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  1. Book ; Online ; E-Book: Carbohydrate-based therapeutics

    Adamo, Roberto / Lay, Luigi

    2024  

    Author's details edited by Roberto Adamo and Luigi Lay
    Keywords Carbohydrates ; Chemistry
    Subject code 547.78
    Language English
    Size 1 online resource (411 pages)
    Edition 1st ed.
    Publisher WILEY-VCH GmbH
    Publishing place Weinheim, Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-527-83132-0 ; 3-527-83133-9 ; 3-527-83131-2 ; 9783527348701 ; 978-3-527-83132-6 ; 978-3-527-83133-3 ; 978-3-527-83131-9 ; 3527348700
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Broadening the concept of glycoconjugates: glycoRNA and ubiquitinylated lipopolysaccharide.

    Adamo, Roberto

    Glycoconjugate journal

    2021  Volume 38, Issue 5, Page(s) 609–610

    Abstract: Two recent papers ( https://doi.org/10.1016/j.cell.2021.04.023 and https://doi.org/10.1038/s41586-021-03566-4 ) extend the definition of glycoconjugates to new classes of carbohydrate containing molecules and show how dynamic is the field of glycoscience. ...

    Abstract Two recent papers ( https://doi.org/10.1016/j.cell.2021.04.023 and https://doi.org/10.1038/s41586-021-03566-4 ) extend the definition of glycoconjugates to new classes of carbohydrate containing molecules and show how dynamic is the field of glycoscience.
    MeSH term(s) Glycoconjugates/chemistry ; Lipopolysaccharides ; RNA/chemistry
    Chemical Substances Glycoconjugates ; Lipopolysaccharides ; RNA (63231-63-0)
    Language English
    Publishing date 2021-07-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 283770-5
    ISSN 1573-4986 ; 0282-0080
    ISSN (online) 1573-4986
    ISSN 0282-0080
    DOI 10.1007/s10719-021-10006-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Glycoconjugate vaccines: classic and novel approaches.

    Adamo, Roberto

    Glycoconjugate journal

    2021  Volume 38, Issue 4, Page(s) 397–398

    Abstract: Glycoconjugate vaccines, obtained by carbohydrates covalently bound to protein carriers, have contributed to fight diseases such as meningitidis, pneumonia and typhoid fever. Despite new technologies such as RNA and adenovirus based vaccine have now ... ...

    Abstract Glycoconjugate vaccines, obtained by carbohydrates covalently bound to protein carriers, have contributed to fight diseases such as meningitidis, pneumonia and typhoid fever. Despite new technologies such as RNA and adenovirus based vaccine have now reached the market, these approaches are unable to target carbohydrates which are key virulence factors.This issue intends to provide an overview on relevant directions where the field is evolving and serve as starting point to increase interest in this exciting and fundamental part of vaccinology.
    MeSH term(s) Bacterial Vaccines/classification ; Bacterial Vaccines/immunology ; Glycoconjugates/chemistry ; Humans ; Vaccines, Conjugate/immunology ; Viral Vaccines/classification ; Viral Vaccines/immunology
    Chemical Substances Bacterial Vaccines ; Glycoconjugates ; Vaccines, Conjugate ; Viral Vaccines
    Language English
    Publishing date 2021-06-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 283770-5
    ISSN 1573-4986 ; 0282-0080
    ISSN (online) 1573-4986
    ISSN 0282-0080
    DOI 10.1007/s10719-021-09997-5
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  4. Article ; Online: Correction to "Advancing Homogeneous Antimicrobial Glycoconjugate Vaccines".

    Adamo, Roberto

    Accounts of chemical research

    2017  Volume 50, Issue 7, Page(s) 1794

    Language English
    Publishing date 2017-06-27
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 1483291-4
    ISSN 1520-4898 ; 0001-4842
    ISSN (online) 1520-4898
    ISSN 0001-4842
    DOI 10.1021/acs.accounts.7b00256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Joint pressure stimuli increase quadriceps strength and neuromuscular activity in patients with knee osteoarthritis.

    Temporiti, Federico / Moro, Sara / Adamo, Paola / Gatti, Roberto

    Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology

    2023  Volume 73, Page(s) 102814

    Abstract: The study investigated the effects of periarticular knee pressure stimuli on quadriceps strength and neuromuscular activity in subjects with knee osteoarthritis. Twenty-five subjects with knee osteoarthritis and 25 age-matched healthy controls performed ... ...

    Abstract The study investigated the effects of periarticular knee pressure stimuli on quadriceps strength and neuromuscular activity in subjects with knee osteoarthritis. Twenty-five subjects with knee osteoarthritis and 25 age-matched healthy controls performed maximal voluntary knee extension tasks on an isometric dynamometer. Three different pressure stimuli (no-pressure, 60-mmHg, 120-mmHg) were applied using a sphygmomanometer via the cuff covering the knee joint. Peak torque and root-mean-square peak of rectus femoris (RF), vastus medialis (VM), and vastus lateralis (VL) were collected and normalized for the no-pressure condition (nTorque-peak and nRMS-peak). Normalized Torque-peak increased from no-pressure to 60-mmHg and 120-mmHg in patients, which revealed higher nTorque-peak during 60-mmHg (MD: 10.9%, IC
    MeSH term(s) Humans ; Quadriceps Muscle/physiology ; Osteoarthritis, Knee ; Muscle, Skeletal/physiology ; Electromyography ; Isometric Contraction/physiology ; Knee Joint/physiology ; Torque
    Language English
    Publishing date 2023-08-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1073161-1
    ISSN 1873-5711 ; 1050-6411
    ISSN (online) 1873-5711
    ISSN 1050-6411
    DOI 10.1016/j.jelekin.2023.102814
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3218: Show issues Location:
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  6. Article ; Online: Outer Membrane Vesicle Vaccine Platforms.

    Micoli, Francesca / Adamo, Roberto / Nakakana, Usman

    BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy

    2023  Volume 38, Issue 1, Page(s) 47–59

    Abstract: Outer membrane vesicles (OMVs) are spontaneously released by many gram-negative bacteria during their growth and constitute an important virulence factor for bacteria, helping them to survive through harsh environmental conditions. Native OMVs, naturally- ...

    Abstract Outer membrane vesicles (OMVs) are spontaneously released by many gram-negative bacteria during their growth and constitute an important virulence factor for bacteria, helping them to survive through harsh environmental conditions. Native OMVs, naturally-released from bacteria, are produced at a level too low for vaccine manufacturing, requiring chemical treatment (detergent-extracted) or genetic manipulation, resulting in generalized modules for membrane antigens (GMMAs). Over the years, the nature and properties of OMVs have made them a viable platform for vaccine development. There are a few licensed OMV vaccines mainly for the prevention of meningitis caused by Neisseria meningitidis serogroup B (MenB) and Haemophilus influenzae type b (Hib). There are several candidates in clinical development against other gram-negative organisms from which the OMVs are derived, but also against heterologous targets in which the OMVs are used as carriers (e.g. coronavirus disease 2019 [COVID-19]). The use of OMVs for targets other than those from which they are derived is a major advancement in OMV technology, improving its versatility by being able to deliver protein or polysaccharide antigens. Other advances include the range of genetic modifications that can be made to improve their safety, reduce reactogenicity, and increase immunogenicity and protective efficacy. However, significant challenges remain, such as identification of general tools for high-content surface expression of heterologous proteins on the OMV surface. Here, we outline the progress of OMV vaccines to date, particularly discussing licensed OMV-based vaccines and candidates in clinical development. Recent trends in preclinical research are described, mainly focused on genetic manipulation and chemical conjugation for the use of OMVs as carriers for heterologous protein and polysaccharide antigens. Remaining challenges with the use of OMVs and directions for future research are also discussed.
    MeSH term(s) Humans ; Bacterial Outer Membrane Proteins/genetics ; Bacterial Outer Membrane Proteins/chemistry ; Vaccines ; Polysaccharides
    Chemical Substances Bacterial Outer Membrane Proteins ; Vaccines ; Polysaccharides
    Language English
    Publishing date 2023-10-05
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 1364202-9
    ISSN 1179-190X ; 1173-8804
    ISSN (online) 1179-190X
    ISSN 1173-8804
    DOI 10.1007/s40259-023-00627-0
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    Zs.A 4112: Show issues Location:
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  7. Article ; Online: Advancing Homogeneous Antimicrobial Glycoconjugate Vaccines.

    Adamo, Roberto

    Accounts of chemical research

    2017  Volume 50, Issue 5, Page(s) 1270–1279

    Abstract: Since 2004, when the first synthetic glycoconjugate vaccine against the pneumonia and meningitis causing bacterium Haemophilus influenza type b (Hib) approved for human use in Cuba was reported, 34 million doses of the synthetic vaccine have been already ...

    Abstract Since 2004, when the first synthetic glycoconjugate vaccine against the pneumonia and meningitis causing bacterium Haemophilus influenza type b (Hib) approved for human use in Cuba was reported, 34 million doses of the synthetic vaccine have been already distributed in several countries under the commercial name of Quimi-Hib. However, despite the success of this product, no other synthetic glycoconjugate vaccine has been licensed in the following 13 years. As well as avoiding the need to handle pathogens, synthetic glycoconjugates offer clear advantages in terms of product characterization and the possibility to understand the parameters influencing immunogenicity. Nevertheless, large scale application of synthetic sugars has been perceived as challenging because of manufacturing costs and process complexity compared to natural polysaccharides. Chemoenzymatic approaches, one-pot protocols, and automated solid-phase synthesis are rendering carbohydrate production considerably more attractive for industrialization. Here we identify three areas where chemical approaches can advance this progress: (i) chemical or enzymatic methods enabling the delivery of the minimal polysaccharide portion responsible for an effective immune response; (ii) site-selective chemical or enzymatic conjugation strategies for the exploration of the conjugation point in immune responses against carbohydrate-based vaccines, and the consistent preparation of more homogeneous products; (iii) multicomponent constructs targeting receptors responsible for immune response modulation in order to control its quality and magnitude. We discuss how synthesis of bacterial oligosaccharides is useful toward understanding the polysaccharide portion responsible for immunogenicity, and for developing robust and consistent alternatives to natural heterogeneous polysaccharides. The synthesis of sugar analogues can lead to the identification of hydrolytically more stable versions of oligosaccharide antigens. The study of bacterial polysaccharide biosynthesis aids the development of in vitro hazard-free oligosaccharide production. Novel site-selective conjugation methods contribute toward deciphering the role of conjugation sites in the immunogenicity of glycoconjugates and prove to be particularly useful when glycans are conjugated to protein serving as carrier and antigen. The orthogonal incorporation of two different carbohydrate haptens enables the reduction of vaccine components. Finally, coordinated conjugation of glycans and small molecule immunopotentiators supports simplification of vaccine formulation and localization of adjuvant. Synergistic advancement of these areas, combined with competitive manufacturing processes, will contribute to a better understanding of the features guiding the immunological activity of glycoconjugates and, ultimately, to the design of improved, safer vaccines.
    MeSH term(s) Amino Acid Sequence ; Animals ; Bacteria/immunology ; Bacterial Proteins/chemistry ; Bacterial Vaccines/chemical synthesis ; Bacterial Vaccines/chemistry ; Fungal Vaccines/chemical synthesis ; Fungal Vaccines/chemistry ; Glycoconjugates/chemical synthesis ; Glycoconjugates/chemistry ; Humans ; Mice ; Polysaccharides/chemical synthesis ; Polysaccharides/chemistry ; Vaccines/chemical synthesis ; Vaccines/chemistry ; Vaccines, Conjugate
    Chemical Substances Bacterial Proteins ; Bacterial Vaccines ; Fungal Vaccines ; Glycoconjugates ; Polysaccharides ; Vaccines ; Vaccines, Conjugate
    Language English
    Publishing date 2017-05-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1483291-4
    ISSN 1520-4898 ; 0001-4842
    ISSN (online) 1520-4898
    ISSN 0001-4842
    DOI 10.1021/acs.accounts.7b00106
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  8. Article ; Online: Editorial: Glycoconjugates in vaccines and immunotherapeutics.

    Shivatare, Sachin / Sanjiv, Kumar / Kikkeri, Raghavendra / Adamo, Roberto

    Frontiers in immunology

    2022  Volume 13, Page(s) 941474

    MeSH term(s) Glycoconjugates ; Immunotherapy ; Vaccines
    Chemical Substances Glycoconjugates ; Vaccines
    Language English
    Publishing date 2022-08-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.941474
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  9. Article ; Online: Reliability of Shoulder Helical Axes During Intransitive and Transitive Upper Limb Tasks.

    Adamo, Paola / Temporiti, Federico / Maffeis, Martina / Bolzoni, Francesco / Gatti, Roberto

    Journal of applied biomechanics

    2023  Volume 39, Issue 6, Page(s) 440–445

    Abstract: Shoulder complex stability can be estimated in vivo through the analysis of helical axes (HAs) dispersion during upper limb movements. The study aimed at investigating test-retest reliability of shoulder HAs dispersion parameters during upper limb tasks. ...

    Abstract Shoulder complex stability can be estimated in vivo through the analysis of helical axes (HAs) dispersion during upper limb movements. The study aimed at investigating test-retest reliability of shoulder HAs dispersion parameters during upper limb tasks. Twenty healthy volunteers performed 2 intransitive (shoulder flexion and rotation) and one transitive (combing) tasks with the dominant and nondominant upper limbs during 2 recording sessions at 1-week distance. Kinematics was detected through an optoelectronic system. Mean distance and mean angle (MA) were adopted as HAs dispersion indexes. Reliability was excellent for mean distance (intraclass correlation coefficient [ICC]: .91) and MA (ICC: .92) during dominant flexion, and good for MA (ICC: .90) during nondominant flexion. Moderate reliability was found for HAs parameters during rotation (ICCs from .70 to .59), except for MA during dominant rotation where reliability was poor. Reliability was good for mean distance (ICC: .83) and moderate for MA (ICC: .67) during the dominant combing task, whereas no reliability was found during the nondominant combing task. HAs dispersion parameters revealed high reliability during simple intransitive tasks with the dominant limb. Reliability decreased with the increase in task complexity due to the increase in movement variability. HAs dispersion technique could be used to assess shoulder complex stability in patients after rehabilitation or surgery.
    MeSH term(s) Humans ; Shoulder ; Reproducibility of Results ; Upper Extremity ; Shoulder Joint ; Movement
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1145288-2
    ISSN 1543-2688 ; 1065-8483
    ISSN (online) 1543-2688
    ISSN 1065-8483
    DOI 10.1123/jab.2022-0321
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    Zs.B 2776: Show issues Location:
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  10. Article ; Online: Vaccinology Gets Help from Chemistry.

    Adamo, Roberto

    Cell chemical biology

    2015  Volume 23, Issue 9, Page(s) 1047–1048

    Abstract: A recent report on the immunological activity of protein conjugates of synthetic lipoteicoic fragments from Clostridium difficile underpins the use of these molecules for the development of a vaccine. In a recent issue of Cell Chemical Biology, Broecker ... ...

    Abstract A recent report on the immunological activity of protein conjugates of synthetic lipoteicoic fragments from Clostridium difficile underpins the use of these molecules for the development of a vaccine. In a recent issue of Cell Chemical Biology, Broecker et al. (2016) illustrate the utility of glycoarray-based selection of bacterial carbohydrates with the potential to become vaccine candidates.
    MeSH term(s) Bacterial Vaccines ; Clostridium Infections ; Humans ; Lipopolysaccharides ; Polysaccharides ; Teichoic Acids ; Vaccinology
    Chemical Substances Bacterial Vaccines ; Lipopolysaccharides ; Polysaccharides ; Teichoic Acids ; lipoteichoic acid (56411-57-5)
    Language English
    Publishing date 2015-10-12
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2016.09.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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