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Article ; Online: Standardization of cumulative antimicrobial susceptibility reports: A need.

Brezmes Valdivieso, María Felipa / Asensio Calle, María Luz / Martín Gómez, Cristina / Ochoa Sangrador, Carlos

Enfermedades infecciosas y microbiologia clinica (English ed.)

2024 Volume 42, Issue 3, Page(s) 166–168

MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Microbial Sensitivity Tests ; Reference Standards
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-02-21
Publishing country	Spain
Document type	Letter
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2024.02.004
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Article ; Online: Authors' reply.

Ochoa-Sangrador, Carlos / Fernández-Rodríguez, Alejandro

Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias

2022 Volume 34, Issue 2, Page(s) 157–158

Title translation	Respuesta de los autores.
MeSH term(s)	Humans ; Urinary Bladder ; Urine Specimen Collection
Language	Spanish
Publishing date	2022-03-11
Publishing country	Spain
Document type	Letter ; Comment
ZDB-ID	2127173-2
ISSN	2386-5857 ; 2386-5857
ISSN (online)	2386-5857
ISSN	2386-5857
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Article ; Online: Efficacy of bladder stimulation techniques for urine collection from infants: a systematic review and meta􀀎analysis.

Ochoa-Sangrador, Carlos / Fernández-Rodríguez, Alejandro

Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias

2022 Volume 34, Issue 2, Page(s) 128–135

Abstract: Objectives: Collecting a urine sample from an infant is one of the most frequently performed emergency department procedures. We aimed to evaluate noninvasive bladder stimulation techniques to obtain urine samples from infants.: Material and methods: ...

Title translation	Eficacia de las técnicas de estimulación de la micción para la recogida de orina en el lactante: revisión sistemática y metanálisis.
Abstract	Objectives: Collecting a urine sample from an infant is one of the most frequently performed emergency department procedures. We aimed to evaluate noninvasive bladder stimulation techniques to obtain urine samples from infants. Material and methods: Systematic review and meta-analysis of published experimental and observational studies indexed in MEDLINE (PubMed Central); the Cumulative Index of Nursing and Allied Health Literature (CINAHL); the Ibero-American index, CUIDEN; and Embase. Eligible studies had to have assessed the success rate of a technique, time until urination, level of acceptance, and risk of contamination. Comparison of a stimulation technique to nonstimulation was not necessary. Results: We selected 15 studies enrolling newborns or older infants. The setting was usually an emergency department. The probability of success was 2.4-fold higher with stimulation than without it (relative risk, 2.47; 95% CI, 1.84-3.31; I2, 0%) in 2 studies. The rate of success was higher in newborns (81%; 95% CI, 72.9%-89.1%) in 6 studies totaling 331 cases (I2, 73.2%) than in older infants (51.5%; 95% CI, 35.3%-67.7%) in 9 studies with 809 cases (I2, 96.4%). The mean time required to obtain a sample was 83 (95% CI, 65-101) seconds in 10 studies (I2, 94.3%). The stimulation technique of Herreros had the highest success rate (68.4%; 95% CI, 56.2%-80.7%; I2 95,1%). Conclusion: New stimulation techniques for taking urine samples from infants are useful, especially in newborns. Advantages are the short time to urination, the high success rate, and the possibility of lowering the infant's levels of stress and pain.
MeSH term(s)	Aged ; Emergency Service, Hospital ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Pain ; Urinary Bladder ; Urinary Tract Infections ; Urine Specimen Collection/methods
Language	Spanish
Publishing date	2022-03-11
Publishing country	Spain
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2127173-2
ISSN	2386-5857 ; 2386-5857
ISSN (online)	2386-5857
ISSN	2386-5857
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Article ; Online: Author's reply to the Letter to the Editor on the original article "Lack of changes in preterm delivery and stillbirths during COVID-19 lockdown in a European region" by Juan Arnaez.

Arnaez, Juan / Ochoa-Sangrador, Carlos / Garcia-Alix, Alfredo

European journal of pediatrics

2021 Volume 180, Issue 6, Page(s) 2005–2006

MeSH term(s)	COVID-19 ; Communicable Disease Control ; Female ; Humans ; Infant, Newborn ; Pregnancy ; Premature Birth ; SARS-CoV-2 ; Stillbirth
Language	English
Publishing date	2021-04-12
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-021-04072-5
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Article: Incidence of encephalopathy and comorbidity in infants with perinatal asphyxia: a comparative prospective cohort study.

Vega-Del-Val, Cristina / Arnaez, Juan / Ochoa-Sangrador, Carlos / Garrido-Barbero, María / García-Alix, Alfredo

Frontiers in pediatrics

2024 Volume 12, Page(s) 1363576

Abstract: Background: Programs that aim to improve the detection hypoxic-ischemic encephalopathy (HIE) should establish which neonates suffering from perinatal asphyxia need to be monitored within the first 6 h of life.: Method: An observational prospective ... ...

Abstract	Background: Programs that aim to improve the detection hypoxic-ischemic encephalopathy (HIE) should establish which neonates suffering from perinatal asphyxia need to be monitored within the first 6 h of life. Method: An observational prospective cohort study of infants with gestational age ≥35 weeks, and above 1,800g, were included according to their arterial cord pH value (ApH): ≤7.00 vs. 7.01-7.10. Data was collected including obstetrical history, as well as neonatal comorbidities, including the presence of HIE, that happened within 6 h of life. A standardized neurological exam was performed at discharge. Results: There were 9,537 births; 176 infants with ApH 7.01-7.10 and 117 infants with ApH ≤7.00. All 9 cases with moderate-to-severe HIE occurred among infants with ApH ≤7.00. The incidence of global and moderate-severe HIE was 3/1,000 and 1/1,000 births, respectively. Outcome at discharge (abnormal exam or death) showed an OR 12.03 (95% CI 1.53, 94.96) in infants with ApH ≤7.00 compared to ApH 7.01-7.10 cohort. Ventilation support was 5.1 times (95% CI 2.87, 9.03) more likely to be needed by those with cord ApH ≤7.00 compared to those with ApH 7.01-7.10, as well as hypoglycemia (37% vs. 25%; Conclusions: Cord pH 7.00 might be a safe pH cut-off point when developing protocols to monitor infants born with acidemia in order to identify infants with moderate or severe HIE early on. There is non-negligible comorbidity in the ApH ≤7.00 cohort, but also in the 7.01-7.10 cohort.
Language	English
Publishing date	2024-03-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2024.1363576
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Article ; Online: Psychological and social impact on parents of children with feeding difficulties.

Fernández de Valderrama Rodríguez, Ana / Ochoa Sangrador, Carlos / Pedrón Giner, Consuelo / Sánchez Hernández, Jesús

Anales de pediatria

2022 Volume 97, Issue 5, Page(s) 317–325

Abstract: Objectives: The prevalence of feeding disorders (FDs) and picky eating in children is high in our region, based on the parents' perceptions. Although organic disease or a nutritional impact is rarely observed in these children, the problem frequently ... ...

Abstract	Objectives: The prevalence of feeding disorders (FDs) and picky eating in children is high in our region, based on the parents' perceptions. Although organic disease or a nutritional impact is rarely observed in these children, the problem frequently has an effect on family dynamics. We aimed to estimate the impact of these disorders on the stress level, quality of life and psychological health of families. Methods: Study of cases (FDs) and controls (healthy controls and controls with digestive disorders or other illness). We assessed parental stress and the risk of psychological distress in these families using validated scales (Parent Stress Index Short Form [PSI-SF] and Goldberg's General Health Questionnaire [GHQ-28]) and a parental opinion survey. Results: We collected a total of 238 surveys, 102 corresponding to healthy controls, 88 to controls with digestive disorders and 48 to children with FDs. We found that 45.8% of parents in the FD group felt neglected by their paediatricians and 47.9% did not agree with the paediatrician's recommendations. In addition, 54.2% reported limitations to their social life, 25% problems in their relationship, 47.9% feeling judged by others (12.5% by their own partner) for how they managed mealtimes, and 37.5% having sought or considered seeking psychological support. All these problems were significantly more frequent compared to controls. Based on the GHQ-28, the risk of anxiety and depression was more frequent in parents in the FD group: 54.2% compared to the reference (adjusted odds ratio [aOR] compared to controls, 4.18; 95% confidence interval [CI], 1.96-8.87; OR compared to sick controls, 6.25; 95% CI, 2.79-13.98) and 33.3% compared to the healthy control group. They also had higher stress scores (PSI-SF) compared to the healthy control group (adjusted mean difference [AMD], 21; 95% CI, 12.19-29.81) and the sick control group (AMD, 20; 95% CI, 9.81-30.19). Conclusions: Parents of children with FDs have a high level of stress and risk of anxiety and depression, with repercussions at the social, family, couple and work levels. The relationship with the paediatrician may also be affected.
MeSH term(s)	Child ; Humans ; Quality of Life ; Social Change ; Parents/psychology ; Anxiety/epidemiology ; Surveys and Questionnaires
Language	English
Publishing date	2022-10-03
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2830901-7
ISSN	2341-2879 ; 2341-2879
ISSN (online)	2341-2879
ISSN	2341-2879
DOI	10.1016/j.anpede.2022.09.004
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Article ; Online: Impact of different nebulisation systems on patient comfort in bronchiolitis: a randomised controlled cross-over trial.

Valencia-Ramos, Juan / Ochoa Sangrador, Carlos / García, María / Oyagüez, Pablo / Arnaez, Juan

Archives of disease in childhood

2022 Volume 107, Issue 12, Page(s) 1122–1127

Abstract: Objective: To test the hypothesis that greater comfort is achieved using a nebuliser integrated into a high-flow nasal cannula (nebulisation system integrated in high-flow nasal cannula (NHF)) than using a jet nebuliser (JN), and to explore differences ... ...

Abstract	Objective: To test the hypothesis that greater comfort is achieved using a nebuliser integrated into a high-flow nasal cannula (nebulisation system integrated in high-flow nasal cannula (NHF)) than using a jet nebuliser (JN), and to explore differences in analgesia requirement and the possibility of feeding during nebulisation. Design: Randomised cross-over trial. Setting: Paediatric intensive care unit. Patients: Children aged <24 months diagnosed with bronchiolitis between November 2016 and May 2017. Interventions: Nebulisations using NHF and JN. Main outcome measures: COMFORT-Behaviour Scale (CBS) and Numerical Rating Comfort Scale (NRSc) were used to measure comfort, and Numerical Rating Satisfaction Scale (NRSs) was used to assess satisfaction before, during and after nebulisation. Other variables included feeding, analgesia, need for being held and respiratory and heart rates. Results: Thirty-three children with 233 nebulisations were included in the study. The median age was 3.0 (IQR 2-9) months. Comfort and satisfaction were greater with NHF than with JN. The median staff-recorded CBS, NRSc and NRSs scores for NHF versus JN were 13 (IQR 9-15) vs 17 (IQR 13-23), 8 (IQR 7-0) vs 7 (IQR 4-8), and 4 (IQR 3-4) vs 2 (IQR 2-3), respectively; and caregiver-recorded scores were 12 (IQR 10-15) vs 19 (IQR 13-24), 9 (IQR 7-10) vs 4 (IQR 1-6), and 4 (IQR 3-4) vs 2 (IQR 1-3), respectively (p<0.001). Children who received NHF had lower cardiac and respiratory rates, needed to be held less often during therapy and required less analgesia (p<0.001). Conclusion: Nebulisation through NHF appears to be a better alternative to JN in terms of comfort and satisfaction as well as making feeding possible during nebulisation.
MeSH term(s)	Child ; Humans ; Child, Preschool ; Oxygen Inhalation Therapy ; Cross-Over Studies ; Patient Comfort ; Bronchiolitis/therapy ; Cannula
Language	English
Publishing date	2022-09-26
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	524-1
ISSN	1468-2044 ; 0003-9888 ; 1359-2998
ISSN (online)	1468-2044
ISSN	0003-9888 ; 1359-2998
DOI	10.1136/archdischild-2021-323161
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Article ; Online: Effectiveness of high-flow oxygen therapy in a second-level hospital in bronchiolitis.

Moreno, Miriam Gutiérrez / Sánchez, Verísima Barajas / Rivas, Teresa Gil / González, Natalio Hernández / Isabel, Víctor Manuel Marugán / Ochoa-Sangrador, Carlos

Anales de pediatria

2022 Volume 96, Issue 6, Page(s) 485–491

Abstract: Introduction: To estimate the impact of the incorporation of high-flow nasal cannule (HFNC) in patients admitted with acute bronchiolitis in a hospital without pediatric intensive care unit (PICU).: Material and methods: Cohort study with historical ... ...

Abstract	Introduction: To estimate the impact of the incorporation of high-flow nasal cannule (HFNC) in patients admitted with acute bronchiolitis in a hospital without pediatric intensive care unit (PICU). Material and methods: Cohort study with historical control of bronchiolitis in a second-level hospital, before (2009-2012) and after (2015-2020) the implementation of HFNC. The main outcome was the need for admission to the PICU. Results: 301 patients were included. Respiratory syncytial viruses were identified in 64.7% of them and influenza viruses in 0.3%. No differences in age nor comorbility between periods were observed. The average stay was 3.67 days (standard deviation [SE] 2.10) in the first period and 4.00 days (SE 2.35) in the second. Three patients were transferred to UCIP (2.6%) before the availability of HFCN and 13 patients (9.4%) after, which supposed an important increase of the risk (relative risk 3.58; confidence interval [CI] 95%: 1.04-12.27), although not significant in adjusted analyses (Odds ratio 3.48; IC95% 0.95-12.72). A significant increase in readmission risk was also observed (from 5.3%-13.7%) and a shortening of the time to transfer. Conclusions: The incorporation of HFNC was not associated with a lower risk of transfer to PICU nor a shorter length of oxygen therapy. In the absence of evidence, that supports the effectiveness and efficiency of the HFNC and establishes its indications, we must reassess its use.
MeSH term(s)	Bronchiolitis/therapy ; Child ; Cohort Studies ; Hospitals ; Humans ; Oxygen ; Retrospective Studies
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2022-05-28
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2830901-7
ISSN	2341-2879 ; 2341-2879
ISSN (online)	2341-2879
ISSN	2341-2879
DOI	10.1016/j.anpede.2021.08.007
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Article ; Online: Adherence of Spanish pediatricians to "do not do" guidelines to avoid low-value care in pediatrics.

Piñeiro-Pérez, Roi / Ochoa-Sangrador, Carlos / López-Martín, David / Martínez-Campos, Leticia / Calvo-Rey, Cristina / Nievas-Soriano, Bruno José

European journal of pediatrics

2022 Volume 181, Issue 11, Page(s) 3965–3975

Abstract: The main objective of this study was to analyze the degree of knowledge and compliance of Spanish pediatricians with the "do not do" recommendations of the Spanish Association of Pediatrics. A nationwide cross-sectional, descriptive study was carried out ...

Abstract	The main objective of this study was to analyze the degree of knowledge and compliance of Spanish pediatricians with the "do not do" recommendations of the Spanish Association of Pediatrics. A nationwide cross-sectional, descriptive study was carried out using a 25-item questionnaire among Spanish pediatricians. Univariate, bivariate, and multivariate analyses were performed. A total of 1137 pediatricians participated in the study. Most of them were women (75.1%), older than 55 (28.3%), worked in specialized care (56.9%), with public financing (91.2%), and had been working for more than 20 years (44.9%). The median of inappropriate answers per question was 9.1%. The bivariate and multivariate analyses showed that the factors that influenced higher adequacy to the "do not do" recommendations were younger than 45 years, working in specialized care, and working in the public health system. Conclusion: This research is the first nationwide study in Spain to analyze the adequacy of "do not do" pediatric clinical recommendations. The study showed a high level of compliance by Spanish pediatricians with these recommendations. However, there is a lack of knowledge in less frequent infectious pathologies such as HIV or fungal infections, in not prolonging antibiotic treatment unnecessarily and directing it appropriately according to the antibiogram results. These aspects may be improved by designing measures to enhance pediatricians' knowledge in these specific aspects. Some demographical factors are related to higher adequacy. Performing this research in other countries may allow assessing the current clinical practice of pediatricians. What is known: • Low-value care is defined as care that delivers little or no benefit, may cause patients harm, or outcomes marginal benefits at a disproportionately increased cost. • Few nationwide studies have assessed adherence to "do not do" guidelines, especially in pediatric settings. What is new: • Albeit there is a high level of compliance by Spanish pediatricians with the «do not do» recommendations, there is a lack of knowledge in different aspects that may be improved. • Some demographical factors are related to higher adequacy. Performing this research in other countries may allow assessing the current clinical practice of pediatricians.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Child ; Cross-Sectional Studies ; Female ; Humans ; Low-Value Care ; Male ; Pediatricians ; Practice Patterns, Physicians' ; Surveys and Questionnaires
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-09-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-022-04613-6
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Article ; Online: Day-care center attendance and risk of Asthma-A systematic review.

Ochoa Sangrador, Carlos / Vázquez Blanco, Alba

Allergologia et immunopathologia

2018 Volume 46, Issue 6, Page(s) 578–584

Abstract: Introduction and objectives: Asthma and other wheezing disorders are common chronic health problems in childhood. We aim to evaluate whether the attendance by children under three years of age to day-care centers is a protector or risk factor in the ... ...

Abstract	Introduction and objectives: Asthma and other wheezing disorders are common chronic health problems in childhood. We aim to evaluate whether the attendance by children under three years of age to day-care centers is a protector or risk factor in the development of recurrent wheezing or asthma in the following years of their lives. Methods: Systematic review of published cohort or cross-sectional studies, without any time limitation. We searched in PubMed, Cinhal, Cuiden and Scopus (EMBASE included). The quality of the studies was evaluated using the Newcastle-Ottawa Scale. Disagreements were solved by mutual consensus. Weighted odds ratio (ORs) were estimated using RevMan 5.3, following random effects models. Results: We selected 18 studies for qualitative analysis, nine cohort studies and nine cross-sectional studies. Day-care center attendance is associated with an increased risk of early recurrent wheezing (four studies; 50,619 subjects; adjusted OR 1.87 [1.21 to 2.88]; I Conclusions: Children attending day-care center during the first years of life have a higher risk of recurrent wheezing during the first three years and asthma before the age of six, but not later. This risk must be taken into account to inform parents in order to choose what kind of care children should have throughout infancy and to implement preventive measures to reduce its impact.
MeSH term(s)	Asthma/epidemiology ; Child ; Child Day Care Centers ; Child, Preschool ; Humans ; Infant ; Parents ; Respiratory Sounds ; Risk Factors ; Spain/epidemiology
Language	English
Publishing date	2018-07-07
Publishing country	Spain
Document type	Journal Article ; Systematic Review
ZDB-ID	193144-1
ISSN	1578-1267 ; 0301-0546
ISSN (online)	1578-1267
ISSN	0301-0546
DOI	10.1016/j.aller.2018.03.006
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