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Article ; Online: Factors associated with the use of the prescription monitoring program by prescribers and pharmacists in Texas.

Thornton, James Douglas / Varisco, Tyler J / Downs, Callie G

2021 Volume 30, Issue 4, Page(s) 492–503

Abstract: Purpose: To describe Texas Prescription Monitoring Program (PMP) use and identify predictors of PMP query for opioid and benzodiazepine prescriptions by prescribers and pharmacists.: Methods: Dispensation and query records from the Texas PMP for ... ...

Abstract	Purpose: To describe Texas Prescription Monitoring Program (PMP) use and identify predictors of PMP query for opioid and benzodiazepine prescriptions by prescribers and pharmacists. Methods: Dispensation and query records from the Texas PMP for opioid and benzodiazepine medications dispensed between October 1, 2016 and December 31, 2018 were linked using common patient identifiers. Autoregressive linear regression was used to assess trends in utilization. Hierarchical logistic models were specified to identify factors associated with provider and pharmacist query of opioid and benzodiazepine prescriptions. Results: Despite a significant increase in the total number of pharmacists (β = 169.85, p < 0.0001) and prescribers (β = 301.59, p < 0.0001) who used the PMP every month, the ratio of active to registered pharmacists (β = -0.0001, p = 0.75) and prescribers (β = -0.0015, p = 0.10) did not change. Pharmacists and prescribers were significantly more likely to query opioid and benzodiazepine prescriptions of 14 days or more, and those issued to patients new to their practice. Pharmacists were most likely to query opioid prescriptions for oxycodone (aOR = 4.51, 95%CI = 4.42-4.60) and prescribers were most likely to query prescriptions for buprenorphine (aOR = 2.24, 95%CI = 2.15-2.35) compared to codeine. Conclusion: Changes in PMP utilization between October 2016 and December 2018 were driven by increasing registration, not increasing frequency of use among registered users. Use of the PMP is inconsistent and dependent upon patient characteristics thus limiting the utility of the PMP as a decision support tool. These results support the need for policy mandating PMP use in Texas and provide a useful baseline and framework to evaluate the effectiveness of mandate implementation.
MeSH term(s)	Analgesics, Opioid ; Humans ; Pharmacists ; Practice Patterns, Physicians' ; Prescription Drug Monitoring Programs ; Prescriptions ; Texas
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2021-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1099748-9
ISSN	1099-1557 ; 1053-8569
ISSN (online)	1099-1557
ISSN	1053-8569
DOI	10.1002/pds.5198
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Parents' intention to have their child vaccinated at a community pharmacy: A national cross-sectional survey.

Varisco, Tyler J / Downs, Callie G / Sansgiry, Sujit S / Al Saadi, Randa / Hastings, Tessa / Thornton, J Douglas

Journal of the American Pharmacists Association : JAPhA

2022 Volume 63, Issue 2, Page(s) 511–517.e8

Abstract: Background: During the coronavirus disease 2019 pandemic, pediatric vaccination rates for routine childhood vaccines have been declining. To boost pediatric immunizations, pharmacists in the United States may order and administer age-appropriate ... ...

Abstract	Background: During the coronavirus disease 2019 pandemic, pediatric vaccination rates for routine childhood vaccines have been declining. To boost pediatric immunizations, pharmacists in the United States may order and administer age-appropriate vaccines to children of 3 years of age and older without a prescription. Objective: The objective of this study was to examine parents' intention to have their young children between 3 and 10 years of age vaccinated in a community pharmacy setting. Methods: A survey instrument was designed based on the health belief model (HBM). The cross-sectional survey was administered online via Qualtrics Panels to parents in the United States with at least 1 child between the ages of 3 and 10 years. Confirmatory factor analysis was used to estimate the correlation between each of the HBM constructs and a 3-item scale measuring parents' intention to have their children between the ages of 3 and 10 vaccinated in a community pharmacy. Results: There were 416 usable responses collected for an effective response rate of 25.95%. Most participants were white (79.09%) and female (51.44%), and many had a graduate degree (48.32%). More than half of parents (69.7%) indicated they would be willing to have their child vaccinated in a community pharmacy. Intention to have their child vaccinated in a pharmacy was most strongly corrected with health benefit beliefs (ψ 0.79 [95% CI 0.75-0.83]), (ψ 0.86 [95% CI 0.83-0.89])cues to action, and perceived convenience.(ψ 0.71 [95% CI 0.66-0.76]). Conclusion: Many parents have high intention to vaccinate their young children in community pharmacies. Parents should be educated and informed about services that community pharmacies offer. Stakeholders need to engage in interventions targeted at promoting health benefits of getting vaccinations at a pharmacy and strong recommendations from health care providers.
MeSH term(s)	Humans ; Child ; Female ; United States ; Child, Preschool ; Pharmacies ; Cross-Sectional Studies ; Intention ; COVID-19/prevention & control ; Parents ; Vaccines ; Vaccination ; Health Knowledge, Attitudes, Practice
Chemical Substances	Vaccines
Language	English
Publishing date	2022-10-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2118585-2
ISSN	1544-3450 ; 1544-3191 ; 1086-5802
ISSN (online)	1544-3450
ISSN	1544-3191 ; 1086-5802
DOI	10.1016/j.japh.2022.10.008
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Article ; Online: Impact of COVID-19 Related Policy Changes on Buprenorphine Dispensing in Texas.

Thornton, James Douglas / Varisco, Tyler J / Bapat, Shweta S / Downs, Callie G / Shen, Chan

Journal of addiction medicine

2020 Volume 14, Issue 6, Page(s) e372–e374

Abstract: Objectives: To measure the change in the daily number of patients receiving buprenorphine and buprenorphine prescribers during the early phase of the COVID-19 (SARS-CoV-2) pandemic in Texas.: Methods: Counts of the number of patients filling and ... ...

Abstract	Objectives: To measure the change in the daily number of patients receiving buprenorphine and buprenorphine prescribers during the early phase of the COVID-19 (SARS-CoV-2) pandemic in Texas. Methods: Counts of the number of patients filling and number of providers prescribing buprenorphine were calculated for each weekday between November 4, 2019 and May 12, 2020. The change in daily patients and prescribers between March 2, 2020 and May 12, 2020, was modeled as a change in slope compared to the baseline period using autoregressive, interrupted time series regression. Results: The rate of change of daily buprenorphine prescriptions (β = -1.75, 95% CI = -5.8-2.34) and prescribers (β = -0.32, 95% CI = -1.47-0.82) declined insignificantly during the COVID-19 period compared to the baseline. Conclusions: Despite a 57% decline in ambulatory care utilization in the south-central US during March and April of 2020, health services utilization related to buprenorphine in Texas remained robust. Protecting access to buprenorphine as the COVID-19 pandemic continues to unfold will require intensive efforts from clinicians and policy makers alike. While the presented results are promising, researchers must continue monitoring and exploring the clinical and humanistic impact of COVID-19 on the treatment of substance use disorders.
MeSH term(s)	Buprenorphine/therapeutic use ; COVID-19 ; Coronavirus Infections/epidemiology ; Drug Prescriptions/statistics & numerical data ; Health Policy ; Humans ; Interrupted Time Series Analysis ; Narcotic Antagonists/therapeutic use ; Opiate Substitution Treatment/methods ; Opiate Substitution Treatment/statistics & numerical data ; Pandemics ; Pneumonia, Viral/epidemiology ; Practice Patterns, Physicians'/statistics & numerical data ; Texas
Chemical Substances	Narcotic Antagonists ; Buprenorphine (40D3SCR4GZ)
Keywords	covid19
Language	English
Publishing date	2020-10-08
Publishing country	United States
Document type	Journal Article
ISSN	1935-3227
ISSN (online)	1935-3227
DOI	10.1097/ADM.0000000000000756
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of COVID-19 related policy changes on filling of opioid and benzodiazepine medications.

Downs, Callie G / Varisco, Tyler J / Bapat, Shweta S / Shen, Chan / Thornton, J Douglas

Research in social & administrative pharmacy : RSAP

2020 Volume 17, Issue 1, Page(s) 2005–2008

Abstract: Background: Healthcare access has changed drastically during the COVID-19 pandemic. Elective medical procedures, including routine office visits, were restricted raising concerns regarding opioid and benzodiazepine provider and prescription availability. ...

Abstract	Background: Healthcare access has changed drastically during the COVID-19 pandemic. Elective medical procedures, including routine office visits, were restricted raising concerns regarding opioid and benzodiazepine provider and prescription availability. Objective: To examine how the cancelation of elective medical procedures due to COVID-19 impacted the dispensing of opioid and benzodiazepine prescriptions in Texas. Methods: Interrupted time series analyses were preformed to examine changes in prescription trends for opioids and benzodiazepines before and after the restriction on elective medical procedures. Samples of patients who filled an opioid or benzodiazepine prescription from January 5, 2020 to May 12, 2020 were identified from the Texas Prescription Monitoring Program. Elective medical procedures were restricted starting March 23, 2020 indicating the beginning of the intervention period. Results: Restricting elective procedures was associated with a significant decrease in the number of patients (β = -6029, 95%CI = -8810.40, -3246.72) and prescribers (β = -2784, 95%CI = -3671.09, -1896.19) filling and writing opioid prescriptions, respectively. Also, the number of patients filling benzodiazepine prescriptions decreased significantly (β = -1982, 95%CI = -3712.43, -252.14) as did the number of prescribers (β = -708.62, 95%CI = -1190.54, -226.71). Conclusion: Restricting elective procedures resulted in a large care gap for patients taking opioid or benzodiazepine prescriptions.
MeSH term(s)	Analgesics, Opioid/administration & dosage ; Benzodiazepines/administration & dosage ; COVID-19 ; Drug Prescriptions ; Health Policy ; Health Services Accessibility ; Humans ; Interrupted Time Series Analysis ; Practice Patterns, Physicians'/statistics & numerical data ; Prescription Drug Monitoring Programs ; Texas
Chemical Substances	Analgesics, Opioid ; Benzodiazepines (12794-10-4)
Language	English
Publishing date	2020-06-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2192059-X
ISSN	1934-8150 ; 1551-7411
ISSN (online)	1934-8150
ISSN	1551-7411
DOI	10.1016/j.sapharm.2020.06.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Applying the capability, opportunity, motivation, and behavior model to identify opportunities to increase pharmacist comfort dispensing naloxone in Texas: A structural equation modeling approach.

Varisco, Tyler J / Downs, Callie G / Rathburn, Kaycie R / Fleming, Marc L / Thornton, J Douglas

The International journal on drug policy

2020 Volume 83, Page(s) 102827

Abstract: Background: The prevalence of opioid use and misuse in the United States contributed to 48,000 opioid related deaths in 2018. Naloxone, a potent opioid reversal agent, can be dispensed by pharmacists without a prescription, however few do so. Previous ... ...

Abstract	Background: The prevalence of opioid use and misuse in the United States contributed to 48,000 opioid related deaths in 2018. Naloxone, a potent opioid reversal agent, can be dispensed by pharmacists without a prescription, however few do so. Previous studies on naloxone dispensing have contributed to our understanding of the determinants of naloxone in community pharmacy, however, none have focused on comprehensive behavioral change. This study utilized the Capability, Opportunity, Motivation, and Behavior (COM-B) model, a behavioral change and intervention design framework, to examine community pharmacists' comfort dispensing naloxone. Methods: A 48-item questionnaire grounded in the COM-B and theoretical domains framework was developed and mailed to 1,000 community pharmacists in Texas, USA using a modified Dillman cross-sectional survey design. Confirmatory factor analysis was used to refine and establish dimensionality of the hypothesized scales and structural equation modeling was used to estimate the fit of the COM-B in explaining pharmacists' comfort dispensing naloxone. Results: The usable response rate was 19.4%. Of surveyed pharmacists, 29.7% had ever had a patient request naloxone and 35.1% had dispensed naloxone without a prescription. Capability and opportunity explained 60% of the variance in motivation. Opportunity and motivation were the most salient predictors of comfort dispensing naloxone. Together, capability, opportunity, and motivation explained 78.1% of variance in pharmacists' comfort dispensing naloxone, indicating that the COM-B model is useful in this setting. Conclusion: Despite previous findings, policy interventions to increase naloxone dispensing should go beyond providing additional education to the pharmacy workforce. Rather, these results suggest that a complex intervention designed with pharmacist input that enables them to act autonomously and evaluate whether patients need naloxone may increase their comfort dispensing. Without collaboration from pharmacy and managed care corporations, dissemination efforts will continue to be limited.
MeSH term(s)	Cross-Sectional Studies ; Drug Overdose/drug therapy ; Humans ; Latent Class Analysis ; Motivation ; Naloxone/therapeutic use ; Narcotic Antagonists/therapeutic use ; Opioid-Related Disorders/drug therapy ; Pharmacists ; Texas
Chemical Substances	Narcotic Antagonists ; Naloxone (36B82AMQ7N)
Language	English
Publishing date	2020-06-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2010000-0
ISSN	1873-4758 ; 0955-3959
ISSN (online)	1873-4758
ISSN	0955-3959
DOI	10.1016/j.drugpo.2020.102827
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of COVID-19 related policy changes on filling of opioid and benzodiazepine medications

Downs, Callie G. / Varisco, Tyler J. / Bapat, Shweta S. / Shen, Chan / Thornton, J. Douglas

Research in Social and Administrative Pharmacy ; ISSN 1551-7411

2020

Keywords	Pharmaceutical Science ; Pharmacy ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.1016/j.sapharm.2020.06.003
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Impact of COVID-19 Related Policy Changes on Buprenorphine Dispensing in Texas

Thornton, James Douglas / Varisco, Tyler J. / Bapat, Shweta S. / Downs, Callie G. / Shen, Chan

Journal of Addiction Medicine

2020 Volume 14, Issue 6, Page(s) e372–e374

Keywords	Pharmacology (medical) ; Psychiatry and Mental health ; covid19
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publishing country	us
Document type	Article ; Online
ISSN	1932-0620
DOI	10.1097/adm.0000000000000756
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Impact of COVID-19 Related Policy Changes on Buprenorphine Dispensing in Texas

Thornton, James Douglas / Varisco, Tyler J / Bapat, Shweta S / Downs, Callie G / Shen, Chan

J Addict Med

Abstract: OBJECTIVES: To measure the change in the daily number of patients receiving buprenorphine and buprenorphine prescribers during the early phase of the COVID-19 (SARS-CoV-2) pandemic in Texas. METHODS: Counts of the number of patients filling and number of ...

Abstract	OBJECTIVES: To measure the change in the daily number of patients receiving buprenorphine and buprenorphine prescribers during the early phase of the COVID-19 (SARS-CoV-2) pandemic in Texas. METHODS: Counts of the number of patients filling and number of providers prescribing buprenorphine were calculated for each weekday between November 4, 2019 and May 12, 2020. The change in daily patients and prescribers between March 2, 2020 and May 12, 2020, was modeled as a change in slope compared to the baseline period using autoregressive, interrupted time series regression. RESULTS: The rate of change of daily buprenorphine prescriptions (ß = -1.75, 95% CIâ=â-5.8-2.34) and prescribers (ß = -0.32, 95% CIâ=â-1.47-0.82) declined insignificantly during the COVID-19 period compared to the baseline. CONCLUSIONS: Despite a 57% decline in ambulatory care utilization in the south-central US during March and April of 2020, health services utilization related to buprenorphine in Texas remained robust. Protecting access to buprenorphine as the COVID-19 pandemic continues to unfold will require intensive efforts from clinicians and policy makers alike. While the presented results are promising, researchers must continue monitoring and exploring the clinical and humanistic impact of COVID-19 on the treatment of substance use disorders.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #841712
Database	COVID19

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Article: Impact of COVID-19 related policy changes on filling of opioid and benzodiazepine medications

Downs, Callie G. / Varisco, Tyler J. / Bapat, Shweta S. / Shen, Chan / Thornton, J. Douglas

Res. Soc. Adm. Pharm.

Abstract	Background: Healthcare access has changed drastically during the COVID-19 pandemic. Elective medical procedures, including routine office visits, were restricted raising concerns regarding opioid and benzodiazepine provider and prescription availability. Objective: To examine how the cancelation of elective medical procedures due to COVID-19 impacted the dispensing of opioid and benzodiazepine prescriptions in Texas. Methods: Interrupted time series analyses were preformed to examine changes in prescription trends for opioids and benzodiazepines before and after the restriction on elective medical procedures. Samples of patients who filled an opioid or benzodiazepine prescription from January 5, 2020 to May 12, 2020 were identified from the Texas Prescription Monitoring Program. Elective medical procedures were restricted starting March 23, 2020 indicating the beginning of the intervention period. Results: Restricting elective procedures was associated with a significant decrease in the number of patients (β = −6029, 95%CI = −8810.40, −3246.72) and prescribers (β = −2784, 95%CI = −3671.09, −1896.19) filling and writing opioid prescriptions, respectively. Also, the number of patients filling benzodiazepine prescriptions decreased significantly (β = −1982, 95%CI = −3712.43, −252.14) as did the number of prescribers (β = −708.62, 95%CI = −1190.54, −226.71). Conclusion: Restricting elective procedures resulted in a large care gap for patients taking opioid or benzodiazepine prescriptions.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #505793
Database	COVID19

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Article ; Online: Systematic Improvement in the Patient Transfer Process to a Tertiary Care Children's Hospital.

Sutton, Ashley G / Smith, Hunter G / Dawes, Melanie Edwards / O'Connor, Megan / Hayes, Andrea A / Downs, John P / Steiner, Michael J

Hospital pediatrics

2022 Volume 12, Issue 9, Page(s) 816–825

Abstract: ... to the other services in Phase 2. Data were manually extracted monthly from call transcripts and monitored by using ... statistical process control (SPC) charts. Primary outcome measures were time from call to connection ... to a provider and number of providers added to the call before making a disposition decision.: Results ...

Abstract	Objective: Interfacility transfer of pediatric patients to a children's hospital is a complex process that can be time consuming and dissatisfying for referring providers. We aimed to improve the efficiency of communication and acceptance for interfacility transfers to our hospital. Methods: We implemented iterative improvements to the process in 2 phases from 2013 to 2016 (pediatric medicine) and 2019 to 2022 (pediatric critical care and surgery). Key interventions included creation of a hospitalist position to manage transfers with broad ability to accept patients and transition to direct phone access for transfer requests to streamline connection. Effective initiatives from Phase 1 were adapted and spread to the other services in Phase 2. Data were manually extracted monthly from call transcripts and monitored by using statistical process control (SPC) charts. Primary outcome measures were time from call to connection to a provider and number of providers added to the call before making a disposition decision. Results: Average time from call initiation to provider connection for pediatric medicine calls decreased from 11 minutes to 5 minutes. The average number of internal physicians on each call before acceptance decreased from 2.1 to 1.3. In Phase 2, time to provider connection decreased from 11 to 4 minutes for pediatric critical care calls and 16 to 5 minutes for pediatric surgery calls. Conclusions: We streamlined the process of accepting incoming transfer requests throughout our children's hospital. Prioritizing direct communication led to efficient disposition decisions and progression toward transfer and was effective for multiple service lines.
MeSH term(s)	Child ; Hospitalists ; Hospitals, Pediatric ; Humans ; Patient Transfer ; Telephone ; Tertiary Healthcare
Language	English
Publishing date	2022-08-09
Publishing country	United States
Document type	Journal Article
ISSN	2154-1671
ISSN (online)	2154-1671
DOI	10.1542/hpeds.2021-006390
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