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  1. Article ; Online: PCI for Nonculprit Lesions in Patients with STEMI - No Role for FFR.

    Jüni, Peter

    The New England journal of medicine

    2021  Volume 385, Issue 4, Page(s) 370–371

    MeSH term(s) Coronary Stenosis ; Coronary Vessels ; Fractional Flow Reserve, Myocardial ; Humans ; Percutaneous Coronary Intervention ; ST Elevation Myocardial Infarction/therapy
    Language English
    Publishing date 2021-07-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2108328
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  2. Article ; Online: School-based health care: improving academic outcomes for inner-city children-a prospective cohort quasi-experimental study.

    Rasiah, Saisujani / Jüni, Peter / Sgro, Michael D / Thorpe, Kevin E / Maguire, Jonathon / Freeman, Sloane J

    Pediatric research

    2023  Volume 94, Issue 4, Page(s) 1488–1495

    Abstract: Background: We examined whether a school-based health center model improved academic achievement compared to usual care.: Methods: This was a quasi-experimental prospective cohort study. The primary outcome was an academic achievement. In addition, ... ...

    Abstract Background: We examined whether a school-based health center model improved academic achievement compared to usual care.
    Methods: This was a quasi-experimental prospective cohort study. The primary outcome was an academic achievement. In addition, we analyzed sociodemographic characteristics and their relationship to academic achievement, and the wait time for a developmental assessment.
    Results: The differences in change of grades over time (from 2016/2017 to 2018/2019) were small for reading (-0.83, 95% CI -3.48, 1.82, p = 0.51), writing (-1.11, 95% CI -3.25, 1.03, p = 0.28), and math (0.06, 95% CI -3.08, 2.94, p = 0.98). The experimental arm's average wait time for developmental assessment was 3.4 months.
    Conclusion: In this small, quasi-experimental prospective cohort study, we did not find evidence that our SBHC model improved academic achievement; however, the wait time at the SBHCs was considerably less than the provincial wait time for a developmental assessment.
    Trial registration: NCT04540003.
    Impact: This study describes a unique and innovative school-based health center model. Our findings support the benefits of school-based health centers in diagnosing and treating children with developmental and mental health disorders for disadvantaged communities. This study did not find an improvement in academic achievement for school-based health center users. This study found that the wait time to developmental assessment was shorter for school-based health center users compared to the wait time reported in the community. Pandemic-associated school disruptions have highlighted the importance of accessible school-based health services for children requiring mental health and developmental assessments and care.
    MeSH term(s) Child ; Humans ; Prospective Studies ; Educational Status ; Academic Success ; School Health Services ; Delivery of Health Care
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-023-02473-w
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  3. Article ; Online: Biomechanical Footwear for Osteoarthritic Knee Pain-Reply.

    Reichenbach, Stephan / Felson, David T / Jüni, Peter

    JAMA

    2020  Volume 324, Issue 13, Page(s) 1351–1352

    MeSH term(s) Humans ; Knee Joint ; Pain
    Language English
    Publishing date 2020-10-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.14825
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  4. Article ; Online: Cardiovascular meta-analyses: fool's gold or gold for fools?

    Biondi-Zoccai, Giuseppe / Windecker, Stephan / Juni, Peter / Bhatt, Deepak L

    European heart journal

    2022  Volume 43, Issue 32, Page(s) 3008–3013

    MeSH term(s) Cardiovascular System ; Heart ; Humans
    Language English
    Publishing date 2022-06-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehac312
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  5. Article ; Online: Interview - Knorpelbestandteile futtern hilft nicht gegen Arthrose.

    Jüni, Peter

    Zeitschrift fur Orthopadie und Unfallchirurgie

    2010  Volume 148, Issue 6, Page(s) 622–624

    Title translation Interview - cartilage components do not help against arthritis.
    MeSH term(s) Anti-Inflammatory Agents/therapeutic use ; Cartilage, Articular/chemistry ; Chondroitin/therapeutic use ; Glucosamine/therapeutic use ; Humans ; Osteoarthritis, Hip/drug therapy ; Osteoarthritis, Knee/drug therapy ; Randomized Controlled Trials as Topic ; Treatment Outcome
    Chemical Substances Anti-Inflammatory Agents ; Chondroitin (9007-27-6) ; Glucosamine (N08U5BOQ1K)
    Language German
    Publishing date 2010-12
    Publishing country Germany
    Document type Interview
    ZDB-ID 2280747-0
    ISSN 1864-6743 ; 1438-941X ; 1864-6697 ; 0044-3220
    ISSN (online) 1864-6743 ; 1438-941X
    ISSN 1864-6697 ; 0044-3220
    DOI 10.1055/s-0030-1270267
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  6. Article ; Online: Limiting Dynamic Driving Pressure in Patients Requiring Mechanical Ventilation.

    Urner, Martin / Jüni, Peter / Rojas-Saunero, L Paloma / Hansen, Bettina / Brochard, Laurent J / Ferguson, Niall D / Fan, Eddy

    Critical care medicine

    2023  Volume 51, Issue 7, Page(s) 861–871

    Abstract: Objectives: Previous studies reported an association between higher driving pressure (∆P) and increased mortality for different groups of mechanically ventilated patients. However, it remained unclear if sustained intervention on ∆P, in addition to ... ...

    Abstract Objectives: Previous studies reported an association between higher driving pressure (∆P) and increased mortality for different groups of mechanically ventilated patients. However, it remained unclear if sustained intervention on ∆P, in addition to traditional lung-protective ventilation, improves outcomes. We investigated if ventilation strategies limiting daily static or dynamic ∆P reduce mortality compared with usual care in adult patients requiring greater than or equal to 24 hours of mechanical ventilation.
    Design: For this comparative effectiveness study, we emulated pragmatic clinical trials using data from the Toronto Intensive Care Observational Registry recorded between April 2014 and August 2021. The per-protocol effect of the interventions was estimated using the parametric g-formula, a method that controls for baseline and time-varying confounding, as well as for competing events in the analysis of longitudinal exposures.
    Setting: Nine ICUs from seven University of Toronto-affiliated hospitals.
    Patients: Adult patients (≥18 yr) requiring greater than or equal to 24 hours of mechanical ventilation.
    Interventions: Receipt of a ventilation strategy that limited either daily static or dynamic ∆P less than or equal to 15 cm H 2 O compared with usual care.
    Measurements and main results: Among the 12,865 eligible patients, 4,468 of (35%) were ventilated with dynamic ∆P greater than 15 cm H 2 O at baseline. Mortality under usual care was 20.1% (95% CI, 19.4-20.9%). Limiting daily dynamic ∆P less than or equal to 15 cm H 2 O in addition to traditional lung-protective ventilation reduced adherence-adjusted mortality to 18.1% (95% CI, 17.5-18.9%) (risk ratio, 0.90; 95% CI, 0.89-0.92). In further analyses, this effect was most pronounced for early and sustained interventions. Static ∆P at baseline were recorded in only 2,473 patients but similar effects were observed. Conversely, strict interventions on tidal volumes or peak inspiratory pressures, irrespective of ∆P, did not reduce mortality compared with usual care.
    Conclusions: Limiting either static or dynamic ∆P can further reduce the mortality of patients requiring mechanical ventilation.
    MeSH term(s) Adult ; Humans ; Respiration, Artificial/methods ; Critical Care ; Intensive Care Units ; Tidal Volume ; Registries
    Language English
    Publishing date 2023-03-27
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005844
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  7. Article ; Online: Biodegradable-polymer stents versus durable-polymer stents - Authors' reply.

    Jüni, Peter / Heg, Dik / Windecker, Stephan / Pilgrim, Thomas

    Lancet (London, England)

    2019  Volume 393, Issue 10184, Page(s) 1933

    MeSH term(s) Absorbable Implants ; Drug-Eluting Stents ; Everolimus ; Percutaneous Coronary Intervention ; Polymers ; Single-Blind Method ; Sirolimus ; Stents
    Chemical Substances Polymers ; Everolimus (9HW64Q8G6G) ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2019-05-24
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(19)30032-7
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  8. Article ; Online: The effect of sodium-glucose cotransporter-2 inhibitors on inflammatory biomarkers: A meta-analysis of randomized controlled trials.

    Buttice, Leonardo / Ghani, Maryam / Suthakar, Janahan / Gnanalingham, Sathyan / Carande, Elliott / Kennedy, Brett W C / Pitcher, Alex / Gamble, James H P / Ahmad, Mahmood / Lewis, Andrew / Jüni, Peter / Rider, Oliver J / Stephens, Jeffrey W / Bray, Jonathan J H

    Diabetes, obesity & metabolism

    2024  

    Abstract: Aims: To conduct a meta-analysis of randomized controlled trials (RCTs) to assess the effect of sodium-glucose cotransporter-2 (SGLT2) inhibitors on inflammatory biomarkers.: Methods: Medline, Embase and the Cochrane Library were searched for RCTs ... ...

    Abstract Aims: To conduct a meta-analysis of randomized controlled trials (RCTs) to assess the effect of sodium-glucose cotransporter-2 (SGLT2) inhibitors on inflammatory biomarkers.
    Methods: Medline, Embase and the Cochrane Library were searched for RCTs investigating the effect of SGLT2 inhibitors on inflammatory biomarkers, adipokine profiles and insulin sensitivity.
    Results: Thirty-eight RCTs were included (14 967 participants, 63.3% male, mean age 62 ± 8.6 years) with a median (interquartile range) follow-up of 16 (12-24) weeks. Meta-analysis showed that SGLT2 inhibitors significantly improved adiponectin, interleukin-6, tumour necrosis factor receptor-1 (vs. placebo alone: standardized mean difference [SMD] 0.34 [95% confidence interval {CI} 0.23, 0.45], mean difference [MD] -0.85 pg/mL [95% CI -1.32, -0.38], SMD -0.13 [95% CI -0.20, -0.06], respectively), leptin and homeostatic model assessment of insulin resistance index (vs.
    Control: SMD -0.20 [95% CI -0.33, -0.07], MD -0.83 [95% CI -1.32, -0.33], respectively). There were no significant changes in C-reactive protein (CRP), tumour necrosis factor-α, plasminogen activator inhibitor-1, fibroblast growth factor-21 or monocyte chemoattractant protein-1.
    Conclusions: Our analysis shows that SGLT2 inhibitors likely improve adipokine biomarkers and insulin sensitivity, but there is little evidence that SGLT2 inhibitors improve other inflammatory biomarkers including CRP.
    Language English
    Publishing date 2024-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.15586
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  9. Article ; Online: Blood glucose, diabetes and metabolic control in patients with community-acquired pneumonia.

    Lepper, Philipp M / Bals, Robert / Jüni, Peter / von Eynatten, Maximilian

    Diabetologia

    2020  Volume 63, Issue 11, Page(s) 2488–2490

    MeSH term(s) Betacoronavirus ; Blood Glucose ; COVID-19 ; Community-Acquired Infections/epidemiology ; Coronavirus Infections ; Diabetes Mellitus/epidemiology ; Humans ; Inpatients ; Pandemics ; Pneumonia ; Pneumonia, Viral ; Prognosis ; SARS-CoV-2
    Chemical Substances Blood Glucose
    Keywords covid19
    Language English
    Publishing date 2020-07-17
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 1694-9
    ISSN 1432-0428 ; 0012-186X
    ISSN (online) 1432-0428
    ISSN 0012-186X
    DOI 10.1007/s00125-020-05225-1
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  10. Article ; Online: Revisiting the evidence for physical distancing, face masks, and eye protection.

    Jüni, Peter / da Costa, Bruno R / Bobos, Pavlos / Bodmer, Nicolas S / McGeer, Allison

    Lancet (London, England)

    2021  Volume 398, Issue 10301, Page(s) 663

    MeSH term(s) COVID-19 ; Humans ; Masks ; Physical Distancing ; SARS-CoV-2
    Language English
    Publishing date 2021-08-21
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)01758-X
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