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Article ; Online: Enhancing Biotic Stress Tolerance in Soybean Affected by Rhizoctonia solani Root Rot Through an Integrated Approach of Biocontrol Agent and Fungicide.

Paliwal, Kiran / Jajoo, Anjana / Tomar, Rupal Singh / Prakash, Anil / Syed, Asad / Bright, Jeberlin Prabina / Sayyed, R Z

Current microbiology

2023 Volume 80, Issue 9, Page(s) 304

Abstract: ... on photosynthetic reactions and growth in soybean in the presence of the fungal pathogen R. solani. The study showed ... that P. fluorescence significantly inhibited the mycelial growth of R. solani (43%) and tolerated 0.05-0 ... in the presence of R. solani treated with an integrated system showed better overall growth despite being infected ...

Abstract	Rhizoctonia solani causes root rot in soybean, a worldwide severe concern for soybean cultivation. The fungus grows and clogs the xylem tissue of the host plant by producing numerous sclerotia, which results in disease symptoms, such as yellowing of leaves, wilt, and plant death. Overuse of chemical fungicides increases the threat of developing resistance to pathogens, reduces soil productivity, and negatively impacts the health of the soil, the environment, and humans. An integrated pest management strategy improves crop yield, profit, and safety. The present study focused on a fungicide (carbendazim) compatibility test with a biocontrol agent (Pseudomonas fluorescence). It evaluated the effect of this combined approach on photosynthetic reactions and growth in soybean in the presence of the fungal pathogen R. solani. The study showed that P. fluorescence significantly inhibited the mycelial growth of R. solani (43%) and tolerated 0.05-0.15% concentration of carbendazim. This confirms the suitability compatibility of P. fluorescence with chemical fungicides for IPM. These novel blending significantly reduced the disease incidence by about 75%, and a 72% decrease in disease severity was observed compared to pathogen control. Moreover, this combined approach has also improved plant growth, yield parameters, and photosynthetic efficiency in the presence of R. solani treated with an integrated system showed better overall growth despite being infected by the pathogen.
MeSH term(s)	Humans ; Fungicides, Industrial/pharmacology ; Glycine max ; Benzimidazoles/pharmacology ; Rhizoctonia ; Plants ; Plant Diseases/prevention & control ; Plant Diseases/microbiology
Chemical Substances	Fungicides, Industrial ; carbendazim (H75J14AA89) ; Benzimidazoles
Language	English
Publishing date	2023-07-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-023-03404-y
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Zs.A 1446: Show issues

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Article: Gut Microbiota and Stroke.

Tan, Benjamin Y Q / Paliwal, Prakash R / Sharma, Vijay K

Annals of Indian Academy of Neurology

2020 Volume 23, Issue 2, Page(s) 155–158

Abstract: Ischemic stroke remains a significant health problem, which is expected to increase owing to an aging population. A considerable proportion of stroke patients suffer from gastrointestinal complications, including dysphagia, gastrointestinal hemorrhage, ... ...

Abstract	Ischemic stroke remains a significant health problem, which is expected to increase owing to an aging population. A considerable proportion of stroke patients suffer from gastrointestinal complications, including dysphagia, gastrointestinal hemorrhage, and constipation. Often, these complications adversely affect stroke outcomes. Recent research postulates the role of "brain-gut axis" in causing gut microbiota dysbiosis and various complications and outcomes. In this review, we present our current understanding about the interaction between commensal gut microbiome and brain in determining the course of stroke.
Language	English
Publishing date	2020-02-25
Publishing country	India
Document type	Journal Article
ZDB-ID	2240174-X
ISSN	1998-3549 ; 0972-2327
ISSN (online)	1998-3549
ISSN	0972-2327
DOI	10.4103/aian.AIAN_483_19
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Article ; Online: Headache and hand numbness in a young female.

Paliwal, Prakash R / Sharma, Vijay K

European journal of internal medicine

2016 Volume 31, Page(s) e3–4

MeSH term(s)	Female ; Hand/physiopathology ; Headache/etiology ; Humans ; Hypesthesia/etiology ; Magnetic Resonance Imaging ; Syringomyelia/complications ; Syringomyelia/diagnostic imaging ; Young Adult
Language	English
Publishing date	2016-06
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2016.01.020
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Zs.A 2608: Show issues

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Article: Use of Oral Empagliflozin to Obtain Optimal Blood Sugar Levels for Conducting

Mahato, Abhishek / Jain, Anurag / Prakash, V S / Nair, Rajesh / Joshi, Richa / Paliwal, Dharmesh / Tiwari, Awadhesh / Khandpur, Sukhanshi / Singh, Harkirat

World journal of nuclear medicine

2023 Volume 22, Issue 3, Page(s) 191–195

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2023-09-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2911903-0
ISSN	1607-3312 ; 1450-1147
ISSN (online)	1607-3312
ISSN	1450-1147
DOI	10.1055/s-0043-1771283
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Zs.A 7137: Show issues

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Article ; Online: Subclinical Cardiomyopathy in Miyoshi Myopathy Detected by Late Gadolinium Enhancement Cardiac Magnetic Resonance Imaging.

Tan, Sarah Ming Li / Ong, Ching Ching / Tan, Kong Bing / Chin, Hui-Lin / Paliwal, Prakash R / Ng, Kay Wei Ping / Lin, Weiqin

International heart journal

2021 Volume 62, Issue 1, Page(s) 186–192

Abstract: Dysferlin is a sarcolemmal protein present in muscle cells. It is responsible for muscle membrane repair. Dysferlin gene (DYSF) mutation, resulting in deficiency in this protein, is termed dysferlinopathy. Clinically, it manifests as early adulthood ... ...

Abstract	Dysferlin is a sarcolemmal protein present in muscle cells. It is responsible for muscle membrane repair. Dysferlin gene (DYSF) mutation, resulting in deficiency in this protein, is termed dysferlinopathy. Clinically, it manifests as early adulthood onset of muscle weakness with markedly elevated creatine kinase levels. The main phenotypes are limb-girdle muscular dystrophy type 2B (LGMD2B), affecting proximal muscles, and Miyoshi myopathy (MM), affecting distal muscles. Dysferlin is also present in cardiomyocytes, and case reports have emerged of cardiac abnormalities in dysferlinopathy. While routine methods of cardiac screening, namely, electrocardiography or echocardiography, are convenient and noninvasive, they often exhibit insufficient diagnostic sensitivity for detecting subclinical cardiac remodeling during early stages of cardiomyopathy. Cardiac magnetic resonance imaging though can provide accurate assessment of cardiac chamber sizes and function. With gadolinium administration, it can also detect areas of myocardial scarring and fibrosis. Early diagnosis of neuromuscular disease-related cardiomyopathy is of clinical significance, as appropriate treatment can retard myocardial fibrosis, delaying cardiomyopathy progression. We present a case of a patient with MM incidentally diagnosed with concomitant cardiomyopathy.
MeSH term(s)	Adult ; Cardiac Imaging Techniques ; Cardiomyopathies/diagnostic imaging ; Cardiomyopathies/etiology ; Distal Myopathies/complications ; Female ; Gadolinium ; Humans ; Magnetic Resonance Imaging ; Muscular Atrophy/complications
Chemical Substances	Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2021-01-31
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	2187806-7
ISSN	1349-3299 ; 1349-2365
ISSN (online)	1349-3299
ISSN	1349-2365
DOI	10.1536/ihj.20-354
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Zs.A 211: Show issues

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Article ; Online: Plaque Inflammation Imaging in Severe Carotid Stenosis and Recurrent Cerebral Ischemia.

Sharma, Vijay K / Paliwal, Prakash R / Sinha, Arvind K

Journal of nuclear medicine technology

2015 Volume 43, Issue 4, Page(s) 299–300

Abstract: A strong relationship exists between the severity of carotid stenosis and early stroke risk. Inflammation is believed to be an important event for atherosclerotic plaque destabilization and subsequent thromboembolism. (18)F-FDG can image atherosclerotic ... ...

Abstract	A strong relationship exists between the severity of carotid stenosis and early stroke risk. Inflammation is believed to be an important event for atherosclerotic plaque destabilization and subsequent thromboembolism. (18)F-FDG can image atherosclerotic inflammation, providing information about plaque biology, which may serve as a useful biomarker for the assessment of early stroke risk.
MeSH term(s)	Brain Ischemia/complications ; Carotid Stenosis/complications ; Fluorodeoxyglucose F18 ; Humans ; Inflammation/complications ; Male ; Middle Aged ; Plaque, Atherosclerotic/complications ; Plaque, Atherosclerotic/diagnostic imaging ; Positron-Emission Tomography ; Recurrence
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2015-12
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	189163-7
ISSN	1535-5675 ; 0091-4916
ISSN (online)	1535-5675
ISSN	0091-4916
DOI	10.2967/jnmt.114.153627
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Zs.B 2211: Show issues

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Article ; Online: Effect of erroneous body-weight estimation on outcome of thrombolyzed stroke patients.

Paliwal, Prakash R / Sharma, Arvind K / Komal Kumar, R N / Wong, Lily Y H / Chan, Bernard P L / Teoh, Hock Luen / Sharma, Vijay K

Journal of thrombosis and thrombolysis

2020 Volume 50, Issue 4, Page(s) 921–928

Abstract: Intravenously administered tissue plasminogen activator (IV-tPA), dose determined by patients' body-weight, remains the only approved drug treatment for acute ischemic stroke (AIS). Since a shorter onset-to-treatment time results in better functional ... ...

Abstract	Intravenously administered tissue plasminogen activator (IV-tPA), dose determined by patients' body-weight, remains the only approved drug treatment for acute ischemic stroke (AIS). Since a shorter onset-to-treatment time results in better functional outcome, treatment is often initiated according to the estimated or last-known body-weight of the patient. This approach may result in underdosing or overdosing of tPA. In this multicenter retrospective study, we evaluated the extent of error in tPA dosing in our AIS cohort and its impact on functional outcome and symptomatic intracranial hemorrhage (SICH). Consecutive AIS patients, receiving IV-tPA, dose determined by the estimated body-weight, at three tertiary centers between January and December 2017 were included. Collected data included information about demographics, cardiovascular risk factors, stroke subtype and National Institute of Health Stroke Scale (NIHSS) score. Estimated and measured body-weights were recorded. Modified Rankin scale (mRS) of 2 or more defined unfavorable outcome. The study included 150 patients. Median age was 64 -years (IQR 55-75) with male preponderance (67%) and median NIHSS score of 9 points (IQR 6-17). Mean measured weight of our study population was 58 (SD 13) kg. Median difference between actual and estimated body-weight was 3 kg (IQR 1.5-6). Difference was more than 10% in 35 (23.3%) patients. Good functional outcome (mRS 0-1) was achieved by 74 (49.3%) patients and 10 (6.8%) developed SICH. NIHSS (OR 1.288; 95% CI 1.157-1.435, p < 0.001) and large artery atherosclerosis (OR 5.878; 95% CI 1.929-17.910, p = 0.002) were independent predictors of unfavorable functional outcome. Our finding of the statistically insignificant 2.5-fold increase in poor outcomes among patients where the estimated and actual weight differed by more than 10% should be interpreted with caution due to the limited sample size. Significant difference occurs between estimated and actual body-weight in a considerable proportion of thrombolysed AIS patients. However, this discrepancy does not affect functional outcome or the risk of SICH.
Language	English
Publishing date	2020-04-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1230645-9
ISSN	1573-742X ; 0929-5305
ISSN (online)	1573-742X
ISSN	0929-5305
DOI	10.1007/s11239-020-02118-3
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Zs.A 4352: Show issues

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Article ; Online: Valsalva maneuver in detection of right-to-left shunt by transcranial Doppler.

Paliwal, Prakash R / Sharma, Vijay K

Arquivos de neuro-psiquiatria

2010 Volume 68, Issue 6, Page(s) 979

MeSH term(s)	Embolism, Paradoxical/diagnostic imaging ; Humans ; Ultrasonography, Doppler, Transcranial/methods ; Valsalva Maneuver
Language	English
Publishing date	2010-12-30
Publishing country	Brazil
Document type	Letter ; Comment
ZDB-ID	418916-4
ISSN	1678-4227 ; 0004-282X
ISSN (online)	1678-4227
ISSN	0004-282X
DOI	10.1590/s0004-282x2010000600034
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Article ; Online: Immunogenicity and safety of a 14-valent pneumococcal polysaccharide conjugate vaccine (PNEUBEVAX 14™) administered to 6-8 weeks old healthy Indian Infants: A single blind, randomized, active-controlled, Phase-III study.

Matur, Ramesh V / Thuluva, Subhash / Gunneri, Subbareddy / Yerroju, Vijay / Reddy Mogulla, Rammohan / Thammireddy, Kamal / Paliwal, Piyush / Mahantshetty, Niranjana S / Ravi, Mandyam Dhati / Prashanth, S / Verma, Savita / Narayan, Jai Prakash

Vaccine

2024 Volume 42, Issue 13, Page(s) 3157–3165

Abstract: Background: Introduction of pneumococcal conjugate vaccines (PCVs) reduced the number of cases of pneumococcal disease (PD). However, there is an increase in clinical and economic burden of PD from serotypes that are not part of the existing ... ...

Abstract	Background: Introduction of pneumococcal conjugate vaccines (PCVs) reduced the number of cases of pneumococcal disease (PD). However, there is an increase in clinical and economic burden of PD from serotypes that are not part of the existing pneumococcal vaccines, particularly impacting pediatric and elder population. In addition, the regions where the PCV is not available, the disease burden remains high. In this study, immunogenicity and safety of the BE's 14-valent PCV (PNEUBEVAX 14™; BE-PCV-14) containing two additional epidemiologically important serotypes (22F and 33F) was evaluated in infants in comparison to licensed vaccine, Prevenar-13 (PCV-13). Methods: This is a pivotal phase-3 single blind randomized active-controlled study conducted at 12 sites across India in 6-8 weeks old healthy infants at 6-10-14 weeks dosing schedule to assess immunogenic non-inferiority and safety of a candidate BE-PCV-14. In total, 1290 infants were equally randomized to receive either BE-PCV-14 or PCV-13. Solicited local reactions and systemic events, adverse events (AEs), serious AEs (SAEs), and medically attended AEs (MAAEs) were recorded. Immunogenicity was assessed by measuring anti-PnCPS (anti-pneumococcal capsular polysaccharide) IgG concentration and functional antibody titers through opsonophagocytic activity (OPA), one month after completing three dose schedule. Cross protection to serotype 6A offered by serotype 6B was also assessed in this study. Findings: The safety profile of BE-PCV-14 was comparable to PCV-13 vaccine. Majority of reported AEs were mild in nature. No severe or serious AEs were reported in both the treatment groups. For the twelve common serotypes and for the additional serotypes (22F and 33F) in BE-PCV-14, NI criteria was demonstrated as defined by WHO TRS-977. Primary immunogenicity endpoint was met in terms of IgG immune responses for all 14 serotypesof BE-PCV-14. Moreover, a significant proportion of subjects (69%) seroconverted against serotype 6A, even though this antigen was not present in BE-PCV-14. This indicates that serotype 6B of BE-PCV-14 cross protects serotype 6A. BE-PCV-14 also elicited comparable serotype specific functional OPA immune responses to all the serotypes common to PCV-13. Interpretations: BE-PCV-14 was found to be safe and induced robust and functional serotype specific immune responses to all 14 serotypes. It also elicited cross protective immune response against serotype 6B.These findings suggest that BE-PCV-14 can be safely administered to infants and achieve protection against pneumococcal disease caused by serotypes covered in the vaccine. The study was prospectively registered with clinical trial registry of India - CTRI/2020/02/023129.
MeSH term(s)	Humans ; Pneumococcal Vaccines/immunology ; Pneumococcal Vaccines/adverse effects ; Pneumococcal Vaccines/administration & dosage ; Infant ; India ; Antibodies, Bacterial/blood ; Male ; Vaccines, Conjugate/immunology ; Vaccines, Conjugate/adverse effects ; Vaccines, Conjugate/administration & dosage ; Female ; Pneumococcal Infections/prevention & control ; Pneumococcal Infections/immunology ; Single-Blind Method ; Streptococcus pneumoniae/immunology ; Immunogenicity, Vaccine ; Serogroup ; Immunoglobulin G/blood
Chemical Substances	Pneumococcal Vaccines ; Antibodies, Bacterial ; Vaccines, Conjugate ; Immunoglobulin G ; 13-valent pneumococcal vaccine
Language	English
Publishing date	2024-04-17
Publishing country	Netherlands
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't ; Clinical Trial, Phase III ; Multicenter Study
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2024.03.056
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Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

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Article ; Online: Association between reversible cerebral vasoconstriction syndrome and thrombotic thrombocytopenic purpura.

Paliwal, Prakash R / Teoh, Hock L / Sharma, Vijay K

Journal of the neurological sciences

2014 Volume 338, Issue 1-2, Page(s) 223–225

Abstract: Background: Reversible cerebrovascular constriction syndrome (RCVS) presents with thunderclap headache and ischemic neurological deficits due to focal vasoconstrictions in major intracranial arteries. Reversibility of focal vasoconstrictions is the ... ...

Abstract	Background: Reversible cerebrovascular constriction syndrome (RCVS) presents with thunderclap headache and ischemic neurological deficits due to focal vasoconstrictions in major intracranial arteries. Reversibility of focal vasoconstrictions is the hallmark of RCVS. The commonest conditions associated with RCVS are a post-partum state and administration of vasoactive agents. Methods: We describe a series of 3 cases of thrombotic thrombocytopenic purpura (TTP) who presented with thunderclap headache and focal neurological deficits. Results: Vascular imaging revealed focal areas of constrictions in multiple intracranial arteries. All cases were treated with plasmapheresis and serial transcranial Doppler (TCD) and magnetic resonance angiography revealed resolution of cerebral vasoconstriction, accompanied by clinical recovery. Conclusion: RCVS should be considered in patients with TTP who presented with thunderclap headache. TCD is an important tool for monitoring the course of cerebral vasoconstriction in TTP.
MeSH term(s)	Adult ; Female ; Headache Disorders, Primary/etiology ; Humans ; Magnetic Resonance Angiography ; Purpura, Thrombotic Thrombocytopenic/complications ; Purpura, Thrombotic Thrombocytopenic/diagnosis ; Purpura, Thrombotic Thrombocytopenic/etiology ; Ultrasonography, Doppler, Duplex ; Vasospasm, Intracranial/complications
Language	English
Publishing date	2014-03-15
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	80160-4
ISSN	1878-5883 ; 0022-510X ; 0374-8642
ISSN (online)	1878-5883
ISSN	0022-510X ; 0374-8642
DOI	10.1016/j.jns.2013.12.043
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