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Article ; Online: Antibacterial and immunological properties of piperine evidenced by preclinical studies: a systematic review.

Murase, Letícia Sayuri / Perez de Souza, João Vítor / Meneguello, Jean Eduardo / Palomo, Carolina Trevisolli / Fernandes Herculano Ramos Milaré, Áquila Carolina / Negri, Melyssa / Dias Siqueira, Vera Lúcia / Demarchi, Izabel Galhardo / Vieira Teixeira, Jorge Juarez / Cardoso, Rosilene Fressatti

Future microbiology

2023 Volume 18, Page(s) 1279–1299

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Alkaloids/pharmacology ; Benzodioxoles/pharmacology ; Piperidines/pharmacology ; Microbial Sensitivity Tests
Chemical Substances	piperine (U71XL721QK) ; Anti-Bacterial Agents ; Alkaloids ; Benzodioxoles ; Piperidines
Language	English
Publishing date	2023-10-26
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2254620-0
ISSN	1746-0921 ; 1746-0913
ISSN (online)	1746-0921
ISSN	1746-0913
DOI	10.2217/fmb-2023-0101
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Meteorological conditions affect the seasonal development and yield of green dwarf coconut

Gabriel Siqueira Tavares Fernandes / Luis Roberto da Trindade Ribeiro / Matheus Lima Rua / Wendel Gabriel Magalhães Vieira / João Vitor de Nóvoa Pinto / Paulo Jorge de Oliveira Ponte de Souza

Pesquisa Agropecuária Tropical, Vol 54, p e

2024 Volume 77037

Abstract: Understanding the green dwarf coconut palm development is essential to improve its management. This study aimed to characterize and understand the seasonality of the green dwarf coconut palm development and yield under rainfed and irrigated conditions in ...

Abstract	Understanding the green dwarf coconut palm development is essential to improve its management. This study aimed to characterize and understand the seasonality of the green dwarf coconut palm development and yield under rainfed and irrigated conditions in the northeastern region of the Pará state, Brazil. The longitudinal and transverse diameters, fruit mass and yield, in addition to the number of live leaves, live bunches, fruits of the bunches nº 11 and 14 and female flowers were monitored. The coconuts between the bunches nº 20 and 22 showed larger dimensions and biomass (fresh and dry). The partition of the production components varies according to the time of the year, with the liquid albumen mass, which is a component of greater commercial focus, being higher in the rainy season, with lower percentage losses in the irrigated cultivation. The meteorological seasonality plays a key role in flower dropping and fruit abortion, directly contributing to the amount of produced fruits.
Keywords	cocos nucifera l ; fruit biomass ; inflorescence abortion ; Agriculture (General) ; S1-972
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Universidade Federal de Goiás
Document type	Article ; Online
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Article ; Online: Phytoremediation, bioaccessibility and ecotoxicological risk assessment of arsenic in a gold mining area.

Oliveira, Elida Cristina Monteiro de / Pires, Luís Paulo / Santos, Vanessa Santana Vieira / Caixeta, Evelyn Siqueira / Bravo, João Vitor M / Pereira, Boscolli Barbosa

Chemosphere

2023 Volume 319, Page(s) 138030

Abstract: The physicochemical and biological parameters of aquatic ecosystems are directly affected by mining activities, increasing the ecotoxicological risk related to exposure to contaminants and pollutants. In this study, a native and adapted floating aquatic ... ...

Abstract	The physicochemical and biological parameters of aquatic ecosystems are directly affected by mining activities, increasing the ecotoxicological risk related to exposure to contaminants and pollutants. In this study, a native and adapted floating aquatic macrophyte was used in a gold mining area as a model organism to assess the environmental risk and its potential application in bioremediation of heavy metals. The physicochemical parameters of water and sediments were evaluated, as well as the phytoremediation parameters (bioconcentration and translocation factors) of Hydrocotyle ranunculoides L. The results showed a significant bioconcentration of Cr, Pb, Cu, and Zn in the roots of the macrophyte (high BCF: As > Cu > Zn > Pb > Cr), confirming its suitability for use in rhizofiltration. Regarding arsenic bioconcentration, H. ranunculoides demonstrated a high BCF and TF > 1, indicating its phytoextraction potential, an essential requirement for plants to be used in bioremediation programs.
MeSH term(s)	Arsenic/analysis ; Biodegradation, Environmental ; Gold ; Ecosystem ; Lead ; Soil Pollutants/analysis ; Metals, Heavy/analysis ; Mining ; Risk Assessment
Chemical Substances	Arsenic (N712M78A8G) ; Gold (7440-57-5) ; Lead (2P299V784P) ; Soil Pollutants ; Metals, Heavy
Language	English
Publishing date	2023-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2023.138030
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Article: Impact of obesity on hospitalizations and mortality, due to COVID-19: A systematic review.

de Siqueira, João Vitor Vieira / Almeida, Lucas Garrido / Zica, Bruno Otávio / Brum, Ingred Batista / Barceló, Alberto / de Siqueira Galil, Arise Garcia

Obesity research & clinical practice

2020 Volume 14, Issue 5, Page(s) 398–403

Abstract: The aim of the current review was to assess whether there was an association between obesity and higher levels of hospitalization, poor outcomes and mortality due to the disease of novel coronavirus (COVID-19).: Methodology: A systematic review of ... ...

Abstract	The aim of the current review was to assess whether there was an association between obesity and higher levels of hospitalization, poor outcomes and mortality due to the disease of novel coronavirus (COVID-19). Methodology: A systematic review of articles on the novel coronavirus, containing information on obesity and its association with COVID-19 morbidity and mortality. In the bibliographic research, four databases were used, with the terms ['COVID-19'] AND ['hospitalization'] AND ['obesity'] AND ['mortality']. Studies published from 12/01/2019 until 05/01/2020 were included. The research contains inclusive criteria targeting studies of humans adults infected by Sars-Cov-2, with or without comorbidities. This research was selected from publications in Spanish and English languages. Results: 96 articles were identified, 15 being presented in two databases. Twenty articles were included, with a population total estimated from 1 to 7671 patients, with a prevalence of obesity ranging from 13.3% to 68.6%. The association of obesity and mortality has been observed in at least 4 studies, that 85.3% of the population was hospitalized. Among 19 of the 20 studies, more severe forms of the disease were observed and in 14 of them, higher rates of complications among obese people infected with the new coronavirus. Limitation differences in the definition of obesity was observed among publications, of which obesity was considered from a body mass index >25 kg/m². Conclusions: In the current review, obesity and overweight were represented an unfavorable factor for infection of novel coronavirus, where the higher the BMI the worse the outcomes. This occurred by worsening the infection itself, as well as increasing the prevalence of hospitalizations, worst outcomes and greater lethality; especially when co-occurring with other chronic conditions and in the elderly as well. Given this evidence, greater attention is suggested to the obese and overweight population in the face of the current pandemic.
MeSH term(s)	Adult ; Aged ; Betacoronavirus ; Body Mass Index ; COVID-19 ; Coronavirus Infections/mortality ; Coronavirus Infections/virology ; Female ; Hospitalization/statistics & numerical data ; Humans ; Male ; Middle Aged ; Obesity/mortality ; Obesity/virology ; Overweight/mortality ; Overweight/virology ; Pandemics ; Pneumonia, Viral/mortality ; Pneumonia, Viral/virology ; Prevalence ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-07-23
Publishing country	Netherlands
Document type	Journal Article ; Systematic Review
ZDB-ID	2274031-4
ISSN	1878-0318 ; 1871-403X
ISSN (online)	1878-0318
ISSN	1871-403X
DOI	10.1016/j.orcp.2020.07.005
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Article ; Online: Impact of obesity on hospitalizations and mortality, due to COVID-19

de Siqueira, João Vitor Vieira / Almeida, Lucas Garrido / Zica, Bruno Otávio / Brum, Ingred Batista / Barceló, Alberto / de Siqueira Galil, Arise Garcia

Obesity Research & Clinical Practice

A systematic review

2020 Volume 14, Issue 5, Page(s) 398–403

Keywords	Nutrition and Dietetics ; Endocrinology, Diabetes and Metabolism ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	2274031-4
ISSN	1878-0318 ; 1871-403X
ISSN (online)	1878-0318
ISSN	1871-403X
DOI	10.1016/j.orcp.2020.07.005
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Systematic review of disulfiram as an antibacterial agent: what is the evidence?

Meneguello, Jean Eduardo / Murase, Letícia Sayuri / de Souza, João Vitor Perez / de Oliveira, Cheila Guimarães / Ghiraldi-Lopes, Luciana Dias / Teixeira, Jorge Juarez Vieira / Scodro, Regiane Bertin de Lima / Ferracioli, Katiany Rizzieri Caleffi / Siqueira, Vera Lucia Dias / Campanerut-Sá, Paula Aline Zanetti / Cardoso, Rosilene Fressatti

International journal of antimicrobial agents

2022 Volume 59, Issue 5, Page(s) 106578

Abstract: The objective of this systematic review was to retrieve and examine published studies related to in vitro and in vivo evaluation of disulfiram for the treatment of bacterial infections. Five scientific databases (PubMed, Embase, Scopus, Web of Science, ... ...

Abstract	The objective of this systematic review was to retrieve and examine published studies related to in vitro and in vivo evaluation of disulfiram for the treatment of bacterial infections. Five scientific databases (PubMed, Embase, Scopus, Web of Science, and Latin American and Caribbean Health Sciences Literature) were searched to retrieve the maximum literature regarding the study's aim. The search strategy retrieved a total of 870 studies, of which 31 were included and 19 approached disulfiram as the primary aim and 12 included it as a secondary finding from other investigational objectives. The evidence pointed out five main aspects of pre-clinical testing regarding disulfiram antibacterial activity, namely spectrum of antimicrobial action, drug combinations, intracellular studies, animal studies and bacterial targets. Findings to emerge from this study are the observed potential of disulfiram as a non-antibiotic drug being proposed as a potential drug to contribute to the treatment of bacterial diseases usually with few treatment alternatives in the context of drug resistance. We evaluated the potency and selectivity of disulfiram, which indeed until now shows potential to be explored for use as an adjunctive chemical to antimicrobial ones. Even with the level of evidence being reserved, the potential of combining disulfiram with other drugs, already used or new to be used for the treatment of mycobacterial diseases, as well as its likely immunomodulatory effect, deserve to be further investigated. Furthermore, the copper-dependent mode of action in Gram-positive bacteria is an alternative to be explored in drug design or repurposing of chemicals.
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents ; Bacterial Infections/drug therapy ; Disulfiram/pharmacology ; Disulfiram/therapeutic use ; Gram-Positive Bacteria
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents ; Disulfiram (TR3MLJ1UAI)
Language	English
Publishing date	2022-04-01
Publishing country	Netherlands
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2022.106578
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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Impact of obesity on hospitalizations and mortality, due to COVID-19: A systematic review

de Siqueira, João Vitor Vieira / Almeida, Lucas Garrido / Zica, Bruno Otávio / Brum, Ingred Batista / Barceló, Alberto / de Siqueira Galil, Arise Garcia

Obes Res Clin Pract

Abstract	The aim of the current review was to assess whether there was an association between obesity and higher levels of hospitalization, poor outcomes and mortality due to the disease of novel coronavirus (COVID-19). METHODOLOGY: A systematic review of articles on the novel coronavirus, containing information on obesity and its association with COVID-19 morbidity and mortality. In the bibliographic research, four databases were used, with the terms ['COVID-19'] AND ['hospitalization'] AND ['obesity'] AND ['mortality']. Studies published from 12/01/2019 until 05/01/2020 were included. The research contains inclusive criteria targeting studies of humans adults infected by Sars-Cov-2, with or without comorbidities. This research was selected from publications in Spanish and English languages. RESULTS: 96 articles were identified, 15 being presented in two databases. Twenty articles were included, with a population total estimated from 1 to 7671 patients, with a prevalence of obesity ranging from 13.3% to 68.6%. The association of obesity and mortality has been observed in at least 4 studies, that 85.3% of the population was hospitalized. Among 19 of the 20 studies, more severe forms of the disease were observed and in 14 of them, higher rates of complications among obese people infected with the new coronavirus. Limitation differences in the definition of obesity was observed among publications, of which obesity was considered from a body mass index >25 kg/m². CONCLUSIONS: In the current review, obesity and overweight were represented an unfavorable factor for infection of novel coronavirus, where the higher the BMI the worse the outcomes. This occurred by worsening the infection itself, as well as increasing the prevalence of hospitalizations, worst outcomes and greater lethality; especially when co-occurring with other chronic conditions and in the elderly as well. Given this evidence, greater attention is suggested to the obese and overweight population in the face of the current pandemic.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #663355
Database	COVID19

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Article ; Online: Neurodevelopmental delay in normocephalic children with in utero exposure to Zika virus.

Faiçal, Adriana Virginia / de Oliveira, Juliana Cabral / Oliveira, João Vitor Vieira / de Almeida, Breno Lima / Agra, Iluska Andrade / Alcantara, Luiz Carlos Junior / Acosta, Angelina Xavier / de Siqueira, Isadora Cristina

BMJ paediatrics open

2019 Volume 3, Issue 1, Page(s) e000486

Abstract: Neurodevelopment in 29 normocephalic children with in utero exposure to Zika virus (ZIKV) was evaluated by the Bayley Scales of Infant and Toddler Development-Third Edition. Ten (35%) infants presented neurodevelopment delay. Language, cognitive and ... ...

Abstract	Neurodevelopment in 29 normocephalic children with in utero exposure to Zika virus (ZIKV) was evaluated by the Bayley Scales of Infant and Toddler Development-Third Edition. Ten (35%) infants presented neurodevelopment delay. Language, cognitive and motor delays were identified in 9 (31%), 4 (14%) and 1 (3%) infants, respectively. Children exposed to ZIKV in utero must undergo careful evaluations for the early detection of any neurodevelopment delays in order to implement prompt intervention.
Language	English
Publishing date	2019-07-05
Publishing country	England
Document type	Journal Article
ISSN	2399-9772
ISSN (online)	2399-9772
DOI	10.1136/bmjpo-2019-000486
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Article: Systematic review of disulfiram as an antibacterial agent: what is the evidence?

International journal of antimicrobial agents. 2022 Mar. 20,

2022

Abstract	The objective of this systematic review was to retrieve and examine published studies related to in vitro and in vivo evaluation of disulfiram for the treatment of bacterial infections. Five scientific databases (PubMed, Embase, Scopus, Web of Science, and Latin American and Caribbean Health Sciences Literature) were searched to retrieve the maximum literature regarding the study's aim. The search strategy retrieved a total of 870 studies, of which 31 were included and 19 approached disulfiram as the primary aim and 12 included it as a secondary finding from other investigational objectives. The evidence pointed out five main aspects of pre-clinical testing regarding disulfiram antibacterial activity, namely spectrum of antimicrobial action, drug combinations, intracellular studies, animal studies and bacterial targets. Findings to emerge from this study are the observed potential of disulfiram as a non-antibiotic drug being proposed as a potential drug to contribute to the treatment of bacterial diseases usually with few treatment alternatives in the context of drug resistance. We evaluated the potency and selectivity of disulfiram, which indeed until now shows potential to be explored for use as an adjunctive chemical to antimicrobial ones. Even with the level of evidence being reserved, the potential of combining disulfiram with other drugs, already used or new to be used for the treatment of mycobacterial diseases, as well as its likely immunomodulatory effect, deserve to be further investigated. Furthermore, the copper-dependent mode of action in Gram-positive bacteria is an alternative to be explored in drug design or repurposing of chemicals.
Keywords	animals ; antibacterial properties ; antibiotics ; disulfiram ; drug design ; drug resistance ; immunomodulators ; mechanism of action ; systematic review ; Caribbean
Language	English
Dates of publication	2022-0320
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2022.106578
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: REDD+ implementation in a high forest low deforestation area: Constraints on monitoring forest carbon emissions

Guadalupe, Vicente / de Oliveira, Cinthia Pereira / Gonçalves Aguiar, Leonardo José / Nascimento Siqueira, João Vitor / Santos, Valdenira Ferreira / Sotta, Eleneide Doff / Vieira, Marta

Land use policy. 2018 July, v. 76

2018

Abstract: Reducing emissions from deforestation and forest degradation and the role of conservation, sustainable management of forests and enhancement of forest carbon stocks in developing countries (REDD+), is still a promising mechanism of the UNFCCC for many ... ...

Abstract	Reducing emissions from deforestation and forest degradation and the role of conservation, sustainable management of forests and enhancement of forest carbon stocks in developing countries (REDD+), is still a promising mechanism of the UNFCCC for many tropical countries that would like to receive a fair financial compensation for their historical and current efforts to avoid forest conversion at the expense of more economically land uses. Brazil has a great opportunity to successfully participate in REDD+ not only because of its huge Amazon forest area (ca. 4 million km2) but also because of its advanced forest monitoring system “PRODES”. However, this opportunity could be threatened due to the current differentiated monitoring capacities of most Brazilian Amazon states, markedly in High-Forest and Low-Deforestation (HFLD) regions. This is evident in the State of Amapá, which despite its political will to support actions towards the design of its REDD+ strategy, is still struggling with key technical aspects of forest monitoring. To address this issue and to strengthen the on-going REDD+ design process we assessed a) land use and land cover (LULC) changes for period of 23 years (1985–2008); b) estimated CO2 emissions associated to these LULC changes; c) identified the main drivers and agents of deforestation, and d) discussed policy implications for REDD+ implementation in a HFLD area. We applied a methodology, which is capable of reducing cloud cover using temporal filters on the classified images, detecting deforestation (and forest degradation) in areas as small as 1 ha, and used the decision tree method to identify different LULC types. This methodology was able to demonstrate that forest cover in northern Amapá has remained almost untouched during the observed period of 23-years. As many other HFLD areas, this region has a great potential to receive financial benefits from the REDD+ mechanism, especially from voluntary markets that are largely interested in the conservation value of these areas. However, the use of high accuracy LULC classification approaches, with appropriate Measuring, Reporting and Verification systems should be part of the REDD+ implementation strategy of HFLD areas towards having high standards for certified carbon, and therefore improved chances to receive better prices for carbon offsets. The potential of REDD+ to be a fair and efficient mechanism will also depend on the recognition of the historical efforts to avoid deforestation in HFLD areas, mainly by Federal Governments, as an incentive for low-carbon development.
Keywords	carbon ; carbon dioxide ; carbon markets ; carbon sinks ; cloud cover ; decision support systems ; deforestation ; developing countries ; forests ; greenhouse gas emissions ; issues and policy ; land use ; land use and land cover maps ; monitoring ; politics ; prices ; United Nations Framework Convention on Climate Change ; Amazonia ; Brazil
Language	English
Dates of publication	2018-07
Size	p. 414-421.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	852476-2
ISSN	0264-8377
ISSN	0264-8377
DOI	10.1016/j.landusepol.2018.02.015
Database	NAL-Catalogue (AGRICOLA)

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