable to coaches and support staff in preparing player profiles for similar-level rugby players to help manage their workloads.
    Mesh-Begriff(e) Accelerometry ; Athletic Performance ; Football ; Geographic Information Systems ; Humans ; Male ; Rugby ; Running
    Sprache Englisch
    Erscheinungsdatum 2022-07-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1156349-7
    ISSN 1533-4287 ; 1064-8011
    ISSN (online) 1533-4287
    ISSN 1064-8011
    DOI 10.1519/JSC.0000000000003523
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Actin cytoskeleton remodeling disrupts physical barriers to infection and presents entry receptors to respiratory syncytial virus.

    Kieser, Quinten J / Granoski, Madison J / McClelland, Ryley D / Griffiths, Cameron / Bilawchuk, Leanne M / Stojic, Aleksandra / Elawar, Farah / Jamieson, Kyla / Proud, David / Marchant, David J

    The Journal of general virology

    2024  Band 104, Heft 11

    Abstract: RSV is the leading cause of infant hospitalizations and a significant cause of paediatric and geriatric morbidity worldwide. Recently, we reported that insulin-like growth factor 1 receptor (IGF1R) was a receptor for respiratory syncytial virus (RSV) in ... ...

    Abstract RSV is the leading cause of infant hospitalizations and a significant cause of paediatric and geriatric morbidity worldwide. Recently, we reported that insulin-like growth factor 1 receptor (IGF1R) was a receptor for respiratory syncytial virus (RSV) in airway epithelial cells and that activation of IGF1R recruited the coreceptor, nucleolin (NCL), to the cell surface. Cilia and mucus that line the airways pose a significant barrier to viral and bacterial infection. The cortical actin cytoskeleton has been shown by others to mediate RSV entry, so we studied the roles of the RSV receptors and actin remodelling during virus entry. We found that IGF1R expression and phosphorylation were associated with the ability of RSV to infect cells. Confocal immunofluorescence imaging showed that actin projections, a hallmark of macropinocytosis, formed around viral particles 30 min after infection. Consistent with prior reports we also found that virus particles were internalized into early endosome antigen-1 positive endosomes within 90 min. Inhibiting actin polymerization significantly reduced viral titre by approximately ten-fold. Inhibiting PI3 kinase and PKCζ in stratified air-liquid interface (ALI) models of the airway epithelium had similar effects on reducing the actin remodelling observed during infection and attenuating viral entry. Actin projections were associated with NCL interacting with RSV particles resting on apical cilia of the ALIs. We conclude that macropinocytosis-like actin projections protrude through normally protective cilia and mucus layers of stratified airway epithelium that helps present the IGF1R receptor and the NCL coreceptor to RSV particles waiting at the surface.
    Mesh-Begriff(e) Infant ; Humans ; Child ; Aged ; Actins ; Respiratory Syncytial Virus, Human ; Cell Physiological Phenomena ; Actin Cytoskeleton ; Cell Membrane
    Chemische Substanzen Actins
    Sprache Englisch
    Erscheinungsdatum 2024-04-01
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 219316-4
    ISSN 1465-2099 ; 0022-1317
    ISSN (online) 1465-2099
    ISSN 0022-1317
    DOI 10.1099/jgv.0.001923
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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