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  1. Journal ; Article ; Online: A legacy of progress in clinical pharmacology and social justice; remembering Peter Ian Folb

    Barnes, Karen I / Olliaro, Piero / Gomes, Melba F

    2023  

    Abstract: ... 3 ... ...

    Abstract 3

    3A
    Keywords Editorials
    Language English
    Publisher World Health Organization
    Document type Journal ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Characterisation of populations at risk of sub-optimal dosing of artemisinin-based combination therapy in Africa.

    Takyi, Abena / Carrara, Verena I / Dahal, Prabin / Przybylska, Marianna / Harriss, Eli / Insaidoo, Genevieve / Barnes, Karen I / Guerin, Philippe J / Stepniewska, Kasia

    PLOS global public health

    2023  Volume 3, Issue 12, Page(s) e0002059

    Abstract: Selection of resistant malaria strains occurs when parasites are exposed to inadequate antimalarial drug concentrations. The proportion of uncomplicated falciparum malaria patients at risk of being sub-optimally dosed with the current World Health ... ...

    Abstract Selection of resistant malaria strains occurs when parasites are exposed to inadequate antimalarial drug concentrations. The proportion of uncomplicated falciparum malaria patients at risk of being sub-optimally dosed with the current World Health Organization (WHO) recommended artemisinin-based combination therapies (ACTs) is unknown. This study aims to estimate this proportion and the excess number of treatment failures (recrudescences) associated with sub-optimal dosing in Sub-Saharan Africa. Sub-populations at risk of sub-optimal dosing include wasted children <5 years of age, patients with hyperparasitaemia, pregnant women, people living with HIV, and overweight adults. Country-level data on population structure were extracted from openly accessible data sources. Pooled adjusted Hazard Ratios for PCR-confirmed recrudescence were estimated for each risk group from published meta-analyses using fixed-effect meta-analysis. In 2020, of the estimated 153.1 million uncomplicated P. falciparum malaria patients in Africa, the largest risk groups were the hyperparasitaemic patients (13.2 million, 8.6% of uncomplicated malaria cases) and overweight adults (10.3 million, 6.7% of uncomplicated cases). The estimated excess total number of treatment failures ranged from 0.338 million for a 98% baseline ACT efficacy to 1.352 million for a 92% baseline ACT efficacy. Our study shows that an estimated nearly 1 in 4 people with uncomplicated confirmed P. falciparum malaria in Africa are at risk of receiving a sub-optimal antimalarial drug dosing. This increases the risk of antimalarial drug resistance and poses a serious threat to malaria control and elimination efforts. Changes in antimalarial dosing or treatment duration of current antimalarials may be needed and new antimalarials development should ensure sufficient drug concentration levels in these sub-populations that carry a high malaria burden.
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ISSN 2767-3375
    ISSN (online) 2767-3375
    DOI 10.1371/journal.pgph.0002059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A Physiologically-Based Pharmacokinetic Framework for Prediction of Drug Exposure in Malnourished Children.

    Sjögren, Erik / Tarning, Joel / Barnes, Karen I / Jonsson, E Niclas

    Pharmaceutics

    2021  Volume 13, Issue 2

    Abstract: Malnutrition in children is a global health problem, particularly in developing countries. The effects of an insufficient supply of nutrients on body composition and physiological functions may have implications for drug disposition and ultimately affect ...

    Abstract Malnutrition in children is a global health problem, particularly in developing countries. The effects of an insufficient supply of nutrients on body composition and physiological functions may have implications for drug disposition and ultimately affect the clinical outcome in this vulnerable population. Physiologically-based pharmacokinetic (PBPK) modeling can be used to predict the effect of malnutrition as it links physiological changes to pharmacokinetic (PK) consequences. However, the absence of detailed information on body composition and the limited availability of controlled clinical trials in malnourished children complicates the establishment and evaluation of a generic PBPK model in this population. In this manuscript we describe the creation of physiologically-based bridge to a malnourished pediatric population, by combining information on (a) the differences in body composition between healthy and malnourished adults and (b) the differences in physiology between healthy adults and children. Model performance was confirmed using clinical reference data. This study presents a physiologically-based translational framework for prediction of drug disposition in malnourished children. The model is readily applicable for dose recommendation strategies to address the urgent medicinal needs of this vulnerable population.
    Language English
    Publishing date 2021-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics13020204
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  4. Article ; Online: Interpretation of Drug Interactions between Dolutegravir and Artemether-Lumefantrine or Artesunate-Amodiaquine.

    Banda, Clifford G / Barnes, Karen I / Maartens, Gary

    Antimicrobial agents and chemotherapy

    2019  Volume 63, Issue 6

    MeSH term(s) Amodiaquine ; Antimalarials ; Artemether ; Artemether, Lumefantrine Drug Combination ; Artesunate ; Drug Interactions ; Heterocyclic Compounds, 3-Ring
    Chemical Substances Antimalarials ; Artemether, Lumefantrine Drug Combination ; Heterocyclic Compounds, 3-Ring ; Amodiaquine (220236ED28) ; Artesunate (60W3249T9M) ; Artemether (C7D6T3H22J) ; dolutegravir (DKO1W9H7M1)
    Language English
    Publishing date 2019-05-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.00576-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Characterisation of populations at risk of sub-optimal dosing of artemisinin-based combination therapy in Africa

    Abena Takyi / Verena I. Carrara / Prabin Dahal / Marianna Przybylska / Eli Harriss / Genevieve Insaidoo / Karen I. Barnes / Philippe J. Guerin / Kasia Stepniewska

    PLOS Global Public Health, Vol 3, Iss

    2023  Volume 12

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Strength in Numbers: The WWARN Case Study of Purpose-Driven Data Sharing.

    Humphreys, Georgina S / Tinto, Halidou / Barnes, Karen I

    The American journal of tropical medicine and hygiene

    2018  Volume 100, Issue 1, Page(s) 13–15

    Abstract: Data are the basis for all scientific output. The sharing of data supporting that output is an important aspect of scientific communication, and is increasingly required by funders and publishers. Yet, academic advancement seldom recognizes or rewards ... ...

    Abstract Data are the basis for all scientific output. The sharing of data supporting that output is an important aspect of scientific communication, and is increasingly required by funders and publishers. Yet, academic advancement seldom recognizes or rewards data sharing. This article argues that although mandating data sharing will increase the amount of data available, this will not necessarily enable or encourage the secondary analyses needed to achieve its purported public good. We, therefore, need to build models that maximize the efficiency of processes for data collation and curation, and genuinely reward those engaged in data sharing and reuse. The WorldWide Antimalarial Resistance Network has 10 years of experience as a data platform, and its study group approach provides an example of how some of the challenges in equitable and impactful data-sharing and secondary use can be addressed, with a focus on the priorities of researchers in resource-limited settings.
    MeSH term(s) Biomedical Research/methods ; Biomedical Research/organization & administration ; Global Health ; Humans ; Information Dissemination ; Malaria ; Meta-Analysis as Topic ; Organizational Case Studies ; Research Personnel/education
    Language English
    Publishing date 2018-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.18-0649
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  7. Article ; Online: Why is WHO failing women with falciparum malaria in the first trimester of pregnancy?

    McGready, Rose / Nosten, François / Barnes, Karen I / Mokuolu, Olugbenga / White, Nicholas J

    Lancet (London, England)

    2020  Volume 395, Issue 10226, Page(s) 779

    MeSH term(s) Adult ; Antimalarials/adverse effects ; Antimalarials/therapeutic use ; Artemisinins/adverse effects ; Female ; Humans ; Malaria, Falciparum/drug therapy ; Practice Guidelines as Topic ; Pregnancy ; Pregnancy Complications, Parasitic/drug therapy ; Pregnancy Trimester, First ; World Health Organization
    Chemical Substances Antimalarials ; Artemisinins ; artemisinin (9RMU91N5K2)
    Language English
    Publishing date 2020-03-06
    Publishing country England
    Document type Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)30161-6
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  8. Article ; Online: Review of Objective Structured Clinical Examination Practices Within Pharmacy Programs Throughout the United States.

    Barnes, Kylie N / Hardinger, Karen L / Graham, Maqual R

    American journal of pharmaceutical education

    2024  Volume 88, Issue 4, Page(s) 100686

    Abstract: Objective: To update the description of current objective structured clinical examination (OSCE) practices within pharmacy schools in the United States and identify barriers to OSCE implementation and expansion.: Methods: A survey was deployed to all ...

    Abstract Objective: To update the description of current objective structured clinical examination (OSCE) practices within pharmacy schools in the United States and identify barriers to OSCE implementation and expansion.
    Methods: A survey was deployed to all accredited Doctor of Pharmacy programs within the United States. The survey was designed to collect information regarding the curricular mapping of OSCEs, OSCE design, OSCE delivery, assessment of OSCE performance, and barriers to OSCE implementation and expansion.
    Results: Of the 135 US-accredited programs identified, 109 (81%) programs completed the survey. In total, 93 (85%) programs reported using OSCEs to assess students; however, implementation throughout the curriculum and current practices varied by institution. Most programs place OSCEs within specific courses (96%), with the applied skills coursework being the most used (80%). The most common number of OSCEs that occur throughout a curriculum is 6 (18%), however, 20 (22%) programs execute 10 or more OSCEs throughout their curriculum. Forty (43%) programs use OSCEs as high-stakes assessments where poor performance could prevent a student from progressing to advanced pharmacy practice experiences. Of the responding programs, over half (56%) use teaching objective structured examinations to enhance learning. Common barriers to OSCE expansion exist and are related to resource utilization.
    Conclusion: Significant expansion of OSCE development and implementation has occurred over the last decade. There is substantial variability in implementation and utilization among programs. Although standards of best practice for OSCEs exist for other health professions, best practices in pharmacy education have not been widely accepted or adopted.
    MeSH term(s) Humans ; Clinical Competence ; Curriculum ; Education, Pharmacy ; Educational Measurement ; Pharmacy ; United States
    Language English
    Publishing date 2024-03-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603807-4
    ISSN 1553-6467 ; 0002-9459
    ISSN (online) 1553-6467
    ISSN 0002-9459
    DOI 10.1016/j.ajpe.2024.100686
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    Zs.A 924: Show issues Location:
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  9. Article ; Online: Characterisation of populations at risk of sub-optimal dosing of artemisinin-based combination therapy in Africa.

    Abena Takyi / Verena I Carrara / Prabin Dahal / Marianna Przybylska / Eli Harriss / Genevieve Insaidoo / Karen I Barnes / Philippe J Guerin / Kasia Stepniewska

    PLOS Global Public Health, Vol 3, Iss 12, p e

    2023  Volume 0002059

    Abstract: Selection of resistant malaria strains occurs when parasites are exposed to inadequate antimalarial drug concentrations. The proportion of uncomplicated falciparum malaria patients at risk of being sub-optimally dosed with the current World Health ... ...

    Abstract Selection of resistant malaria strains occurs when parasites are exposed to inadequate antimalarial drug concentrations. The proportion of uncomplicated falciparum malaria patients at risk of being sub-optimally dosed with the current World Health Organization (WHO) recommended artemisinin-based combination therapies (ACTs) is unknown. This study aims to estimate this proportion and the excess number of treatment failures (recrudescences) associated with sub-optimal dosing in Sub-Saharan Africa. Sub-populations at risk of sub-optimal dosing include wasted children <5 years of age, patients with hyperparasitaemia, pregnant women, people living with HIV, and overweight adults. Country-level data on population structure were extracted from openly accessible data sources. Pooled adjusted Hazard Ratios for PCR-confirmed recrudescence were estimated for each risk group from published meta-analyses using fixed-effect meta-analysis. In 2020, of the estimated 153.1 million uncomplicated P. falciparum malaria patients in Africa, the largest risk groups were the hyperparasitaemic patients (13.2 million, 8.6% of uncomplicated malaria cases) and overweight adults (10.3 million, 6.7% of uncomplicated cases). The estimated excess total number of treatment failures ranged from 0.338 million for a 98% baseline ACT efficacy to 1.352 million for a 92% baseline ACT efficacy. Our study shows that an estimated nearly 1 in 4 people with uncomplicated confirmed P. falciparum malaria in Africa are at risk of receiving a sub-optimal antimalarial drug dosing. This increases the risk of antimalarial drug resistance and poses a serious threat to malaria control and elimination efforts. Changes in antimalarial dosing or treatment duration of current antimalarials may be needed and new antimalarials development should ensure sufficient drug concentration levels in these sub-populations that carry a high malaria burden.
    Keywords Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Erratum for Banda et al., "Impact of Dolutegravir-Based Antiretroviral Therapy on Piperaquine Exposure following Dihydroartemisinin-Piperaquine Intermittent Preventive Treatment of Malaria in Pregnant Women Living with HIV".

    Banda, Clifford G / Nkosi, Dumisile / Allen, Elizabeth / Workman, Lesley / Madanitsa, Mwayiwawo / Chirwa, Marumbo / Kapulula, Mayamiko / Muyaya, Sharon / Munharo, Steven / Tarning, Joel / Phiri, Kamija S / Mwapasa, Victor / Ter Kuile, Feiko O / Maartens, Gary / Barnes, Karen I

    Antimicrobial agents and chemotherapy

    2023  Volume 67, Issue 1, Page(s) e0156222

    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.01562-22
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