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  1. Article ; Online: Extracorporeal membrane oxygenation for COVID-19: Some answers and a remaining question.

    Laverdure, Florent / Frossard, Benjamin / Monet, Clément / Amour, Julien

    Anaesthesia, critical care & pain medicine

    2021  Volume 41, Issue 1, Page(s) 100986

    MeSH term(s) COVID-19 ; Extracorporeal Membrane Oxygenation ; Humans ; Respiration, Artificial ; Respiratory Distress Syndrome ; SARS-CoV-2
    Language English
    Publishing date 2021-11-25
    Publishing country France
    Document type Editorial ; Comment
    ISSN 2352-5568
    ISSN (online) 2352-5568
    DOI 10.1016/j.accpm.2021.100986
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  2. Article ; Online: Extubation Failure Prediction by Echography of the Diaphragm After Cardiothoracic Surgery: The EXPEDIA Study.

    Genty, Thibaut / Laverdure, Florent / Peyrouset, Olivier / Rezaiguia-Delclaux, Saïda / Thès, Jacques / Stéphan, François

    Respiratory care

    2022  Volume 67, Issue 3, Page(s) 308–315

    Abstract: Background: Successful extubation is difficult to predict. Ultrasound measurement of the diaphragm thickening fraction (DTF) might help predict weaning failure after cardiothoracic surgery.: Methods: We assessed the predictive performance of ... ...

    Abstract Background: Successful extubation is difficult to predict. Ultrasound measurement of the diaphragm thickening fraction (DTF) might help predict weaning failure after cardiothoracic surgery.
    Methods: We assessed the predictive performance of diaphragm ultrasound in a derivation cohort of 50 prospectively included cardiothoracic surgery subjects ready for a weaning trial and in a validation cohort of 39 subjects ventilated for ≥ 48 h. DTF was assessed by ultrasound during pressure support ventilation (PSV) then during a T-piece spontaneous breathing trial (SBT). DTF was the percentage change in diaphragm thickness between expiration and inspiration and DTF
    Results: In the derivation cohort, DTF
    Conclusions: Measuring DTF
    Clinical trial registration number: U1111-1180-1999.
    MeSH term(s) Airway Extubation ; Diaphragm/diagnostic imaging ; Humans ; Predictive Value of Tests ; Respiration, Artificial ; Ultrasonography ; Ventilator Weaning
    Language English
    Publishing date 2022-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603252-7
    ISSN 1943-3654 ; 0098-9142 ; 0020-1324
    ISSN (online) 1943-3654
    ISSN 0098-9142 ; 0020-1324
    DOI 10.4187/respcare.09476
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  3. Article ; Online: Impact of initial respiratory compliance in ventilated patients with acute respiratory distress syndrome related to COVID-19.

    Laverdure, Florent / Delaporte, Amélie / Bouteau, Astrid / Genty, Thibaut / Decailliot, François / Stéphan, François

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 412

    MeSH term(s) Adult ; COVID-19 ; Coronavirus Infections/complications ; Female ; Humans ; Lung Compliance ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Respiration, Artificial ; Respiratory Distress Syndrome/therapy ; Respiratory Distress Syndrome/virology ; Treatment Outcome
    Keywords covid19
    Language English
    Publishing date 2020-07-09
    Publishing country England
    Document type Letter
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03133-9
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  4. Article ; Online: Metabolomic profiling of cardiac allografts after controlled circulatory death.

    Hautbergue, Thaïs / Laverdure, Florent / Van, Simon Dang / Vallee, Aurelien / Sanchis-Borja, Mateo / Decante, Benoît / Gaillard, Maïra / Junot, Christophe / Fenaille, François / Mercier, Olaf / Colsch, Benoit / Guihaire, Julien

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2023  Volume 42, Issue 7, Page(s) 870–879

    Abstract: Background: Assessment of myocardial viability during ex situ heart perfusion (ESHP) is based on the measurement of lactate concentrations. As this provides with limited information, we sought to investigate the metabolic signature associated with ... ...

    Abstract Background: Assessment of myocardial viability during ex situ heart perfusion (ESHP) is based on the measurement of lactate concentrations. As this provides with limited information, we sought to investigate the metabolic signature associated with donation after circulatory death (DCD) and the impact of ESHP on the myocardial metabolome.
    Methods: Porcine hearts were retrieved either after warm ischemia (DCD group, N = 6); after brain-stem death (BSD group, N = 6); or without DCD nor BSD (Control group, N = 6). Hearts were perfused using normothermic oxygenated blood for 240 minutes. Plasma and myocardial samples were collected respectively every 30 and 60 minutes, and analyzed by an untargeted metabolomic approach using liquid chromatography coupled to high-resolution mass spectrometry.
    Results: Median duration of warm ischemia was 23 minutes [19-29] in DCD animals. Lactate level within myocardial biopsies was not significantly different between groups at T0 (p = 0.281), and remained stable over the 4-hour period of ESHP. More than 300 metabolites were detected in plasma and heart biopsy samples. Compared to BSD animals, metabolomics changes involving energy and nucleotide metabolisms were observed in plasma samples of DCD animals before initiation of ESHP, whereas 2 metabolites (inosine monophosphate and methylbutyrate) exhibited concentration changes in biopsy samples. Normalization of DCD metabolic profile was remarkable after 4 hours of ESHP.
    Conclusion: A specific metabolic profile was observed in DCD hearts, mainly characterized by an increased nucleotide catabolism. DCD and BSD metabolomes proved normalized during ESHP. Complementary investigations are needed to correlate these findings to cardiac performances.
    MeSH term(s) Swine ; Animals ; Heart Transplantation/methods ; Perfusion/methods ; Metabolomics ; Lactates ; Nucleotides ; Allografts ; Tissue Donors ; Death ; Organ Preservation/methods
    Chemical Substances Lactates ; Nucleotides
    Language English
    Publishing date 2023-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2023.02.1492
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  5. Article ; Online: Reimplantation of Venoarterial Extracorporeal Membrane Oxygenation (ECMO) After Withdrawal Failure.

    Guimaron, Samantha / Laverdure, Florent / Andrei, Stefan / Kortchinsky, Talna / Thès, Jacques / Stéphan, Francois

    Journal of cardiothoracic and vascular anesthesia

    2019  Volume 33, Issue 8, Page(s) 2360–2361

    MeSH term(s) Adult ; Extracorporeal Membrane Oxygenation ; Heart Failure ; Humans ; Replantation ; Respiratory Insufficiency ; Shock, Cardiogenic
    Language English
    Publishing date 2019-01-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2019.01.053
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  6. Article ; Online: Impact of initial respiratory compliance in ventilated patients with acute respiratory distress syndrome related to COVID-19

    Florent Laverdure / Amélie Delaporte / Astrid Bouteau / Thibaut Genty / François Decailliot / François Stéphan

    Critical Care, Vol 24, Iss 1, Pp 1-

    2020  Volume 4

    Keywords COVID-19 ; Acute respiratory distress syndrome ; Invasive mechanical ventilation ; Respiratory compliance ; Prone positioning ; Positive end-expiratory pressure ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; covid19
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
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  7. Article ; Online: Effect of Recruitment Maneuvers and PEEP on Respiratory Failure After Cardiothoracic Surgery in Obese Subjects: A Randomized Controlled Trial.

    Amaru, Priscilla / Delannoy, Bertrand / Genty, Thibaut / Desebbe, Olivier / Laverdure, Florent / Rezaiguia-Delclaux, Saida / Stéphan, François

    Respiratory care

    2021  Volume 66, Issue 8, Page(s) 1306–1314

    Abstract: Background: Obesity may increase the risk of respiratory failure after cardiothoracic surgery. A recruitment maneuver followed by PEEP might decrease the risk of respiratory failure in obese subjects. We hypothesized that the routine use after heart ... ...

    Abstract Background: Obesity may increase the risk of respiratory failure after cardiothoracic surgery. A recruitment maneuver followed by PEEP might decrease the risk of respiratory failure in obese subjects. We hypothesized that the routine use after heart surgery of a recruitment maneuver followed by high or low PEEP level would decrease the frequency of respiratory failure in obese subjects.
    Methods: In a pragmatic, randomized controlled trial, we assigned obese subjects (ie, with body mass index [BMI]
    Results: The study included 192 subjects: 65 in the control group (BMI 33.5 ± 3.2 kg/m
    Conclusions: The routine use after heart surgery of a recruitment maneuver followed by 5 or 10 cm H
    MeSH term(s) Body Mass Index ; Humans ; Obesity/complications ; Positive-Pressure Respiration ; Pulmonary Atelectasis ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy
    Language English
    Publishing date 2021-05-11
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 603252-7
    ISSN 1943-3654 ; 0098-9142 ; 0020-1324
    ISSN (online) 1943-3654
    ISSN 0098-9142 ; 0020-1324
    DOI 10.4187/respcare.08607
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  8. Article ; Online: Connection of a Renal Replacement Therapy or Plasmapheresis Device to the ECMO Circuit.

    Laverdure, Florent / Masson, Laurent / Tachon, Guillaume / Guihaire, Julien / Stephan, François

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2018  Volume 64, Issue 1, Page(s) 122–125

    Abstract: In patients under extracorporeal membrane oxygenation (ECMO) support requiring renal replacement therapy or plasmapheresis, connecting such extracorporeal therapy device to the ECMO circuit provides many advantages compared with central venous ... ...

    Abstract In patients under extracorporeal membrane oxygenation (ECMO) support requiring renal replacement therapy or plasmapheresis, connecting such extracorporeal therapy device to the ECMO circuit provides many advantages compared with central venous catheterization. However, high pressures of the ECMO circuit limit the usefulness of this technique. We propose a new approach to connect extracorporeal therapy lines to the ECMO circuit. Inlet line is connected to the oxygenator, and outlet line is connected either to the femoral artery antegrade perfusion cannula in case of venoarterial ECMO or to the lateral vent of the return cannula in case of venovenous ECMO. We report the successful management of 21 patients using this connection, with much longer hemofilter average lifetime than previously reported.
    MeSH term(s) Adult ; Aged ; Cannula ; Catheterization, Central Venous ; Extracorporeal Membrane Oxygenation/methods ; Female ; Humans ; Male ; Middle Aged ; Plasmapheresis/methods ; Renal Replacement Therapy/methods
    Language English
    Publishing date 2018-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000000621
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  9. Article ; Online: Specific Considerations for Venovenous Extracorporeal Membrane Oxygenation During Coronavirus Disease 2019 Pandemic.

    Guihaire, Julien / Owyang, Clark G / Madhok, Jai / Laverdure, Florent / Gaillard, Maïra / Girault, Antoine / Lebreton, Guillaume / Mercier, Olaf

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2021  Volume 66, Issue 10, Page(s) 1069–1072

    Abstract: Extracorporeal membrane oxygenation (ECMO) is recognized as organ support for potentially reversible acute respiratory distress syndrome (ARDS). However, limited resource during the outbreak and the coagulopathy associated with coronavirus disease 2019 ( ... ...

    Abstract Extracorporeal membrane oxygenation (ECMO) is recognized as organ support for potentially reversible acute respiratory distress syndrome (ARDS). However, limited resource during the outbreak and the coagulopathy associated with coronavirus disease 2019 (COVID-19) make the utilization of venovenous (VV) ECMO highly challenging. We herein report specific considerations for cannulation configurations and ECMO management during the pandemic. High blood flow and anticoagulation at higher levels than usual practice for VV ECMO may be required because of thrombotic hematologic profile of COVID-19. Among our first 24 cases (48.8 ± 8.9 years), 17 patients were weaned from ECMO after a mean duration of 19.0 ± 10.1 days and 16 of them have been discharged from ICU.
    MeSH term(s) Anticoagulants/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/therapy ; Extracorporeal Membrane Oxygenation/adverse effects ; Extracorporeal Membrane Oxygenation/methods ; Female ; Heparin/therapeutic use ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/therapy ; Respiratory Distress Syndrome/virology ; SARS-CoV-2 ; Thrombosis/etiology ; Thrombosis/prevention & control
    Chemical Substances Anticoagulants ; Heparin (9005-49-6)
    Keywords covid19
    Language English
    Publishing date 2021-01-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000001251
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  10. Article ; Online: Fatal Covid-19 vasoplegic shock in a recipient few hours before double lung transplantation in high emergency.

    Mercier, Olaf / Laverdure, Florent / Filaire, Laura / Mal, Hervé / Bunel, Vincent / Deblauwe, Delphine / Wemeau, Lidwine / Dauriat, Gaëlle / Fadel, Elie / Vincentelli, André

    Transplant infectious disease : an official journal of the Transplantation Society

    2020  Volume 23, Issue 1, Page(s) e13445

    MeSH term(s) COVID-19/complications ; Fatal Outcome ; Humans ; Lung Transplantation ; Male ; Middle Aged ; Pulmonary Fibrosis/complications ; SARS-CoV-2 ; Shock/complications ; Shock/pathology ; Vasoplegia/complications ; Vasoplegia/pathology
    Keywords covid19
    Language English
    Publishing date 2020-11-04
    Publishing country Denmark
    Document type Case Reports ; Letter
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.13445
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