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  1. Article ; Online: Effect of surgery-induced weight loss on immune function.

    Moulin, Cristiane Martins / Rizzo, Luiz Vicente / Halpern, Alfredo

    Expert review of gastroenterology & hepatology

    2008  Volume 2, Issue 5, Page(s) 617–619

    MeSH term(s) Bariatric Surgery ; Humans ; Immune System/physiology ; Killer Cells, Natural/physiology ; Neoplasms/prevention & control ; Obesity/immunology ; Obesity/surgery ; Weight Loss/physiology
    Language English
    Publishing date 2008-10
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2481021-6
    ISSN 1747-4132 ; 1747-4124
    ISSN (online) 1747-4132
    ISSN 1747-4124
    DOI 10.1586/17474124.2.5.617
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6978: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Bariatric surgery reverses natural killer (NK) cell activity and NK-related cytokine synthesis impairment induced by morbid obesity.

    Moulin, Cristiane Martins / Marguti, Ivo / Peron, Jean Pierre Schatzmann / Halpern, Alfredo / Rizzo, Luiz Vicente

    Obesity surgery

    2010  Volume 21, Issue 1, Page(s) 112–118

    Abstract: Background: Obesity is related to a higher rate of infections and some types of cancer. Here we analyzed the impact of obesity and weight loss induced by Roux-en-Y gastric bypass (RYGB) on immunological parameters, i.e., cytokine productions and natural ...

    Abstract Background: Obesity is related to a higher rate of infections and some types of cancer. Here we analyzed the impact of obesity and weight loss induced by Roux-en-Y gastric bypass (RYGB) on immunological parameters, i.e., cytokine productions and natural killer cell function.
    Methods: We analyzed 28 morbidly obese patients before and 6 months after RYGB. Biochemical parameters were analyzed in plasma. The percent of natural killer (NK) cells, their cytotoxicity, and the production of cytokines by peripheral blood mononuclear cells were analyzed. The percent of NK cells was determined by flow cytometry and cytokine production determined by enzyme-linked immunosorbent assay. NK cytotoxicity was determined by the lactate dehydrogenase release assay.
    Results: The weight loss 6 months following surgery was 35.3 ± 4.5 kg. RYGB also improves biochemical parameters. No significant difference was found in the percent of NK cells after surgery. We found an increase in the production of interferon-γ, interleukin (IL)-12 and IL-18, but not in IL-2, 6 months after RYGB. Cytotoxic activity of NK cells was significantly enhanced 6 months after RYGB [17.1 ± 14.7% before RYGB vs 51.8 ± 11.3% at 6 months after, at 40:1 effector to target cell ratio; p < 0.001]. We observed significant post-surgical improvement in the cytotoxic activity curve in 22 out of 28 patients (78.6%), irrespective of the target to effector cell ratio.
    Conclusions: The weight loss induced by RYGB modifies the production of cytokines related with NK cell function and improves its activity.
    MeSH term(s) Adult ; Cytokines/biosynthesis ; Cytokines/immunology ; Female ; Gastric Bypass ; Humans ; Killer Cells, Natural/immunology ; Male ; Middle Aged ; Obesity, Morbid/immunology ; Obesity, Morbid/surgery ; Weight Loss/immunology
    Chemical Substances Cytokines
    Language English
    Publishing date 2010-08-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-010-0250-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3381: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Impact of adiposity on immunological parameters.

    Moulin, Cristiane Martins / Marguti, Ivo / Peron, Jean Pierre S / Rizzo, Luiz Vicente / Halpern, Alfredo

    Arquivos brasileiros de endocrinologia e metabologia

    2009  Volume 53, Issue 2, Page(s) 183–189

    Abstract: Studies evaluating immune function in obese humans and experimental animals indicate that the excess adiposity is associated with impaired in immune responses. Obesity is related to a higher rate of infections and to some types of cancer. Nutritional, ... ...

    Abstract Studies evaluating immune function in obese humans and experimental animals indicate that the excess adiposity is associated with impaired in immune responses. Obesity is related to a higher rate of infections and to some types of cancer. Nutritional, metabolic and endocrine factors are implicated in the immunological changes. The adipose tissue directly produces substances with various functions related to immune system. Furthermore, some investigations suggest that certain types of weight reduction strategies can alter the immune function. Nevertheless, long-term studies should be carried out to address whether these changes positively affects the ability of these obese individuals to control infections and tumor development.
    MeSH term(s) Adipose Tissue/immunology ; Animals ; Bariatric Surgery ; Body Composition/immunology ; Humans ; Immune System/physiology ; Obesity/immunology ; Obesity/surgery ; Weight Loss/physiology
    Language English
    Publishing date 2009-04-15
    Publishing country Brazil
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 603919-4
    ISSN 1677-9487 ; 0004-2730
    ISSN (online) 1677-9487
    ISSN 0004-2730
    DOI 10.1590/s0004-27302009000200010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 264: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Impact of adiposity on immunological parameters Impacto da adiposidade nos parâmetros imunológicos

    Cristiane Martins Moulin / Ivo Marguti / Jean Pierre S. Peron / Luiz Vicente Rizzo / Alfredo Halpern

    Arquivos brasileiros de Endocrinologia e Metabologia, Vol 53, Iss 2, Pp 183-

    2009  Volume 189

    Abstract: Studies evaluating immune function in obese humans and experimental animals indicate that the excess adiposity is associated with impaired in immune responses. Obesity is related to a higher rate of infections and to some types of cancer. Nutritional, ... ...

    Abstract Studies evaluating immune function in obese humans and experimental animals indicate that the excess adiposity is associated with impaired in immune responses. Obesity is related to a higher rate of infections and to some types of cancer. Nutritional, metabolic and endocrine factors are implicated in the immunological changes. The adipose tissue directly produces substances with various functions related to immune system. Furthermore, some investigations suggest that certain types of weight reduction strategies can alter the immune function. Nevertheless, long-term studies should be carried out to address whether these changes positively affects the ability of these obese individuals to control infections and tumor development. Estudos acerca da função imunológica em animais experimentais e humanos obesos indicam que o excesso de adiposidade associa-se ao prejuízo da resposta imune. A obesidade está relacionada a uma taxa maior de infecções e a alguns tipos de câncer. Fatores nutricionais, metabólicos e endócrinos estão implicados nessas alterações imunológicas. O próprio tecido adiposo produz diretamente substâncias com várias funções relacionadas ao sistema imune. Além disso, algumas investigações sugerem que certas estratégias para perda de peso podem alterar a função imune. Entretanto, estudos em longo prazo são necessários para avaliar se tais alterações afetam positivamente a capacidade desses pacientes obesos de controlar infecções e desenvolver tumores.
    Keywords Obesidade ; tecido adiposo ; imunidade ; perda de peso ; Obesity ; adipose tissue ; immunity ; weight loss ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language Portuguese
    Publishing date 2009-03-01T00:00:00Z
    Publisher Sociedade Brasileira de Endocrinologia e Metabologia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Physicochemical composition, lipid oxidation, and microbiological quality of ram mortadella supplemented with

    do Santos Junior, Alexandre Cristiano / de Oliveira, Rodrigo Fortunato / Henry, Fabio da Costa / Maia Junior, Jonhny de Azevedo / Moulin, Monique Moreira / Della Lucia, Suzana Maria / Quirino, Célia Raquel / Martins, Meire Lelis Leal / Rampe, Maria Cecília Cabral

    Food science & nutrition

    2020  Volume 8, Issue 11, Page(s) 5953–5961

    Abstract: This study evaluated the physicochemical, lipid peroxidation, and microbiological quality of mortadellas prepared with ram and supplemented with different amounts ... ...

    Abstract This study evaluated the physicochemical, lipid peroxidation, and microbiological quality of mortadellas prepared with ram and supplemented with different amounts of
    Language English
    Publishing date 2020-09-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703010-6
    ISSN 2048-7177
    ISSN 2048-7177
    DOI 10.1002/fsn3.1880
    Database MEDical Literature Analysis and Retrieval System OnLINE

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