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Article ; Online: The eQTL analysis to discover unique eGFR-related SNPs for the Taiwanese population.

Wu, Ping-Hsun / Lin, Johnathan / Kuo, Mei-Chuan / Yu, Sung-Huan

2023 Volume 37, Issue 1, Page(s) 249–252

MeSH term(s)	Humans ; Polymorphism, Single Nucleotide ; Genetic Predisposition to Disease ; Genome-Wide Association Study
Language	English
Publishing date	2023-10-19
Publishing country	Italy
Document type	Letter
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-023-01793-8
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Article ; Online: Therapeutic plasma exchange for refractory vaccine-induced immune thrombotic thrombocytopenia.

Fan, Sheng-Bin / Tsai, Ming-Ju / Kuo, Mei-Chuan / Chuang, Cheng-Hao

The Kaohsiung journal of medical sciences

2022 Volume 38, Issue 8, Page(s) 804–805

MeSH term(s)	Humans ; Plasma Exchange ; Thrombocytopenia/therapy ; Thrombosis ; Vaccines
Chemical Substances	Vaccines
Language	English
Publishing date	2022-04-12
Publishing country	China (Republic : 1949- )
Document type	Letter
ZDB-ID	639302-0
ISSN	2410-8650 ; 0257-5655
ISSN (online)	2410-8650
ISSN	0257-5655
DOI	10.1002/kjm2.12549
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Article ; Online: Influence of Staphylococcal enterotoxin-specific IgE sensitization on therapeutic efficacy of omalizumab therapy in severe asthma.

Weng, Chih-Ming / Wu, Wei-Ciao / Lee, Meng-Jung / Chen, Mei-Chuan / Chou, Chun-Liang / Lin, Chun-Yu / Chung, Kian Fan / Kuo, Han-Pin

Respirology (Carlton, Vic.)

2024 Volume 29, Issue 3, Page(s) 252–255

MeSH term(s)	Humans ; Omalizumab/therapeutic use ; Enterotoxins/therapeutic use ; Asthma/drug therapy ; Anti-Asthmatic Agents/therapeutic use ; Immunoglobulin E
Chemical Substances	Omalizumab (2P471X1Z11) ; Enterotoxins ; Anti-Asthmatic Agents ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2024-01-31
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1435849-9
ISSN	1440-1843 ; 1323-7799
ISSN (online)	1440-1843
ISSN	1323-7799
DOI	10.1111/resp.14663
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Article ; Online: Therapeutic plasma exchange for refractory vaccine‐induced immune thrombotic thrombocytopenia

Sheng‐Bin Fan / Ming‐Ju Tsai / Mei‐Chuan Kuo / Cheng‐Hao Chuang

Kaohsiung Journal of Medical Sciences, Vol 38, Iss 8, Pp 804-

2022 Volume 805

Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Podocentric view of glomerular proteinuria: Focused on cytoskeletal changes and toward promising targeted therapies and challenges.

Kuo, Mei-Chuan / Liang, Peir-In / Chang, Jer-Ming

The Kaohsiung journal of medical sciences

2021 Volume 37, Issue 7, Page(s) 539–546

Abstract: Among renal cells, podocytes (glomerular epithelial cells) are the most critical to prevent plasma proteins from excessive loss by forming their sophisticated foot processes (FP) and slit diaphragms (SD). A general finding in the glomeruli of patients ... ...

Abstract	Among renal cells, podocytes (glomerular epithelial cells) are the most critical to prevent plasma proteins from excessive loss by forming their sophisticated foot processes (FP) and slit diaphragms (SD). A general finding in the glomeruli of patients with nephrotic syndrome is the foot processes "effacement" resulted from dysregulated actin cytoskeleton reorganization. Ultrastructural analysis in patients with nephrotic syndrome has demonstrated that such changes tend to be dynamic and can sometimes be reversible. In a more molecular sense, injured podocytes can no longer maintain their tight regulation and "retract" their FP, but not "efface" them. Past studies have revealed multiple exquisite mechanisms and arrays of proteins participating in the regulation of cytoskeletal rearrangement, and these mechanisms serve as potential targets to treat. A major challenge to develop specific therapies is the targeted mechanism has to be crucial and specific enough for podocyte-oriented kidney diseases, and it would be even better to manifest in most of the glomerulonephritis. Studies have shown many approaches targeting different mechanisms, but none of them has been proved to be effective in clinical medicine. Up to the present, Abatacept (Orencia) is the first (and the only) clinical targeted therapy demonstrating limited success. It inhibits the co-stimulatory response of B7-1 (CD80) induced in various types of glomerulonephritis. Future clinical studies have to be expanded to substantiate this highly specific targeted therapy because the Abatacept effect is not generally accepted even within the nephrology community. Nevertheless, there are ongoing searches for specific treatment targeting podocytes through various approaches.
MeSH term(s)	Abatacept/pharmacology ; Animals ; B7-1 Antigen/metabolism ; Basement Membrane/metabolism ; Cytoskeleton/metabolism ; Epithelial Cells ; Glomerulonephritis/metabolism ; Glomerulonephritis/therapy ; Humans ; Kidney/metabolism ; Kidney Glomerulus/metabolism ; Mice ; Nephrology/methods ; Nephrotic Syndrome/metabolism ; Nephrotic Syndrome/therapy ; Podocytes/metabolism ; Proteinuria ; Rats ; Signal Transduction
Chemical Substances	B7-1 Antigen ; CD80 protein, human ; Abatacept (7D0YB67S97)
Language	English
Publishing date	2021-05-04
Publishing country	China (Republic : 1949- )
Document type	Journal Article ; Review
ZDB-ID	639302-0
ISSN	2410-8650 ; 0257-5655
ISSN (online)	2410-8650
ISSN	0257-5655
DOI	10.1002/kjm2.12385
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Article ; Online: The clinical outcomes and effectiveness of antiviral agents among underweight patients with COVID-19.

Wu, Jheng-Yan / Liu, Mei-Yuan / Lee, Mei-Chuan / Hung, Kuo-Chuan / Hsu, Wan-Hsuan / Tsai, Ya-Wen / Liu, Ting-Hui / Huang, Po-Yu / Chuang, Min-Hsiang / Tseng, Shu-Ching / Lu, Chih-Ying / Lai, Chih-Cheng

Expert review of anti-infective therapy

2024 , Page(s) 1–10

Abstract: Objectives: This study investigated the outcomes of underweight patients with COVID-19 and the effectiveness of antiviral agents in this population.: Methods: A retrospective cohort study using theTriNetX research network was conducted. Propensity ... ...

Abstract	Objectives: This study investigated the outcomes of underweight patients with COVID-19 and the effectiveness of antiviral agents in this population. Methods: A retrospective cohort study using theTriNetX research network was conducted. Propensity score matching (PSM) was employed to balance the first cohort involving COVID-19 patients with underweight and normal-weight. In the second cohort, underweight patients receiving antiviral agents and untreated individuals were matched using PSM. The primary outcome was a composite of all-cause hospitalization and death during the 7-30-day follow-up period. Results: After PSM, the first cohort including each group of 13,502 patients with balanced baseline characteristics were identified for comparing the outcome of patients with underweight and normal weight. The underweight group had a higher risk of the composite primary outcome than those with normal weight (hazard ratio [HR], 1.251; 95% confidence interval [CI], 1.132-1.382). The second cohort included each 884 underweight patients with and without receiving antivirals.Compared with untreated patients, those receiving antiviral treatment had a lower risk of composite primary outcomes (HR, 0.426; 95% CI, 0.278-0.653). Conclusion: Underweight status may be associated with a higher risk of all-cause hospitalization and death in patients with COVID-19.Among underweight patients, antiviral agents demonstrated clinically beneficial effects.
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2181279-2
ISSN	1744-8336 ; 1478-7210
ISSN (online)	1744-8336
ISSN	1478-7210
DOI	10.1080/14787210.2024.2303017
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Article ; Online: Podocentric view of glomerular proteinuria

Mei‐Chuan Kuo / Peir‐In Liang / Jer‐Ming Chang

Kaohsiung Journal of Medical Sciences, Vol 37, Iss 7, Pp 539-

Focused on cytoskeletal changes and toward promising targeted therapies and challenges

2021 Volume 546

Abstract: Abstract Among renal cells, podocytes (glomerular epithelial cells) are the most critical to prevent plasma proteins from excessive loss by forming their sophisticated foot processes (FP) and slit diaphragms (SD). A general finding in the glomeruli of ... ...

Abstract	Abstract Among renal cells, podocytes (glomerular epithelial cells) are the most critical to prevent plasma proteins from excessive loss by forming their sophisticated foot processes (FP) and slit diaphragms (SD). A general finding in the glomeruli of patients with nephrotic syndrome is the foot processes “effacement” resulted from dysregulated actin cytoskeleton reorganization. Ultrastructural analysis in patients with nephrotic syndrome has demonstrated that such changes tend to be dynamic and can sometimes be reversible. In a more molecular sense, injured podocytes can no longer maintain their tight regulation and “retract” their FP, but not “efface” them. Past studies have revealed multiple exquisite mechanisms and arrays of proteins participating in the regulation of cytoskeletal rearrangement, and these mechanisms serve as potential targets to treat. A major challenge to develop specific therapies is the targeted mechanism has to be crucial and specific enough for podocyte‐oriented kidney diseases, and it would be even better to manifest in most of the glomerulonephritis. Studies have shown many approaches targeting different mechanisms, but none of them has been proved to be effective in clinical medicine. Up to the present, Abatacept (Orencia) is the first (and the only) clinical targeted therapy demonstrating limited success. It inhibits the co‐stimulatory response of B7‐1 (CD80) induced in various types of glomerulonephritis. Future clinical studies have to be expanded to substantiate this highly specific targeted therapy because the Abatacept effect is not generally accepted even within the nephrology community. Nevertheless, there are ongoing searches for specific treatment targeting podocytes through various approaches.
Keywords	actin cytoskeleton ; foot processes ; podocytes ; proteinuria ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Exploring the Relationship between Gut Microbiome Composition and Blood Indole-3-acetic Acid in Hemodialysis Patients.

Wu, Ping-Hsun / Tseng, Yu-Fang / Liu, Wangta / Chuang, Yun-Shiuan / Tai, Chi-Jung / Tung, Chun-Wei / Lai, Kean-Yee / Kuo, Mei-Chuan / Chiu, Yi-Wen / Hwang, Shang-Jyh / Hung, Wei-Chun / Lin, Yi-Ting

Biomedicines

2024 Volume 12, Issue 1

Abstract: Indole-3-acetic acid (IAA), a protein-bound uremic toxin resulting from gut microbiota-driven tryptophan metabolism, increases in hemodialysis (HD) patients. IAA may induce endothelial dysfunction, inflammation, and oxidative stress, elevating ... ...

Abstract	Indole-3-acetic acid (IAA), a protein-bound uremic toxin resulting from gut microbiota-driven tryptophan metabolism, increases in hemodialysis (HD) patients. IAA may induce endothelial dysfunction, inflammation, and oxidative stress, elevating cardiovascular and cognitive risk in HD patients. However, research on the microbiome-IAA association is limited. This study aimed to explore the gut microbiome's relationship with plasma IAA levels in 72 chronic HD patients aged over 18 (August 2016-January 2017). IAA levels were measured using tandem mass spectrometry, and gut microbiome analysis utilized 16s rRNA next-generation sequencing. Linear discriminative analysis effect size and random forest analysis distinguished microbial species linked to IAA levels. Patients with higher IAA levels had reduced microbial diversity. Six microbial species significantly associated with IAA levels were identified;
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12010148
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Article ; Online: Clinical effectiveness of oral antiviral agents for treating non-hospitalized COVID-19 patients with chronic kidney disease.

Chen, Chia-Chen / Huang, Chi-Ya / Wu, Jheng-Yan / Liu, Mei-Yuan / Chuang, Min-Hsiang / Liu, Ting-Hui / Tsai, Ya-Wen / Hsu, Wan-Hsuan / Huang, Po-Yu / Chen, Ming-Hui / Liu, Su-Yen / Lee, Mei-Chuan / Hung, Kuo-Chuan / Lai, Chih-Cheng / Yang, I-Ning

Expert review of anti-infective therapy

2024 , Page(s) 1–8

Abstract: Objectives: This study examined the effectiveness of nirmatrelvir plus ritonavir (NMV-r) and molnupiravir (MOV) in treating COVID-19 among chronic kidney disease (CKD) patients.: Methods: This retrospective cohort study, using the TriNetX research ... ...

Abstract	Objectives: This study examined the effectiveness of nirmatrelvir plus ritonavir (NMV-r) and molnupiravir (MOV) in treating COVID-19 among chronic kidney disease (CKD) patients. Methods: This retrospective cohort study, using the TriNetX research network, identified stage 3-5 CKD and end-stage kidney disease (ESKD) patients with non-hospitalized COVID-19 between 1 January 2022, and 31 May 2023. Propensity score matching (PSM) was used to compare patients on NMV-r or MOV (antiviral group) against those not receiving these treatments (control group). The primary composite outcome was the cumulative hazard ratio (HR) for all-cause hospitalization or death within the 30-day follow-up. Results: After PSM, two balanced cohorts of 6,275 patients each were established. The antiviral group exhibited a lower incidence of all-cause hospitalization or mortality (5.93% vs. 9.53%; HR: 0.626; 95% CI: 0.550-0.713) than controls. Additionally, antiviral recipients were associated with a lower risk of all-cause hospitalization (HR: 0.679; 95% CI: 0.594-0.777) and mortality (HR: 0.338; 95% CI: 0.227-0.504). The beneficial effects of antiviral agents were consistent across sex, age, vaccination status, antiviral type, and CKD stage. Conclusion: Oral antiviral agents could be associated with lower rates of all-cause hospitalization or death among non-hospitalized COVID-19 patients with CKD.
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2181279-2
ISSN	1744-8336 ; 1478-7210
ISSN (online)	1744-8336
ISSN	1478-7210
DOI	10.1080/14787210.2024.2334052
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Article ; Online: Proximal tubule-derived exosomes contribute to mesangial cell injury in diabetic nephropathy via miR-92a-1-5p transfer.

Tsai, Yi-Chun / Kuo, Mei-Chuan / Hung, Wei-Wen / Wu, Ping-Hsun / Chang, Wei-An / Wu, Ling-Yu / Lee, Su-Chu / Hsu, Ya-Ling

Cell communication and signaling : CCS

2023 Volume 21, Issue 1, Page(s) 10

Abstract: Background: Diabetic nephropathy (DN) is an increasing threat to human health and regarded to be the leading cause of end-stage renal disease worldwide. Exosomes delivery may play a key role in cross-talk among kidney cells and the progression of DN. ... ...

Abstract	Background: Diabetic nephropathy (DN) is an increasing threat to human health and regarded to be the leading cause of end-stage renal disease worldwide. Exosomes delivery may play a key role in cross-talk among kidney cells and the progression of DN. However, the mechanisms underlying exosomes in DN remain unclear. Methods: The cross-disciplinary study, including in vivo, in vitro, and human studies was conducted to explore the cross-talk between proximal tubular epithelial cells (PTECs) and mesangial cells (MCs) in DN. We purified exosome from PTECs treated with high glucose and db/db mice and assessed their influences in the pathologic change of MCs and downstream signal pathway. Healthy individuals and type 2 diabetic patients were enrolled to examine the role of exosomes in clinical applications. Results: High glucose stimulated PTECs to secrete exosomal miR-92a-1-5p, which was taken-up by glomerular MCs, inducing myofibroblast transdifferentiation (MFT) in vitro and in vivo. PTEC-released exosomal 92a-1-5p decreased reticulocalbin-3 expression, leading to endoplasmic reticulum (ER) stress by downregulating genes essential for ER homeostasis including calreticulin and mesencephalic astrocyte-derived neurotrophic factor. Treatment with miR-92a-1-5p inhibitor ameliorated kidney damage in db/db mice with DN. Urinary miR-92a-1-5p could predict kidney injury in type 2 diabetic patients. Conclusions: PTEC-derived exosomal miR-92a-1-5p modulated the kidney microenvironment in vivo and in vitro models, which altered ER stress and MFT in MCs resulting in DN progression. Further blocking miR-92a-1-5p epigenetic regulatory network could be a potential therapeutic strategy to prevent the progression of DN. Video Abstract.
MeSH term(s)	Animals ; Humans ; Mice ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/metabolism ; Diabetic Nephropathies/metabolism ; Exosomes/metabolism ; Glucose/metabolism ; Mesangial Cells/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism
Chemical Substances	Glucose (IY9XDZ35W2) ; MicroRNAs ; MIRN92 microRNA, human
Language	English
Publishing date	2023-01-13
Publishing country	England
Document type	Video-Audio Media ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2126315-2
ISSN	1478-811X ; 1478-811X
ISSN (online)	1478-811X
ISSN	1478-811X
DOI	10.1186/s12964-022-00997-y
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