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  1. Article ; Online: Natural History and Intervention Thresholds for Ascending Thoracic Aortic Aneurysm-Not an Easy Nut to Crack-Reply.

    Solomon, Matthew D / Liang, David H / Go, Alan S

    JAMA cardiology

    2023  Volume 8, Issue 5, Page(s) 512–513

    MeSH term(s) Humans ; Nuts ; Aortic Aneurysm, Thoracic/surgery
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2023.0156
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  2. Article ; Online: The race coefficient in glomerular filtration rate-estimating equations and its removal.

    Hsu, Chi-Yuan / Go, Alan S

    Current opinion in nephrology and hypertension

    2022  Volume 31, Issue 6, Page(s) 527–533

    Abstract: Purpose of review: To review new publications about the use of the race coefficient in glomerular filtration rate (GFR)-estimating equations since this topic was last reviewed a year ago in Current Opinion in Nephrology and Hypertension .: Recent ... ...

    Abstract Purpose of review: To review new publications about the use of the race coefficient in glomerular filtration rate (GFR)-estimating equations since this topic was last reviewed a year ago in Current Opinion in Nephrology and Hypertension .
    Recent findings: Accounting for race (or genetic ancestry) does improve the performance of GFR-estimating equations when serum creatinine (SCr) is used as the filtration marker but not when cystatin C is used. The National Kidney Foundation (NKF)-American Society of Nephrology (ASN) Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease recommended immediate adoption of a new refitted SCr-based equation without race and increased use of cystatin C. This report has created consensus but the endorsed new SCr equation without race underestimates GFR in Black Americans and overestimates GFR in non-Black Americans, which may result in diminished ability to detect racial disparities.
    Summary: The approach recommended by the NKF-ASN Task Force represents a compromise attempting to balance a number of competing values, including racial justice, benefit of classifying more Black Americans as having (more severe) chronic kidney disease, accuracy compared with measured GFR, and financial cost. The full implications of adopting the race-free refitted CKD-EPI SCr equation are yet to be known.
    MeSH term(s) Creatinine ; Cystatin C ; Glomerular Filtration Rate ; Humans ; Kidney ; Renal Insufficiency, Chronic
    Chemical Substances Cystatin C ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2022-08-26
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000833
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3686: Show issues Location:
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  3. Article ; Online: Timing of Dialysis Initiation and End-Stage Kidney Disease Incidence-Reply.

    Hsu, Chi-Yuan / Go, Alan S

    JAMA internal medicine

    2021  Volume 181, Issue 5, Page(s) 725–726

    MeSH term(s) Cognition ; Glomerular Filtration Rate ; Humans ; Incidence ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/therapy ; Renal Dialysis
    Language English
    Publishing date 2021-02-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2020.8806
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  4. Article ; Online: Gaps in guideline-recommended anticoagulation in patients with atrial fibrillation and elevated thromboembolic risk within an integrated healthcare delivery system.

    Malik, Sushmita / Gustafson, Shanshan / Chang, Huai-En R / Tamrat, Yonas / Go, Alan S / Berry, Natalia

    BMC cardiovascular disorders

    2023  Volume 23, Issue 1, Page(s) 578

    Abstract: Background: Atrial Fibrillation (AF) is the leading cause of stroke, which can be reduced by 70% with appropriate oral anticoagulation (OAC) therapy. Nationally, appropriate anticoagulation rates for patients with AF with elevated thromboembolic risk ... ...

    Abstract Background: Atrial Fibrillation (AF) is the leading cause of stroke, which can be reduced by 70% with appropriate oral anticoagulation (OAC) therapy. Nationally, appropriate anticoagulation rates for patients with AF with elevated thromboembolic risk are as low as 50% even across the highest stroke risk cohorts. This study aims to evaluate the variability of appropriate anticoagulation rates among patients by sex, ethnicity, and socioeconomic status within the Kaiser Permanente Mid-Atlantic States (KPMAS).
    Methods: This retrospective study investigated 9513 patients in KPMAS's AF registry with CHADS
    Results: Appropriately anticoagulated patients had higher rates of diabetes, prior stroke, and congestive heart failure than patients who were not appropriately anticoagulated. There were no significant differences in anticoagulation rates between males and females (71.8% vs. 71.6%%, [OR] 1.01; 95% CI, 0.93-1.11; P = .76) nor by SES-SVI quartiles. There was a statistically significant difference between Black and White patients (70.8% vs. 73.1%, P = .03) and Asian and White patients (68.3% vs. 71.6%, P = .005). After adjusting for CHADS
    Conclusions: Black and Asian patients may have differing rates of appropriate anticoagulation when compared with White patients. Characterizing such disparities is the first step towards addressing treatment gaps in AF.
    MeSH term(s) Male ; Female ; Humans ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Anticoagulants/adverse effects ; Retrospective Studies ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/etiology ; Thromboembolism/diagnosis ; Thromboembolism/etiology ; Thromboembolism/prevention & control ; Delivery of Health Care, Integrated ; Risk Factors ; Risk Assessment
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-11-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059859-2
    ISSN 1471-2261 ; 1471-2261
    ISSN (online) 1471-2261
    ISSN 1471-2261
    DOI 10.1186/s12872-023-03607-y
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  5. Article ; Online: Cardiovascular Disease Consequences of CKD.

    Go, Alan S

    Seminars in nephrology

    2016  Volume 36, Issue 4, Page(s) 293–304

    Abstract: Chronic kidney disease, defined as reduced glomerular filtration rate (estimated using serum creatinine- and/or serum cystatin C-based equations) or excess urinary protein excretion, affects approximately 13% of adult Americans and is linked to a variety ...

    Abstract Chronic kidney disease, defined as reduced glomerular filtration rate (estimated using serum creatinine- and/or serum cystatin C-based equations) or excess urinary protein excretion, affects approximately 13% of adult Americans and is linked to a variety of clinical complications. Although persons with end-stage renal disease requiring chronic dialysis therapy experience a substantially high cardiovascular burden, whether mild-to-moderate chronic kidney disease is an independent risk factor for fatal and nonfatal cardiovascular events has been more controversial. This review evaluates the current evidence about the clinical and subclinical cardiovascular consequences associated with chronic kidney disease of varying levels of severity. In addition, it discusses the predictors of adverse cardiovascular outcomes while also focusing on recent insights into the relationships between chronic kidney disease and cardiovascular disease from the Chronic Renal Insufficiency Cohort study, a large current prospective cohort study of adults from across the spectrum of chronic kidney disease.
    MeSH term(s) Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/mortality ; Cause of Death ; Glomerular Filtration Rate ; Humans ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/metabolism ; Mortality ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/metabolism ; Risk Factors ; Severity of Illness Index
    Language English
    Publishing date 2016-04-22
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2016.05.006
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  6. Article ; Online: Transition From Heart Disease to Cancer as the Leading Cause of Death in the United States.

    Sidney, Stephen / Go, Alan S / Rana, Jamal S

    Annals of internal medicine

    2019  Volume 171, Issue 3, Page(s) 225

    MeSH term(s) Cause of Death ; Death ; Heart Diseases ; Humans ; Neoplasms ; Socioeconomic Factors ; United States
    Language English
    Publishing date 2019-08-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L19-0202
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  7. Article ; Online: Predicting stroke risk after sepsis hospitalization with new-onset atrial fibrillation.

    Myers, Laura C / Peltan, Ithan D / Thai, Khanh K / Kipnis, Patricia / Desai, Manisha / Devis, Ycar / Clancy, Heather / Lu, Yun W / Brown, Samuel M / Go, Alan S / Neugebauer, Romain S / Liu, Vincent X / Walkey, Allan J

    Journal of hospital medicine

    2024  

    Abstract: Background: New-onset atrial fibrillation (AF) during sepsis is common, but models designed to stratify stroke risk excluded patients with secondary AF. We assessed the predictive validity of CHA: Methods: We included patients ≥40 years old who ... ...

    Abstract Background: New-onset atrial fibrillation (AF) during sepsis is common, but models designed to stratify stroke risk excluded patients with secondary AF. We assessed the predictive validity of CHA
    Methods: We included patients ≥40 years old who survived hospitalizations with sepsis and new-onset AF across 21 Kaiser Permanente Northern California hospitals from January 1, 2011 to September 30, 2017. We calculated the area under the receiver operating curve (AUC) for CHA
    Results: Among 82,748 adults hospitalized with sepsis, 3992 with new-onset AF (median age: 80 years, median CHA
    Conclusion: Current models do not accurately stratify risk of stroke following new-onset AF secondary to sepsis. New tools are required to guide anticoagulation decisions following new-onset AF in sepsis.
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2233783-0
    ISSN 1553-5606 ; 1553-5592
    ISSN (online) 1553-5606
    ISSN 1553-5592
    DOI 10.1002/jhm.13343
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  8. Article ; Online: CKD stage-specific utility of two equations for predicting 1-year risk of ESKD

    Sijie Zheng / Rishi V. Parikh / Thida C. Tan / Leonid Pravoverov / Jignesh K. Patel / Kate M. Horiuchi / Alan S. Go

    PLoS ONE, Vol 18, Iss

    2023  Volume 11

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Non-targeted chemical analysis of consumer botanical products labeled as blue cohosh (Caulophyllum thalictroides), goldenseal (Hydrastis canadensis), or yohimbe bark (Pausinystalia yohimbe) by NMR and MS.

    Quiroz-Delfi, Giovanni O / Rider, Cynthia V / Ferguson, Stephen S / Jarmusch, Alan K / Mueller, Geoffrey A

    Analytical and bioanalytical chemistry

    2023  Volume 416, Issue 1, Page(s) 175–189

    Abstract: Consumers have unprecedented access to botanical dietary supplements through online retailers, making it difficult to ensure product quality and authenticity. Therefore, methods to survey and compare chemical compositions across botanical products are ... ...

    Abstract Consumers have unprecedented access to botanical dietary supplements through online retailers, making it difficult to ensure product quality and authenticity. Therefore, methods to survey and compare chemical compositions across botanical products are needed. Nuclear magnetic resonance (NMR) spectroscopy and non-targeted mass spectrometry (MS) were used to chemically analyze commercial products labeled as containing one of three botanicals: blue cohosh, goldenseal, and yohimbe bark. Aqueous and organic phase extracts were prepared and analyzed in tandem with NMR followed by MS. We processed the non-targeted data using multivariate statistics to analyze the compositional similarity across extracts. In each case, there were several product outliers that were identified using principal component analysis (PCA). Evaluation of select known constituents proved useful to contextualize PCA subgroups, which in some cases supported or refuted product authenticity. The NMR and MS data reached similar conclusions independently but were also complementary.
    MeSH term(s) Pausinystalia/chemistry ; Hydrastis/chemistry ; Caulophyllum/chemistry ; Plant Bark/chemistry ; Gas Chromatography-Mass Spectrometry ; Mass Spectrometry/methods ; Magnetic Resonance Spectroscopy ; Biological Products/analysis
    Chemical Substances Biological Products
    Language English
    Publishing date 2023-11-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-023-05004-y
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  10. Article ; Online: Performance of the pooled cohort equation in South Asians: insights from a large integrated healthcare delivery system.

    Mantri, Neha M / Merchant, Maqdooda / Rana, Jamal S / Go, Alan S / Pursnani, Seema K

    BMC cardiovascular disorders

    2022  Volume 22, Issue 1, Page(s) 566

    Abstract: South Asian ethnicity is associated with increased atherosclerotic cardiovascular disease (ASCVD) risk and has been identified as a "risk enhancer" in the 2018 American College of Cardiology/American Heart Association Guidelines. Risk estimation and ... ...

    Abstract South Asian ethnicity is associated with increased atherosclerotic cardiovascular disease (ASCVD) risk and has been identified as a "risk enhancer" in the 2018 American College of Cardiology/American Heart Association Guidelines. Risk estimation and statin eligibility in South Asians is not well understood; we studied the accuracy of 10-years ASCVD risk prediction by the pooled cohort equation (PCE), based on statin use, in a South Asian cohort. This is a retrospective cohort study of Kaiser Permanente Northern California South Asian members without existing ASCVD, age range 30-70, and 10-years follow up. ASCVD events were defined as myocardial infarction, ischemic stroke, and cardiovascular death. The cohort was stratified by statin use during the study period: never; at baseline and during follow-up; and only during follow-up. Predicted probability of ASCVD, using the PCE was calculated and compared to observed ASCVD events for low < 5.0%, borderline 5.0 to < 7.5%, intermediate 7.5 to < 20.0%, and high ≥ 20.0% risk groups. A total of 1835 South Asian members were included: 773 never on statin, 374 on statins at baseline and follow-up, and 688 on statins during follow-up only. ASCVD risk was underestimated by the PCE in low-risk groups: entire cohort: 1.8 versus 4.9%, p < 0.0001; on statin at baseline and follow-up: 2.58 versus 8.43%, p < 0.0001; on statin during follow-up only: 2.18 versus 7.77%, p < 0.0001; and never on statin: 1.37 versus 2.09%, p = 0.12. In this South Asian cohort, the PCE underestimated risk in South Asians, regardless of statin use, in the low risk ASCVD risk category.
    Language English
    Publishing date 2022-12-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059859-2
    ISSN 1471-2261 ; 1471-2261
    ISSN (online) 1471-2261
    ISSN 1471-2261
    DOI 10.1186/s12872-022-02993-z
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