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Article ; Online: Morning Glory Syndrome in a Newborn Aged 2 Weeks.

Giuffrida, Francesco Pozzo / Nassisi, Marco / Osnaghi, Silvia

2024 Volume 142, Issue 4, Page(s) e234844

Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2701705-9
ISSN	2168-6173 ; 2168-6165
ISSN (online)	2168-6173
ISSN	2168-6165
DOI	10.1001/jamaophthalmol.2023.4844
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Article ; Online: Iris Neovascularization After Vitreous Metastasis of a Cutaneous Melanoma.

Leone, Gaia / Nassisi, Marco / Viola, Francesco

JAMA ophthalmology

2023 Volume 141, Issue 12, Page(s) e233540

MeSH term(s)	Humans ; Iris/pathology ; Melanoma, Cutaneous Malignant/pathology ; Skin Neoplasms/pathology ; Neovascularization, Pathologic ; Vitreous Body/pathology ; Eye Neoplasms/secondary
Language	English
Publishing date	2023-12-21
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2701705-9
ISSN	2168-6173 ; 2168-6165
ISSN (online)	2168-6173
ISSN	2168-6165
DOI	10.1001/jamaophthalmol.2023.3540
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Article: Ocular Imaging for Enhancing the Understanding, Assessment, and Management of Age-Related Macular Degeneration.

Nassisi, Marco / Sadda, Srinivas R

Advances in experimental medicine and biology

2021 Volume 1256, Page(s) 33–66

Abstract: Age-related macular degeneration (AMD) is a progressive neuro-retinal disease and the leading cause of central vision loss among elderly individuals in the developed countries. Modern ocular imaging technologies constitute an essential component of the ... ...

Abstract	Age-related macular degeneration (AMD) is a progressive neuro-retinal disease and the leading cause of central vision loss among elderly individuals in the developed countries. Modern ocular imaging technologies constitute an essential component of the evaluation of these patients and have contributed extensively to our understanding of the disease. A challenge with any review of ocular imaging technologies is the rapid pace of progress and evolution of these instruments. Nonetheless, for proper and optimal use of these technologies, it is essential for the user to understand the technical principles underlying the imaging modality and their role in assessing the disease in various settings. Indeed, AMD, like many other retinal diseases, benefits from a multimodal imaging approach to optimally characterize the disease. In this chapter, we will review the various imaging technologies currently used in the assessment and management of AMD.
MeSH term(s)	Aged ; Fluorescein Angiography ; Humans ; Macular Degeneration/diagnostic imaging ; Macular Degeneration/therapy ; Multimodal Imaging ; Retina/diagnostic imaging ; Tomography, Optical Coherence
Language	English
Publishing date	2021-04-13
Publishing country	United States
Document type	Journal Article
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-030-66014-7_2
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Article ; Online: The Extraordinary Phenotypic and Genetic Variability of Retinal and Macular Degenerations: The Relevance to Therapeutic Developments.

Audo, Isabelle / Nassisi, Marco / Zeitz, Christina / Sahel, José-Alain

Cold Spring Harbor perspectives in medicine

2023

Abstract: Inherited retinal diseases (IRDs) are a clinically and genetically heterogeneous group of rare conditions leading to various degrees of visual handicap and to progressive blindness in more severe cases. Besides visual rehabilitation, educational, and ... ...

Abstract	Inherited retinal diseases (IRDs) are a clinically and genetically heterogeneous group of rare conditions leading to various degrees of visual handicap and to progressive blindness in more severe cases. Besides visual rehabilitation, educational, and socio-professional support, there are currently limited therapeutic options, but the approval of the first gene therapy product for
Language	English
Publishing date	2023-08-21
Publishing country	United States
Document type	Journal Article
ISSN	2157-1422
ISSN (online)	2157-1422
DOI	10.1101/cshperspect.a041652
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Article: Adaptive Optics of Kyrieleis Plaques in Varicella Zoster Virus-Associated Posterior Uveitis: A Multimodal Imaging Analysis.

Milella, Paolo / Mapelli, Chiara / Nassisi, Marco / Leone, Gaia / Ruggi, Giada / Scialdone, Antonio / Casalino, Giuseppe / Viola, Francesco

Journal of clinical medicine

2023 Volume 12, Issue 3

Abstract: Kyrieleis plaques (KP) represent a peculiar type of vasculitis affecting retinal arterial branches in a beaded segmental pattern that can be found in several posterior inflammatory ocular conditions. The nature and precise location of KP is unclear. ... ...

Abstract	Kyrieleis plaques (KP) represent a peculiar type of vasculitis affecting retinal arterial branches in a beaded segmental pattern that can be found in several posterior inflammatory ocular conditions. The nature and precise location of KP is unclear. Adaptive Optics (AO) provides an in vivo visualization of retinal vasculature on a microscopic level, thus permitting a more detailed characterization of KP as compared to traditional imaging techniques. This study aims to report AO imaging of KP in Varicella Zoster virus (VZV)-associated posterior uveitis and to correlate the findings with traditional imaging techniques. Three patients diagnosed with VZV posterior uveitis underwent adaptive optics (AO) imaging and traditional multimodal imaging techniques, including fundus photography, fluorescein angiography, indocyanine green angiography and optical coherence tomography. In all subjects, AO imaging revealed segmental hyporeflectivity confined to the vessel wall, with no evidence of arterial wall disruption or extravascular involvement. In our series, AO findings support the view that KP are localized within the inner arterial wall, possibly at the endothelial level.
Language	English
Publishing date	2023-01-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12030884
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Article ; Online: Delaying anti-VEGF therapy during the COVID-19 pandemic: long-term impact on visual outcomes in patients with neovascular age-related macular degeneration.

Nassisi, Marco / Pozzo Giuffrida, Francesco / Milella, Paolo / Ganci, Simone / Aretti, Andrea / Mainetti, Claudia / Dell'Arti, Laura / Mapelli, Chiara / Viola, Francesco

BMC ophthalmology

2023 Volume 23, Issue 1, Page(s) 156

Abstract: Objectives: To evaluate the outcomes of delayed intravitreal injections (IVIs) caused by the outbreak of coronavirus disease 2019 (COVID-19), in patients with neovascular age-related macular degeneration (nAMD).: Methods: nAMD patients with scheduled ...

Abstract	Objectives: To evaluate the outcomes of delayed intravitreal injections (IVIs) caused by the outbreak of coronavirus disease 2019 (COVID-19), in patients with neovascular age-related macular degeneration (nAMD). Methods: nAMD patients with scheduled IVIs between March 1 Results: Two hundred fifteen patients (132 females, mean age: 81.89 ± 5.98 years) delayed their scheduled IVI while 83 (53 females, mean age: 77.92 ± 6.06 years) adhered to their protocol. For both groups, BCVA at v Conclusions: A risk-based selection strategy and a rescue therapy may limit the long-term outcomes of an interruption of the treatment protocol in patients with nAMD.
MeSH term(s)	Aged ; Aged, 80 and over ; Female ; Humans ; Angiogenesis Inhibitors/therapeutic use ; Communicable Disease Control ; COVID-19 ; Intravitreal Injections ; Macular Degeneration/drug therapy ; Pandemics ; Ranibizumab/therapeutic use ; Treatment Outcome ; Wet Macular Degeneration/drug therapy ; Male
Chemical Substances	Angiogenesis Inhibitors ; Ranibizumab (ZL1R02VT79)
Language	English
Publishing date	2023-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2050436-6
ISSN	1471-2415 ; 1471-2415
ISSN (online)	1471-2415
ISSN	1471-2415
DOI	10.1186/s12886-023-02864-x
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Article ; Online: Ocular features in Williams-Beuren syndrome: a review of the literature.

Nassisi, Marco / Mainetti, Claudia / Aretti, Andrea / Sperti, Andrea / Nicotra, Valeria / Rinaldi, Berardo / Natacci, Federica / Bedeschi, Maria Francesca / Viola, Francesco

Current opinion in ophthalmology

2023 Volume 34, Issue 6, Page(s) 514–521

Abstract: Purpose of review: The current review will discuss the pathophysiology, work-up and clinical relevance of the ocular phenotype in Williams-Beuren syndrome in detail.: Recent findings: Few case reports, case series and retrospective studies reported ... ...

Abstract	Purpose of review: The current review will discuss the pathophysiology, work-up and clinical relevance of the ocular phenotype in Williams-Beuren syndrome in detail. Recent findings: Few case reports, case series and retrospective studies reported the ophthalmic features in Williams-Beuren syndrome, focusing on specific aspects of the ocular involvement. Recently, novel retinal findings have been described in association with the disease. Summary: Numerous ocular features have been described in Williams-Beuren syndrome. Some of them, such as the stellate pattern of the iris or the retinal arteriolar tortuosity may be helpful for the diagnosis but have no significant clinical implications; others, such as strabismus and refractive errors require early treatment to reduce the risk of irreversible visual impairment. Finally, some features, such as a broad foveal pit and thinner retina still have unknown significance and require further longitudinal and multimodal studies.
MeSH term(s)	Humans ; Williams Syndrome/diagnosis ; Williams Syndrome/complications ; Williams Syndrome/genetics ; Retrospective Studies ; Strabismus ; Retina ; Iris
Language	English
Publishing date	2023-08-17
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1049383-9
ISSN	1531-7021 ; 1040-8738
ISSN (online)	1531-7021
ISSN	1040-8738
DOI	10.1097/ICU.0000000000000990
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Article ; Online: Twenty-four-month real-life treatment outcomes of polypoidal choroidal vasculopathy versus type 1 macular neovascularization in Caucasians.

Airaldi, Matteo / Invernizzi, Alessandro / Nguyen, Vuong / Vujosevic, Stela / Ricci, Federico / Monaco, Pietro / Nassisi, Marco / Barthelmes, Daniel / Gillies, Mark / Viola, Francesco

Clinical & experimental ophthalmology

2023 Volume 51, Issue 8, Page(s) 799–807

Abstract: Background: To compare 24-month real-world outcomes of Vascular Endothelial Growth Factor (VEGF) inhibitors for Polypoidal Choroidal Vasculopathy (PCV) and type 1 Macular Neovascularization (MNV) in a Caucasian population.: Methods: Retrospective ... ...

Abstract	Background: To compare 24-month real-world outcomes of Vascular Endothelial Growth Factor (VEGF) inhibitors for Polypoidal Choroidal Vasculopathy (PCV) and type 1 Macular Neovascularization (MNV) in a Caucasian population. Methods: Retrospective analysis from a prospectively designed observational database. Data from Italian centres participating in the Fight Retinal Blindness! (FRB!) project were collected. Treatment-naïve PCV or type 1 MNV commencing treatment after January 2009 were included. The primary outcome was 24-month visual acuity (VA) change; other outcomes included baseline characteristics, number of anti-VEGF injections, time to lesion inactivation and proportion of active visits. Results: A total of 322 eyes (114 PCVs) from 291 patients were included. Median [Q1, Q3] VA at baseline was comparable (70 [55, 75.8] vs. 70 [58.8, 75] letters, p = 0.95). Adjusted VA change at 2 years was higher in PCV (mean [95% CI], +1.2 [-1.6, 4.1] vs. -3.6 [-6, -1.2] letters, p = 0.005). PCV received fewer anti-VEGF injections over the first 24 months of treatment than type 1 MNV (median [Q1, Q3], 8 [5, 10] vs. 9 [7, 12.2] injections, p = 0.001), inactivated earlier (median [Q1, Q3], 235 [184, 308] vs. 252 [169, 343] days, p = 0.04) and was less frequently graded 'active' (62% vs. 68% of visits, p = 0.001). Conclusions: PCV had slightly better VA outcomes over 24 months of treatment than type 1 MNV after receiving less anti-VEGF injections. These results suggest a possible overlap of the two clinical entities with similar visual prognosis in Caucasians.
MeSH term(s)	Humans ; Angiogenesis Inhibitors/therapeutic use ; Vascular Endothelial Growth Factor A ; Polypoidal Choroidal Vasculopathy ; Retrospective Studies ; Choroidal Neovascularization/diagnosis ; Choroidal Neovascularization/drug therapy ; Fluorescein Angiography ; Treatment Outcome ; Intravitreal Injections ; Tomography, Optical Coherence
Chemical Substances	Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2023-10-23
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2014008-3
ISSN	1442-9071 ; 1442-6404
ISSN (online)	1442-9071
ISSN	1442-6404
DOI	10.1111/ceo.14305
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Article ; Online: Predictors of lack of response to methotrexate in juvenile idiopathic arthritis associated uveitis.

Mapelli, Chiara / Miserocchi, Elisabetta / Nassisi, Marco / Beretta, Gisella B / Marelli, Luca / Leone, Gaia / Marino, Achille / Chighizola, Cecilia / Cincinelli, Gilberto / Giani, Teresa / Nucci, Paolo / Viola, Francesco / Filocamo, Giovanni / Minoia, Francesca

Rheumatology (Oxford, England)

2024

Abstract: Objectives: To investigate clinical features associated with lack of response to MTX in juvenile idiopathic arthritis associated uveitis (JIA-U).: Methods: Clinical records of JIA-U patients were retrospectively reviewed. Differences among variables ... ...

Abstract	Objectives: To investigate clinical features associated with lack of response to MTX in juvenile idiopathic arthritis associated uveitis (JIA-U). Methods: Clinical records of JIA-U patients were retrospectively reviewed. Differences among variables were assessed by Mann-Whitney and χ 2 or Fisher's exact tests as appropriate. Association between predictors and requirement of a biological disease modifying antirheumatic drug (bDMARD) was evaluated by univariate Cox regression analysis and Kaplan-Meier curves. A multivariable logistic model was applied to estimate strength of association, adjusting for potential confounders. Results: Data from 99 JIA-U patients treated with MTX were analysed (82.8% female), with a mean follow up of 9.2 years and a mean age at uveitis onset of 5.7 years. In 65 patients (65.7%) at least one bDMARD to control uveitis was required. Children requiring a bDMARD for uveitis had lower age at JIA and uveitis onset, more frequent polyarticular course, higher frequency of bilateral uveitis at onset and higher prevalence of systemic steroids' use. Despite similar frequency of ocular damage at onset, MTX non responders showed a higher percentage of ocular damage at last visit. Younger age at JIA onset, polyarticular course and a history of systemic steroids' use resulted independent factors associated to lack of response to MTX at Cox regression analysis. Kaplan-Meier curves and the multivariate model confirms the independent role of both polyarticular course and systemic steroids' use. Conclusions: Younger age at JIA onset, polyarticular course and a history of systemic steroids' use are predictors of a worse response to MTX in JIA-U.
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keae079
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Article ; Online: Longitudinal Evaluation of the Distribution of Intraretinal Hyper-Reflective Foci in Eyes with Intermediate Age-Related Macular Degeneration.

Verma, Aditya / Nittala, Muneeswar G / Corradetti, Giulia / Nassisi, Marco / Velaga, Swetha B / He, Ye / Haines, Jonathan L / Pericak-Vance, Margaret A / Stambolian, Dwight / Sadda, SriniVas R

Current eye research

2024 , Page(s) 1–7

Abstract: Purpose: Intraretinal hyper-reflective foci (IHRF) are optical coherence tomography (OCT) risk factors for progression of age-related macular degeneration (AMD). In this study we assess the change in the number and distribution of IHRF over two years.!## ...

Abstract	Purpose: Intraretinal hyper-reflective foci (IHRF) are optical coherence tomography (OCT) risk factors for progression of age-related macular degeneration (AMD). In this study we assess the change in the number and distribution of IHRF over two years. Methods: The axial distribution of IHRF were quantified in eyes with intermediate AMD (iAMD) at baseline and 24 months, using a series of 5 sequential equidistant en face OCT retinal slabs generated between the outer border of the internal limiting membrane (ILM) and the inner border of the retinal pigment epithelium (RPE). Following thresholding and binarization, IHRF were quantified in each retinal slab using ImageJ. The change in IHRF number in each slab between baseline and month 24 was calculated. Results: Fifty-two eyes showed evidence of IHRF at baseline, and all continued to show evidence of IHRF at 24 months (M24). The total average IHRF count/eye increased significantly from 4.67 ± 0.63 at baseline to 11.62 ± 13.86 at M24 ( Conclusions: IHRF are most common in the outer retinal layers and tend to increase in number over time. The impact of the distribution and frequency of these IHRF on the overall progression of AMD requires further study.
Language	English
Publishing date	2024-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	82079-9
ISSN	1460-2202 ; 0271-3683
ISSN (online)	1460-2202
ISSN	0271-3683
DOI	10.1080/02713683.2024.2343334
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