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Article ; Online: Unprecedented dengue outbreak in Taiwan following COVID-19.

Chiu, Nan-Chang / Chi, Hsin / Weng, Shun-Long / Lin, Chien-Yu

2024 Volume 31, Issue 2

MeSH term(s)	Humans ; Taiwan/epidemiology ; COVID-19/epidemiology ; Dengue/epidemiology ; Dengue Virus ; Disease Outbreaks
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	1212504-0
ISSN	1708-8305 ; 1195-1982
ISSN (online)	1708-8305
ISSN	1195-1982
DOI	10.1093/jtm/taae015
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Zs.A 4120: Show issues

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Article ; Online: Prevention of Group B streptococcus infection.

Chiu, Nan-Chang

Pediatrics and neonatology

2019 Volume 60, Issue 3, Page(s) 233–234

MeSH term(s)	Female ; Humans ; Infant, Newborn ; Pregnancy ; Premature Birth ; Streptococcal Infections ; Streptococcus agalactiae ; Taiwan
Language	English
Publishing date	2019-05-04
Publishing country	Singapore
Document type	Editorial ; Comment
ZDB-ID	2441816-X
ISSN	2212-1692 ; 1875-9572
ISSN (online)	2212-1692
ISSN	1875-9572
DOI	10.1016/j.pedneo.2019.04.008
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Zs.B 1083: Show issues

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Article ; Online: Typical time courses and appearance of skin reactions at the site of Bacillus Calmette-Guérin vaccination for infants inoculated at 5-8 months of age.

Huang, Ching-Ying / Chi, Hsin / Chang, Lung / Chiu, Nan-Chang

Vaccine

2023 Volume 41, Issue 8, Page(s) 1529–1535

Abstract: ... of skin changes at the injection site and in the corresponding lymph nodes are unknown for infants ... change, with most occurring at week 6 (34.1 %), and 9.5 % and 4.1 % of the infants still had ulceration ...

Abstract	Background: Taiwan increased the Bacillus Calmette-Guerin (BCG) vaccination age from 24 h after birth to 5-8 months of age to lower BCG-related osteitis/osteomyelitis in 2016. However, the sequences of skin changes at the injection site and in the corresponding lymph nodes are unknown for infants vaccinated at an older age. Methods: We prospectively collected the photographs of skin reactions within 6 months after vaccination. The type, size, onset time, and duration of the skin reactions were recorded and analyzed. Results: We enrolled 532 infants. The types and median times at onset of skin reactions were as follows: erythema at week 1, induration at week 3, ecchymosis at week 4, and ulceration at week 6. The peak skin responses were at week 6, with average sizes of 8.4 mm, 7.4 mm, and 8.2 mm for erythema, induration, and ecchymosis, respectively. The duration of induration was long, with 57.6 % and 23 % of the infants still having a response at week 12 and 24, respectively. The rate of induration size ≥ 20 mm was 1.7 % (95 % confidence interval: 0.8 %-3.2 %). Overall, 46.4 % of the infants experienced ulcerative change, with most occurring at week 6 (34.1 %), and 9.5 % and 4.1 % of the infants still had ulceration at week 12 and 16, respectively. Twelve infants (2.3 %) had spontaneous resolution of regional lymphadenitis, with the onset time ranging from week 1 to 12. All infants had developed a scar at the end of follow-up. Conclusion: Our study demonstrates the typical appearance and time courses of skin reactions in infants who received the BCG vaccination at older than 5 months of age. Infants vaccinated at this age may have a more potent skin response with longer induration and ulceration than those vaccinated at birth.
MeSH term(s)	Infant, Newborn ; Humans ; Infant ; Child, Preschool ; BCG Vaccine/adverse effects ; Ecchymosis ; Mycobacterium bovis ; Erythema/chemically induced ; Vaccination/adverse effects
Chemical Substances	BCG Vaccine
Language	English
Publishing date	2023-01-31
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.01.051
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Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

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Article ; Online: Reply to Ujiie.

Chiu, Nan-Chang / Huang, Wei

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2020 Volume 73, Issue 7, Page(s) e1786–e1787

Language	English
Publishing date	2020-10-28
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciaa1641
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 480: Show issues

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Article: Jaundice-predominant manifestation of Kawasaki disease in children.

Huang, Ya-Ning / Lin, Chien-Yu / Chi, Hsin / Chiu, Nan-Chang / Huang, Daniel Tsung-Ning / Chang, Lung / Kung, Yen-Hsin / Huang, Ching-Ying

Frontiers in pediatrics

2024 Volume 11, Page(s) 1281909

Abstract: Background: A jaundice-predominant presentation of Kawasaki disease (KD) is atypical.: Methods: A total of 12 children with KD with a predominant manifestation of jaundice at MacKay Children's Hospital were reviewed, along with 42 cases reported in ... ...

Abstract	Background: A jaundice-predominant presentation of Kawasaki disease (KD) is atypical. Methods: A total of 12 children with KD with a predominant manifestation of jaundice at MacKay Children's Hospital were reviewed, along with 42 cases reported in the literature since 1990. Results: The median age of the 12 patients was 1.85 years (range: 3 months-4 years), and 66.6% were male. All of the patients had elevated liver function at presentation, 50% had hydrops of the gallbladder, and almost 60% had gastrointestinal symptoms and signs. Complete KD was evident in 11 of the 12 patients (91.7%), and two patients (16.7%) had recurrent episodes. All of the patients received intravenous immunoglobulin (IVIG); however, one-third were refractory to treatment. Corticosteroids were used in five (41.7%) of the patients. Three (25%) of the patients had shock, and seven (58.3%) had coronary artery abnormalities, of whom one (8.3%) had persistent coronary artery aneurysm and the others recovered. A review of the 42 cases in the literature showed that the children with a jaundice-predominant presentation of KD had high rates of IVIG-refractory disease (25%), coronary artery abnormalities (25%), shock (13.2%), and corticosteroid treatment (24.2%). Conclusions: Children with KD presenting with a jaundice-predominant manifestation are at a higher risk of IVIG-refractory disease, coronary artery abnormalities, and more recurrent episodes. Physicians should be aware of the risk of shock in this population.
Language	English
Publishing date	2024-01-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1281909
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effectiveness of an Inactivated SARS-CoV-2 Vaccine.

Chi, Hsin / Chiu, Nan-Chang / Lin, Chien-Yu

The New England journal of medicine

2021 Volume 385, Issue 14, Page(s) 1337–1338

MeSH term(s)	COVID-19 ; COVID-19 Vaccines ; Humans ; SARS-CoV-2 ; Vaccines, Inactivated ; Viral Vaccines
Chemical Substances	COVID-19 Vaccines ; Vaccines, Inactivated ; Viral Vaccines
Language	English
Publishing date	2021-09-15
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2112423
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Ua VI Zs.34: Show issues

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Article ; Online: Letter to the Editor Regarding "Stroke After Minor Head Trauma in Infants and Young Children With Basal Ganglia Calcification: A Lenticulostriate Vasculopathy?"

Chang, Chaw-Liang / Chiu, Nan-Chang

Journal of child neurology

2018 Volume 33, Issue 8, Page(s) 554–555

MeSH term(s)	Basal Ganglia ; Basal Ganglia Cerebrovascular Disease ; Calcinosis ; Child ; Child, Preschool ; Craniocerebral Trauma ; Humans ; Infant ; Stroke
Language	English
Publishing date	2018-05-01
Publishing country	United States
Document type	Letter
ZDB-ID	639288-x
ISSN	1708-8283 ; 0883-0738
ISSN (online)	1708-8283
ISSN	0883-0738
DOI	10.1177/0883073818772646
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Zs.A 2301: Show issues

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Article: Psychiatric disorders in term-born children with marginally low birth weight: a population-based study.

Wu, Shu-I / Huang, Yu-Hsin / Kao, Kai-Liang / Lin, Yu-Wen / Tsai, Po-Li / Chiu, Nan-Chang / Chung, Ching-Hu / Chen, Chie-Pein

Child and adolescent psychiatry and mental health

2024 Volume 18, Issue 1, Page(s) 23

Abstract: Background: Marginally low birth weight (MLBW) is defined as a birth weight of 2000 ~ 2499 g. Inconsistent findings have been reported on whether children with low birth weight had higher rates of neurological, attention, or cognitive symptoms. No ... ...

Abstract	Background: Marginally low birth weight (MLBW) is defined as a birth weight of 2000 ~ 2499 g. Inconsistent findings have been reported on whether children with low birth weight had higher rates of neurological, attention, or cognitive symptoms. No studies have explored the occurrence of clinically diagnosed psychiatric disorders in term- born MLBW infants. We aimed to investigate the risk of subsequent psychiatric disorders in term-born children with MLBW. Methods: This is a nationwide retrospective cohort study, by analysing the data from Taiwan's National Health Insurance Research Database from 2008 to 2018. The study population includes propensity-score-matched term-born infants with MLBW and those without MLBW (birth weight ≥ 2500 g). Cox proportional hazard analysis was used after adjustment for potential demographic and perinatal comorbidity confounders. Incidence rates and hazard ratios (HR) of 11 psychiatric clinical diagnoses were evaluated. Results: A total of 53,276 term-born MLBW infants and 1,323,930 term-born infants without MLBW were included in the study. After propensity score matching for demographic variables and perinatal comorbidities, we determined that the term-born MLBW infants (n = 50,060) were more likely to have attention deficit and hyperactivity disorder (HR = 1.26, 95% confidence interval (CI) [1.20, 1.33]), autism spectrum disorder (HR = 1.26, 95% CI [1.14, 1.40]), conduct disorder (HR = 1.25, 95% CI [1.03, 1.51]), emotional disturbance (HR: = 1.13, 95% CI [1.02, 1.26]), or specific developmental delays (HR = 1.38, 95% CI [1.33, 1.43]) than term-born infants without MLBW (n = 50,060). Conclusion: MLBW was significantly associated with the risk of subsequent psychiatric disorder development among term-born infants. The study findings demonstrate that further attention to mental health and neurodevelopment issues may be necessary in term-born children with MLBW. However, possibilities of misclassification in exposures or outcomes, and risks of residual and unmeasured confounding should be concerned when interpreting our data.
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2379599-2
ISSN	1753-2000
ISSN	1753-2000
DOI	10.1186/s13034-024-00714-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Risk of infection in neonates born in accidental out-of-hospital deliveries.

Chang, Chia-Jung / Chi, Hsin / Jim, Wai-Tim / Chiu, Nan-Chang / Chang, Lung

PloS one

2022 Volume 17, Issue 2, Page(s) e0263825

Abstract: Accidental out-of-hospital deliveries (OHDs) are known to have a higher incidence of maternal and neonatal complications. However, neonatal infection related to OHDs has not been studied. The aim of this study was to determine the infection risk of OHDs. ...

Abstract	Accidental out-of-hospital deliveries (OHDs) are known to have a higher incidence of maternal and neonatal complications. However, neonatal infection related to OHDs has not been studied. The aim of this study was to determine the infection risk of OHDs. This retrospective cohort study enrolled neonates admitted at a children's hospital in an urban setting from January 2004 to December 2017. Accidental OHDs were compared with in-hospital births, and neonatal infection was assessed. This study also investigated both maternal and neonatal risk factors associated with OHDs. A cohort of 158 OHD neonates was enrolled, of whom 29 (23.2%) were preterm. Prematurity and low birth weight were significantly associated with OHD. Eight neonates in the OHD cohort had a documented infection within the first 72 hours of life, which was 11-fold higher than infections documented for the in-hospital births. Multivariate analysis identified low birth weight as the only factor independently associated with increased risk of infection in OHD neonates. Several specific characteristics of mothers with OHDs were identified. Forty-nine (31%) OHD mothers lacked antenatal care, and 10 (6.3%) were unaware of their pregnancies. The OHD group comprised of more teenage mothers compared to the in-hospital deliveries category. Neonatal infection was more prevalent among OHDs than for in-hospital deliveries, and the infection rate was associated with low birth weight. Hospitalization for further care and observation is suggested for the OHD neonates. Social support should be provided for populations with an increased risk of OHD, such as teenage mothers.
MeSH term(s)	Adolescent ; Adult ; Communicable Diseases/epidemiology ; Delivery, Obstetric/adverse effects ; Delivery, Obstetric/statistics & numerical data ; Female ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Newborn, Diseases/epidemiology ; Infant, Premature ; Infant, Premature, Diseases/epidemiology ; Male ; Maternal Age ; Multivariate Analysis ; Prevalence ; Retrospective Studies ; Young Adult
Language	English
Publishing date	2022-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0263825
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Risk of infection in neonates born in accidental out-of-hospital deliveries.

Chia-Jung Chang / Hsin Chi / Wai-Tim Jim / Nan-Chang Chiu / Lung Chang

PLoS ONE, Vol 17, Iss 2, p e

2022 Volume 0263825

Abstract	Accidental out-of-hospital deliveries (OHDs) are known to have a higher incidence of maternal and neonatal complications. However, neonatal infection related to OHDs has not been studied. The aim of this study was to determine the infection risk of OHDs. This retrospective cohort study enrolled neonates admitted at a children's hospital in an urban setting from January 2004 to December 2017. Accidental OHDs were compared with in-hospital births, and neonatal infection was assessed. This study also investigated both maternal and neonatal risk factors associated with OHDs. A cohort of 158 OHD neonates was enrolled, of whom 29 (23.2%) were preterm. Prematurity and low birth weight were significantly associated with OHD. Eight neonates in the OHD cohort had a documented infection within the first 72 hours of life, which was 11-fold higher than infections documented for the in-hospital births. Multivariate analysis identified low birth weight as the only factor independently associated with increased risk of infection in OHD neonates. Several specific characteristics of mothers with OHDs were identified. Forty-nine (31%) OHD mothers lacked antenatal care, and 10 (6.3%) were unaware of their pregnancies. The OHD group comprised of more teenage mothers compared to the in-hospital deliveries category. Neonatal infection was more prevalent among OHDs than for in-hospital deliveries, and the infection rate was associated with low birth weight. Hospitalization for further care and observation is suggested for the OHD neonates. Social support should be provided for populations with an increased risk of OHD, such as teenage mothers.
Keywords	Medicine ; R ; Science ; Q
Subject code	360
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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