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Article ; Online: Occupational asbestos exposure and urinary bladder cancer: a systematic review and meta-analysis.

Franco, Nicolò / Godono, Alessandro / Clari, Marco / Ciocan, Catalina / Zunarelli, Carlotta / Pira, Enrico / Boffetta, Paolo

World journal of urology

2023 Volume 41, Issue 4, Page(s) 1005–1015

Abstract: Purpose: There is conflicting evidence on the association between asbestos exposure and bladder cancer. We performed a systematic review and meta-analysis to provide evidence on occupational asbestos exposure and the risk of mortality and incidence of ... ...

Abstract	Purpose: There is conflicting evidence on the association between asbestos exposure and bladder cancer. We performed a systematic review and meta-analysis to provide evidence on occupational asbestos exposure and the risk of mortality and incidence of bladder cancer. Methods: We searched three relevant electronic databases (Pubmed, Scopus, and Embase) from inception to October 2021. The methodological quality of included articles was evaluated using the US National Institutes of Health tool. Standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs) for bladder cancer, as well as respective 95% confidence intervals (CIs), were extracted or calculated for each included cohort. Main and subgroup meta-analyses according to first year of employment, industry, sex, asbestos type, and geographic region were performed. Results: Fifty-nine publications comprising 60 cohorts were included. Bladder cancer incidence and mortality were not significantly associated with occupational asbestos exposure (pooled SIR: 1.04, 95% CI: 0.95-1.13, P = 0.000; pooled SMR: 1.06, 95% CI: 0.96-1.17, P = 0.031). Bladder cancer incidence was higher among workers employed between 1908 and 1940 (SIR: 1.15, 95% CI: 1.01-1.31). Mortality was elevated in asbestos workers cohorts (SMR: 1.12, 95% CI: 1.06-1.30) and in the subgroup analysis for women (SMR: 1.83, 95% CI: 1.22-2.75). No association was found between asbestos types and bladder cancer incidence or mortality. We observed no difference in the subgroup analysis for countries and no direct publication bias evidence. Conclusion: There is evidence that workers with occupational asbestos exposure have a bladder cancer incidence and mortality similar to the general population.
MeSH term(s)	Humans ; Female ; Occupational Diseases/epidemiology ; Occupational Diseases/etiology ; Asbestos/adverse effects ; Occupational Exposure/adverse effects ; Urinary Bladder Neoplasms/etiology ; Urinary Bladder Neoplasms/complications ; Incidence ; Lung Neoplasms
Chemical Substances	Asbestos (1332-21-4)
Language	English
Publishing date	2023-02-27
Publishing country	Germany
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	380333-8
ISSN	1433-8726 ; 0724-4983
ISSN (online)	1433-8726
ISSN	0724-4983
DOI	10.1007/s00345-023-04327-w
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Article: Exposure to glyphosate and risk of non-Hodgkin lymphoma: an updated meta-analysis.

Boffetta, Paolo / Ciocan, Catalina / Zunarelli, Carlotta / Pira, Enrico

La Medicina del lavoro

2021 Volume 112, Issue 3, Page(s) 194–199

Abstract: Objective: We updated a recent systematic review and meta-analysis of epidemiologic studies to help clarifying the association between exposure to glyphosate and risk of non-Hodgkin lymphoma (NHL).: Methods: We conducted an updated search of the ... ...

Abstract	Objective: We updated a recent systematic review and meta-analysis of epidemiologic studies to help clarifying the association between exposure to glyphosate and risk of non-Hodgkin lymphoma (NHL). Methods: We conducted an updated search of the literature, and identified a total of 15 relevant publications, from which we extracted results from six non-overlapping studies. We performed random-effects meta-analyses for ever-exposure to glyphosate, dose-response, and risk of specific NHL subtypes Results: The meta-RR for ever-exposure to glyphosate was 1.05 (95% confidence interval [CI] 0.90-1.24; I2 = 0%). The meta-RR for the highest category of exposure was 1.15 (95% CI 0.72-1.83; 3 studies). The meta-RR for diffuse large B-cell lymphoma (DLBCL) was 1.29 (95% CI 1.02-1.63; 4 studies), that for follicular lymphoma was 0.84 (95% CI 0.61-1.17), and that for chronic lymphocytic leukemia/small lymphocytic lymphoma was 1.33 (95% CI 0.65-2.70). There was indication of publication bias. Conclusions: This updated meta-analysis reinforces our previous conclusion of a lack of an association between exposure to glyphosate and risk of NHL overall, although an association with DLBCL cannot be ruled out.
MeSH term(s)	Glycine/adverse effects ; Glycine/analogs & derivatives ; Humans ; Lymphoma, Non-Hodgkin/chemically induced ; Lymphoma, Non-Hodgkin/epidemiology ; Risk Factors ; Glyphosate
Chemical Substances	Glycine (TE7660XO1C)
Language	English
Publishing date	2021-06-15
Publishing country	Italy
Document type	Journal Article ; Meta-Analysis
ZDB-ID	123678-7
ISSN	0025-7818
ISSN	0025-7818
DOI	10.23749/mdl.v112i3.11123
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Article ; Online: Physical Health and Work Ability among Healthcare Workers. A Cross-Sectional Study.

Garzaro, Giacomo / Clari, Marco / Ciocan, Catalina / Albanesi, Beatrice / Guidetti, Gloria / Dimonte, Valerio / Sottimano, Ilaria

Nursing reports (Pavia, Italy)

2022 Volume 12, Issue 2, Page(s) 259–269

Abstract: Healthcare workers' age is increasingly rising, negatively affecting their physical health. In particular, workability is an emerging phenomenon that predominantly affects healthcare workers. This study aims to assess physical health status and ... ...

Abstract	Healthcare workers' age is increasingly rising, negatively affecting their physical health. In particular, workability is an emerging phenomenon that predominantly affects healthcare workers. This study aims to assess physical health status and workability among ageing healthcare workers. A cross-sectional study using the Work Ability Index (WAI) was performed. Data were collected in a university hospital in northern Italy. Data were collected voluntary through a questionnaire. Healthcare workers participating in the survey were contacted personally by two resident physicians. Thus, the total number of study participants was 220 among nursing aides, nurses, and physicians. Data were analyzed by performing ANOVA and regression to assess the differences between the healthcare workers and age groups. A generalized linear model was tested to evaluate the effect of age and task on workability. The majority of healthcare workers had good WAI values. Physicians' workability was higher than nursing aides. Nursing aides suffered more from cardiovascular disorders, while physicians and nurses had more musculoskeletal disorders. However, the distribution was statistically different (χ
Language	English
Publishing date	2022-04-05
Publishing country	Switzerland
Document type	Journal Article
ISSN	2039-4403
ISSN (online)	2039-4403
DOI	10.3390/nursrep12020026
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Article: Exposure to glyphosate and risk of non-Hodgkin lymphoma and multiple myeloma: an updated meta-analysis.

Donato, Francesca / Pira, Enrico / Ciocan, Catalina / Boffetta, Paolo

La Medicina del lavoro

2020 Volume 111, Issue 1, Page(s) 63–73

Abstract: Objective: We carried out a systematic review and meta-analysis of epidemiologic studies on the association between occupational exposure to glyphosate and risk of non-Hodgkin lymphoma (NHL) and multiple myeloma (MM).: Methods: We conducted a ... ...

Abstract	Objective: We carried out a systematic review and meta-analysis of epidemiologic studies on the association between occupational exposure to glyphosate and risk of non-Hodgkin lymphoma (NHL) and multiple myeloma (MM). Methods: We conducted a systematic search of the literature, and identified 18 relevant publications, from which we extracted results from seven non-overlapping studies of NHL and three of MM. We performed random-effects meta-analyses for ever-exposure to glyphosate, dose-response, and risk of specific NHL subtypes. Results: The meta-relative risk (RR) of NHL was 1.03 (95% confidence interval [CI] 0.86-1.21), that of MM was 1.04 (95% CI 0.67-1.41). The meta-RR of NHL for highest category of exposure was 1.49 (95% CI 0.37-2.61; 3 studies). The meta-RR for diffuse large B-cell lymphoma (DLBCL) was 1.31 (95% CI 0.93-1.75); that for follicular lymphoma was 0.82 (95% CI 0.93-1.70), and that for chronic lymphocytic leukemia was 0.85 (95% CI 0.20-1.49). There was indication of publication bias for studies on NHL. Conclusions: Our meta-analysis provided no overall evidence of an increased risk for both NHL and MM in subjects occupationally exposed to glyphosate. In secondary analyses we detected a small increase in risk for the category with highest level of exposure as well as for DLBCL. The evidence of publication bias suggests caution in the interpretation of the results.
MeSH term(s)	Glycine/analogs & derivatives ; Glycine/toxicity ; Humans ; Lymphoma, Non-Hodgkin/epidemiology ; Multiple Myeloma/epidemiology ; Occupational Exposure ; Risk Factors ; Glyphosate
Chemical Substances	Glycine (TE7660XO1C)
Language	English
Publishing date	2020-02-24
Publishing country	Italy
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	123678-7
ISSN	0025-7818
ISSN	0025-7818
DOI	10.23749/mdl.v111i1.8967
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Article ; Online: Risk of Mortality from Respiratory Malignant and Non-Malignant Diseases among Talc Miners and Millers: A Systematic Review and Meta-Analysis.

Ciocan, Catalina / Godono, Alessandro / Stefanin, Sandro / Boffetta, Paolo / Pira, Enrico / Clari, Marco

Toxics

2022 Volume 10, Issue 10

Abstract: There is contrasting data on the association between talc exposure and lung and pleural cancer. Given the potential importance of this aspect, we performed a systematic review and meta-analysis to investigate the association between working in the talc ... ...

Abstract	There is contrasting data on the association between talc exposure and lung and pleural cancer. Given the potential importance of this aspect, we performed a systematic review and meta-analysis to investigate the association between working in the talc extractive industry and mortality from malignant and non-malignant respiratory diseases. We followed PRISMA guidelines to systematically search for pertinent articles in three relevant electronic databases: Pubmed, Scopus, and WebOfScience, from their inception to 30 November 2021. The methodological quality of included articles was evaluated using the US National Institutes of Health tool. Standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs) for malignant and non-malignant respiratory diseases as well as respective 95% confidence intervals (CIs) were extracted or calculated for each included cohort. Six articles comprising 7 cohorts were included in the metanalysis. There was increased mortality for pneumoconiosis, especially in the miner's group (SMR = 7.90, CI 95% 2.77-22.58) and especially in those exposed to higher quartz concentration and for non-malignant respiratory diseases in the overall analysis (SMR = 1.81, CI 95% 1.15-2.82). The risk for lung cancer mortality was slightly increased in the overall analysis (SMR = 1.42, CI 95% 1.07-1.89). The risk for malignant mesothelioma could not be calculated due to an insufficient number of studies assessing this outcome. This systematic review and meta-analysis provides evidence that men working in the talc mining industry have increased mortality for non-malignant respiratory diseases including pneumoconiosis. The small excess in lung cancer mortality may be, in part, explained by the high prevalence of the smokers in some of the analyzed cohorts or by the exposure to other carcinogens like radon decay products and diesel engine exhaust.
Language	English
Publishing date	2022-10-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics10100589
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Article ; Online: Analysis of the Relation between Conservatism and the Amount of Dividends Payable to Shareholders. The Case of Romanian Listed Companies

Claudia-Cătălina Ciocan

Ovidius University Annals: Economic Sciences Series, Vol XIX, Iss 1, Pp 570-

2019 Volume 579

Abstract: This paper has as a main purpose to identify if the use of provisions in accounting is able to produce significant changes in the amount of the distributed earnings (dividends) for the Romanian listed companies. For this purpose, we compute a correction ... ...

Abstract	This paper has as a main purpose to identify if the use of provisions in accounting is able to produce significant changes in the amount of the distributed earnings (dividends) for the Romanian listed companies. For this purpose, we compute a correction of the distributed earnings by excluding expenses and revenues reported for provisions while maintaining the dividend payout ratio at a constant level. The results indicate significant differences between the dividends actually paid and the potential dividends obtained by excluding the effects of the provisions recognition. We conclude that the use of conservatism in order to avoid decapitalization is a real fact for the company even though the investors seem to be placed in the background. Also, the paper aims to identify and systematise the reasons that should lead the management to recognize provisions in accounting despite the impact exerted over the dividends payable.
Keywords	provisions ; conservatism/prudence ; dividends ; decapitalisation ; risk ; Business ; HF5001-6182 ; Economics as a science ; HB71-74
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Ovidius University Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Differential Protective Effect of Zinc and Magnesium for the Hepatic and Renal Toxicity Induced by Acetaminophen and Potentiated with Ciprofloxacin in Rats.

Ciocan Moraru, Alexandra / Ciubotariu, Diana / Ghiciuc, Cristina Mihaela / Hurmuzache, Mihnea Eudoxiu / Lupușoru, Cătălina Elena / Crișan-Dabija, Radu

Medicina (Kaunas, Lithuania)

2024 Volume 60, Issue 4

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Animals ; Ciprofloxacin/pharmacology ; Ciprofloxacin/therapeutic use ; Rats ; Acetaminophen ; Gluconates/pharmacology ; Gluconates/therapeutic use ; Male ; Rats, Wistar ; Zinc/pharmacology ; Zinc/therapeutic use ; Kidney/drug effects ; Magnesium/therapeutic use ; Magnesium/pharmacology ; Liver/drug effects ; Liver/metabolism ; Chemical and Drug Induced Liver Injury/prevention & control ; Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/etiology ; Magnesium Chloride/pharmacology ; Magnesium Chloride/therapeutic use ; Alanine Transaminase/blood ; Aspartate Aminotransferases/blood ; Drug Synergism
Chemical Substances	Ciprofloxacin (5E8K9I0O4U) ; Acetaminophen (362O9ITL9D) ; Gluconates ; gluconic acid (R4R8J0Q44B) ; Zinc (J41CSQ7QDS) ; Magnesium (I38ZP9992A) ; Magnesium Chloride (02F3473H9O) ; Alanine Transaminase (EC 2.6.1.2) ; Aspartate Aminotransferases (EC 2.6.1.1)
Language	English
Publishing date	2024-04-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina60040611
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Article: Mortality in the cohort of talc miners and millers from Val Chisone, Northern Italy: 74 years of follow-up

Ciocan, Catalina / Pira, Enrico / Coggiola, Maurizio / Franco, Nicolò / Godono, Alessandro / La Vecchia, Carlo / Negri, Eva / Boffetta, Paolo

Environmental research. 2022 Jan., v. 203

2022

Abstract: To update the analysis of mortality of a cohort of talc miners and millers in Northern Italy.We analyzed overall mortality and mortality from specific causes of death during 1946–2020 of 1749 male workers in a talc mine where asbestos was not detected ( ... ...

Abstract	To update the analysis of mortality of a cohort of talc miners and millers in Northern Italy.We analyzed overall mortality and mortality from specific causes of death during 1946–2020 of 1749 male workers in a talc mine where asbestos was not detected (1184 miners and 565 millers) employed during 1946–1995.The overall standardized mortality ratio (SMR) was 1.21 (95 % confidence interval [CI] 1.14–1.28); no deaths were observed from pleural cancer. Mortality from lung cancer was not increased (SMR = 1.02 95 % CI 0.82–1.27), while mortality from pneumoconiosis was (SMR 9.55; 95 % CI 7.43–12.08), especially among miners (SMR 12.74; 95 % CI 9.79–16.31). There was a trend in risk of pneumoconiosis with increasing duration of employment in the overall cohort, and the SMR for 25+ years of employment was 15.12 (95 % CI 10.89–20.43).This uniquely long-term follow up confirms the results of previous analyses, namely the lack of association between exposure to talc with no detectable level of asbestos and lung cancer and mesothelioma. Increased mortality from pneumoconiosis among miners is related to past exposure to silica.
Keywords	asbestos ; confidence interval ; death ; employment ; lung neoplasms ; males ; mesothelioma ; mortality ; research ; risk ; silica ; talc ; Italy
Language	English
Dates of publication	2022-01
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2021.111865
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: On the diagnosis of malignant pleural mesothelioma: A necropsy-based study of 171 cases (1997-2016).

Pira, Enrico / Boffetta, Paolo / Ciocan, Catalina

Tumori

2018 Volume 105, Issue 4, Page(s) 359–360

MeSH term(s)	Adenocarcinoma/diagnosis ; Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Diagnosis, Differential ; Female ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Male ; Mesothelioma/diagnosis ; Mesothelioma/genetics ; Mesothelioma/pathology ; Mesothelioma, Malignant ; Neoplasms/diagnosis ; Neoplasms/genetics ; Neoplasms/pathology ; Pleural Neoplasms/diagnosis ; Pleural Neoplasms/genetics ; Pleural Neoplasms/pathology
Language	English
Publishing date	2018-12-20
Publishing country	United States
Document type	Letter
ZDB-ID	280962-x
ISSN	2038-2529 ; 0300-8916
ISSN (online)	2038-2529
ISSN	0300-8916
DOI	10.1177/0300891618820012
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Article: Methodological issues in descriptive environmental epidemiology. The example of study Sentieri.

Ciocan, Catalina / Franco, Nicolò / Pira, Enrico / Mansour, Ihab / Godono, Alessandro / Boffetta, Paolo

La Medicina del lavoro

2021 Volume 112, Issue 1, Page(s) 15–33

Abstract: Background: Descriptive epidemiology identifies associations between environmental exposures and health effects that require results from methodologically stronger studies before causation can be considered.: Objective: To critically review the ... ...

Abstract	Background: Descriptive epidemiology identifies associations between environmental exposures and health effects that require results from methodologically stronger studies before causation can be considered. Objective: To critically review the methodology and results of Sentieri, a descripitive study on residence in areas with one or more industrial source of pollution. Methods: We systematically reviewed the literature quoted by Sentieri for the selection of health effects of nine types of pollution sources of a-priori interest. We also reviewed and meta-analyzed the results of the first report of Sentieri, that analyzed mortality in 44 polluted sites (PS), and 17 causes of deaths during 1995-2002. Results: Among 159 study results quoted by Sentieri, 23.9 % were supportive of an association between residence near a pollution source and a health effect, 30.2 % were partially supportive, 10.7 % were not supportive, and 35.2 % were not relevant. Among 653 standardized mortality ratios for associations between PS-specific pollution sources and causes of death, 14.4% were significantly above 1.02, and 9.0% were significantly below 0.98. Among 48 meta-analysis, seven were significantly above 1.0, including five on exposure to asbestos. Conclusions: Sentieri exemplifies the limitations of descriptive environmental epidemiology studies, in which most hypotheses have limited prior support, most results do not show associations, data on potential confounders and other sources of bias are not available. Such studies tend to replicate well-known associations and occasionally can identify critical situations requiring more investigation, but cannot be used to infer causality either in general or in specific circumstances.
MeSH term(s)	Asbestos/adverse effects ; Environmental Exposure/adverse effects ; Environmental Pollution ; Humans ; Neoplasms
Chemical Substances	Asbestos (1332-21-4)
Language	English
Publishing date	2021-02-23
Publishing country	Italy
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	123678-7
ISSN	0025-7818
ISSN	0025-7818
DOI	10.23749/mdl.v112i1.10099
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