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Artikel ; Online: S

Elmazoglu, Zubeyir / Aydın Bek, Zehra / Sarıbaş, Sanem Gulistan / Özoğul, Candan / Goker, Berna / Bitik, Berivan / Aktekin, Cem Nuri / Karasu, Çimen

Biochemistry and cell biology = Biochimie et biologie cellulaire

2021 Band 99, Heft 5, Seite(n) 645–654

Abstract: The discovery of new pharmacological agents is needed to control the progression of osteoarthritis (OA), characterized by joint cartilage damage. Human OA chondrocyte (OAC) cultures were either applied ... ...

Abstract	The discovery of new pharmacological agents is needed to control the progression of osteoarthritis (OA), characterized by joint cartilage damage. Human OA chondrocyte (OAC) cultures were either applied to
Mesh-Begriff(e)	Aged ; Antigens, Neoplasm/metabolism ; Chondrocytes/drug effects ; Chondrocytes/metabolism ; Cysteine/analogs & derivatives ; Cysteine/pharmacology ; Female ; Humans ; Inflammation/drug therapy ; Inflammation/metabolism ; JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors ; JNK Mitogen-Activated Protein Kinases/metabolism ; Male ; Middle Aged ; Mitogen-Activated Protein Kinases/antagonists & inhibitors ; Mitogen-Activated Protein Kinases/metabolism ; NF-E2-Related Factor 2/antagonists & inhibitors ; NF-E2-Related Factor 2/metabolism ; Osteoarthritis/drug therapy ; Osteoarthritis/metabolism ; Signal Transduction/drug effects ; Toll-Like Receptor 4/antagonists & inhibitors ; Toll-Like Receptor 4/metabolism
Chemische Substanzen	Antigens, Neoplasm ; NF-E2-Related Factor 2 ; NFE2L2 protein, human ; TLR4 protein, human ; Toll-Like Receptor 4 ; S-allylcysteine (81R3X99M15) ; MOK protein, human (EC 2.7.11.22) ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Cysteine (K848JZ4886)
Sprache	Englisch
Erscheinungsdatum	2021-04-30
Erscheinungsland	Canada
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	54104-7
ISSN	1208-6002 ; 0829-8211
ISSN (online)	1208-6002
ISSN	0829-8211
DOI	10.1139/bcb-2021-0004
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Perspectives on current models of Friedreich’s ataxia

Simge Kelekçi / Abdullah Burak Yıldız / Kenan Sevinç / Deniz Uğurlu Çimen / Tamer Önder

Frontiers in Cell and Developmental Biology, Vol

2022 Band 10

Abstract: Friedreich’s ataxia (FRDA, OMIM#229300) is the most common hereditary ataxia, resulting ...

Abstract	Friedreich’s ataxia (FRDA, OMIM#229300) is the most common hereditary ataxia, resulting from the reduction of frataxin protein levels due to the expansion of GAA repeats in the first intron of the FXN gene. Why the triplet repeat expansion causes a decrease in Frataxin protein levels is not entirely known. Generation of effective FRDA disease models is crucial for answering questions regarding the pathophysiology of this disease. There have been considerable efforts to generate in vitro and in vivo models of FRDA. In this perspective article, we highlight studies conducted using FRDA animal models, patient-derived materials, and particularly induced pluripotent stem cell (iPSC)-derived models. We discuss the current challenges in using FRDA animal models and patient-derived cells. Additionally, we provide a brief overview of how iPSC-based models of FRDA were used to investigate the main pathways involved in disease progression and to screen for potential therapeutic agents for FRDA. The specific focus of this perspective article is to discuss the outlook and the remaining challenges in the context of FRDA iPSC-based models.
Schlagwörter	iPSC (induced pluripotent stem cell) ; disease model cell ; triplet repeat disease ; frataxin ; ataxia ; Biology (General) ; QH301-705.5
Sprache	Englisch
Erscheinungsdatum	2022-08-01T00:00:00Z
Verlag	Frontiers Media S.A.
Dokumenttyp	Artikel ; Online
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Artikel ; Online: Thallium Toxicity in Caenorhabditis elegans: Involvement of the SKN-1 Pathway and Protection by S-Allylcysteine.

Hurtado-Díaz, María Ester / Estrada-Valencia, Rubén / Rangel-López, Edgar / Maya-López, Marisol / Colonnello, Alinne / Galván-Arzate, Sonia / Verstraeten, Sandra V / Karasu, Cimen / Túnez, Isaac / Aschner, Michael / Santamaría, Abel

Neurotoxicity research

2020 Band 38, Heft 2, Seite(n) 287–298

Abstract: Monovalent thallium ( ... ...

Abstract	Monovalent thallium (Tl
Mesh-Begriff(e)	Animals ; Animals, Genetically Modified ; Antioxidants/pharmacology ; Body Size/drug effects ; Caenorhabditis elegans/drug effects ; Caenorhabditis elegans/growth & development ; Caenorhabditis elegans Proteins/drug effects ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Cysteine/analogs & derivatives ; Cysteine/pharmacology ; DNA-Binding Proteins/drug effects ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Gene Knockout Techniques ; Glutathione Transferase/drug effects ; Glutathione Transferase/metabolism ; Longevity/drug effects ; Organometallic Compounds/toxicity ; Transcription Factors/drug effects ; Transcription Factors/genetics ; Transcription Factors/metabolism
Chemische Substanzen	Antioxidants ; Caenorhabditis elegans Proteins ; DNA-Binding Proteins ; Organometallic Compounds ; Transcription Factors ; skn-1 protein, C elegans (148733-36-2) ; S-allylcysteine (81R3X99M15) ; Glutathione Transferase (EC 2.5.1.18) ; Cysteine (K848JZ4886) ; thallium acetate (Q2901889VM)
Sprache	Englisch
Erscheinungsdatum	2020-05-28
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2036826-4
ISSN	1476-3524 ; 1029-8428
ISSN (online)	1476-3524
ISSN	1029-8428
DOI	10.1007/s12640-020-00220-1
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Does Surgical Experience Affect the Outcomes During Percutaneous Release of the Trigger Finger?

Çimen, Oğuzhan / Nami, Şahin

Cureus

2023 Band 15, Heft 9, Seite(n) e46049

Abstract: ... of our retrospective study was to determine the effect of the surgeon's learning curve on clinical outcomes in percutaneous ...

Abstract	Background Trigger finger is a condition characterized by clicking or locking during finger movement, sometimes resulting in the freezing of a finger in flexion or extension. The aim of our retrospective study was to determine the effect of the surgeon's learning curve on clinical outcomes in percutaneous release of the trigger finger. In addition, we evaluated the effects of diabetes and local steroid injections on clinical outcomes. Methodology A total of 954 trigger fingers in 678 patients were reviewed from 2012 to 2022. All percutaneous release procedures were performed by a single surgeon in our institute under local anesthesia. The main outcome measures were recurrence and patient satisfaction. In addition, all patients were evaluated in terms of re-operation and complications. The mean follow-up period was 54.87 months. Results There was complete relief of symptoms in 636 (93.81%) patients, and 22 (3.24%) patients had mild pain but were satisfied. We found that the success rate increased over time. The success rate was 91.4% in the first three years and increased to 98.25% in the next seven years (p = 0.001). There was no statistically significant difference between the diabetic and non-diabetic groups in terms of recurrence, satisfaction rate, and complications (p > 0.05). There was no statistically significant difference in terms of recurrence, satisfaction rate, and complications between the groups that received and did not receive steroid injections (p > 0.05). Conclusions Percutaneous release is a safe and reliable procedure in the treatment of trigger fingers, and the success rate increases as the experience increases. Moreover, diabetes mellitus and steroid injections did not affect the clinical results.
Sprache	Englisch
Erscheinungsdatum	2023-09-27
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.46049
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Generation of transgene-free iPSC lines from three patients with Friedreich’s ataxia (FRDA) carrying GAA triplet expansions in the first intron of FXN gene

Simge Kelekçi / Deniz Uğurlu-Çimen / Ata Berk Demir / Burcu Özçimen / Abdullah Burak Yıldız / Mehmet Batuhan Karakuş / Esra Börklü Yücel / Tamer T. Önder

Stem Cell Research, Vol 54, Iss , Pp 102438- (2021)

2021

Abstract: Friedreich’s ataxia (FRDA) is a rare neurodegenerative disorder which is caused by triplet repeat ...

Abstract	Friedreich’s ataxia (FRDA) is a rare neurodegenerative disorder which is caused by triplet repeat expansion (GAA) in the first intron of FXN gene. In this present study, we generated induced pluripotent stem cells (iPSC) lines from fibroblasts of three unrelated FRDA patients using integration-free episomal vectors. All iPSC lines express the pluripotency markers such as OCT4 and SSEA4, display normal karyotypes and can differentiate into all three germ layers via in vivo teratoma formation assay.
Schlagwörter	Biology (General) ; QH301-705.5
Sprache	Englisch
Erscheinungsdatum	2021-07-01T00:00:00Z
Verlag	Elsevier
Dokumenttyp	Artikel ; Online
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Artikel ; Online: The prevalence of sensitization to food allergens in children with atopic dermatitis.

Atakul, Gizem / Çimen, Sevgi Sipahi

Allergologia et immunopathologia

2023 Band 51, Heft 3, Seite(n) 85–90

Abstract: ... in patients with SCORAD (SCORing Atopic Dermatitis) >25 (p < 0.0001). Egg white (39%), egg yolk (31%), cow's ...

Abstract	Introduction: Atopic dermatitis (AD) has a complex pathophysiology. The course of the disease is affected by both environmental factors and allergen hypersensitivities. Food and aeroallergens have a significant role in the pathogenesis and disease control. Objective: In this study, it was aimed to determine the prevalence of food and aeroallergen sensitivity of children with AD. Methods: Children under 18 years with AD who applied to pediatric allergy and immunology outpatient clinics were evaluated. All patients had a skin prick test (SPT) within most common food and aeroallergens. Results: One hundred seventy three patients were studied. Most of the moderate and severe AD patients were boys (boys 64% vs. girls 47%). Symptoms started earlier and positive results in SPTs with food allergens were more common in patients with SCORAD (SCORing Atopic Dermatitis) >25 (p < 0.0001). Egg white (39%), egg yolk (31%), cow's milk (13%) and wheat flour (5%), were the most common allergens, respectively. The SCORAD scores were higher in multiple food sensitized patients' groups (p < 0.001). Although, food sensitizations were prevalent in patients who had higher SCORAD scores (p = 0.001), there was no significant difference in sensitization with aeroallergens. (p = 0.392). Conclusion: Sensitizations to both food and aeroallergens are common in patients with AD. In addition, sensitization to these allergens and SCORAD severity in patients with AD have positive correlation.
Mesh-Begriff(e)	Female ; Animals ; Cattle ; Dermatitis, Atopic/diagnosis ; Prevalence ; Flour ; Triticum ; Food Hypersensitivity/diagnosis ; Skin Tests/methods ; Allergens
Chemische Substanzen	Allergens
Sprache	Englisch
Erscheinungsdatum	2023-05-01
Erscheinungsland	Singapore
Dokumenttyp	Journal Article
ZDB-ID	193144-1
ISSN	1578-1267 ; 0301-0546
ISSN (online)	1578-1267
ISSN	0301-0546
DOI	10.15586/aei.v51i3.828
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: What's New in Arrhythmogenic Cardiomyopathies.

Çimen, Tolga / Saguner, Ardan M

Journal of clinical medicine

2022 Band 11, Heft 16

Abstract: Arrhythmogenic Cardiomyopathy (ACM) is a hereditary cardiomyopathy often presenting with sudden cardiac death (SCD) in young athletic individuals [ ... ]. ...

Abstract	Arrhythmogenic Cardiomyopathy (ACM) is a hereditary cardiomyopathy often presenting with sudden cardiac death (SCD) in young athletic individuals [...].
Sprache	Englisch
Erscheinungsdatum	2022-08-15
Erscheinungsland	Switzerland
Dokumenttyp	Editorial
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11164764
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Artikel ; Online: The Mediating Role of Work Alienation in the Effect of Workplace Ostracism on Employee Voice.

Deniz, Serkan / Çimen, Mesut

Hospital topics

2022 , Seite(n) 1–10

Abstract: The aim of this study was to determine the mediating role of work alienation in the effect of workplace ostracism on employee voice. The research was conducted between 11 December 2020 and 27 April 2021 in Istanbul, Turkey. The research data were ... ...

Abstract	The aim of this study was to determine the mediating role of work alienation in the effect of workplace ostracism on employee voice. The research was conducted between 11 December 2020 and 27 April 2021 in Istanbul, Turkey. The research data were collected from employees of private hospitals in Istanbul. The research showed that workplace ostracism has a positive effect on work alienation. It was also determined that both workplace ostracism and work alienation negatively affect employee voice. Finally, it was established that work alienation has a mediating role in the effect of workplace ostracism on employee voice.
Sprache	Englisch
Erscheinungsdatum	2022-08-27
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	604270-3
ISSN	1939-9278 ; 0018-5868
ISSN (online)	1939-9278
ISSN	0018-5868
DOI	10.1080/00185868.2022.2116375
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Percutaneous release for trigger thumb in children under local anesthesia.

Çimen, Oğuzhan / Irgit, Kaan Süleyman / Nami, Şahin

Journal of pediatric orthopedics. Part B

2023 Band 32, Heft 6, Seite(n) 599–603

Abstract: Trigger thumb surgery can be performed through open surgery or percutaneous release. Open surgery often requires hospitalization, an operating room, a surgical incision, and postoperative wound care; however, percutaneous release does not require ... ...

Abstract	Trigger thumb surgery can be performed through open surgery or percutaneous release. Open surgery often requires hospitalization, an operating room, a surgical incision, and postoperative wound care; however, percutaneous release does not require hospitalization or surgery, and is relatively easier and faster. We aimed to assess the results of percutaneous A-1 pulley release using local anesthesia without hospitalization for the treatment of pediatric trigger thumb. In this retrospective study, we included patients operated on between March 2013 and August 2020 with the diagnosis of trigger thumb. The percutaneous release under local anesthesia was applied to all the children by one orthopedic surgeon. All percutaneous release procedures were performed in outpatient clinic conditions. There were 183 children (218 thumbs) who were enrolled in the clinic. Eighty-seven patients were male (47.5%) and 96 were female (52.5%). The average follow-up duration was 5 years (1-8.5 years). Among the 218 trigger thumb cases, 211 were satisfactory (successful result rate 96.8%). Relapse was seen in only 3 thumbs in the early postoperative period. No patient experienced neurovascular deficit or infection. The percutaneous surgical release in pediatric trigger thumb treatment is a simple, minimally invasive procedure that can be done in an outpatient setting under local anesthesia. In addition, the procedure duration is short and has minimal complication rates and maximum patient satisfaction. Level of Evidence III.
Mesh-Begriff(e)	Humans ; Child ; Male ; Female ; Trigger Finger Disorder/surgery ; Treatment Outcome ; Retrospective Studies ; Anesthesia, Local ; Orthopedic Procedures/adverse effects ; Orthopedic Procedures/methods
Sprache	Englisch
Erscheinungsdatum	2023-03-13
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	1473-5865
ISSN (online)	1473-5865
DOI	10.1097/BPB.0000000000001075
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Effects of various soil structure and irrigation regimes on rio-red grapefruit yield and morpo-physiology

Uğur Kekeç / Berken Çimen

International Journal of Agriculture, Environment and Food Sciences, Vol 7, Iss 1, Pp 148-

2023 Band 155

Abstract: ... Photosynthesis values were measured as 2.64 umol/m2/s for I50, 3.48 umol/m2/s for I70 and 4.77 umol/m2/s for I100 ...

Abstract	The research was carried out in 2011 using Rio-Red grapefruit trees in Research Station of Cukurova University, Agricultural Faculty, Citrus experiment Station, Adana Latitude, 5°2 ’ N Longitude, 6°50’ E, altitude 27 m).In the study, it was aimed to determine the effects of the amount of irrigation water applied at different levels to the trees growing in soils of different soil texture on fruit development and yield, tree trunk development, tree canopy volume development, leaf area index(LAI) and photosynthesis rate. The research area soils contain three different groups in terms of resistivity values and the trees are grown in soils electrical conductivity (ECa) with T1: 86-109, T2: 23-37 and T3: 62-72 ECavalues.In the experiment, three different irrigation levels I100, I70 and I50 water was applied. The average amount of irrigation water applied to grapefruit trees ranged from 332,48 mm (I100) to 178,92 mm (I50). Actual plant water consumption was between 810.5 mm (I100) and 694.4 mm (I50) according to the water budget method. Yields related to irrigation on trees in the plot varied between 883 (I70) and 828 (I50) kg per tree on average. It has been determined as 1050 kg on average from the fully irrigated I100. Photosynthesis values were measured as 2.64 umol/m2/s for I50, 3.48 umol/m2/s for I70 and 4.77 umol/m2/s for I100. Consequently, the effects of irrigation treatmentson fruit yield are not statistically significant, water reduction can be recommended for the region in order to save water for the farmers in this study.
Schlagwörter	fruit size ; deficit irrigation ; citrus paradisi ; photosynthesis ; soil resistivity ; Agriculture (General) ; S1-972
Thema/Rubrik (Code)	571
Sprache	Englisch
Erscheinungsdatum	2023-03-01T00:00:00Z
Verlag	JAEFS
Dokumenttyp	Artikel ; Online
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