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  1. Article ; Online: Characterization of genetic and molecular tools for studying the endogenous expression of Lactate dehydrogenase in Drosophila melanogaster

    Madhulika Rai / Sarah M. Carter / Shefali A. Shefali / Geetanjali Chawla / Jason M. Tennessen

    PLoS ONE, Vol 19, Iss

    2024  Volume 1

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Characterization of genetic and molecular tools for studying the endogenous expression of

    Rai, Madhulika / Carter, Sarah M / Shefali, Shefali A / Chawla, Geetanjali / Tennessen, Jason M

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Drosophila ... ...

    Abstract Drosophila melanogaster
    Language English
    Publishing date 2023-06-23
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.15.545165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Characterization of genetic and molecular tools for studying the endogenous expression of Lactate dehydrogenase in Drosophila melanogaster.

    Rai, Madhulika / Carter, Sarah M / Shefali, Shefali A / Chawla, Geetanjali / Tennessen, Jason M

    PloS one

    2024  Volume 19, Issue 1, Page(s) e0287865

    Abstract: Drosophila melanogaster larval development relies on a specialized metabolic state that utilizes carbohydrates and other dietary nutrients to promote rapid growth. One unique feature of the larval metabolic program is that Lactate Dehydrogenase (Ldh) ... ...

    Abstract Drosophila melanogaster larval development relies on a specialized metabolic state that utilizes carbohydrates and other dietary nutrients to promote rapid growth. One unique feature of the larval metabolic program is that Lactate Dehydrogenase (Ldh) activity is highly elevated during this growth phase when compared to other stages of the fly life cycle, indicating that Ldh serves a key role in promoting juvenile development. Previous studies of larval Ldh activity have largely focused on the function of this enzyme at the whole animal level, however, Ldh expression varies significantly among larval tissues, raising the question of how this enzyme promotes tissue-specific growth programs. Here we characterize two transgene reporters and an antibody that can be used to study Ldh expression in vivo. We find that all three tools produce similar Ldh expression patterns. Moreover, these reagents demonstrate that the larval Ldh expression pattern is complex, suggesting the purpose of this enzyme varies across cell types. Overall, our studies validate a series of genetic and molecular reagents that can be used to study glycolytic metabolism in the fly.
    MeSH term(s) Animals ; Drosophila melanogaster ; L-Lactate Dehydrogenase/genetics ; L-Lactate Dehydrogenase/metabolism ; Glycolysis/genetics
    Chemical Substances L-Lactate Dehydrogenase (EC 1.1.1.27)
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0287865
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  4. Article ; Online: Sympathetic Neural Control in Humans with Anxiety-Related Disorders.

    Bigalke, Jeremy A / Carter, Jason R

    Comprehensive Physiology

    2021  Volume 12, Issue 1, Page(s) 3085–3117

    Abstract: Numerous conceptual models are used to describe the dynamic responsiveness of physiological systems to environmental pressures, originating with Claude Bernard's milieu intérieur and extending to more recent models such as allostasis. The impact of ... ...

    Abstract Numerous conceptual models are used to describe the dynamic responsiveness of physiological systems to environmental pressures, originating with Claude Bernard's milieu intérieur and extending to more recent models such as allostasis. The impact of stress and anxiety upon these regulatory processes has both basic science and clinical relevance, extending from the pioneering work of Hans Selye who advanced the concept that stress can significantly impact physiological health and function. Of particular interest within the current article, anxiety is independently associated with cardiovascular risk, yet mechanisms underlying these associations remain equivocal. This link between anxiety and cardiovascular risk is relevant given the high prevalence of anxiety in the general population, as well as its early age of onset. Chronically anxious populations, such as those with anxiety disorders (i.e., generalized anxiety disorder, panic disorder, specific phobias, etc.) offer a human model that interrogates the deleterious effects that chronic stress and allostatic load can have on the nervous system and cardiovascular function. Further, while many of these disorders do not appear to exhibit baseline alterations in sympathetic neural activity, reactivity to mental stress offers insights into applicable, real-world scenarios in which heightened sympathetic reactivity may predispose those individuals to elevated cardiovascular risk. This article also assesses behavioral and lifestyle modifications that have been shown to concurrently improve anxiety symptoms, as well as sympathetic control. Lastly, future directions of research will be discussed, with a focus on better integration of psychological factors within physiological studies examining anxiety and neural cardiovascular health. © 2022 American Physiological Society. Compr Physiol 12:1-33, 2022.
    MeSH term(s) Allostasis/physiology ; Anxiety ; Anxiety Disorders/psychology ; Anxiety Disorders/therapy ; Humans ; Phobic Disorders ; Stress, Psychological
    Language English
    Publishing date 2021-12-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2040-4603
    ISSN (online) 2040-4603
    DOI 10.1002/cphy.c210027
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  5. Article ; Online: Emerging interleukin targets in the tumour microenvironment: implications for the treatment of gastrointestinal tumours.

    Dickerson, Lindsay Kathleen / Carter, Jason A / Kohli, Karan / Pillarisetty, Venu G

    Gut

    2023  Volume 72, Issue 8, Page(s) 1592–1606

    Abstract: The effectiveness of antitumour immunity is dependent on intricate cytokine networks. Interleukins (ILs) are important mediators of complex interactions within the tumour microenvironment, including regulation of tumour-infiltrating lymphocyte ... ...

    Abstract The effectiveness of antitumour immunity is dependent on intricate cytokine networks. Interleukins (ILs) are important mediators of complex interactions within the tumour microenvironment, including regulation of tumour-infiltrating lymphocyte proliferation, differentiation, migration and activation. Our evolving and increasingly nuanced understanding of the cell type-specific and heterogeneous effects of IL signalling has presented unique opportunities to fine-tune elaborate IL networks and engineer new targeted immunotherapeutics. In this review, we provide a primer for clinicians on the challenges and potential of IL-based treatment. We specifically detail the roles of IL-2, IL-10, IL-12 and IL-15 in shaping the tumour-immune landscape of gastrointestinal malignancies, paying particular attention to promising preclinical findings, early-stage clinical research and innovative therapeutic approaches that may properly place ILs to the forefront of immunotherapy regimens.
    MeSH term(s) Humans ; Interleukins ; Neoplasms ; Cytokines ; Immunotherapy ; Gastrointestinal Neoplasms/drug therapy ; Lymphocytes, Tumor-Infiltrating ; Tumor Microenvironment
    Chemical Substances Interleukins ; Cytokines
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2023-329650
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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Characterization of genetic and molecular tools for studying the endogenous expression of Lactate dehydrogenase in Drosophila melanogaster.

    Madhulika Rai / Sarah M Carter / Shefali A Shefali / Geetanjali Chawla / Jason M Tennessen

    PLoS ONE, Vol 19, Iss 1, p e

    2024  Volume 0287865

    Abstract: Drosophila melanogaster larval development relies on a specialized metabolic state that utilizes carbohydrates and other dietary nutrients to promote rapid growth. One unique feature of the larval metabolic program is that Lactate Dehydrogenase (Ldh) ... ...

    Abstract Drosophila melanogaster larval development relies on a specialized metabolic state that utilizes carbohydrates and other dietary nutrients to promote rapid growth. One unique feature of the larval metabolic program is that Lactate Dehydrogenase (Ldh) activity is highly elevated during this growth phase when compared to other stages of the fly life cycle, indicating that Ldh serves a key role in promoting juvenile development. Previous studies of larval Ldh activity have largely focused on the function of this enzyme at the whole animal level, however, Ldh expression varies significantly among larval tissues, raising the question of how this enzyme promotes tissue-specific growth programs. Here we characterize two transgene reporters and an antibody that can be used to study Ldh expression in vivo. We find that all three tools produce similar Ldh expression patterns. Moreover, these reagents demonstrate that the larval Ldh expression pattern is complex, suggesting the purpose of this enzyme varies across cell types. Overall, our studies validate a series of genetic and molecular reagents that can be used to study glycolytic metabolism in the fly.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Altered Associations Between Task Performance and Dorsolateral Prefrontal Cortex Activation During Cognitive Control in Schizophrenia.

    Smucny, Jason / Hanks, Timothy D / Lesh, Tyler A / Carter, Cameron S

    Biological psychiatry. Cognitive neuroscience and neuroimaging

    2023  Volume 8, Issue 10, Page(s) 1050–1057

    Abstract: Background: Dysfunctional cognitive control processes are now well understood to be core features of schizophrenia (SZ). A body of work suggests that the dorsolateral prefrontal cortex (DLPFC) plays a critical role in explaining cognitive control ... ...

    Abstract Background: Dysfunctional cognitive control processes are now well understood to be core features of schizophrenia (SZ). A body of work suggests that the dorsolateral prefrontal cortex (DLPFC) plays a critical role in explaining cognitive control disruptions in SZ. Here, we examined relationships between DLPFC activation and drift rate (DR), a model-based performance measure that combines reaction time and accuracy, in people with SZ and healthy control (HC) participants.
    Methods: One hundred fifty-one people with recent-onset SZ spectrum disorders and 118 HC participants performed the AX-Continuous Performance Task during functional magnetic resonance imaging scanning. Proactive cognitive control-associated activation was extracted from left and right DLPFC regions of interest. Individual behavior was fit using a drift diffusion model, allowing DR to vary between task conditions.
    Results: Behaviorally, people with SZ showed significantly lower DRs than HC participants, particularly during high proactive control trial types ("B" trials). Recapitulating previous findings, the SZ group also demonstrated reduced cognitive control-associated DLPFC activation compared with HC participants. Furthermore, significant group differences were also observed in the relationship between left and right DLPFC activation with DR, such that positive relationships between DR and activation were found in HC participants but not in people with SZ.
    Conclusions: These results suggest that DLPFC activation is less associated with cognitive control-related behavioral performance enhancements in SZ. Potential mechanisms and implications are discussed.
    MeSH term(s) Humans ; Schizophrenia ; Dorsolateral Prefrontal Cortex ; Prefrontal Cortex ; Task Performance and Analysis ; Cognition
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2879089-3
    ISSN 2451-9030 ; 2451-9022
    ISSN (online) 2451-9030
    ISSN 2451-9022
    DOI 10.1016/j.bpsc.2023.05.010
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  8. Article ; Online: Experiencing violence and other predictors of within-person same-day use of multiple substances in youth: a longitudinal study in emergency settings.

    Lyons, Vivian H / Myers, Matthew G / Cunningham, Rebecca M / Zimmerman, Marc A / Carter, Patrick M / Walton, Maureen A / Goldstick, Jason

    The American journal of drug and alcohol abuse

    2024  Volume 50, Issue 2, Page(s) 218–228

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Male ; Female ; Longitudinal Studies ; Adolescent ; Substance-Related Disorders/epidemiology ; Young Adult ; Risk Factors ; Violence/statistics & numerical data ; Violence/psychology ; Emergency Service, Hospital/statistics & numerical data ; Sex Factors ; Peer Group
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 193086-2
    ISSN 1097-9891 ; 0095-2990
    ISSN (online) 1097-9891
    ISSN 0095-2990
    DOI 10.1080/00952990.2024.2307546
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1137: Show issues Location:
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  9. Article ; Online: Orexin, Sleep, Sympathetic Neural Activity, and Cardiovascular Function.

    Bigalke, Jeremy A / Shan, Zhiying / Carter, Jason R

    Hypertension (Dallas, Tex. : 1979)

    2022  Volume 79, Issue 12, Page(s) 2643–2655

    Abstract: Inadequate sleep duration and quality are associated with reduced cardiovascular health and increased mortality. Experimental evidence points to the sympathetic nervous system as a key mediator in the observed relationship between poor sleep and ... ...

    Abstract Inadequate sleep duration and quality are associated with reduced cardiovascular health and increased mortality. Experimental evidence points to the sympathetic nervous system as a key mediator in the observed relationship between poor sleep and cardiovascular dysfunction. However, brain mechanisms underpinning the impaired sympathetic function associated with poor sleep remain unclear. Recent evidence suggests the central orexin system, particularly orexins A and B and their receptors, have a key regulatory role for sleep in animal and human models. While orexin system activity has been observed to significantly impact sympathetic regulation in animals, the extension of these findings to humans has been difficult due to an inability to directly assess orexin system activity in humans. However, direct measures of sympathetic activity in populations with narcolepsy and chronic insomnia, 2 sleep disorders associated with deficient and excessive orexin neural activity, have allowed indirect assessment of the relationships between orexin, sleep, and sympathetic regulation. Further, the recent pharmaceutical development of dual orexin receptor antagonists for use in clinical insomnia populations offers an unprecedented opportunity to examine the mechanistic role of orexin in sleep and cardiovascular health in humans. The current review assesses the role of orexin in both sleep and sympathetic regulation from a translational perspective, spanning animal and human studies. The review concludes with future research directions necessary to fully elucidate the mechanistic role for orexin in sleep and sympathetic regulation in humans.
    MeSH term(s) Animals ; Humans ; Orexins/pharmacology ; Orexin Receptors/physiology ; Orexin Receptor Antagonists/pharmacology ; Orexin Receptor Antagonists/therapeutic use ; Sleep/physiology ; Sleep Initiation and Maintenance Disorders/drug therapy ; Sympathetic Nervous System
    Chemical Substances Orexins ; Orexin Receptors ; Orexin Receptor Antagonists
    Language English
    Publishing date 2022-09-23
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.122.19796
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    Zs.A 1488: Show issues Location:
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  10. Article ; Online: The heart of physiological reports.

    Lindsey, Merry L / Brunt, Keith R / Kleinbongard, Petra / Carter, Jason R / Ripplinger, Crystal M / Kassiri, Zamaneh / Hansell Keehan, Kara / LeBlanc, Amanda J / Kirk, Jonathan A

    Physiological reports

    2024  Volume 12, Issue 5, Page(s) e15962

    MeSH term(s) Heart ; Thorax
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.15962
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