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Article ; Online: Sedation Practices for Lumbar Punctures in Patients With Acute Lymphoblastic Leukemia: A Multicenter Retrospective Study Using Pediatric Health Information Systems.

Wright, Mariah L / O'Brien, Sarah H / Schloss, Brian / Stanek, Joseph R / Reed, Suzanne

Journal of pediatric hematology/oncology

2022 Volume 44, Issue 7, Page(s) e982–e987

Abstract: Background: Sedation is often used to reduce pain and anxiety in pediatric patients with acute lymphoblastic leukemia (ALL) undergoing lumbar punctures (LPs). There is a potential for long-term effects on neurocognition with repeat sedative exposures in ...

Abstract	Background: Sedation is often used to reduce pain and anxiety in pediatric patients with acute lymphoblastic leukemia (ALL) undergoing lumbar punctures (LPs). There is a potential for long-term effects on neurocognition with repeat sedative exposures in young children. The purpose of this study is to determine the practice habits regarding sedation for LPs in pediatric patients with ALL among multiple institutions. Methods: This is a retrospective study of 48 hospitals in the Pediatric Health Information Systems (PHIS) between October 2015 and December 2019. Children 1 to 18 years old with ALL who received intrathecal chemotherapy in an outpatient setting were included. We analyzed the prevalence of anesthesia usage and the types of anesthetics used. Results: Of the 16,785 encounters with documented use of anesthetic medications, intravenous and inhaled anesthetics were used in 16,486 (98.2%) and local anesthetics alone in 299 (1.8%). The most commonly used medications used for sedation were propofol (n=13,279; 79.1%), midazolam (n=4228; 25.2%), inhaled fluranes (n=3169; 18.9%), and ketamine (n=2100; 12.5%). Conclusion: The majority of children's hospitals in the United States use intravenous and inhaled anesthetics for routine therapeutic LPs in pediatric patients with ALL. Propofol is one of the most common medications used for sedation.
MeSH term(s)	Acute Disease ; Adolescent ; Anesthesia ; Anesthetics, Local/therapeutic use ; Child ; Child, Preschool ; Conscious Sedation ; Health Information Systems ; Humans ; Hypnotics and Sedatives/therapeutic use ; Infant ; Ketamine ; Lipopolysaccharides/therapeutic use ; Midazolam ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Propofol ; Retrospective Studies ; Spinal Puncture
Chemical Substances	Anesthetics, Local ; Hypnotics and Sedatives ; Lipopolysaccharides ; Ketamine (690G0D6V8H) ; Midazolam (R60L0SM5BC) ; Propofol (YI7VU623SF)
Language	English
Publishing date	2022-03-16
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	1231152-2
ISSN	1536-3678 ; 1077-4114 ; 0192-8562
ISSN (online)	1536-3678
ISSN	1077-4114 ; 0192-8562
DOI	10.1097/MPH.0000000000002446
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Zs.A 1537: Show issues

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Article ; Online: Pulmonary Hemorrhage During Computed Tomography-Guided Percutaneous Lung Biopsy: A Case Report and Review of the Literature.

Staker, Kathryn / Schloss, Brian / Tobias, Joseph D

AANA journal

2019 Volume 85, Issue 3, Page(s) 166–170

Abstract: Percutaneous lung biopsy represents a minimally invasive method of obtaining lung tissue to aid in the diagnosis of various pulmonary diseases. Although the technique has major advantages, including being less invasive and having a more rapid recovery ... ...

Abstract	Percutaneous lung biopsy represents a minimally invasive method of obtaining lung tissue to aid in the diagnosis of various pulmonary diseases. Although the technique has major advantages, including being less invasive and having a more rapid recovery than open thoracotomy, complications such as bleeding may occur. To date, there is limited information regarding the complications and their treatment associated with this procedure. We describe a 22-year-old man with chronic granulomatous disease who experienced a pulmonary hemorrhage after percutaneous lung biopsy using computed tomography guidance while he was under general endotracheal anesthesia. Potential treatment algorithms and strategies are presented.
Language	English
Publishing date	2019-09-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	603605-3
ISSN	2162-5239 ; 0094-6354
ISSN (online)	2162-5239
ISSN	0094-6354
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Zs.A 1286: Show issues

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Article ; Online: Context Matters: A Theory of Semantic Discriminability for Perceptual Encoding Systems.

Mukherjee, Kushin / Yin, Brian / Sherman, Brianne E / Lessard, Laurent / Schloss, Karen B

IEEE transactions on visualization and computer graphics

2021 Volume 28, Issue 1, Page(s) 697–706

Abstract: People's associations between colors and concepts influence their ability to interpret the meanings of colors in information visualizations. Previous work has suggested such effects are limited to concepts that have strong, specific associations with ... ...

Abstract	People's associations between colors and concepts influence their ability to interpret the meanings of colors in information visualizations. Previous work has suggested such effects are limited to concepts that have strong, specific associations with colors. However, although a concept may not be strongly associated with any colors, its mapping can be disambiguated in the context of other concepts in an encoding system. We articulate this view in semantic discriminability theory, a general framework for understanding conditions determining when people can infer meaning from perceptual features. Semantic discriminability is the degree to which observers can infer a unique mapping between visual features and concepts. Semantic discriminability theory posits that the capacity for semantic discriminability for a set of concepts is constrained by the difference between the feature-concept association distributions across the concepts in the set. We define formal properties of this theory and test its implications in two experiments. The results show that the capacity to produce semantically discriminable colors for sets of concepts was indeed constrained by the statistical distance between color-concept association distributions (Experiment 1). Moreover, people could interpret meanings of colors in bar graphs insofar as the colors were semantically discriminable, even for concepts previously considered "non-colorable" (Experiment 2). The results suggest that colors are more robust for visual communication than previously thought.
Language	English
Publishing date	2021-12-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1941-0506
ISSN (online)	1941-0506
DOI	10.1109/TVCG.2021.3114780
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Article ; Online: Cardiac output assessment in children: playing catch-up.

Schloss, Brian / Tobias, Joseph D

Paediatric anaesthesia

2015 Volume 25, Issue 2, Page(s) 113–114

MeSH term(s)	Cardiac Output/physiology ; Cardiac Surgical Procedures ; Female ; Heart Defects, Congenital/surgery ; Humans ; Male ; Monitoring, Intraoperative/instrumentation ; Monitoring, Intraoperative/methods ; Stroke Volume/physiology
Language	English
Publishing date	2015-02
Publishing country	France
Document type	Comment ; Editorial
ZDB-ID	1086049-6
ISSN	1460-9592 ; 1155-5645
ISSN (online)	1460-9592
ISSN	1155-5645
DOI	10.1111/pan.12567
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Zs.A 3306: Show issues

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Article: Hemodynamic and Respiratory Effects of Regadenoson During Radiologic Imaging in Infants and Children.

Schloss, Brian / Bekiroglu, Ismail / O'Connor, Colin / Lee, Simon / Rice, Julie / Kim, Stephani S / Tobias, Joseph D

Cardiology research

2021 Volume 12, Issue 6, Page(s) 329–334

Abstract: Background: Myocardial perfusion imaging using radionuclides is a well-validated, noninvasive method to aid in the diagnosis of patients with suspected or known myocardial ischemia. To increase the sensitivity of the technique, pharmacologic agents ... ...

Abstract	Background: Myocardial perfusion imaging using radionuclides is a well-validated, noninvasive method to aid in the diagnosis of patients with suspected or known myocardial ischemia. To increase the sensitivity of the technique, pharmacologic agents which induce coronary vasodilatation are administered. Regadenoson is a novel selective A2A receptor agonist that has similar efficacy to adenosine for cardiac magnetic resonance imaging (MRI) with a more favorable adverse effect profile and is the most widely used pharmacologic stress agent. While widely used in adults, there is limited experience with it in pediatrics, particularly young children. Methods: The current study retrospectively reviews our experience with stress cardiac MRI using regadenoson in children requiring general anesthesia. The study cohort included eight patients, all male, ranging in age from 2 to 6.2 years (mean age of 4.2 years) and in weight from 10 to 30.5 kg (mean weight of 18.5 kg). All patients received general anesthesia with endotracheal intubation and a volatile anesthetic agent. Results: Heart rate 1 min prior to regadenoson was 99 ± 19.2 (mean ± standard deviation (SD)) beats per minute. Peak heart rate was achieved at an average of 4 min post regadenoson administration with a mean heart rate of 122 ± 15 beats per minute. The average of the mean arterial pressure 1 min prior to regadenoson was 53.4 ± 5.2 mm Hg. Mean arterial pressure nadir was noted at 6 min post regadenoson with a value of 44.1 ± 6.3 mm Hg. Blood pressure support with phenylephrine was required in four of the eight (50%) of patients. No adverse respiratory events were noted. Only one of the eight (13%) patients had a perfusion defect but had preserved ventricular function and recovered without incident. Conclusions: Use of regadenoson in pediatric patients requiring general anesthesia is safe and feasible.
Language	English
Publishing date	2021-12-08
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2598593-0
ISSN	1923-2837 ; 1923-2829
ISSN (online)	1923-2837
ISSN	1923-2829
DOI	10.14740/cr1323
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Article ; Online: Small decreases in biventricular pacing percentages are associated with multiple metrics of worsening heart failure as measured from a cardiac resynchronization therapy defibrillator.

Cao, Michael / Stolen, Craig M / Ahmed, Rezwan / Schloss, Edward J / Lobban, John H / Kwan, Brian / Varma, Niraj / Boehmer, John P

International journal of cardiology

2021 Volume 335, Page(s) 73–79

Abstract: Background: Lower BiVentricular (BiV) pacing percentages have been associated with significantly worse survival in patients with chronic heart failure (HF). However, the pathophysiology behind this observation has not been further delineated. This ... ...

Abstract	Background: Lower BiVentricular (BiV) pacing percentages have been associated with significantly worse survival in patients with chronic heart failure (HF). However, the pathophysiology behind this observation has not been further delineated. This analysis evaluated whether small incremental decreases in BiV pacing percentages were associated with worse measures, related to HF physiology using individual sensor trends and the HeartLogic composite index. Methods: Sensor data was obtained from 900 ambulatory HF patients with implanted CRT devices. The percent of cardiac cycles with BiV pacing was assessed for periods (median = 7.3 days) between data downloads (median = 55 periods/patient). Results: The third heart sound (S3), respiration rate, RSBI, and night-time heart rate were significantly elevated with sub-optimal pacing (<98%), while the first heart sound (S1), thoracic impedance, and activity were significantly lower. All sensor changes were in the direction associated with worsening HF. While IN the HeartLogic alert state (threshold above an Index of 16) the odds of optimal BiV pacing (≥98%) were less than when OUT of the HeartLogic alert state for a given subject (OR: 0.655; 95% CI: 0.626-0.686; p < 0.0001). The percent BiV pacing was reduced and the HeartLogic Index was increased in the periods surrounding HFhospitalizations. Conclusion: Lower BiV pacing percent is associated with multiple sensor changes indicative of worsening HF, and patients in HeartLogic alert are more likely to have suboptimal BiV pacing. Collectively, these data provide strong evidence that even small decreases in BiV percent pacing can lead to worsening HF.
MeSH term(s)	Benchmarking ; Cardiac Pacing, Artificial ; Cardiac Resynchronization Therapy ; Defibrillators ; Heart Failure/diagnosis ; Heart Failure/therapy ; Heart Rate ; Humans ; Treatment Outcome
Language	English
Publishing date	2021-04-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2021.03.073
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Zs.A 1673: Show issues

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Book ; Online: Context Matters

Mukherjee, Kushin / Yin, Brian / Sherman, Brianne E. / Lessard, Laurent / Schloss, Karen B.

A Theory of Semantic Discriminability for Perceptual Encoding Systems

2021

Abstract	People's associations between colors and concepts influence their ability to interpret the meanings of colors in information visualizations. Previous work has suggested such effects are limited to concepts that have strong, specific associations with colors. However, although a concept may not be strongly associated with any colors, its mapping can be disambiguated in the context of other concepts in an encoding system. We articulate this view in semantic discriminability theory, a general framework for understanding conditions determining when people can infer meaning from perceptual features. Semantic discriminability is the degree to which observers can infer a unique mapping between visual features and concepts. Semantic discriminability theory posits that the capacity for semantic discriminability for a set of concepts is constrained by the difference between the feature-concept association distributions across the concepts in the set. We define formal properties of this theory and test its implications in two experiments. The results show that the capacity to produce semantically discriminable colors for sets of concepts was indeed constrained by the statistical distance between color-concept association distributions (Experiment 1). Moreover, people could interpret meanings of colors in bar graphs insofar as the colors were semantically discriminable, even for concepts previously considered "non-colorable" (Experiment 2). The results suggest that colors are more robust for visual communication than previously thought. Comment: To Appear in IEEE Transactions on Visualization and Computer Graphics
Keywords	Computer Science - Human-Computer Interaction
Subject code	401
Publishing date	2021-08-08
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Pulse Pressure Analysis to Guide Intraoperative Phlebotomy Prior to Cardiac Surgery.

Schloss, Brian / Tumin, Dmitry / Naguib, Aymen / Rice, Julie / Galantowicz, Mark / Tobias, Joseph D

Cardiology research

2017 Volume 8, Issue 6, Page(s) 276–279

Abstract: Background: The aim of this study was to evaluate the response of the LiDCO-rapid™ during intraoperative phlebotomy in anesthetized children prior to surgery for congenital heart disease.: Methods: After the induction of general anesthesia and ... ...

Abstract	Background: The aim of this study was to evaluate the response of the LiDCO-rapid™ during intraoperative phlebotomy in anesthetized children prior to surgery for congenital heart disease. Methods: After the induction of general anesthesia and endotracheal intubation, baseline vital signs were recorded, along with pulse pressure variability (PPV) and stroke volume variability (SVV) from the LiDCO-rapid™ and cerebral oxygenation (rSO Results: The study cohort included 30 patients (mean age of 21 ± 11 years). Statistically significant changes during the study period were observed in rSO Conclusion: Baseline values as well as changes in the PVV and SVV from the LiDCO-rapid™ did not predict or correlate with changes in cerebral oxygenation measured by NIRS during intraoperative phlebotomy. Our preliminary data suggest that these parameters (PVV and SVV) are not useful in monitoring patient stability or the need for volume replacement during intraoperative phlebotomy prior to cardiac surgery.
Keywords	covid19
Language	English
Publishing date	2017-12-22
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2598593-0
ISSN	1923-2837 ; 1923-2829
ISSN (online)	1923-2837
ISSN	1923-2829
DOI	10.14740/cr634w
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Article ; Online: Bone marrow adipocytes fuel emergency hematopoiesis after myocardial infarction.

Zhang, Shuang / Paccalet, Alexandre / Rohde, David / Cremer, Sebastian / Hulsmans, Maarten / Lee, I-Hsiu / Mentkowski, Kyle / Grune, Jana / Schloss, Maximilian J / Honold, Lisa / Iwamoto, Yoshiko / Zheng, Yi / Bredella, Miriam A / Buckless, Colleen / Ghoshhajra, Brian / Thondapu, Vikas / van der Laan, Anja M / Piek, Jan J / Niessen, Hans W M /

Pallante, Fabio / Carnevale, Raimondo / Perrotta, Sara / Carnevale, Daniela / Iborra-Egea, Oriol / Muñoz-Guijosa, Christian / Galvez-Monton, Carolina / Bayes-Genis, Antoni / Vidoudez, Charles / Trauger, Sunia A / Scadden, David / Swirski, Filip K / Moskowitz, Michael A / Naxerova, Kamila / Nahrendorf, Matthias

Nature cardiovascular research

2023 Volume 2, Issue 12, Page(s) 1277–1290

Abstract: After myocardial infarction (MI), emergency hematopoiesis produces inflammatory myeloid cells that accelerate atherosclerosis and promote heart failure. Since the balance between glycolysis and mitochondrial metabolism regulates hematopoietic stem cell ... ...

Abstract	After myocardial infarction (MI), emergency hematopoiesis produces inflammatory myeloid cells that accelerate atherosclerosis and promote heart failure. Since the balance between glycolysis and mitochondrial metabolism regulates hematopoietic stem cell homeostasis, metabolic cues may influence emergency myelopoiesis. Here, we show in humans and female mice that hematopoietic progenitor cells increase fatty acid metabolism after MI. Blockade of fatty acid oxidation by deleting carnitine palmitoyltransferase (
Language	English
Publishing date	2023-12-05
Publishing country	England
Document type	Journal Article
ISSN	2731-0590
ISSN (online)	2731-0590
DOI	10.1038/s44161-023-00388-7
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Article: A case report of a retained and knotted caudal catheter.

Joselyn, Anita / Bhalla, Tarun / Schloss, Brian / Martin, David / Tobias, Joseph

Saudi journal of anaesthesia

2014 Volume 8, Issue 3, Page(s) 424–427

Abstract: Caudal catheters advanced to the lumbar and thoracic regions can be used to provide excellent analgesia for pre-term neonates undergoing major abdominal and thoracic procedures. Despite their frequent use, attention to detail is mandatory to avoid ... ...

Abstract	Caudal catheters advanced to the lumbar and thoracic regions can be used to provide excellent analgesia for pre-term neonates undergoing major abdominal and thoracic procedures. Despite their frequent use, attention to detail is mandatory to avoid complications related to the medications used or the placement technique. We present a 2-day-old, 2 kg, pre-term infant who was born at 32 weeks gestational age with a tracheoesophageal fistula. Following anesthetic induction, a caudal epidural catheter was placed with the intent of threading it to the mid-thoracic level. The intraoperative and post-operative courses were uneventful with the epidural catheter providing adequate analgesia without the need for supplemental intravenous opioids. During catheter removal, resistance was noted and it could not be easily removed. With repositioning and various other maneuvers, the catheter was removed with some difficulty. On examination of the catheter, a complete knot was noted. Options for catheter advancement from the caudal space to the thoracic dermatomes are reviewed and techniques discussed for removal of a retained epidural catheter.
Language	English
Publishing date	2014-09-01
Publishing country	India
Document type	Case Reports
ZDB-ID	2562174-9
ISSN	0975-3125 ; 1658-354X
ISSN (online)	0975-3125
ISSN	1658-354X
DOI	10.4103/1658-354X.136644
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