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  1. Article ; Online: Plasma Biomarkers of Alzheimer's Disease: A Review of Available Assays, Recent Developments, and Implications for Clinical Practice.

    Pais, Marcos V / Forlenza, Orestes V / Diniz, Breno S

    Journal of Alzheimer's disease reports

    2023  Volume 7, Issue 1, Page(s) 355–380

    Abstract: Recently, low-sensitive plasma assays have been replaced by new ultra-sensitive assays such as single molecule enzyme-linked immunosorbent assay (Simoa), the Mesoscale Discovery (MSD) platform, and immunoprecipitation-mass spectrometry (IP-MS) with ... ...

    Abstract Recently, low-sensitive plasma assays have been replaced by new ultra-sensitive assays such as single molecule enzyme-linked immunosorbent assay (Simoa), the Mesoscale Discovery (MSD) platform, and immunoprecipitation-mass spectrometry (IP-MS) with higher accuracy in the determination of plasma biomarkers of Alzheimer's disease (AD). Despite the significant variability, many studies have established in-house cut-off values for the most promising available biomarkers. We first reviewed the most used laboratory methods and assays to measure plasma AD biomarkers. Next, we review studies focused on the diagnostic performance of these biomarkers to identify AD cases, predict cognitive decline in pre-clinical AD cases, and differentiate AD cases from other dementia. We summarized data from studies published until January 2023. A combination of plasma Aβ
    Language English
    Publishing date 2023-05-03
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2542-4823
    ISSN (online) 2542-4823
    DOI 10.3233/ADR-230029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Impact of SARS-CoV-2 pandemic on mental health in the elderly: perspective from a psychogeriatric clinic at a tertiary hospital in São Paulo, Brazil.

    Forlenza, Orestes V / Stella, Florindo

    International psychogeriatrics

    2020  Volume 32, Issue 10, Page(s) 1147–1151

    MeSH term(s) Aged ; Aging/physiology ; Aging/psychology ; Ambulatory Care Facilities/statistics & numerical data ; Betacoronavirus ; Brazil/epidemiology ; COVID-19 ; Communicable Disease Control/methods ; Communicable Disease Control/organization & administration ; Coronavirus Infections/epidemiology ; Coronavirus Infections/psychology ; Geriatric Psychiatry/methods ; Geriatric Psychiatry/trends ; Health Services Needs and Demand ; Health Services for the Aged/organization & administration ; Health Services for the Aged/trends ; Humans ; Mental Health/trends ; Mental Health Services/organization & administration ; Mental Health Services/trends ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/psychology ; Professional Practice Gaps ; SARS-CoV-2 ; Tertiary Healthcare/methods ; Tertiary Healthcare/trends
    Keywords covid19
    Language English
    Publishing date 2020-06-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1038825-4
    ISSN 1741-203X ; 1041-6102
    ISSN (online) 1741-203X
    ISSN 1041-6102
    DOI 10.1017/S1041610220001180
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  3. Article ; Online: A creative approach to increase social inclusion and reduce stigmatization of people with dementia.

    Oliveira, Alexandra M / Forlenza, Orestes V

    International psychogeriatrics

    2019  Volume 31, Issue 10, Page(s) 1391–1392

    MeSH term(s) Art Therapy ; Caregivers ; Dementia ; Humans ; Stereotyping
    Language English
    Publishing date 2019-11-11
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1038825-4
    ISSN 1741-203X ; 1041-6102
    ISSN (online) 1741-203X
    ISSN 1041-6102
    DOI 10.1017/S1041610219001327
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  4. Article ; Online: Cognitive impairment: an (in)dependent risk factor for mortality in older men?

    Loureiro, Júlia C / Pais, Marcos V / Forlenza, Orestes V

    Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

    2020  Volume 42, Issue 6, Page(s) 577–578

    MeSH term(s) Aged ; Cognitive Dysfunction ; Humans ; Male ; Risk Factors
    Language English
    Publishing date 2020-09-02
    Publishing country Brazil
    Document type Editorial
    ISSN 1809-452X
    ISSN (online) 1809-452X
    DOI 10.1590/1516-4446-2020-0017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Anti-amyloid agents for treating incipient Alzheimer's disease: a new hope?

    Loureiro, Julia C / Silva, Luiz Fernando A L / Pais, Marcos V / Forlenza, Orestes V

    Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

    2022  Volume 44, Issue 4, Page(s) 368–369

    MeSH term(s) Alzheimer Disease/drug therapy ; Amyloid beta-Peptides ; Animals ; Disease Models, Animal ; Humans
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2022-08-20
    Publishing country Brazil
    Document type Editorial
    ZDB-ID 2024119-7
    ISSN 1809-452X ; 1809-452X
    ISSN (online) 1809-452X
    ISSN 1809-452X
    DOI 10.47626/1516-4446-2022-2503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Impact of SARS-CoV-2 pandemic on mental health in the elderly: perspective from a psychogeriatric clinic at a tertiary hospital in São Paulo, Brazil

    Forlenza, Orestes V / Stella, Florindo

    Int Psychogeriatr

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #594213
    Database COVID19

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  7. Article ; Online: Impact of SARS-CoV-2 pandemic on mental health in the elderly

    Forlenza, Orestes V. / Stella, Florindo

    International Psychogeriatrics

    perspective from a psychogeriatric clinic at a tertiary hospital in São Paulo, Brazil

    2020  Volume 32, Issue 10, Page(s) 1147–1151

    Keywords Gerontology ; Clinical Psychology ; Geriatrics and Gerontology ; Psychiatry and Mental health ; covid19
    Language English
    Publisher Cambridge University Press (CUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1038825-4
    ISSN 1741-203X ; 1041-6102
    ISSN (online) 1741-203X
    ISSN 1041-6102
    DOI 10.1017/s1041610220001180
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: Spirituality, health and well-being in the elderly.

    Forlenza, Orestes V / Vallada, Homero

    International psychogeriatrics

    2018  Volume 30, Issue 12, Page(s) 1741–1742

    Abstract: Bailly et al. (2018) examined the trajectory of spirituality in a cohort of 567 non-institutionalized older adults living in Tours, France, during a period of five years. The measurements for spirituality (Daily Spiritual Experience Scale, DES), social ... ...

    Abstract Bailly et al. (2018) examined the trajectory of spirituality in a cohort of 567 non-institutionalized older adults living in Tours, France, during a period of five years. The measurements for spirituality (Daily Spiritual Experience Scale, DES), social support (Satisfaction with Social Support subscale of the Duke Social Support Index), and accommodative tendencies (Flexible Goal Adjustment) were longitudinally collected at three time points (2007, 2009, and 2012). The results of the study confirmed some expected observations, such as higher levels of spirituality among religious older adults when compared with the ones without religion, and older women reporting higher levels of spirituality than older men. But the most interesting finding was the observation that the measured levels of spirituality among older adults remained stable during this five-year period. Based on a growing number of studies and theories of aging suggesting that the levels of spirituality increases during a person's lifetime, one would expect an increase in the levels of spirituality along the study follow-up. The authors, however, interpreted the stable level of spirituality informed by the participants as having already reached a relatively high mean rating score of spirituality at baseline. From the beginning of the trail, many participants expressed self-contentment and reported having found meaning in their lives. Moreover, the responders had, in general, more years of education than expected for people in their age group, lived at home independently with a good self-health evaluation, had relatively fewer diseases, and a good perception of financial satisfaction; these characteristics perhaps make this group not representative of the French general population in the same age bracket.
    MeSH term(s) Aged ; Female ; France ; Humans ; Longitudinal Studies ; Male ; Religion ; Social Support ; Spirituality
    Language English
    Publishing date 2018-12-25
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1038825-4
    ISSN 1741-203X ; 1041-6102
    ISSN (online) 1741-203X
    ISSN 1041-6102
    DOI 10.1017/S1041610218001874
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  9. Article ; Online: Mitochondrial dysfunction in Alzheimer's disease: Therapeutic implications of lithium.

    Singulani, Monique P / De Paula, Vanessa J R / Forlenza, Orestes V

    Neuroscience letters

    2021  Volume 760, Page(s) 136078

    Abstract: Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, characterized by the accumulation of abnormal tau proteins within neurons and amyloid plaques in the brain parenchyma, which leads to progressive loss of neurons in the ... ...

    Abstract Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, characterized by the accumulation of abnormal tau proteins within neurons and amyloid plaques in the brain parenchyma, which leads to progressive loss of neurons in the brain. While the detailed mechanism of the pathogenesis of AD is still unknown, evidence suggests that mitochondrial dysfunction likely plays a fundamental role in the pathogenesis of this disease. Due to the relevance of mitochondrial alterations in AD, recent works have suggested the therapeutic potential of mitochondrial-targeted lithium. Lithium has been shown to possess neuroprotective and neurotrophic properties that could also be related to the upregulation of mitochondrial function. In the current work, we perform a comprehensive investigation of the significance of mitochondrial dysfunction in AD and pharmacological treatment with lithium as imperative in this pathology, through a brief review of the major findings on the effects of lithium as a therapeutic approach targeting mitochondria in the context of AD.
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/pathology ; Brain/cytology ; Brain/drug effects ; Brain/pathology ; Cell Line ; Clinical Trials as Topic ; Drug Evaluation, Preclinical ; Glycogen Synthase Kinase 3 beta/antagonists & inhibitors ; Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Lithium Compounds/pharmacology ; Lithium Compounds/therapeutic use ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/pathology ; Neurons/cytology ; Neurons/drug effects ; Neurons/metabolism ; Oxidative Phosphorylation/drug effects ; Oxidative Stress/drug effects
    Chemical Substances Lithium Compounds ; GSK3B protein, human (EC 2.7.11.1) ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1)
    Language English
    Publishing date 2021-06-20
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2021.136078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Corrigendum: Neuronal-Glial Interaction in a Triple-Transgenic Mouse Model of Alzheimer's Disease: Gene Ontology and Lithium Pathways.

    Rocha, Nicole Kemberly R / Themoteo, Rafael / Brentani, Helena / Forlenza, Orestes V / De Paula, Vanessa De Jesus Rodrigues

    Frontiers in neuroscience

    2021  Volume 15, Page(s) 726983

    Abstract: This corrects the article DOI: 10.3389/fnins.2020.579984.]. ...

    Abstract [This corrects the article DOI: 10.3389/fnins.2020.579984.].
    Language English
    Publishing date 2021-09-23
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2021.726983
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