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Book: Câncer ambiental e ocupacional na América Latina

Koifman, Sergio

= Environmental and occupational cancer in Latin America

(Cadernos de saúde pública ; 14, Supl. 3)

1998

Title variant	Environmental and occupational cancer in Latin America
Author's details	ed. convidado Sergio Koifman
Series title	Cadernos de saúde pública ; 14, Supl. 3
Collection
Keywords	Lateinamerika ; Carcinogenese ; Umweltfaktor ; Arbeitsbedingungen
Subject	Arbeitssituation ; Arbeit ; Arbeitsbedingung ; Krebs ; Krebsentstehung ; Karzinogenese ; Kanzerogenese ; Onkogenese ; Umwelteinfluss ; Ökologischer Faktor ; Exogener Faktor ; Standortbedingungen ; Standortfaktor
Language	English ; Portuguese
Size	200 S. : Kt.
Publisher	Escola Nacional de Saúde Pública
Publishing place	Rio de Janeiro
Publishing country	Brazil
Document type	Book
Note	Zsfassung in engl. und portug. Sprache
HBZ-ID	HT009515617
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Formação Profissional e a Reforma Sanitária

Lilian Koifman / Sergio Rego

Revista Brasileira de Educação Médica, Vol 28, Iss 3, Pp 187-

2020 Volume 189

Keywords	Education (General) ; L7-991 ; Medicine (General) ; R5-920
Language	Portuguese
Publishing date	2020-07-01T00:00:00Z
Publisher	Associção Brasileira de Educação Médica
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cancer incidence in indigenous populations of Western Amazon, Brazil.

Borges, Maria Fernanda de Sousa Oliveira / Koifman, Sergio / Koifman, Rosalina Jorge / da Silva, Ilce Ferreira

Ethnicity & health

2021 Volume 27, Issue 6, Page(s) 1465–1481

Abstract: Objectives: This study aims to estimate a population-based cancer incidence among indigenous populations in the State of Acre, Brazilian Western Amazon, to provide knowledge about cancer epidemiological profiles contributing to healthcare policies and ... ...

Abstract	Objectives: This study aims to estimate a population-based cancer incidence among indigenous populations in the State of Acre, Brazilian Western Amazon, to provide knowledge about cancer epidemiological profiles contributing to healthcare policies and service planning. Although cancer epidemiology in Brazil is well described through incidence and mortality estimate in the general population, cancer estimates among indigenous peoples are still unknown. Design: This is a descriptive study of cancer incidence among the indigenous population (2000-2012) in the State of Acre, Brazil. The sources used were population-based cancer registries of Goiânia, hospital-based cancer registry of Acre, São Paulo, and Porto Velho; Special Indigenous Health Districts databases of Acre, Goiânia, and São Paulo; Mortality Information System, and Rio Branco's public and private laboratories' reports. Standardized Incidence Ratio (SIR) was calculated using cancer incidence rates of Goiânia as reference. Results: From 137 cancer cases, 51.8% occurred in women and 32.1% in people aged 70 + . Among men, the most frequent cancer sites were stomach (25.8%), liver (15.1%), colorectal (7.6%), leukemia (7.6%), and prostate (6.1%). Among women, the most frequent were cervical (50.7%), stomach (8.5%), leukemia (5.6%), liver (4.3%), and breast (4.3%). Among men, there was an excess of cancer cases for stomach (SIR=1.75; 95%CI:1.67-1.83), liver (SIR=1.77; 95%CI:1.66-1.88), and leukemia (SIR=1.64; 95%CI:1.49-1.78). In women, an excess of cancer cases was observed for cervical (SIR=4.49; 95%CI:4.34-4.64) and liver (SIR=2.11; 95%CI:1.88-2.34). A lower cancer incidence for prostate (SIR=0.06; 95%CI:0.05-0.07) and female breast (SIR=0.12; 95%CI:0.11-0.14) was observed. Conclusions: Cervical, stomach, and liver cancers corresponded to 52% of the cases and were highly incident among the Brazilian indigenous population of Western Amazon compared to non-indigenous counterparts. Despite the low frequency of breast and prostate cancer, the fact they were present among indigenous peoples suggests a complex epidemiological transition framework in these populations.
MeSH term(s)	Brazil/epidemiology ; Humans ; Incidence ; Indigenous Peoples ; Leukemia/complications ; Male ; Neoplasms/epidemiology ; Prostatic Neoplasms ; Registries ; Risk Factors
Language	English
Publishing date	2021-03-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1497968-8
ISSN	1465-3419 ; 1355-7858
ISSN (online)	1465-3419
ISSN	1355-7858
DOI	10.1080/13557858.2021.1893663
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Article ; Online: Occupational exposure to pesticides and hematological alterations: A survey of farm residents in the South of Brazil.

Piccoli, Camila / Cremonese, Cleber / Koifman, Rosalina / Koifman, Sérgio / Freire, Carmen

Ciencia & saude coletiva

2019 Volume 24, Issue 6, Page(s) 2325–2340

Abstract: This study sought to investigate the association of exposure to organochlorine (OC) and non-persistent pesticides with hematological parameters in an agricultural population in Southern Brazil. A cross-sectional study was conducted with a random sample ... ...

Abstract	This study sought to investigate the association of exposure to organochlorine (OC) and non-persistent pesticides with hematological parameters in an agricultural population in Southern Brazil. A cross-sectional study was conducted with a random sample of 275 farm workers and their families in Farroupilha-RS. A questionnaire was used to collect information on sociodemographic and lifestyle factors, duration, frequency and type of pesticide used, among others. Blood samples were collected and analyzed for serum concentration of 24 OC pesticides and hematological parameters. Associations were explored through linear regression, controlling for confounders. Lifetime use of chemical classes other than organophosphates and dithiocarbamates were associated with decreased number of lymphocytes, while subjects sampled in the high pesticide use season showed higher number of erythrocytes and hemoglobin level. Detectable serum levels of many OC pesticides were associated with lower counts of white blood cells, particularly eosinophils. Although mostly null associations were observed between pesticide use and hematological parameters, findings may suggest that OC pesticides could lead to hematological alterations among agricultural workers.
MeSH term(s)	Adolescent ; Adult ; Agricultural Workers' Diseases/blood ; Agricultural Workers' Diseases/epidemiology ; Blood Cell Count ; Brazil/epidemiology ; Cross-Sectional Studies ; Farmers ; Farms ; Female ; Humans ; Hydrocarbons, Chlorinated/blood ; Hydrocarbons, Chlorinated/toxicity ; Male ; Middle Aged ; Occupational Exposure/adverse effects ; Pesticides/blood ; Pesticides/toxicity ; Young Adult
Chemical Substances	Hydrocarbons, Chlorinated ; Pesticides
Language	English
Publishing date	2019-06-27
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2078799-6
ISSN	1678-4561 ; 1413-8123
ISSN (online)	1678-4561
ISSN	1413-8123
DOI	10.1590/1413-81232018246.13142017
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Article ; Online: Thyroid cancer in Brazil: a descriptive study of cases held on hospital-based cancer registries, 2000-2016.

Borges, Anne Karin da Mota / Ferreira, Jeniffer Dantas / Koifman, Sérgio / Koifman, Rosalina Jorge

Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil

2020 Volume 29, Issue 4, Page(s) e2019503

Abstract: Objective To describe the clinical and epidemiological profile of primary thyroid cancer hospital cases in Brazil. Methods This is a descriptive study of cases held on hospital cancer records who had their first consultation for treatment in the period ... ...

Title translation	Câncer de tireoide no Brasil: estudo descritivo dos casos informados pelos registros hospitalares de câncer, 2000-2016.
Abstract	Objective To describe the clinical and epidemiological profile of primary thyroid cancer hospital cases in Brazil. Methods This is a descriptive study of cases held on hospital cancer records who had their first consultation for treatment in the period 2000-2016 and who were monitored by the hospitals providing those records. Results Of the 52,912 cases, 83.4% were female and 96.9% were differentiated carcinoma cases. The median time to diagnosis was shorter for anaplastic cases (11 days) and for those living in Brazil's Southern region (5 days). Treatment was initiated within 60 days in 88.8% of cases that arrived at the hospitals without diagnosis and in 34.9% of those who arrived with diagnosis. Conclusion The findings are consistent with thyroid cancer epidemiology, with a predominance of female cases and differentiated carcinomas. Analysis of time-to-treatment suggests access difficulties for those who already had diagnosis when they arrived at the hospitals.
MeSH term(s)	Brazil/epidemiology ; Female ; Hospitals ; Humans ; Male ; Registries ; Thyroid Neoplasms/epidemiology
Language	Portuguese
Publishing date	2020-08-19
Publishing country	Brazil
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2880588-4
ISSN	2237-9622 ; 1679-4974
ISSN (online)	2237-9622
ISSN	1679-4974
DOI	10.5123/s1679-49742020000400012
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Article ; Online: Serum levels of organochlorine pesticides in blood donors: A biomonitoring survey in the North of Brazil, 2010-2011.

Freire, Carmen / Koifman, Rosalina Jorge / Koifman, Sergio

The Science of the total environment

2017 Volume 598, Page(s) 722–732

Abstract: Data on exposure to organochlorine (OC) pesticides in the Brazilian population are lacking. The purpose of this study was to investigate the distribution of serum levels of OC pesticides in Brazilian blood donors and to determine factors potentially ... ...

Abstract	Data on exposure to organochlorine (OC) pesticides in the Brazilian population are lacking. The purpose of this study was to investigate the distribution of serum levels of OC pesticides in Brazilian blood donors and to determine factors potentially influencing exposure levels. To conduct this biomonitoring survey, blood samples were collected from blood donors attending the Hematherapic Unit in Rio Branco, North of Brazil, in 2010-2011. A total of 1183 (99%) subjects answered to a questionnaire including information on sociodemographics, lifestyle, and dietary habits. Twenty four OC pesticides were measured in serum samples from 978 donors (82%). Associations of OC pesticide serum levels and the number of OCs detected per donor with their potential predictors were explored by logistic and Poisson regression, respectively. Of the 24 OC pesticides analyzed, the highest prevalence was observed for p,p'-dichlorodiphenylethane (p,p'-DDE) (32%), followed by lindane (γ-hexachlorocyclohexane) (20%), heptachlor (16%), and p,p'-dichlorodiphenyltrichloroethane (p,p'-DDT) (13%). 95th percentiles of levels of these four OC pesticides were: 3.85ng/mL (p,p'-DDE) (median<0.09ng/mL), 0.09ng/mL (lindane) (median<0.04ng/mL), 0.23ng/mL (heptachlor) (median<0.09ng/mL), and 0.27ng/mL (p,p'-DDT) (median<0.02ng/mL). Factors significantly associated with a more frequent detection of OC pesticides included age, gender, education, and frequency of fish, manioc flour, açai pulp, and Brazil nuts intake. Major predictors of the number of OC pesticides detected were age, marital status, income, education, and frequency of consumption of manioc flour, açai pulp, and Brazil nuts. For the first time in Brazil, a biomonitoring study has assessed the internal doses of OC pesticides in a large sample of the adult population and potential exposure determinants. Except for lindane, which was permitted for use as a wood preservative until 2007 in Brazil, occurrence of OC pesticides was lower than or in the same range as those observed in other countries.
MeSH term(s)	Adolescent ; Adult ; Aged ; Blood Donors ; Brazil ; Environmental Monitoring ; Female ; Humans ; Hydrocarbons, Chlorinated/blood ; Male ; Middle Aged ; Pesticides/blood ; Surveys and Questionnaires ; Young Adult
Chemical Substances	Hydrocarbons, Chlorinated ; Pesticides
Language	English
Publishing date	2017-11-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2017.04.128
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Zs.A 949: Show issues

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Article ; Online: Embolisation of a prosthetic mitral valve fragment during valve-in-valve transcatheter mitral valve implantation.

Alnsasra, Hilmi / Koifman, Edward / Abu-Salman, Amjad / Kobal, Sergio L / Cafri, Carlos

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

2021 Volume 17, Issue 18, Page(s) 1534–1535

MeSH term(s)	Cardiac Catheterization/adverse effects ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation/adverse effects ; Humans ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/surgery ; Treatment Outcome
Language	English
Publishing date	2021-11-28
Publishing country	France
Document type	Journal Article
ZDB-ID	2457174-X
ISSN	1969-6213 ; 1774-024X
ISSN (online)	1969-6213
ISSN	1774-024X
DOI	10.4244/EIJ-D-21-00630
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Zs.A 6680: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 571: Show issues

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Article ; Online: Câncer de tireoide no Brasil

Anne Karin da Mota Borges / Jeniffer Dantas Ferreira / Sérgio Koifman / Rosalina Jorge Koifman

Epidemiologia e Serviços de Saúde, Vol 29, Iss

estudo descritivo dos casos informados pelos registros hospitalares de câncer, 2000-2016

2020 Volume 4

Abstract: Resumo Objetivo Descrever o perfil clínico-epidemiológico de casos hospitalares de câncer primário de tireoide no Brasil. Métodos Estudo descritivo dos casos informados pelos registros hospitalares de câncer que tiveram primeira consulta para tratamento ... ...

Abstract	Resumo Objetivo Descrever o perfil clínico-epidemiológico de casos hospitalares de câncer primário de tireoide no Brasil. Métodos Estudo descritivo dos casos informados pelos registros hospitalares de câncer que tiveram primeira consulta para tratamento no período 2000-2016 e cujo acompanhamento foi realizado pela instituição do registro informante. Resultados Dos 52.912 casos, 83,4% eram femininos e 96,9% eram carcinomas diferenciados. Apresentaram menor tempo mediano para diagnóstico os casos anaplásicos (11 dias) e os residentes da região Sul do país (5 dias). O tratamento foi iniciado em até 60 dias em 88,8% dos casos que chegaram à instituição do registro sem diagnóstico e em 34,9% dos que chegaram com diagnóstico. Conclusão Os achados são consistentes com a epidemiologia do câncer de tireoide, com predominância do sexo feminino e do carcinoma diferenciado. A análise do tempo para início do tratamento sugere dificuldades de acesso para aqueles que chegaram às instituições dos registros com diagnóstico.
Keywords	Neoplasias da Glândula Tireoide ; Sistemas de Informações em Saúde ; Perfil de Saúde ; Epidemiologia Descritiva ; Tempo para o Tratamento ; Medicine ; R ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	Ministério da Saúde do Brasil
Document type	Article ; Online
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Article ; Online: Mortalidade por câncer em populações indígenas no Estado do Acre, Brasil.

Borges, Maria Fernanda de Sousa Oliveira / Koifman, Sergio / Koifman, Rosalina Jorge / Silva, Ilce Ferreira da

Cadernos de saude publica

2019 Volume 35, Issue 5, Page(s) e00143818

Abstract: The study aimed to estimate cancer mortality among indigenous peoples in Acre State, Brazil. This was a descriptive observational study based on the nominal bank of the Brazilian Mortality Information System for the period from January 1st, 2000, to ... ...

Title translation	Cancer mortality among indigenous population in Acre State, Brazil.
Abstract	The study aimed to estimate cancer mortality among indigenous peoples in Acre State, Brazil. This was a descriptive observational study based on the nominal bank of the Brazilian Mortality Information System for the period from January 1st, 2000, to December 31st, 2012. The study analyzed the distribution death frequencies by sex and age. Standardized mortality ratio (SMR) was calculated taking Goiânia (Goiás State), Acre State, and the North Region of Brazil as the references. A total of 81 deaths were identified, the majority in men (59.3%) and in individuals over 70 years of age. The five main sites in men were stomach, liver, colon and rectum, leukemia, and prostate. The five main sites in women were uterine cervix, stomach, liver, leukemia, and uterus. In indigenous men there was an excess of deaths from stomach cancer compared to the populations of Goiânia (SMR = 2.72; 2.58-2.87), Acre State (SMR = 2.05; 1.94-2.16) and North region (SMR = 3.10; 2.93-3.27). The same was observed for deaths from hepatic cell carcinomas referenced against Goiânia (SMR = 3.89; 3.66-4.14), Acre State (SMR = 1.79; 1.68-1.91), and the North of Brazil (SMR = 4.04; 3.77-4.30). Among indigenous women, there was an excess of cervical cancer in comparison to Goiânia (SMR = 4.67; 4.41-4.93), Acre State (SMR = 2.12; 2.00-2.24), and the North (SMR = 2.60; 2.45-2.75). The estimates show that preventable neoplasms such as cervical cancer and those linked to underdevelopment, such as stomach and liver cancer, account for 49.4% of deaths among indigenous peoples. Compared to the reference population, mortality from liver, stomach, and colorectal cancer and leukemias was more than twice as high in indigenous men; among indigenous women, cervical, stomach, and liver cancer and leukemias were 30% higher.
MeSH term(s)	Adolescent ; Adult ; Aged ; Brazil/epidemiology ; Cause of Death ; Child ; Child, Preschool ; Female ; Humans ; Incidence ; Indians, South American ; Indigenous Peoples/statistics & numerical data ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Neoplasms/classification ; Neoplasms/diagnosis ; Neoplasms/mortality ; Population Groups ; Prevalence ; Risk Factors ; Sex Factors ; Young Adult
Language	Portuguese
Publishing date	2019-05-23
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	1115730-6
ISSN	1678-4464 ; 0102-311X
ISSN (online)	1678-4464
ISSN	0102-311X
DOI	10.1590/0102-311X00143818
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Zs.A 4981: Show issues

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Article ; Online: Differentiated thyroid carcinoma: a 5-years survival study at a referral hospital in Brazil.

Borges, Anne Karin da Mota / Ferreira, Jeniffer Dantas / Koifman, Sergio / Koifman, Rosalina Jorge

Revista de saude publica

2019 Volume 53, Page(s) 106

Abstract: Background: Although the prognosis of differentiated thyroid carcinoma (DTC) therapy is considered excellent over time, some cases have a poorer prognosis and evolve into death.: Objective: This study aimed to estimate the 5-year specific survival ... ...

Abstract	Background: Although the prognosis of differentiated thyroid carcinoma (DTC) therapy is considered excellent over time, some cases have a poorer prognosis and evolve into death. Objective: This study aimed to estimate the 5-year specific survival and to identify prognosis factors in a cohort of DTC adult subjects. Methods: Survival probability was estimated by Kaplan-Meier's method in a retrospective hospital-based cohort study. Comparisons were made by log-rank test. Prognosis factors were identified using Cox risk modeling and crude and adjusted Hazard Ratio measures were obtained. Two models were estimated, considering age grouping of the 7th and 8th editions of TNM. Results: Specific 5-year survival in the cohort was 98.5% (95%CI: 94.2 - 97.5). Considering TNM 7th edition, the risk estimates were 9.88 (95%CI: 1.67 - 58.33) for age group ≥ 55 years, 18.87 (95%CI: 7.38 - 48.29) for individuals with distant metastasis, 6.36 (95%CI: 2.26 - 17.91) for patients who underwent lymphadenectomy and 0.16 (95%CI: 0.06 - 0.43) for those who received radioiodine therapy. For TNM 8th edition, the risk estimates were 10.12 (95%CI: 2.05 - 50.09) for age group ≥ 55 years, 12.43 (95%CI: 4.58 - 33.77) for individuals with distant metastasis, 5.06 (95%CI: 1.82 - 14.05) for patients who underwent lymphadenectomy and 0.19 (95%CI: 0.07 - 0.51) for those who received radioiodine therapy. Conclusions: This cohort had a very high survival over a 5-year period. The prognosis was negatively influenced by age, distant metastasis and lymphadenectomy, whereas radioiodine therapy was found to be protective.
MeSH term(s)	Adult ; Age Factors ; Aged ; Aged, 80 and over ; Analysis of Variance ; Brazil/epidemiology ; Carcinoma/mortality ; Carcinoma/pathology ; Female ; Follow-Up Studies ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Staging ; Prognosis ; Referral and Consultation/statistics & numerical data ; Retrospective Studies ; Survival Rate ; Thyroid Neoplasms/mortality ; Thyroid Neoplasms/pathology ; Time Factors ; Tumor Burden ; Young Adult
Language	English
Publishing date	2019-11-28
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	732179-x
ISSN	1518-8787 ; 0034-8910
ISSN (online)	1518-8787
ISSN	0034-8910
DOI	10.11606/S1518-8787.2019053001496
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