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  1. Article ; Online: The Yun/Prohibitin complex regulates adult

    Zhao, Hang / Shi, Lin / Li, Zhengran / Kong, Ruiyan / Ren, Xuejing / Ma, Rui / Jia, Lemei / Ma, Meifang / Lu, Shan / Xu, Ran / Binari, Richard / Wang, Jian-Hua / Dong, Meng-Qiu / Perrimon, Norbert / Li, Zhouhua

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 6

    Abstract: Stem cells constantly divide and differentiate to maintain adult tissue homeostasis, and uncontrolled stem cell proliferation leads to severe diseases such as cancer. How stem cell proliferation is precisely controlled remains poorly understood. Here, ... ...

    Abstract Stem cells constantly divide and differentiate to maintain adult tissue homeostasis, and uncontrolled stem cell proliferation leads to severe diseases such as cancer. How stem cell proliferation is precisely controlled remains poorly understood. Here, from an RNA interference (RNAi) screen in adult
    MeSH term(s) Adult Stem Cells/metabolism ; Animals ; Animals, Genetically Modified ; Cell Differentiation/physiology ; Cell Proliferation/physiology ; Drosophila Proteins/metabolism ; Drosophila melanogaster/metabolism ; E2F1 Transcription Factor/metabolism ; Homeostasis/physiology ; Intestines/metabolism ; Prohibitins/metabolism ; RNA Interference/physiology ; Signal Transduction/physiology
    Chemical Substances Drosophila Proteins ; E2F1 Transcription Factor ; Prohibitins
    Language English
    Publishing date 2022-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2111711119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Phosphorylation of Yun is required for stem cell proliferation and tumorigenesis.

    Ren, Xuejing / Zhao, Hang / Shi, Lin / Li, Zhengran / Kong, Ruiyan / Ma, Rui / Jia, Lemei / Lu, Shan / Wang, Jian-Hua / Dong, Meng-Qiu / Wang, Yingchun / Li, Zhouhua

    Cell proliferation

    2022  Volume 55, Issue 5, Page(s) e13230

    Abstract: ... understood. Phosphorylation of Yun is essential for ISC proliferation. Yun is essential for the proliferation ... of normal and transformed intestinal stem cells. Our mass spectrometry and biochemical data suggest that Yun ... among these residues is likely interdependent. Furthermore, phosphorylation of each residue in Yun is important ...

    Abstract Stem cells maintain adult tissue homeostasis under physiological conditions. Uncontrolled stem cell proliferation will lead to tumorigenesis. How stem cell proliferation is precisely controlled is still not fully understood. Phosphorylation of Yun is essential for ISC proliferation. Yun is essential for the proliferation of normal and transformed intestinal stem cells. Our mass spectrometry and biochemical data suggest that Yun can be phosphorylated at multiple residues in vivo. Interestingly, we show that the phosphorylation among these residues is likely interdependent. Furthermore, phosphorylation of each residue in Yun is important for its function in ISC proliferation regulation. Thus, our study unveils the important role of post-translational modification of Yun in stem cell proliferation.
    MeSH term(s) Adult ; Cell Proliferation ; Cell Transformation, Neoplastic ; Drosophila Proteins/metabolism ; Humans ; Intestines ; Phosphorylation
    Chemical Substances Drosophila Proteins
    Language English
    Publishing date 2022-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1064202-x
    ISSN 1365-2184 ; 0008-8730 ; 0960-7722
    ISSN (online) 1365-2184
    ISSN 0008-8730 ; 0960-7722
    DOI 10.1111/cpr.13230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 532: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article ; Online: Erratum: SHUO QI, ZHI-TONG LYU, JIAN WANG, YUN-MING MO, ZHAO-CHI ZENG, YANG-JIN ZENG, KE-YUAN DAI, YUAN-QIU LI, L. LEE GRISMER amp; YING-YONG WANG (2022) Three new species of the genus Boulenophrys (Anura, Megophryidae) from southern China. Zootaxa, 5072: 401438.

    Qi, Shuo / Lyu, Zhi-Tong / Wang, Jian / Mo, Yun-Ming / Zeng, Zhao-Chi / Zeng, Yang-Jin / Dai, Ke-Yuan / Li, Yuan-Qiu / Grismer, L Lee / Wang, Ying-Yong

    Zootaxa

    2022  Volume 5115, Issue 4, Page(s) 600

    Language English
    Publishing date 2022-03-16
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.5115.4.10
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  4. Book: Tai wan xue sheng yun dong

    Qiu, Weijun

    1949-1979

    (Taiwan wen hua xi lie ; 27 ; 臺灣文化系列 ; 27)

    2003  

    Author's details Qiu wei jun bian zhu
    Series title Taiwan wen hua xi lie ; 27
    臺灣文化系列 ; 27
    Keywords Student movements/History ; Students/Political activity
    Language Chinese
    Size xviii, iii, 174 pages, illustrations, 21 cm
    Edition Chu ban
    Publisher Dao xiang chu ban she
    Publishing place Tai bei xian ban qiao shi
    Document type Book
    ISBN 9789867862266 ; 9867862260
    Database Former special subject collection: coastal and deep sea fishing

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  5. Article ; Online: A phosphorylation switch controls androgen biosynthesis in prostate cancer.

    Qiu, Yun

    The Journal of clinical investigation

    2023  Volume 133, Issue 2

    Abstract: Androgen biosynthesis enzyme 3β-hydroxysteroid dehydrogenase type 1 (3βHSD1) encoded by HSD3B1 has emerged as a potential driver for therapeutic resistance in prostate cancer. Patients with homozygous HSD3B1(1245C) inheritance are intrinsically more ... ...

    Abstract Androgen biosynthesis enzyme 3β-hydroxysteroid dehydrogenase type 1 (3βHSD1) encoded by HSD3B1 has emerged as a potential driver for therapeutic resistance in prostate cancer. Patients with homozygous HSD3B1(1245C) inheritance are intrinsically more resistant to currently available androgen/androgen receptor-targeting (AR-targeting) drugs. In this issue of the JCI, Li et al. present data on the regulation of 3βHSD1 phosphorylation and activity by tyrosine kinase BMX. Inhibition of BMX activity by genetic or pharmacologic approaches blocked androgen biosynthesis in prostate cancer cells and inhibited tumor growth in preclinical xenograft models. The findings provide insights into mechanisms underlying castration resistance in prostate cancer and reveal a potential strategy to circumvent therapeutic resistance in patients with homozygous HSD3B1(1245C) inheritance.
    MeSH term(s) Male ; Humans ; Androgens/therapeutic use ; Phosphorylation ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/genetics ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism ; Multienzyme Complexes/genetics ; Prostatic Neoplasms, Castration-Resistant/genetics ; Cell Line, Tumor
    Chemical Substances Androgens ; Receptors, Androgen ; Multienzyme Complexes
    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI166499
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    Ua VI Zs.184: Show issues Location:
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  6. Article ; Online: A phosphorylation switch controls androgen biosynthesis in prostate cancer

    Yun Qiu

    The Journal of Clinical Investigation, Vol 133, Iss

    2023  Volume 2

    Abstract: Androgen biosynthesis enzyme 3β-hydroxysteroid dehydrogenase type 1 (3βHSD1) encoded by HSD3B1 has emerged as a potential driver for therapeutic resistance in prostate cancer. Patients with homozygous HSD3B1(1245C) inheritance are intrinsically more ... ...

    Abstract Androgen biosynthesis enzyme 3β-hydroxysteroid dehydrogenase type 1 (3βHSD1) encoded by HSD3B1 has emerged as a potential driver for therapeutic resistance in prostate cancer. Patients with homozygous HSD3B1(1245C) inheritance are intrinsically more resistant to currently available androgen/androgen receptor–targeting (AR-targeting) drugs. In this issue of the JCI, Li et al. present data on the regulation of 3βHSD1 phosphorylation and activity by tyrosine kinase BMX. Inhibition of BMX activity by genetic or pharmacologic approaches blocked androgen biosynthesis in prostate cancer cells and inhibited tumor growth in preclinical xenograft models. The findings provide insights into mechanisms underlying castration resistance in prostate cancer and reveal a potential strategy to circumvent therapeutic resistance in patients with homozygous HSD3B1(1245C) inheritance.
    Keywords Medicine ; R
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Author's reply: Assessing disease severity in inflammatory bowel disease - Can we reliably encompass the full disease burden?

    Yun, Qiu / Ren, Mao

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2024  

    Language English
    Publishing date 2024-02-12
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2024.01.204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1134: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article: Taxonomic notes on the genus

    Song, Zhu-Qiu / Zhang, Bu-Yun

    PhytoKeys

    2024  Volume 239, Page(s) 59–72

    Abstract: ... The ... ...

    Abstract The genus
    Language English
    Publishing date 2024-03-12
    Publishing country Bulgaria
    Document type Journal Article
    ZDB-ID 2579891-1
    ISSN 1314-2003 ; 1314-2011
    ISSN (online) 1314-2003
    ISSN 1314-2011
    DOI 10.3897/phytokeys.239.117851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Universal adversarial perturbations for multiple classification tasks with quantum classifiers

    Yun-Zhong Qiu

    Machine Learning: Science and Technology, Vol 4, Iss 4, p

    2023  Volume 045009

    Abstract: Quantum adversarial machine learning is an emerging field that studies the vulnerability of quantum learning systems against adversarial perturbations and develops possible defense strategies. Quantum universal adversarial perturbations are small ... ...

    Abstract Quantum adversarial machine learning is an emerging field that studies the vulnerability of quantum learning systems against adversarial perturbations and develops possible defense strategies. Quantum universal adversarial perturbations are small perturbations, which can make different input samples into adversarial examples that may deceive a given quantum classifier. This is a field that was rarely looked into but worthwhile investigating because universal perturbations might simplify malicious attacks to a large extent, causing unexpected devastation to quantum machine learning models. In this paper, we take a step forward and explore the quantum universal perturbations in the context of heterogeneous classification tasks. In particular, we find that quantum classifiers that achieve almost state-of-the-art accuracy on two different classification tasks can be both conclusively deceived by one carefully-crafted universal perturbation. This result is explicitly demonstrated with well-designed quantum continual learning models with elastic weight consolidation method to avoid catastrophic forgetting, as well as real-life heterogeneous datasets from hand-written digits and medical MRI images. Our results provide a simple and efficient way to generate universal perturbations on heterogeneous classification tasks and thus would provide valuable guidance for future quantum learning technologies.
    Keywords adversarial machine learning ; quantum computing ; quantum continual learning ; Computer engineering. Computer hardware ; TK7885-7895 ; Electronic computers. Computer science ; QA75.5-76.95
    Subject code 006
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher IOP Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Book ; Online: Universal adversarial perturbations for multiple classification tasks with quantum classifiers

    Qiu, Yun-Zhong

    2023  

    Abstract: Quantum adversarial machine learning is an emerging field that studies the vulnerability of quantum learning systems against adversarial perturbations and develops possible defense strategies. Quantum universal adversarial perturbations are small ... ...

    Abstract Quantum adversarial machine learning is an emerging field that studies the vulnerability of quantum learning systems against adversarial perturbations and develops possible defense strategies. Quantum universal adversarial perturbations are small perturbations, which can make different input samples into adversarial examples that may deceive a given quantum classifier. This is a field that was rarely looked into but worthwhile investigating because universal perturbations might simplify malicious attacks to a large extent, causing unexpected devastation to quantum machine learning models. In this paper, we take a step forward and explore the quantum universal perturbations in the context of heterogeneous classification tasks. In particular, we find that quantum classifiers that achieve almost state-of-the-art accuracy on two different classification tasks can be both conclusively deceived by one carefully-crafted universal perturbation. This result is explicitly demonstrated with well-designed quantum continual learning models with elastic weight consolidation method to avoid catastrophic forgetting, as well as real-life heterogeneous datasets from hand-written digits and medical MRI images. Our results provide a simple and efficient way to generate universal perturbations on heterogeneous classification tasks and thus would provide valuable guidance for future quantum learning technologies.
    Keywords Quantum Physics ; Computer Science - Cryptography and Security ; Computer Science - Machine Learning
    Subject code 006
    Publishing date 2023-06-20
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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