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  1. Article ; Online: An Interview with Tim Gautreaux

    Margaret D. Bauer

    Southern Spaces (2009)

    "Cartographer of Louisiana Back Roads"

    2009  

    Abstract: In this interview with Louisiana native Margaret D. Bauer, author Tim Gautreaux discusses a quarter ...

    Abstract In this interview with Louisiana native Margaret D. Bauer, author Tim Gautreaux discusses a quarter century of his fiction writing. Resisting simplistic labels of "Cajun" and "southern," Gautreaux's storytelling reveals an intimate understanding of southern Louisiana's white, working-class people and culture. Often drawn from his own background, Gautreaux's characters are shaped by a range of experiences, from working on steamboats and fighting in world wars, to struggling in the 1980s oil bust.
    Keywords Literary Criticism ; Regional Studies ; Social Class ; Geography. Anthropology. Recreation ; G ; United States local history ; F1-975
    Language English
    Publishing date 2009-05-01T00:00:00Z
    Publisher Emory Center for Digital Scholarship
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Protein translocation into mitochondria: the role of TIM complexes.

    Bauer, M F / Hofmann, S / Neupert, W / Brunner, M

    Trends in cell biology

    2000  Volume 10, Issue 1, Page(s) 25–31

    Abstract: ... the TIM23 complex and the TIM22 complex. Both TIM complexes cooperate with the TOM complex but facilitate ... of the translocases of the inner membrane and the possible role of Tim proteins in the development of the Mohr ...

    Abstract Import of nuclear-encoded mitochondrial preproteins is mediated by a general translocase in the outer membrane, the TOM complex, and by two distinct translocases in the mitochondrial inner membrane, the TIM23 complex and the TIM22 complex. Both TIM complexes cooperate with the TOM complex but facilitate import of different classes of precursor proteins. Precursors with an N-terminal presequence are imported via the TIM23 complex, whereas mitochondrial carrier proteins require the TIM22 complex for insertion into the inner membrane. This review discusses recent advances in understanding the structure and function of the translocases of the inner membrane and the possible role of Tim proteins in the development of the Mohr-Tranebjaerg syndrome, a mitochondrial disorder leading to neurodegeneration.
    MeSH term(s) Animals ; Biological Transport ; Carrier Proteins ; Humans ; Membrane Proteins ; Membrane Transport Proteins ; Mitochondria/physiology ; Mitochondrial Membrane Transport Proteins ; Mitochondrial Myopathies ; Saccharomyces cerevisiae Proteins
    Chemical Substances Carrier Proteins ; Membrane Proteins ; Membrane Transport Proteins ; Mitochondrial Membrane Transport Proteins ; Saccharomyces cerevisiae Proteins ; TIM22 protein, S cerevisiae ; TIM23 protein, S cerevisiae
    Language English
    Publishing date 2000-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/s0962-8924(99)01684-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria.

    Mühlenbein, Nicole / Hofmann, Sabine / Rothbauer, Uli / Bauer, Matthias F

    The Journal of biological chemistry

    2004  Volume 279, Issue 14, Page(s) 13540–13546

    Abstract: Tim9, Tim10a, and Tim10b are members of the family of small Tim proteins located ... During import, the small Tim complexes directly interact with human adenine nucleotide translocator (ANT ... the human small Tim proteins directly interact with human Tim22, the putative insertion pore of the TIM22 ...

    Abstract Tim9, Tim10a, and Tim10b are members of the family of small Tim proteins located in the intermembrane space of mammalian mitochondria. In yeast, members of this family act along the TIM22 import pathway during import of metabolite carriers and other integral inner membrane proteins. Here, we show that the human small proteins form two distinct hetero-oligomeric complexes. A 70-kDa complex that contains Tim9 and Tim10a and a Tim9-10a-10b that is part of a higher molecular weight assembly of 450 kDa. This distribution among two complexes suggests Tim10b to be the functional homologue of yeast Tim12. Both human complexes are tightly associated with the inner membrane and, compared with yeast, soluble 70-kDa complexes appear to be completely absent in the intermembrane space. Thus, the function of soluble 70-kDa complexes as trans-site receptors for incoming carrier proteins is not conserved from lower to higher eukaryotes. During import, the small Tim complexes directly interact with human adenine nucleotide translocator (ANT) in transit in a metal-dependent manner. For insertion of carrier preproteins into the inner membrane, the human small Tim proteins directly interact with human Tim22, the putative insertion pore of the TIM22 translocase. However, in contrast to yeast, only a small fraction of Tim9-Tim10a-Tim10b complex is in a stable association with Tim22. We conclude that different mechanisms and specific requirements for import and insertion of mammalian carrier preproteins have evolved in higher eukaryotes.
    MeSH term(s) Animals ; Biological Transport ; Evolution, Molecular ; HeLa Cells ; Humans ; Mammals ; Membrane Transport Proteins/metabolism ; Mice ; Mitochondria, Liver/metabolism ; Mitochondrial Proteins/metabolism ; Yeasts/metabolism
    Chemical Substances Membrane Transport Proteins ; Mitochondrial Proteins
    Language English
    Publishing date 2004-01-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.M312485200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Biogenesis of Tim23 and Tim17, integral components of the TIM machinery for matrix-targeted preproteins.

    Káldi, K / Bauer, M F / Sirrenberg, C / Neupert, W / Brunner, M

    The EMBO journal

    1998  Volume 17, Issue 6, Page(s) 1569–1576

    Abstract: We analysed the import pathway of Tim23 and of Tim17, components of the mitochondrial import machinery for matrix-targeted preproteins. Tim23 contains two independent import signals. One is located within the first 62 amino acid residues of the ... ...

    Abstract We analysed the import pathway of Tim23 and of Tim17, components of the mitochondrial import machinery for matrix-targeted preproteins. Tim23 contains two independent import signals. One is located within the first 62 amino acid residues of the hydrophilic domain that, in the assembled protein, is exposed to the intermembrane space. This signal mediates translocation of Tim23 across the outer membrane independently of the membrane potential, DeltaPsi. A second import signal is located in the C-terminal membrane-integrated portion of Tim23. It mediates translocation across the outer membrane and insertion into the inner membrane in a strictly DeltaPsi-dependent fashion. Structurally, Tim17 is related to Tim23 but lacks a hydrophilic domain. It contains an import signal in the C-terminal half and its import requires DeltaPsi. The DeltaPsi-dependent import signals of Tim23 and Tim17 are located at corresponding sites in these two homologous proteins. They exhibit features reminiscent of the positively charged N-terminal presequences of matrix-targeted precursors. Import of Tim23 and its insertion into the inner membrane requires Tim22 but not functional Tim23. Thus, biogenesis of the Tim23.17 complex depends on the Tim22 complex, which is the translocase identified as mediating the import of carrier proteins.
    MeSH term(s) Amino Acid Sequence ; Biological Transport ; Carrier Proteins/chemistry ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Intracellular Membranes/metabolism ; Membrane Potentials ; Membrane Proteins/chemistry ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Membrane Transport Proteins ; Mitochondria/metabolism ; Mitochondrial Membrane Transport Proteins ; Molecular Sequence Data ; Protein Precursors/metabolism ; Recombinant Fusion Proteins/metabolism ; Repressor Proteins ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae Proteins
    Chemical Substances Carrier Proteins ; Membrane Proteins ; Membrane Transport Proteins ; Mitochondrial Membrane Transport Proteins ; Protein Precursors ; Recombinant Fusion Proteins ; Repressor Proteins ; Saccharomyces cerevisiae Proteins ; TIM17 protein, S cerevisiae ; TIM23 protein, S cerevisiae
    Language English
    Publishing date 1998-03-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.1093/emboj/17.6.1569
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  5. Article: Biogenesis of Tim23 and Tim17, integral components of the TIM machinery for matrix-targeted preproteins

    Kaldi, K / Bauer, M.F / Sirrenberg, C / Neupert, W / Brunner, M

    EMBO journal. Mar 16, 1998. v. 17 (6)

    1998  

    Keywords Saccharomyces cerevisiae ; mitochondria ; cell membranes ; protein transport ; binding proteins ; signal peptide ; membrane potential ; recombinant proteins ; dihydrofolate reductase ; amino acid sequences
    Language English
    Dates of publication 1998-0316
    Size p. 1569-1576.
    Document type Article
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: A gut response: Modulating chemotherapy efficacy with microbial metabolites.

    Bauer, Kylynda C / Greten, Tim F

    Immunity

    2023  Volume 56, Issue 4, Page(s) 750–752

    Abstract: Despite clinical advances, chemotherapy largely fails in metastatic cancers. Commensal bacteria can indicate chemotherapy efficacy. In a recent issue of Nature, Tintelnot et al. ...

    Abstract Despite clinical advances, chemotherapy largely fails in metastatic cancers. Commensal bacteria can indicate chemotherapy efficacy. In a recent issue of Nature, Tintelnot et al.
    MeSH term(s) Humans ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/pathology ; Adenocarcinoma ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/pathology
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2023.03.011
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  7. Conference proceedings: Annäherung an ein Rollen-, Aufgaben- und Kompetenzprofil von SP-Trainer:innen

    Bauer, Daniel / Brem, Beate / Strohmer, Renate / Peters, Tim

    2024  , Page(s) PS2

    Event/congress 17. Internationales SkillsLab Symposium 2023; Köln; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2024-01-15
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23isls47
    Database German Medical Science

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  8. Article: Thema: Logistik. Anwenderbericht: effiziente Digitalisierung im Krankenhaus. Der innovative Einsatz von Barcode-Scannern und smarten Apps im Klinikum Region Hannover

    Bauer, Tim / Sakkal, Elias

    Das Krankenhaus

    2023  Volume 115, Issue 6, Page(s) 508

    Language German
    Document type Article
    ZDB-ID 3262-1
    ISSN 0340-3602
    Database Current Contents Medicine

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  9. Article: Thema: Logistik. Anwenderbericht: effiziente Digitalisierung im Krankenhaus. Der innovative Einsatz von Barcode-Scannern und smarten Apps im Klinikum Region Hannover

    Bauer, Tim / Sakkal, Elias

    Das Krankenhaus

    2023  Volume 115, Issue 6, Page(s) 508

    Language German
    Document type Article
    ZDB-ID 3262-1
    ISSN 0340-3602
    Database Current Contents Medicine

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  10. Article: Thema: Logistik. Anwenderbericht: effiziente Digitalisierung im Krankenhaus. Der innovative Einsatz von Barcode-Scannern und smarten Apps im Klinikum Region Hannover

    Bauer, Tim / Sakkal, Elias

    Das Krankenhaus

    2023  Volume 115, Issue 6, Page(s) 508

    Language German
    Document type Article
    ZDB-ID 3262-1
    ISSN 0340-3602
    Database Current Contents Medicine

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