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  1. Article: Prognostic Factors in Anti-Neutrophil Cytoplasmic Antibody-Associated Glomerulonephritis with Severe Glomerular Sclerosis: A National Registry-Based Cohort Study.

    Bjørneklett, Rune / Solbakken, Vilde / Bostad, Leif / Fismen, Anne-Siri

    Pathology research international

    2018  Volume 2018, Page(s) 5653612

    Abstract: Background: Classification of patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN) into histological classes is useful for predicting a patient's risk of progression to end-stage renal disease (ESRD). However, even ... ...

    Abstract Background: Classification of patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN) into histological classes is useful for predicting a patient's risk of progression to end-stage renal disease (ESRD). However, even in the worst prognostic group, the 5-year end-stage renal disease-free survival rate is as high as 50%.
    Objectives: To investigate those prognostic factors indicative of progression to ESRD in patients with ANCA-GN and sclerosing histology.
    Methods: Patients from the Norwegian Kidney Biopsy Registry between 1991 and 2012 who had biopsy verified pauci-immune glomerulonephritis, positive ANCA serology, and sclerosing histology were included. Cases with ESRD during follow-up were identified via linkage with the Norwegian Renal Registry. Potential prognostic factors with relevant cut-offs were compared in patients with and without progression to ESRD during follow-up.
    Results: Of 23 included patients, 10 progressed to ESRD. ESRD patients had a lower initial estimated glomerular filtration rate (eGFR; 21 versus 52 ml/min/1.73 m
    Conclusions: eGFR and percentage of normal glomeruli are strong risk factors for ESRD in ANCA-GN with sclerosing histology.
    Language English
    Publishing date 2018-06-03
    Publishing country United States
    Document type Journal Article
    ISSN 2090-8091
    ISSN 2090-8091
    DOI 10.1155/2018/5653612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Impact of Proteinase 3 versus Myeloperoxidase Positivity on Risk of End-Stage Renal Disease in ANCA-Associated Glomerulonephritis Stratified by Histological Classification: A Population-Based Cohort Study.

    Solbakken, Vilde / Fismen, Anne-Siri / Bostad, Leif / Bjørneklett, Rune

    Disease markers

    2018  Volume 2018, Page(s) 3251517

    Abstract: Background: End-stage renal disease (ESRD) risk in patients with antineutrophil cytoplasmic antibody- (ANCA-) associated glomerulonephritis (ANCA-GN) according to ANCA serotype and stratified by histological classification has not been previously ... ...

    Abstract Background: End-stage renal disease (ESRD) risk in patients with antineutrophil cytoplasmic antibody- (ANCA-) associated glomerulonephritis (ANCA-GN) according to ANCA serotype and stratified by histological classification has not been previously investigated.
    Methods: Patients from the Norwegian Kidney Biopsy Registry (NKBR) between 1991 and 2012 who had biopsy-verified pauci-immune glomerulonephritis and positive antineutrophil cytoplasmic antibody serology were included. Cases with ESRD during follow-up were identified in the Norwegian Renal Registry. ESRD-free survival with proteinase 3 (PR3) versus myeloperoxidase- (MPO-) ANCA positivity stratified into 4 histological classes was investigated.
    Results: Three hundred fifty-eight patients, of whom 87 progressed to ESRD during follow-up, were included. Patients with PR3- as compared to MPO-ANCA were younger (58 versus 64 years,
    Conclusion: Advanced glomerular sclerosis is found more frequently in patients with MPO-ANCA, explaining the higher risk of ESRD. ANCA serotypes have no impact on prognosis of patients with similar histological findings.
    MeSH term(s) Adult ; Aged ; Antibodies, Antineutrophil Cytoplasmic/blood ; Biomarkers/blood ; Female ; Glomerulonephritis/blood ; Glomerulonephritis/complications ; Glomerulonephritis/pathology ; Humans ; Kidney Failure, Chronic/blood ; Kidney Failure, Chronic/etiology ; Kidney Failure, Chronic/pathology ; Male ; Middle Aged ; Myeloblastin/blood ; Peroxidase/blood
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic ; Biomarkers ; Peroxidase (EC 1.11.1.7) ; Myeloblastin (EC 3.4.21.76)
    Language English
    Publishing date 2018-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604951-5
    ISSN 1875-8630 ; 0278-0240
    ISSN (online) 1875-8630
    ISSN 0278-0240
    DOI 10.1155/2018/3251517
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1856: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Einzelsignatur: Show issues

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  3. Article ; Online: Exploring sex-specific differences in the presentation and outcomes of ANCA-associated vasculitis: a nationwide registry-based cohort study.

    Bjørneklett, Rune / Solbakken, Vilde / Bostad, Leif / Fismen, Anne-Siri

    International urology and nephrology

    2018  Volume 50, Issue 7, Page(s) 1311–1318

    Abstract: Purpose: Sex-specific differences in the risk of end-stage renal disease (ESRD) in patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN) stratified by histological classification have not been previously investigated. ...

    Abstract Purpose: Sex-specific differences in the risk of end-stage renal disease (ESRD) in patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN) stratified by histological classification have not been previously investigated.
    Methods: Patients with biopsy-verified pauci-immune necrotizing GN and positive ANCA serology in the Norwegian Kidney Biopsy Registry between 1991 and 2012 were included. Patients with ESRD during follow-up were identified from the Norwegian Renal Registry. ESRD-free survival stratified by histological classifications was investigated.
    Results: We analyzed 358 patients, of whom 87 progressed to ESRD during follow-up. Overall ESRD-free survival at 1 and 5 years in the entire cohort was 81 and 71% in males versus 90 and 80% in females, respectively; 94 and 84% in males versus 98 and 98% in females with focal histology, respectively; 85 and 76% in males versus 89 and 77% in females with mixed histology, respectively; 72 and 58% in males versus 90 and 78% in females with crescentic histology, respectively; and 52 and 46% in males versus 60 and 38% in females with sclerotic histology, respectively. Males had an increased risk of ESRD (adjusted hazard ratio, 2.44 [1.56-3.82]; p < 0.001).
    Conclusion: Male sex is associated with increased risk of ESRD across all histological classes of ANCA-GN.
    MeSH term(s) Adult ; Aged ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/epidemiology ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/pathology ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/therapy ; Biopsy, Needle ; Cohort Studies ; Disease Progression ; Female ; History, Medieval ; Humans ; Immunohistochemistry ; Incidence ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/pathology ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Norway/epidemiology ; Prognosis ; Proportional Hazards Models ; Registries ; Severity of Illness Index ; Sex Distribution ; Survival Analysis
    Language English
    Publishing date 2018-05-22
    Publishing country Netherlands
    Document type Historical Article ; Journal Article
    ZDB-ID 204048-7
    ISSN 1573-2584 ; 0301-1623 ; 0042-1162
    ISSN (online) 1573-2584
    ISSN 0301-1623 ; 0042-1162
    DOI 10.1007/s11255-018-1888-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 733: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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