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Article: The ALDH2 gene rs671 polymorphism is associated with cardiometabolic risk factors in East Asian population: an updated meta-analysis.

Liu, Ruikang / Peng, Miaomiao / Zhang, Jiaoyue / Qiu, Kangli / Zeng, Tianshu / Chen, Lulu

2024 Volume 15, Page(s) 1333595

Abstract: Introduction: Acetaldehyde dehydrogenase 2 (ALDH2) had reported as a prominent role in the development of cardiometabolic diseases among Asians. Our study aims to investigate the relationship between ALDH2 polymorphism and cardiometabolic risk factors ... ...

Abstract	Introduction: Acetaldehyde dehydrogenase 2 (ALDH2) had reported as a prominent role in the development of cardiometabolic diseases among Asians. Our study aims to investigate the relationship between ALDH2 polymorphism and cardiometabolic risk factors in East Asian population. Method: We searched databases of PubMed, Web of Science, and Embase updated to Oct 30 Result: In total, 46 studies were finally included in our meta-analysis, containing, 54068 GG and, 36820 GA/AA participants. All outcomes related to blood pressure revealed significant results (hypertension OR=0.83 [0.80, 0.86]; SBP MD=-1.48 [-1.82, -1.14]; DBP MD=-1.09 [-1.58, -0.61]). FBG showed a significant difference (MD=-0.10 [-0.13, -0.07]), and the lipid resulted significantly in some outcomes (TG MD=-0.07 [-0.09, -0.04]; LDL-C MD=-0.04 [-0.05, -0.02]). As for subgroups analysis, we found that in populations without severe cardiac-cerebral vascular diseases (CCVDs), GG demonstrated a significantly higher incidence of T2DM (T2DM OR=0.88 [0.79, 0.97]), while the trend was totally opposite in population with severe CCVDs (T2DM OR=1.29 [1.00, 1.66]) with significant subgroup differences. Conclusion: Our updated meta-analysis demonstrated that ALDH2 rs671 GG populations had significantly higher levels of BMI, blood pressure, FBG, TG, LDL-C and higher risk of hypertension than GA/AA populations. Besides, to the best of our knowledge, we first report GG had a higher risk of T2DM in population without severe CCVDs, and GA/AA had a higher risk of T2DM in population with severe CCVDs.
MeSH term(s)	Humans ; Aldehyde Dehydrogenase, Mitochondrial/genetics ; Asian People/genetics ; Cardiometabolic Risk Factors ; Cholesterol, LDL ; Diabetes Mellitus, Type 2 ; East Asian People ; Hypertension/epidemiology ; Hypertension/genetics
Chemical Substances	Aldehyde Dehydrogenase, Mitochondrial (EC 1.2.1.3) ; ALDH2 protein, human (EC 1.2.1.3) ; Cholesterol, LDL
Language	English
Publishing date	2024-03-19
Publishing country	Switzerland
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2024.1333595
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The reporting quality of randomized controlled trials in Chinese herbal medicine (CHM) formulas for diabetes based on the consort statement and its extension for CHM formulas.

Liu, Yan / Hu, Chaoyue / Zhou, Kehua / Zhang, Ye / Kang, Jing / Wen, Yalu / Yuan, Ruyue / Li, Jiaoyue / Zhao, Qiyao / Zhang, Li / Yang, Xiaohui

Frontiers in pharmacology

2024 Volume 15, Page(s) 1288479

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-01-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1288479
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Article ; Online: Revealing the mechanisms of Weishi Huogu I capsules used for treating osteonecrosis of the femoral head based on systems pharmacology with one mechanism validated with in vitro experiments.

Zhang, Jiaoyue / Wang, Fanli / Wu, Dengbin / Zhao, Dewei

Journal of ethnopharmacology

2022 Volume 295, Page(s) 115354

Abstract: Ethnopharmacological relevance: Weishi Huogu I (WH I) capsules, developed through traditional Chinese medicine, have been used to treat clinical osteonecrosis of the femoral head (ONFH) for decades. However, the mechanisms have not been systematically ... ...

Abstract	Ethnopharmacological relevance: Weishi Huogu I (WH I) capsules, developed through traditional Chinese medicine, have been used to treat clinical osteonecrosis of the femoral head (ONFH) for decades. However, the mechanisms have not been systematically studied. Aim of the study: In this study, the mechanisms of WH I capsules used in treating ONFH were examined through a systems pharmacology strategy, and one mechanism was validated with in vitro experiments. Materials and methods: WH I capsules compounds were identified by screening databases; then, a database of the potential active compounds was constructed after absorption, distribution, metabolism and excretion (ADME) evaluation. The compounds were identified through a systematic approach in which the probability of an interaction of every candidate compound with each corresponding target in the DrugBank database was calculated. Gene Ontology (GO) and pathway enrichment analyses of the targets was performed with the Metascape and KEGG DISEASE databases. Then, a compound-target network (C-T) and target-pathway network (T-P) of WH I capsule components were constructed, and network characteristics and related information were used for systematically identifying WH I capsule multicomponent-target interactions. Furthermore, the effects of WH I capsule compounds identified through the systematic pharmacology analysis of the osteogenic transformation of human umbilical mesenchymal stem cells (HUMSCs) were validated in vitro. Results: In total, 152 potentially important compounds and 176 associated targets were identified. Twenty-two crucial GO biological process (BP) or pathways were related to ONFH, mainly in regulatory modules regulating blood circulation, modulating growth, and affecting pathological processes closely related to ONFH. Furthermore, the GO enrichment analysis showed that corydine, isorhamnetin, and bicuculline were enriched in "RUNX2 regulates osteoblast differentiation", significantly increased alkaline phosphatase activity and calcium deposition and upregulated runt-related transcription factor 2 mRNA and protein expression and osteocalcin mRNA expression in HUMSCs, suggesting that these compounds promoted the mesenchymal stem cell (MSC) osteogenic transformation. Conclusions: The study showed that the pharmacological mechanisms of WH I capsule attenuation of ONFH mainly involve three therapeutic modules: blood circulation, modulating growth, and regulating pathological processes. The crosstalk between GOBPs/pathways may constitute the basis of the synergistic effects of the compounds in WH I capsules in attenuating ONFH. One of the pharmacological mechanisms in the WH I capsule effect on ONFH involves enhancement of the osteogenic transformation of MSCs, as validated in experiments performed in vitro; however, more mechanisms should be validated in further studies.
MeSH term(s)	Capsules/therapeutic use ; Femur Head/metabolism ; Femur Head/pathology ; Femur Head Necrosis/drug therapy ; Humans ; Network Pharmacology ; RNA, Messenger
Chemical Substances	Capsules ; RNA, Messenger
Language	English
Publishing date	2022-05-14
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115354
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Article ; Online: Recent Developments of Gramine: Chemistry and Biological Activity.

Zhang, Jiaoyue / Jia, Qitao / Li, Na / Gu, Liqiang / Dan, Wenjia / Dai, Jiangkun

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 15

Abstract: The natural alkaloid gramine has attracted significant attention in both academic and industrial circles because of its potential and diverse biological activities, including antiviral, antibacterial, antifungal, anti-inflammatory and antitumor ... ...

Abstract	The natural alkaloid gramine has attracted significant attention in both academic and industrial circles because of its potential and diverse biological activities, including antiviral, antibacterial, antifungal, anti-inflammatory and antitumor activities; application in therapy for Alzheimer's disease; serotonin-receptor-related activity; insecticidal activity; and application as an algicide. In this review, we focus on the research advances that have been made for gramine-based molecules since their discovery, providing key information on their extraction and separation, chemical synthesis and diverse biological activities. Data regarding their mechanisms of action are also presented. This comprehensive and critical review will serve as a guide for developing more drug candidates based on gramine skeletons.
MeSH term(s)	Indole Alkaloids/pharmacology ; Alkaloids/pharmacology ; Alkaloids/chemistry
Chemical Substances	gramine (FGQ8A78L14) ; Indole Alkaloids ; Alkaloids
Language	English
Publishing date	2023-07-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28155695
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Article: Revealing the mechanisms of Weishi Huogu I capsules used for treating osteonecrosis of the femoral head based on systems pharmacology with one mechanism validated with in vitro experiments

Zhang, Jiaoyue / Wang, Fanli / Wu, Dengbin / Zhao, Dewei

Journal of ethnopharmacology. 2022 Sept. 15, v. 295

2022

Abstract: Weishi Huogu I (WH I) capsules, developed through traditional Chinese medicine, have been used to treat clinical osteonecrosis of the femoral head (ONFH) for decades. However, the mechanisms have not been systematically studied. Aim of the study: In this ...

Abstract	Weishi Huogu I (WH I) capsules, developed through traditional Chinese medicine, have been used to treat clinical osteonecrosis of the femoral head (ONFH) for decades. However, the mechanisms have not been systematically studied. Aim of the study: In this study, the mechanisms of WH I capsules used in treating ONFH were examined through a systems pharmacology strategy, and one mechanism was validated with in vitro experiments. WH I capsules compounds were identified by screening databases; then, a database of the potential active compounds was constructed after absorption, distribution, metabolism and excretion (ADME) evaluation. The compounds were identified through a systematic approach in which the probability of an interaction of every candidate compound with each corresponding target in the DrugBank database was calculated. Gene Ontology (GO) and pathway enrichment analyses of the targets was performed with the Metascape and KEGG DISEASE databases. Then, a compound-target network (C-T) and target-pathway network (T-P) of WH I capsule components were constructed, and network characteristics and related information were used for systematically identifying WH I capsule multicomponent-target interactions. Furthermore, the effects of WH I capsule compounds identified through the systematic pharmacology analysis of the osteogenic transformation of human umbilical mesenchymal stem cells (HUMSCs) were validated in vitro. In total, 152 potentially important compounds and 176 associated targets were identified. Twenty-two crucial GO biological process (BP) or pathways were related to ONFH, mainly in regulatory modules regulating blood circulation, modulating growth, and affecting pathological processes closely related to ONFH. Furthermore, the GO enrichment analysis showed that corydine, isorhamnetin, and bicuculline were enriched in “RUNX2 regulates osteoblast differentiation”, significantly increased alkaline phosphatase activity and calcium deposition and upregulated runt-related transcription factor 2 mRNA and protein expression and osteocalcin mRNA expression in HUMSCs, suggesting that these compounds promoted the mesenchymal stem cell (MSC) osteogenic transformation. The study showed that the pharmacological mechanisms of WH I capsule attenuation of ONFH mainly involve three therapeutic modules: blood circulation, modulating growth, and regulating pathological processes. The crosstalk between GOBPs/pathways may constitute the basis of the synergistic effects of the compounds in WH I capsules in attenuating ONFH. One of the pharmacological mechanisms in the WH I capsule effect on ONFH involves enhancement of the osteogenic transformation of MSCs, as validated in experiments performed in vitro; however, more mechanisms should be validated in further studies.
Keywords	Oriental traditional medicine ; absorption ; alkaline phosphatase ; blood circulation ; bone formation ; calcium ; excretion ; femur ; gene expression ; gene ontology ; humans ; isorhamnetin ; mesenchymal stromal cells ; osteoblasts ; osteocalcin ; osteonecrosis ; pharmacology ; probability ; protein synthesis ; therapeutics ; transcription factors
Language	English
Dates of publication	2022-0915
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115354
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Identification of the rare variant p.Val803Met of WFS1 gene as a cause of Wolfram-like syndrome in a Chinese family.

Deng, Hongjun / Zhang, Jiaoyue / Zhu, Feng / Deng, Xiuling / Yuan, Li

Acta diabetologica

2020 Volume 57, Issue 11, Page(s) 1399–1404

Language	English
Publishing date	2020-07-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1097676-0
ISSN	1432-5233 ; 0940-5429
ISSN (online)	1432-5233
ISSN	0940-5429
DOI	10.1007/s00592-020-01572-y
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Zs.A 611: Show issues

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Article ; Online: Novel N

Dan, Wenjia / Cao, Yidan / Sun, Yifan / Zhang, Jiaoyue / Liu, Jinyi / Gao, Jixiang / Han, Rui / Dai, Jiangkun

Bioorganic chemistry

2023 Volume 133, Page(s) 106378

Abstract: A series of new α-carboline analogues modified at ... ...

Abstract	A series of new α-carboline analogues modified at N
MeSH term(s)	Animals ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Zebrafish/metabolism ; Hydrogen Peroxide ; Carbolines/pharmacology ; Carbolines/therapeutic use ; Neuroprotective Agents ; Cholinesterase Inhibitors ; Acetylcholinesterase/metabolism
Chemical Substances	alpha-carboline (244-76-8) ; Hydrogen Peroxide (BBX060AN9V) ; Carbolines ; Neuroprotective Agents ; Cholinesterase Inhibitors ; Acetylcholinesterase (EC 3.1.1.7)
Language	English
Publishing date	2023-01-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2023.106378
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Article ; Online: Social determinants of health and hypertension in women compared with men in the United States: An analysis of the NHANES study.

Wang, Li / Zhang, Hao / Yao, Hong / Gong, Chunlin / Zhong, Jiaoyue / Liu, Dongxue / Liang, Zhaoguang

Clinical cardiology

2023 Volume 46, Issue 8, Page(s) 958–966

Abstract: Background: Social determinants of health (SDH) reflecting social deprivation have been developed for population health management. There is a paucity of data on the prevalence of SDH and its associations with prevalent hypertension in women compared ... ...

Abstract	Background: Social determinants of health (SDH) reflecting social deprivation have been developed for population health management. There is a paucity of data on the prevalence of SDH and its associations with prevalent hypertension in women compared with men. Methods: A total of 49 791 participants aged over 20 years from the 1999-2018 National Health and Nutrition Examination Surveys, were included. Information on the SDH, including race/ethnicity, education level, family income, housing, marriage status, employment, were collected. We calculated the prevalence ratio (PR) for each adverse SDH with prevalent hypertension and uncontrolled hypertension by using Cox regression with equal times of follow-up assigned to all individuals with adjustment for age, diabetes, taking lipid-lowering medication, and health behaviors. The population-attributable fractions (PAF) of the SDH were also assessed. Results: A lower proportion of low education attainment was observed in women than men (women: 16.8% vs. men: 17.9%, p = .003), but women had higher proportions of low family income (15.3% vs. 12.5%, p < .001), unmarried state (47.3% vs. 40.9%, p < .001), and unemployment (22.7% vs. 10.7%, p < .001). All the SDH was significantly associated with hypertension in women. There were significant dose-response associations between the numbers of adverse SDH with hypertension. The total PAF of SDH for prevalent hypertension was greater in women (22.2%) than in men (13.9%). Conclusions: The widely influential SDH is associated with prevalent hypertension and uncontrolled hypertension. To improve hypertension management, health resources should prioritize socioeconomically disadvantaged groups considering gender differences.
MeSH term(s)	Male ; Humans ; United States/epidemiology ; Female ; Adult ; Nutrition Surveys ; Social Determinants of Health ; Hypertension/diagnosis ; Hypertension/epidemiology ; Income ; Poverty
Language	English
Publishing date	2023-07-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	391935-3
ISSN	1932-8737 ; 0160-9289
ISSN (online)	1932-8737
ISSN	0160-9289
DOI	10.1002/clc.24079
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Article ; Online: Role of Circulating Exosomal miRNA-3976 in Early Diabetic Retinopathy.

Yang, Songtao / Zhang, Jiaoyue / Zeng, Tianshu / Zheng, Juan / Min, Jie / Chen, Lulu

International journal of nanomedicine

2023 Volume 18, Page(s) 3695–3709

Abstract: Background: Diabetic retinopathy (DR) remains as the most frequent complication of diabetes, and is the major cause of vision loss for middle-aged to elderly people. With longer life expectancies for people with diabetes, there is a significant rise in ... ...

Abstract	Background: Diabetic retinopathy (DR) remains as the most frequent complication of diabetes, and is the major cause of vision loss for middle-aged to elderly people. With longer life expectancies for people with diabetes, there is a significant rise in diabetic retinopathy worldwide. The treatment of DR is limited; and therefore, our study aimed to investigate the possibilities of circulating exosomal miRNAs in the early screening and prevention of DR; and to explore the function of the exosomal miRNAs in DR. Materials and methods: Eighteen participants were recruited and divided into two groups: the diabetes mellitus (DM) group and the DR group. We analyzed the expression profile of exosomal miRNAs derived from serum using RNA sequencing. Additionally, we conducted co-culture experiments of RGC-5 and HUVEC cells with DR-derived exosomes to examine the role of highly expressed exosomal miRNA-3976 in DR. Furthermore, we transfected RGC-5 and HUVEC cells with miRNA-3976 to investigate its effects. Results: Among the 1059 miRNAs analyzed, we identified eighteen up-regulated exosomal miRNAs. Treatment with DR-derived exosomes resulted in increased proliferation and reduced apoptosis of RGC-5 cells, and these effects were partially reversed by the miRNA-3976 inhibitor. Moreover, over-expression of miRNA-3976 led to increased apoptosis of RGC-5 cells and indirectly reduced the abundance of NFκB1. Conclusion: Serum-derived exosomal miRNA-3976 has the potential to serve as a biomarker for DR, primarily exerting its effects in the early stages of DR through the regulation of NFκB-associated mechanisms.
MeSH term(s)	Middle Aged ; Aged ; Humans ; Diabetic Retinopathy/genetics ; Diabetic Retinopathy/metabolism ; MicroRNAs/metabolism ; Biomarkers/metabolism ; Exosomes/genetics ; Exosomes/metabolism ; Apoptosis ; Diabetes Mellitus/metabolism
Chemical Substances	MicroRNAs ; Biomarkers
Language	English
Publishing date	2023-07-04
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S414393
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Article ; Online: Elevated temperature decreases cardiovascular toxicity of nanoplastics but adds to their lethality: A case study during zebrafish (Danio rerio) development.

Duan, Zhenghua / Wang, Jing / Zhang, Haihong / Wang, Yudi / Chen, Yizhuo / Cong, Jiaoyue / Gong, Zhiyuan / Sun, Hongwen / Wang, Lei

Journal of hazardous materials

2023 Volume 458, Page(s) 131679

Abstract: To highlight the key role of global warming on the toxicity of contaminants, the cardiovascular toxicity of nanoparticles (NPs) was estimated in developing zebrafish (Danio rerio) at different exposure temperatures, and the toxicity mechanisms were ... ...

Abstract	To highlight the key role of global warming on the toxicity of contaminants, the cardiovascular toxicity of nanoparticles (NPs) was estimated in developing zebrafish (Danio rerio) at different exposure temperatures, and the toxicity mechanisms were explored via multi-omic analyses. Polystyrene NPs (50 nm) at 0.1 mg·L
MeSH term(s)	Animals ; Zebrafish/metabolism ; Microplastics/metabolism ; Temperature ; Embryo, Nonmammalian ; Larva ; Myocardium/metabolism ; Water Pollutants, Chemical/toxicity
Chemical Substances	Microplastics ; Water Pollutants, Chemical
Language	English
Publishing date	2023-05-22
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2023.131679
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