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Article ; Online: Defining the Standard of the Terminology of the Mechanical Ventilation Data in Japan.

Saito, Kenichi / Kobayashi, Shinji / Tsutsumi, Takahiko / Takaki, Shunsuke / Hashimoto, Satoru

Studies in health technology and informatics

2024 Volume 310, Page(s) 1343–1344

Abstract: To effectively use data from intensive care unit patient information systems at multiple hospitals, it is necessary to standardize the data into a well-ordered form. However, terms often vary between devices. We designed a mechanical ventilation concept ... ...

Abstract	To effectively use data from intensive care unit patient information systems at multiple hospitals, it is necessary to standardize the data into a well-ordered form. However, terms often vary between devices. We designed a mechanical ventilation concept model and applied data to that model using existing tools and expert opinions. The JSICM glossary was revised based on this study.
MeSH term(s)	Humans ; Japan ; Respiration, Artificial ; Critical Care ; Hospitals
Language	English
Publishing date	2024-01-25
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI231186
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Article ; Online: Development of a processing factor prediction model for pesticides in processed tomato foods using elastic net regularization.

Yamasaki, Yuki / Nakamura, Kosuke / Kashiwabara, Nao / Chiba, Shinji / Akiyama, Hiroshi / Tsutsumi, Tomoaki

Food chemistry

2024 Volume 447, Page(s) 138943

Abstract: A novel regularized elastic net regression model was developed to predict processing factor (PF) for pesticide residues, which represents a change in the residue levels during food processing. The PF values for tomato juice, wet pomace and dry pomace in ... ...

Abstract	A novel regularized elastic net regression model was developed to predict processing factor (PF) for pesticide residues, which represents a change in the residue levels during food processing. The PF values for tomato juice, wet pomace and dry pomace in the evaluations and reports published by the Joint FAO/WHO Meeting on Pesticide Residues significantly correlated with the physicochemical properties of pesticides, and subsequently the correlation was observed in the present tomato processing study. The elastic net regression model predicted the PF values using the physicochemical properties as predictor variables for both training and test data within a 2-fold range for 80-100% of the pesticides tested in the tomato processing study while overcoming multicollinearity. These results suggest that the PF values are predictable at a certain degree of accuracy from the unique sets of physicochemical properties of pesticides using the developed model based on a processing study with representative pesticides.
MeSH term(s)	Pesticides/analysis ; Pesticide Residues/analysis ; Solanum lycopersicum ; Food Handling ; Fruit and Vegetable Juices ; Food Contamination/analysis
Chemical Substances	Pesticides ; Pesticide Residues
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.138943
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Article: [A Case of Double Cancer of Squamous Cell Carcinoma of the Rectum and Adenocarcinoma of the Sigmoid Colon].

Tsutsumi, Shinji / Ogasawara, Hirokazu / Umetsu, Satoko / Suto, Akiko / Akasaka, Harue / Shibata, Shigeru

Gan to kagaku ryoho. Cancer & chemotherapy

2024 Volume 50, Issue 13, Page(s) 1423–1425

Abstract: A 72-year-old male was transported to our hospital with complaints of heart palpitations and dyspnea since a month earlier and was immobile. Blood examination showed severe anemia, and colonoscopy revealed circumferential tumors in the rectum and the ... ...

Abstract	A 72-year-old male was transported to our hospital with complaints of heart palpitations and dyspnea since a month earlier and was immobile. Blood examination showed severe anemia, and colonoscopy revealed circumferential tumors in the rectum and the sigmoid colon. Histopathologic examination revealed the tumors as squamous cell carcinoma of the rectum and adenocarcinoma of the sigmoid colon. Therefore, they were diagnosed as double colorectal cancers. CT and MRI showed that rectal cancer invaded the seminal vesicles and the prostate; therefore, the patient underwent neoadjuvant chemoradiotherapy(oral capecitabine and concomitant radiation therapy: a total dose of 50.4 Gy/28 Fr)followed by total pelvic exenteration. Subsequent specimen pathology revealed a tumor regression grading of Grade 2 for the rectal and sigmoid colon cancers, and both were staged as ypT3N0M0, ypStage Ⅱa. Herein, we report a rare case of double cancer of adenocarcinoma of the sigmoid colon and squamous cell carcinoma of the rectum with a literature review.
MeSH term(s)	Male ; Humans ; Aged ; Rectum/pathology ; Colon, Sigmoid/surgery ; Colon, Sigmoid/pathology ; Rectal Neoplasms/surgery ; Rectal Neoplasms/pathology ; Adenocarcinoma/surgery ; Adenocarcinoma/pathology ; Sigmoid Neoplasms/surgery ; Sigmoid Neoplasms/pathology ; Carcinoma, Squamous Cell/surgery
Language	Japanese
Publishing date	2024-02-01
Publishing country	Japan
Document type	Review ; Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article: End-Systolic Eccentricity Index Obtained by Enhanced Computed Tomography Is a Predictor of Pulmonary Vascular Resistance in Patients with Chronic Thromboembolic Pulmonary Hypertension.

Tsutsumi, Yoshinori / Adachi, Shiro / Nakano, Yoshihisa / Iwano, Shingo / Abe, Shinji / Kato, Katsuhiko / Naganawa, Shinji

Life (Basel, Switzerland)

2022 Volume 12, Issue 4

Abstract: The usefulness of the parameters of biventricular function simultaneously measured using enhanced multi-detector computed tomography (MDCT) pulmonary angiography in patients with chronic thromboembolic pulmonary hypertension (CTEPH) has not been ... ...

Abstract	The usefulness of the parameters of biventricular function simultaneously measured using enhanced multi-detector computed tomography (MDCT) pulmonary angiography in patients with chronic thromboembolic pulmonary hypertension (CTEPH) has not been clarified. This study aimed to verify the correlation between left and right ventricular (RV) parameters and pulmonary vascular resistance (PVR). Patients who underwent enhanced MDCT before diagnostic right heart catheterization at Nagoya University Hospital between October 2014 and April 2021 were enrolled. The correlation of biventricular function and volume parameters with PVR was assessed. Eighty patients were retrospectively analyzed. Patients’ mean age was 65 ± 13 years, mean PVR was 9.1 (range, 6.1−11.3) Wood units, and mean end-systolic eccentricity index (esEI) was 1.76 ± 0.50. RV end-systolic volume (ESV) (p = 0.007), RV cardiac output (CO) (p < 0.001), RV ejection fraction (p < 0.001), LV end-diastolic volume (EDV) (p < 0.001), left ventricular (LV) ESV (p = 0.006), LVCO (p < 0.001), end-diastolic EI (p < 0.001), and esEI (p < 0.001) were significantly correlated with PVR. The LVEDV (p = 0.001) and esEI (p < 0.009) were independent predictors of PVR. Systolic pulmonary arterial pressure (PAP) (p < 0.001), diastolic PAP (p < 0.001), mean PAP (p < 0.001), right atrial pressure (p < 0.023), and PVR (p < 0.001) were significantly higher in the high esEI group than in the low esEI group. The esEI was a simple predictor of CTEPH severity.
Language	English
Publishing date	2022-04-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life12040593
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Article ; Online: End-Systolic Eccentricity Index Obtained by Enhanced Computed Tomography Is a Predictor of Pulmonary Vascular Resistance in Patients with Chronic Thromboembolic Pulmonary Hypertension

Yoshinori Tsutsumi / Shiro Adachi / Yoshihisa Nakano / Shingo Iwano / Shinji Abe / Katsuhiko Kato / Shinji Naganawa

Life, Vol 12, Iss 4, p

2022 Volume 593

Abstract	The usefulness of the parameters of biventricular function simultaneously measured using enhanced multi-detector computed tomography (MDCT) pulmonary angiography in patients with chronic thromboembolic pulmonary hypertension (CTEPH) has not been clarified. This study aimed to verify the correlation between left and right ventricular (RV) parameters and pulmonary vascular resistance (PVR). Patients who underwent enhanced MDCT before diagnostic right heart catheterization at Nagoya University Hospital between October 2014 and April 2021 were enrolled. The correlation of biventricular function and volume parameters with PVR was assessed. Eighty patients were retrospectively analyzed. Patients’ mean age was 65 ± 13 years, mean PVR was 9.1 (range, 6.1–11.3) Wood units, and mean end-systolic eccentricity index (esEI) was 1.76 ± 0.50. RV end-systolic volume (ESV) ( p = 0.007), RV cardiac output (CO) ( p < 0.001), RV ejection fraction ( p < 0.001), LV end-diastolic volume (EDV) ( p < 0.001), left ventricular (LV) ESV ( p = 0.006), LVCO ( p < 0.001), end-diastolic EI ( p < 0.001), and esEI ( p < 0.001) were significantly correlated with PVR. The LVEDV ( p = 0.001) and esEI ( p < 0.009) were independent predictors of PVR. Systolic pulmonary arterial pressure (PAP) ( p < 0.001), diastolic PAP ( p < 0.001), mean PAP ( p < 0.001), right atrial pressure ( p < 0.023), and PVR ( p < 0.001) were significantly higher in the high esEI group than in the low esEI group. The esEI was a simple predictor of CTEPH severity.
Keywords	chronic thromboembolic pulmonary hypertension ; computed tomography ; biventricular function ; pulmonary angiography ; Science ; Q
Subject code	610
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Strangulated bowel obstruction caused by an ileo-ileal knot: a rare case report.

Umetsu, Satoko / Shibata, Shigeru / Akasaka, Harue / Tsutsumi, Shinji / Uchida, Chiaki / Ogasawara, Hirokazu

Surgical case reports

2023 Volume 9, Issue 1, Page(s) 140

Abstract: Background: Intestinal knot formation is a condition wherein two segments of the intestine are knotted together; however, reports of small-intestinal ileo-ileal knot formation are rare.: Case presentation: The patient was a 62-year-old Asian male ... ...

Abstract	Background: Intestinal knot formation is a condition wherein two segments of the intestine are knotted together; however, reports of small-intestinal ileo-ileal knot formation are rare. Case presentation: The patient was a 62-year-old Asian male with a history of endoscopic colorectal adenoma resection and a spontaneous pneumothorax. The patient had no history of a laparotomy. He consulted his local doctor with the chief complaint of abdominal pain and was admitted to our hospital with suspicion of an acute abdomen. The abdomen had muscular guarding with tenderness and rebound tenderness. Contrast-enhanced computed tomography (CT) showed torsion of the mesentery of the small intestine with poor contrast filling. The patient was referred to our department with strangulated bowel obstruction and underwent an emergency laparotomy. Intraoperative findings revealed that two segments of the ileum were wrapped around each other to form a knot, and the strangulated small bowel was necrotic. After the release of the knot, partial resection of the small intestine was performed from 220 cm distal to the ligament of Treitz to 80 cm proximal to the cecum. The patient had a good postoperative course and was discharged on the 11th postoperative day. Conclusion: Ileo-ileal knots should be considered as part of the differential diagnosis when treating strangulated bowel obstruction.
Language	English
Publishing date	2023-08-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2809613-7
ISSN	2198-7793
ISSN	2198-7793
DOI	10.1186/s40792-023-01724-6
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Article ; Online: Comprehensive analysis of a decade of cumulative radiocesium testing data for foodstuffs throughout Japan after the 2011 Fukushima Daiichi Nuclear Power Plant accident.

Nakamura, Kosuke / Chiba, Shinji / Kiuchi, Takashi / Nabeshi, Hiromi / Tsutsumi, Tomoaki / Akiyama, Hiroshi / Hachisuka, Akiko

PloS one

2022 Volume 17, Issue 9, Page(s) e0274070

Abstract: The unexpected accident at the Fukushima Daiichi Nuclear Power Station in Japan, which occurred on March 11th, 2011, after the Great East Japan Earthquake and tsunami struck the north-eastern coast of Japan, released radionuclides into the environment. ... ...

Abstract	The unexpected accident at the Fukushima Daiichi Nuclear Power Station in Japan, which occurred on March 11th, 2011, after the Great East Japan Earthquake and tsunami struck the north-eastern coast of Japan, released radionuclides into the environment. Today, because of the amounts of radionuclides released and their relatively long half-life, the levels of radiocesium contaminating foodstuffs remain a significant food safety concern. Foodstuffs in Japan have been sampled and monitored for 134,137Cs since the accident. More than 2.5 million samples of foodstuffs have been examined with the results reported monthly during each Japanese fiscal year (FY, from April 1st to March 31st) from 2012 to 2021. A total of 5,695 samples of foodstuffs within the "general foodstuffs" category collected during this whole period and 13 foodstuffs within the "drinking water including soft drinks containing tea as a raw material" category sampled in FY 2012 were found to exceed the Japanese maximum permitted level (JML) set at 100 and 10 Bq/kg, respectively. No samples from the "milk and infant foodstuffs" category exceeded the JML (50 Bq/kg). The annual proportions of foodstuffs exceeding the JML in the "general foodstuffs" category varied between 0.37% and 2.57%, and were highest in FY 2012. The 134,137Cs concentration for more than 99% of the foodstuffs monitored and reported has been low and not exceeding the JML in recent years, except for those foodstuffs that are difficult to cultivate, feed or manage, such as wild mushrooms, plants, animals and fish. The monitoring data for foodstuffs show the current status of food safety risks from 134,137Cs contamination, particularly for cultured and aquaculture foodstuffs on the market in Japan.
MeSH term(s)	Animals ; Cesium Radioisotopes/analysis ; Drinking Water/analysis ; Fukushima Nuclear Accident ; Humans ; Japan ; Nuclear Power Plants ; Radiation Monitoring/methods ; Tea
Chemical Substances	Cesium Radioisotopes ; Drinking Water ; Tea ; Cesium-137 (4T2E65IAR7)
Language	English
Publishing date	2022-09-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0274070
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Article: Olanzapine treatment effectively relieves breakthrough chemotherapy-induced nausea and vomiting: a real-world experience.

Uchiike, Akihiro / Kono, Haruka / Miura, Katsuhiro / Hayama, Tatsuya / Tsutsumi, Daisuke / Tsuboi, Shinya / Ohtsuka, Susumu / Hidaka, Shinji

Journal of pharmaceutical health care and sciences

2023 Volume 9, Issue 1, Page(s) 24

Abstract: Background: Olanzapine treatment prevents chemotherapy-induced nausea and vomiting (CINV) in patients receiving highly emetogenic chemotherapy (HEC). However, its role in the secondary prevention of breakthrough CINV in real-world cancer care should be ... ...

Abstract	Background: Olanzapine treatment prevents chemotherapy-induced nausea and vomiting (CINV) in patients receiving highly emetogenic chemotherapy (HEC). However, its role in the secondary prevention of breakthrough CINV in real-world cancer care should be further evaluated. Method: We conducted a retrospective study on patients receiving olanzapine to prevent breakthrough CINV refractory to standard antiemetic therapy. The major outcome was improvement in CINV, defined as any downgrade in CINV symptoms, according to the Common Terminology Criteria for Adverse Events. Comprete response was defined as no symptoms in CINV, i.e., Grade 0. These outcomes were compared in the HEC versus non-HEC groups and the standard- (5 or 10 mg/day) versus low- (2.5 mg/day) dose groups. The other outcome measurement was adverse events (AEs). Results: We analyzed 127 patients, including 92 women, with a median age of 50 years (range: 19-89 years). Baseline CINV severity was grade 1, 2, and 3 in 18%, 69%, and 13% of the patients, respectively. After prophylaxis with olanzapine at doses of 2.5, 5, or 10 mg/day, improvement was observed in 105 (83%) patients, with a complete response in 42 patients (33%). The improvement and complete remission rates for the HEC (n = 96) and non-HEC (n = 31) groups were 86% and 71% (p = 0.048) versus 38% and 19% (p = 0.062), respectively. The rates for the standard- (n = 98) and low- (n = 29) dose groups were 86% and 82% (p = 0.568) versus 28% and 52% (p = 0.015), respectively. Thirty-four patients (27%) experienced olanzapine-related AEs, mainly somnolence (n = 28). Grade 3 or higher AEs were not observed. Conclusion: Our study results support the clinical application of olanzapine for the secondary prevention of breakthrough CINV.
Language	English
Publishing date	2023-08-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2809913-8
ISSN	2055-0294
ISSN	2055-0294
DOI	10.1186/s40780-023-00293-y
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Article ; Online: In vitro study on the effect of fibrinogen γ-chain peptide-coated ADP-encapsulated liposomes on postcardiopulmonary bypass coagulopathy using patient blood.

Ishida, Osamu / Hagisawa, Kohsuke / Yamanaka, Nozomu / Nakashima, Hiroyuki / Kearney, Bradley M / Tsutsumi, Koji / Takeoka, Shinji / Kinoshita, Manabu

Journal of thrombosis and haemostasis : JTH

2023 Volume 21, Issue 7, Page(s) 1934–1942

Abstract: Background: Fibrinogen γ-chain peptide-coated, adenosine 5'-diphosphate (ADP)-encapsulated liposomes (H12-ADP-liposomes) are potent hemostatic adjuvants that promote platelet thrombi formation at bleeding sites. Although we have reported the efficacy of ...

Abstract	Background: Fibrinogen γ-chain peptide-coated, adenosine 5'-diphosphate (ADP)-encapsulated liposomes (H12-ADP-liposomes) are potent hemostatic adjuvants that promote platelet thrombi formation at bleeding sites. Although we have reported the efficacy of these liposomes in a rabbit model of cardiopulmonary bypass coagulopathy, we are yet to address the possibility of their hypercoagulative potential, especially in human beings. Objectives: Considering its future clinical applications, we herein investigated the safety of using H12-ADP-liposomes in vitro using blood samples from patients who had received platelet transfusion after cardiopulmonary bypass surgeries. Methods: Ten patients receiving platelet transfusions after cardiopulmonary bypass surgery were enrolled. Blood samples were collected at the following 3 points: at the time of incision, at the end of the cardiopulmonary bypass, and immediately after platelet transfusion. After incubating the samples with H12-ADP-liposomes or phosphate-buffered saline (PBS, as a control), blood coagulation, platelet activation, and platelet-leukocyte aggregate formation were evaluated. Results: Patients' blood incubated with H12-ADP-liposomes did not differ from that incubated with PBS in coagulation ability, degree of platelet activation, and platelet-leukocyte aggregation at any of the time points. Conclusion: H12-ADP-liposomes did not cause abnormal coagulation, platelet activation, or platelet-leukocyte aggregation in the blood of patients who received platelet transfusion after a cardiopulmonary bypass. These results suggest that H12-ADP-liposomes could likely be safely used in these patients, providing hemostasis at the bleeding sites without causing considerable adverse reactions. Future studies are needed to ensure robust safety in human beings.
MeSH term(s)	Animals ; Humans ; Rabbits ; Liposomes/pharmacology ; Adenosine Diphosphate/pharmacology ; Fibrinogen/pharmacology ; Blood Coagulation Disorders ; Blood Platelets ; Hemorrhage ; Platelet Aggregation ; Peptides/pharmacology ; Cardiopulmonary Bypass/adverse effects
Chemical Substances	Liposomes ; Adenosine Diphosphate (61D2G4IYVH) ; Fibrinogen (9001-32-5) ; Peptides
Language	English
Publishing date	2023-03-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2112661-6
ISSN	1538-7836 ; 1538-7933
ISSN (online)	1538-7836
ISSN	1538-7933
DOI	10.1016/j.jtha.2023.03.018
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Zs.A 5805: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Inhibitory effect of 405-nm blue LED light on the growth of Candida albicans and Streptococcus mutans dual-species biofilms on denture base resin.

Tsutsumi-Arai, Chiaki / Arai, Yuki / Terada-Ito, Chika / Imamura, Takahiro / Tatehara, Seiko / Ide, Shinji / Shirakawa, Jumpei / Wakabayashi, Noriyuki / Satomura, Kazuhito

Lasers in medical science

2022 Volume 37, Issue 4, Page(s) 2311–2319

Abstract: We investigated whether irradiation with 405-nm blue LED light could inhibit the growth of not only single- but dual-species biofilms formed by Candida albicans and Streptococcus mutans on denture base resin and cause the alteration in gene expression ... ...

Abstract	We investigated whether irradiation with 405-nm blue LED light could inhibit the growth of not only single- but dual-species biofilms formed by Candida albicans and Streptococcus mutans on denture base resin and cause the alteration in gene expression related to adhesion and biofilm formation. C. albicans and S. mutans single-/dual-species biofilms were formed on the denture base specimens. The biofilms were irradiated with 405-nm blue LED light (power density output: 280 mW/cm
MeSH term(s)	Biofilms ; Candida albicans ; Denture Bases ; Humans ; Light ; Streptococcus mutans/genetics
Language	English
Publishing date	2022-01-16
Publishing country	England
Document type	Journal Article
ZDB-ID	632808-8
ISSN	1435-604X ; 0268-8921
ISSN (online)	1435-604X
ISSN	0268-8921
DOI	10.1007/s10103-022-03507-1
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