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  1. Article: Liver Abscess as an Uncommon Complication of Laparoscopic Appendectomy: A Case Report.

    Savage-Lobeck, David / Pereira, Nicholas / Saggi, Robert

    Cureus

    2024  Volume 16, Issue 2, Page(s) e54713

    Abstract: Pyogenic liver abscess (PLA) is an infrequently seen complication of appendicitis that once was common, but now is so rare many textbooks omit the condition entirely. In this report, we document a recent case of post-appendicitis PLA in an eight-year-old ...

    Abstract Pyogenic liver abscess (PLA) is an infrequently seen complication of appendicitis that once was common, but now is so rare many textbooks omit the condition entirely. In this report, we document a recent case of post-appendicitis PLA in an eight-year-old Hispanic female treated with a combination of medical and surgical management. We have detailed the course of treatment, both to raise awareness of this uncommon complication of appendicitis and to help provide a guide for other clinicians treating similar cases. While cases of pediatric PLA post-appendicitis are rare in the modern world, timely diagnosis and treatment of the lesions are paramount to patient recovery and prevention of long-term sequelae. Study of prior literature and research is likely to be of vital importance to the treatment of the condition. Multiple treatment modalities may be considered, and there is no true standard of care for pediatric populations presenting with PLA.
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.54713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Treg-tissue cell interactions in repair and regeneration.

    Loffredo, Lucas F / Savage, Thomas M / Ringham, Olivia R / Arpaia, Nicholas

    The Journal of experimental medicine

    2024  Volume 221, Issue 6

    Abstract: Regulatory T (Treg) cells are classically known for their critical immunosuppressive functions that support peripheral tolerance. More recent work has demonstrated that Treg cells produce pro-repair mediators independent of their immunosuppressive ... ...

    Abstract Regulatory T (Treg) cells are classically known for their critical immunosuppressive functions that support peripheral tolerance. More recent work has demonstrated that Treg cells produce pro-repair mediators independent of their immunosuppressive function, a process that is critical to repair and regeneration in response to numerous tissue insults. These factors act on resident parenchymal and structural cells to initiate repair in a tissue-specific context. This review examines interactions between Treg cells and tissue-resident non-immune cells-in the context of tissue repair, fibrosis, and cancer-and discusses areas for future exploration.
    MeSH term(s) T-Lymphocytes, Regulatory/immunology ; Humans ; Animals ; Regeneration/physiology ; Cell Communication/immunology ; Wound Healing/immunology ; Fibrosis ; Neoplasms/immunology ; Neoplasms/pathology
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20231244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Valley formation aridifies East Africa and elevates Congo Basin rainfall.

    Munday, Callum / Savage, Nicholas / Jones, Richard G / Washington, Richard

    Nature

    2023  Volume 615, Issue 7951, Page(s) 276–279

    Abstract: East African aridification during the past 8 million years is frequently invoked as a driver of large-scale shifts in ... ...

    Abstract East African aridification during the past 8 million years is frequently invoked as a driver of large-scale shifts in vegetation
    MeSH term(s) Animals ; Africa, Eastern ; Biological Evolution ; Congo ; Hominidae ; Kenya ; Rain ; Desert Climate ; Plants ; Volatilization ; Rainforest
    Language English
    Publishing date 2023-03-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-022-05662-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Theta tACS impairs episodic memory more than tDCS.

    Murray, Nicholas W G / Graham, Petra L / Sowman, Paul F / Savage, Greg

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 716

    Abstract: Episodic memory deficits are a common consequence of aging and are associated with a number of neurodegenerative disorders (e.g., Alzheimer's disease). Given the importance of episodic memory, a great deal of research has investigated how we can improve ... ...

    Abstract Episodic memory deficits are a common consequence of aging and are associated with a number of neurodegenerative disorders (e.g., Alzheimer's disease). Given the importance of episodic memory, a great deal of research has investigated how we can improve memory performance. Transcranial electrical stimulation (TES) represents a promising tool for memory enhancement but the optimal stimulation parameters that reliably boost memory are yet to be determined. In our double-blind, randomised, sham-controlled study, 42 healthy adults (36 females; 23.3 ± 7.7 years of age) received anodal transcranial direct current stimulation (tDCS), theta transcranial alternating current stimulation (tACS) and sham stimulation during a list-learning task, over three separate sessions. Stimulation was applied over the left temporal lobe, as encoding and recall of information is typically associated with mesial temporal lobe structures (e.g., the hippocampus and entorhinal cortex). We measured word recall within each stimulation session, as well as the average number of intrusion and repetition errors. In terms of word recall, participants recalled fewer words during tDCS and tACS, compared to sham stimulation, and significantly fewer words recalled during tACS compared with tDCS. Significantly more memory errors were also made during tACS compared with sham stimulation. Overall, our findings suggest that TES has a deleterious effect on memory processes when applied to the left temporal lobe.
    MeSH term(s) Adult ; Female ; Humans ; Transcranial Direct Current Stimulation ; Memory, Episodic ; Prefrontal Cortex/physiology ; Learning/physiology ; Mental Recall/physiology
    Language English
    Publishing date 2023-01-13
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-27190-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Vascular surgery patients in intensive care: a bi-national cohort study over 15 years.

    Doherty, Zakary / Savage, Nicholas / Milne, Charles / Pilcher, David

    ANZ journal of surgery

    2022  Volume 93, Issue 6, Page(s) 1517–1524

    Abstract: Background: To describe the characteristics and outcomes of patients admitted to Intensive Care following vascular surgery, and their subsequent usage of Intensive Care resources, over a 15-year period in Australia and New Zealand.: Methods: This was ...

    Abstract Background: To describe the characteristics and outcomes of patients admitted to Intensive Care following vascular surgery, and their subsequent usage of Intensive Care resources, over a 15-year period in Australia and New Zealand.
    Methods: This was a retrospective, bi-national study of 69 676 adult patients admitted to 179 Intensive Care Unit (ICUs) following vascular surgery between January 2005 and December 2019, using the Australian and New Zealand Intensive Care Society Adult Patient Database.
    Results: The proportion of ICU bed days used by vascular surgery patients decreased during the study period from 3.6% in 2005 to 2.9% in 2019 (P < 0.001). The cohort had a median age of 73 years, and were most frequently admitted after a carotid endarterectomy (22%) or elective open aneurysm repair (20%). A total of 5.2% of patients did not survive to discharge. Mean annual adjusted mortality decreased during the study period from 6.1% in 2005 to 3.7% in 2019 (P < 0.001). Multiple factors were associated with higher mortality, including gender, hospital case volume and hospital type.
    Conclusions: Between 2005 and 2019 survival for vascular surgery patients requiring ICU admission in Australia and New Zealand improved. During the same time the proportion of ICU bed days used by these patients decreased.
    MeSH term(s) Adult ; Humans ; Aged ; Cohort Studies ; Retrospective Studies ; Australia/epidemiology ; Critical Care ; Intensive Care Units ; Vascular Surgical Procedures ; New Zealand/epidemiology ; Hospital Mortality
    Language English
    Publishing date 2022-10-03
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.18080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Partial facial palsy from a surfboard injury.

    Savage, Nicholas / Thomas, Damon / Goldie, Stephen J

    ANZ journal of surgery

    2021  Volume 91, Issue 10, Page(s) E644–E645

    MeSH term(s) Facial Nerve ; Facial Paralysis/epidemiology ; Facial Paralysis/etiology ; Humans
    Language English
    Publishing date 2021-02-24
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.16679
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Correction to: The Impact of Right Temporal Lobe Epilepsy on Nonverbal Memory: Meta-regression of Stimulus- and Task-related Moderators.

    Bentvelzen, Adam C / Kessels, Roy P C / Badcock, Nicholas A / Savage, Greg

    Neuropsychology review

    2022  Volume 32, Issue 3, Page(s) 558–565

    Language English
    Publishing date 2022-06-13
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1062572-0
    ISSN 1573-6660 ; 1040-7308
    ISSN (online) 1573-6660
    ISSN 1040-7308
    DOI 10.1007/s11065-022-09545-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A Review of Petrol Burns in Australia and New Zealand.

    Savage, Nicholas / Doherty, Zakary / Singer, Yvonne / Menezes, Hana / Cleland, Heather / Goldie, Stephen J

    Journal of burn care & research : official publication of the American Burn Association

    2023  Volume 44, Issue 5, Page(s) 1162–1168

    Abstract: Petrol-related thermal burns cause significant morbidity and mortality worldwide and it has been established that they affect young males disproportionately. Beyond this, we sought to identify the difference in the characteristics and outcomes of burns ... ...

    Abstract Petrol-related thermal burns cause significant morbidity and mortality worldwide and it has been established that they affect young males disproportionately. Beyond this, we sought to identify the difference in the characteristics and outcomes of burns between males and females in an international population. Such differences may highlight areas for future preventative strategies. The Burns Registry of Australia and New Zealand was used. Petrol burns that resulted in a hospital admission in those 16 years or older between January 2010 and December 2019 were included. A total of 2833 patients were included. The median age was 35 years with most patients being male (88%). Burns from a campfire or burnoffs were most common. Females were more likely to suffer burns due to assault or from deliberate self-harm. The total body surface area affected by burns was higher for females than males (10% vs 8%). Furthermore, females more frequently required ICU admission, escharotomies, and had a longer hospital length of stay. The unadjusted mortality rate for females was more than double the rate for males (5.8% vs 2.3%). This international study demonstrates that whilst men more frequently suffer petrol burns, women suffer more severe burns, require more intensive and longer hospitalizations and have a higher mortality rate. These findings may inform changes in preventative health policies globally to mitigate against these concerning findings.
    MeSH term(s) Humans ; Male ; Female ; Adult ; Burns/epidemiology ; Burns/etiology ; Burns/therapy ; New Zealand/epidemiology ; Australia/epidemiology ; Hospitalization ; Body Surface Area ; Retrospective Studies ; Length of Stay
    Language English
    Publishing date 2023-01-20
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2224246-6
    ISSN 1559-0488 ; 1559-047X
    ISSN (online) 1559-0488
    ISSN 1559-047X
    DOI 10.1093/jbcr/irad008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Impacts of the COVID-19 pandemic on medical students in Australia.

    Savage, Nicholas / Jain, Anshini / Ng, Suat Chin

    ANZ journal of surgery

    2020  Volume 90, Issue 7-8, Page(s) 1244–1245

    MeSH term(s) Australia ; COVID-19 ; Education, Medical ; Humans ; Students, Medical
    Keywords covid19
    Language English
    Publishing date 2020-07-02
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.16103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Recyclable Waste in the Cardiac Catheterization Laboratory: The Potential to Curb the Carbon Footprint.

    Doshi, Harsh / Savage, Michael P / Ruggiero, Nicholas / Walinsky, Paul / Davis, Marguerite / Troia, Jennifer / Ahmed, Bina / Fischman, David L

    JACC. Cardiovascular interventions

    2023  Volume 16, Issue 6, Page(s) 737–738

    MeSH term(s) Humans ; Carbon Footprint ; Treatment Outcome ; Cardiac Catheterization/adverse effects
    Language English
    Publishing date 2023-02-27
    Publishing country United States
    Document type Letter
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2023.01.367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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