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Article ; Online: Aerobic and anoxic utilization of organic matter for flexible nitrite supply in nutrient conversion pathways based on anaerobic ammonium oxidation: Microbial interactive mechanism.

Yun, Wonsang / Cho, Kyungjin / Jung, Jinyoung / Choi, Daehee

2024 Volume 397, Page(s) 130473

Abstract: This study investigated nutrient conversion pathways and corresponding interactive mechanisms in a mainstream partial-nitritation (PN)/anaerobic ammonium oxidation (anammox)/partial-denitrification-(PD)-enhanced biological phosphorus-removal (EBPR) (PN/A/ ...

Abstract	This study investigated nutrient conversion pathways and corresponding interactive mechanisms in a mainstream partial-nitritation (PN)/anaerobic ammonium oxidation (anammox)/partial-denitrification-(PD)-enhanced biological phosphorus-removal (EBPR) (PN/A/PD-EBPR) process. A laboratory-scale sequencing batch reactor was operated for 301 days under different operational strategies. Mainstream PN/A/PD-EBPR was successfully operated with aerobic and anoxic utilization of organic matter. Aerobic utilization of organic matter was an effective strategy for conversion to denitrifying polyphosphate-accumulating organism-based phosphorus removal, referring to a biological reaction that outperformed nitrite-oxidizing bacteria. Aerobically adsorbed organic matter could be used as a carbon source for PD, which further enhanced nitrogen removal by PN/A. Ultimately, the interaction between complex nutrient conversion pathways served to achieve stable performance. High-throughput sequencing results elucidated the core microbe functioning in the mainstream PN/A/PD-EBPR process with respect to various nutrients. The outcomes of this study will be beneficial to those attempting to implement mainstream PN/A/PD-EBPR.
MeSH term(s)	Nitrites ; Anaerobiosis ; Bioreactors/microbiology ; Oxidation-Reduction ; Nutrients ; Nitrogen ; Phosphorus ; Ammonium Compounds ; Sewage ; Denitrification
Chemical Substances	Nitrites ; Nitrogen (N762921K75) ; Phosphorus (27YLU75U4W) ; Ammonium Compounds ; Sewage
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2024.130473
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Article ; Online: Effectiveness of a Fire Disaster PFA Simulation Game: A Single-Blinded Trial.

Choi, Yun-Jung / Song, Heewon

Disaster medicine and public health preparedness

2024 Volume 18, Page(s) e64

Abstract: Objective: As societies become more complex, disasters are increasing in frequency and magnitude. To respond to the psychological problems that may arise in such situations, it is necessary to develop the psychological first aid (PFA) training program ... ...

Abstract	Objective: As societies become more complex, disasters are increasing in frequency and magnitude. To respond to the psychological problems that may arise in such situations, it is necessary to develop the psychological first aid (PFA) training program that is more engaging for disaster relief workers and less limited in time and space. This study aimed to investigate the effectiveness of a web-based PFA simulation game for disaster relief workers to provide to fire disaster victims. Methods: This was a non-randomized controlled experimental study with 30 participants in the experimental and control groups. The experimental group learned through the web-based PFA simulation game developed in this study, and the control group was provided with written educational materials regarding general disaster. The effects of time between groups and interaction between groups were tested. Results: Compared to the control group, the experimental group showed significant effects on core competencies in disaster response, self-efficacy, and problem-solving process, and the persistence of the effects was also significantly different. Conclusion: The web-based PFA simulation game was found to be effective in improving core competencies in disaster response, self-efficacy, and problem-solving process of disaster relief workers. These results suggest that simulation games can be an effective learning method for learning PFA for disaster relief workers. Since it is difficult to learn through direct participation in disaster situations, a web-based simulation game may be a more effective way to improve and maintain the competence of PFA.
MeSH term(s)	Humans ; Psychological First Aid ; Disasters ; Learning
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Controlled Clinical Trial ; Randomized Controlled Trial ; Journal Article
ZDB-ID	2375268-3
ISSN	1938-744X ; 1935-7893
ISSN (online)	1938-744X
ISSN	1935-7893
DOI	10.1017/dmp.2024.47
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Article: Efficacy of a virtual nursing simulation-based education to provide psychological support for patients affected by infectious disease disasters: a randomized controlled trial.

Ko, Eunjung / Choi, Yun-Jung

BMC nursing

2024 Volume 23, Issue 1, Page(s) 230

Abstract: Background: Virtual simulation-based education for healthcare professionals has emerged as a strategy for dealing with infectious disease disasters, particularly when training at clinical sites is restricted due to the risk of infection and a lack of ... ...

Abstract	Background: Virtual simulation-based education for healthcare professionals has emerged as a strategy for dealing with infectious disease disasters, particularly when training at clinical sites is restricted due to the risk of infection and a lack of personal protective equipment. This research evaluated a virtual simulation-based education program intended to increase nurses' perceived competence in providing psychological support to patients affected by infectious disease disasters. Methods: The efficacy of the program was evaluated via a randomized controlled trial. We recruited 104 nurses for participation in the study and allocated them randomly and evenly to an experimental group and a control group. The experimental group was given a web address through which they could access the program, whereas the control group was provided with a web address that directed them to text-based education materials. Data were then collected through an online survey of competence in addressing disaster mental health, after which the data were analyzed using the Statistical Package for the Social Sciences(version 23.0). Results: The analysis showed that the experimental group's disaster mental health competence (F = 5.149, p =.026), problem solving process (t = 3.024, p =.003), self-leadership (t = 2.063, p =.042), learning self-efficacy (t = 3.450, p =.001), and transfer motivation (t = 2.095, p =.039) significantly statistically differed from those of the control group. Conclusions: A virtual nursing simulation-based education program for psychological support can overcome limitations of time and space. The program would also be an effective learning resource during infectious disease outbreaks. Clinical trial registration: This Korean clinical trial was retrospectively registered (21/11/2023) in the Clinical Research Information Service ( https://cris.nih.go.kr ) with trial registration number KCT0008965.
Language	English
Publishing date	2024-04-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2091496-9
ISSN	1472-6955
ISSN	1472-6955
DOI	10.1186/s12912-024-01901-4
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Article ; Online: The Development, Implementation, and Evaluation of a Geriatric Disaster Nursing Simulation Intervention With Supportive Debriefing.

Jin, Joo-Young / Choi, Yun-Jung

Simulation in healthcare : journal of the Society for Simulation in Healthcare

2024

Abstract: Introduction: Geriatric disaster nursing simulation curriculum use scenarios with trauma-based topics that may contribute to lack of psychological safety in learners. This learning condition lowers students' self-efficacy, so supportive debriefing is ... ...

Abstract	Introduction: Geriatric disaster nursing simulation curriculum use scenarios with trauma-based topics that may contribute to lack of psychological safety in learners. This learning condition lowers students' self-efficacy, so supportive debriefing is needed to provide psychological safety for learners. The aims of this study are to develop and apply a geriatric disaster nursing simulation and to evaluate the effectiveness of a supportive debriefing model on psychological safety, learning self-efficacy, and counseling self-efficacy. Methods: A geriatric nursing simulation scenario, checklists, and a standardized patient were developed based on the Analysis-Design-Development-Implementation-Evaluation model. Nursing students were recruited as participants and randomly assigned to either the experimental group, conventional group, or control group. All 3 groups participated in the same geriatric disaster nursing simulation scenario, after which the experimental group used a supportive debriefing model-the SENSE (share-explore-notice-support-extend) model. The conventional group used a common debriefing model, the GAS (gathering-analyzing-summarizing) model, and the control group received simple comments with no debriefing model. The effects of the debriefing models on psychological safety, learning self-efficacy, and counseling self-efficacy were measured by self-report questionnaires. The aggregate scores of the measures were 222 for counseling self-efficacy, 70 for learning self-efficacy, and 50 for psychological safety. Higher scores within these measures corresponded to heightened capabilities. Results: The mean score of counseling self-efficacy in the SENSE model group was significantly increased after the simulation with the supportive debriefing from 142.80 ± 11.43 to 164.53 ± 15.48 (Z = -3.411, P = 0.001). In addition, the SENSE model group and the GAS model group had significantly higher scores in counseling self-efficacy, learning self-efficacy, and psychological safety than those of the control group. However, the SENSE model group had a significantly higher score in psychological safety than that of the GAS model group. Conclusions: The SENSE debriefing model is recommended as a supportive debriefing model to foster students' psychological safety in disaster nursing simulations.
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2223429-9
ISSN	1559-713X ; 1559-2332
ISSN (online)	1559-713X
ISSN	1559-2332
DOI	10.1097/SIH.0000000000000780
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Article ; Online: Learning outcomes of a mobile application for dental infection control education.

Choi, Eun-Mi / Mun, So-Jung / Han, Sun-Young / Kang, Jung-Yun / Choi, Ji-Hea / Noh, Hie-Jin

Journal of dental education

2022 Volume 86, Issue 12, Page(s) 1678–1684

Abstract: Purpose/objectives: This study aimed to apply and verify the effectiveness of a mobile-based dental infection control education application to enable students majoring in dental hygiene to learning dental infection control education without time and ... ...

Abstract	Purpose/objectives: This study aimed to apply and verify the effectiveness of a mobile-based dental infection control education application to enable students majoring in dental hygiene to learning dental infection control education without time and space constraints. Methods: This study used a nonequivalent control group pretest-posttest design to examine differences in learning outcomes between an experimental group that learned through the mobile application and a control group that learned with handouts. The Infection Prevention and Control Mobile Application (IPC App) and handouts were developed by referring to the Center for Disease Control's (CDC) guidelines for Infection Prevention and Control in Dental Settings. Both the experimental and control groups were guided to perform self-regulated learning, where they independently led and managed their learning for two weeks. The study was conducted at the D university college with 42 students from the second grade in the Department of Dental Hygiene from August to October 2021. Differences in knowledge, self-efficacy, and summative evaluation were analyzed using an independent sample t-test and repeated measures analysis of variance (p < 0.05). Results: The findings confirmed that the experimental group who learned through the IPC mobile application had improved their knowledge and indicated a higher summative evaluation than the control group that learned via learning documents (p < 0.05). Conclusions: Owing to the high accessibility and repeatability of the learning content, the mobile application recommended in this study may serve as an effective self-directed learning tool for students to gain knowledge on the standard precautions for dental infection control.
Language	English
Publishing date	2022-09-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	410579-5
ISSN	1930-7837 ; 0022-0337
ISSN (online)	1930-7837
ISSN	0022-0337
DOI	10.1002/jdd.13069
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Article ; Online: Simulation-Based Education for Nurses in Caring for the Psychological Well-being of Survivors of Disaster.

Yun, Sun-Mi / Choi, Yun-Jung

Journal of continuing education in nursing

2022 Volume 53, Issue 3, Page(s) 131–136

Abstract: Background Nurses require continuing education and training to maintain comprehensive and cooperative relationships with the survivors of disasters, understand their environment, and secure their safety. Method The aim of this study was to develop and ... ...

Abstract	Background Nurses require continuing education and training to maintain comprehensive and cooperative relationships with the survivors of disasters, understand their environment, and secure their safety. Method The aim of this study was to develop and test a psychological first aid nursing simulation that involved a standardized patient admitted to the emergency department after an earthquake. A nonrandomized feasibility trial was applied to test the effects of the program. The effects of the simulation were measured according to the participants' psychological first aid knowledge, performance competence, and self-efficacy. Data were analyzed using descriptive, difference, and correlation analyses. Results A total of 24 emergency nurses participated in this study. The results showed significant differences in psychological first aid knowledge, performance competence, and self-efficacy between the experimental group and the control group. Conclusion The psychological first aid training program used in this study was effective in improving nurses' psychological first aid knowledge, performance competence, and self-efficacy.
MeSH term(s)	Clinical Competence ; Disasters ; Humans ; Self Efficacy ; Survivors
Language	English
Publishing date	2022-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	410520-5
ISSN	1938-2472 ; 0022-0124
ISSN (online)	1938-2472
ISSN	0022-0124
DOI	10.3928/00220124-20220210-08
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Article ; Online: Reply to: Comments on "Randomized, two-arm, non-comparative phase 2 study of olaparib plus cediranib or durvalumab in HRR-mutated, platinum-resistant ovarian cancer: A substudy of KGOG 3045".

Kim, Yoo-Na / Joung, Je-Gun / Park, Eunhyang / Kim, Jae-Weon / Lee, Jung Bok / Lim, Jinyeong / Kim, Sunghoon / Choi, Chel Hun / Kim, Hee Seung / Chung, Jongsuk / Kim, Byoung-Gie / Lee, Jung-Yun

International journal of cancer

2023 Volume 154, Issue 4, Page(s) 764–765

MeSH term(s)	Female ; Humans ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Carcinoma, Ovarian Epithelial ; Neoplasm Recurrence, Local/drug therapy ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Phthalazines/adverse effects
Chemical Substances	cediranib (NQU9IPY4K9) ; durvalumab (28X28X9OKV) ; olaparib (WOH1JD9AR8) ; Phthalazines
Language	English
Publishing date	2023-10-31
Publishing country	United States
Document type	Letter
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.34786
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Durvalumab with or without tremelimumab plus chemotherapy in HRR non-mutated, platinum-resistant ovarian cancer (KGOG 3045): A phase II umbrella trial.

Kim, Se Ik / Joung, Je-Gun / Kim, Yoo-Na / Park, Junsik / Park, Eunhyang / Kim, Jae-Weon / Lee, Sungyoung / Lee, Jung Bok / Kim, Sunghoon / Choi, Chel Hun / Kim, Hee Seung / Lim, Jinyeong / Chung, Jongsuk / Kim, Byoung-Gie / Lee, Jung-Yun

Gynecologic oncology

2024 Volume 182, Page(s) 7–14

Abstract: Aim: We investigated the efficacy and safety of durvalumab (D) with or without tremelimumab (T) in addition to single-agent chemotherapy (CT) in patients with platinum-resistant recurrent ovarian cancer (PROC) lacking homologous recombination repair ( ... ...

Abstract	Aim: We investigated the efficacy and safety of durvalumab (D) with or without tremelimumab (T) in addition to single-agent chemotherapy (CT) in patients with platinum-resistant recurrent ovarian cancer (PROC) lacking homologous recombination repair (HRR) gene mutations. Patients and methods: KGOG 3045 was an open-label, investigator-initiated phase II umbrella trial. Patients with PROC without HRR gene mutations who had received ≥2 prior lines of therapy were enrolled. Patients with high PD-L1 expression (TPS ≥25%) were assigned to arm A (D + CT), whereas those with low PD-L1 expression were assigned to arm B (D + T75 + CT). After completing arm B recruitment, patients were sequentially assigned to arms C (D + T300 + CT) and D (D + CT). Results: Overall, 58 patients were enrolled (5, 18, 17, and 18 patients in arms A, B, C, and D, respectively). The objective response rates were 20.0, 33.3, 29.4, and 22.2%, respectively. Grade 3-4 treatment-related adverse events were observed in 20.0, 66.7, 47.1, and 66.7 of patients, respectively, but were effectively managed. Multivariable analysis demonstrated that adding T to D + CT improved progression-free survival (adjusted HR, 0.435; 95% CI, 0.229-0.824; P = 0.011). Favorable response to chemoimmunotherapy was associated with MUC16 mutation (P = 0.0214), high EPCAM expression (P = 0.020), high matrix remodeling gene signature score (P = 0.017), and low FOXP3 expression (P = 0.047). Patients showing favorable responses to D + T + CT exhibited significantly higher EPCAM expression levels (P = 0.008) and matrix remodeling gene signature scores (P = 0.031) than those receiving D + CT. Conclusions: Dual immunotherapy with chemotherapy showed acceptable response rates and tolerable safety in HRR non-mutated PROC, warranting continued clinical investigation.
MeSH term(s)	Humans ; Female ; B7-H1 Antigen ; Epithelial Cell Adhesion Molecule ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized
Chemical Substances	durvalumab (28X28X9OKV) ; tremelimumab (QEN1X95CIX) ; B7-H1 Antigen ; Epithelial Cell Adhesion Molecule ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2024-01-20
Publishing country	United States
Document type	Clinical Trial, Phase II ; Journal Article
ZDB-ID	801461-9
ISSN	1095-6859 ; 0090-8258
ISSN (online)	1095-6859
ISSN	0090-8258
DOI	10.1016/j.ygyno.2023.12.029
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Article: Two-step thermoresponsive membrane with tunable separation properties and improved cleaning efficiency

Choi, Jung-Yun / Taeseon Yun / Seung-Yeop Kwak

Journal of membrane science. 2018 May 15, v. 554

2018

Abstract: We developed two-step thermoresponsive membranes that have two different lower critical solution temperatures. To achieve this, poly(2-dimethylaminoethyl methacrylate)-block-poly(N-isopropylacrylamide) (PDMAEMA-b-PNIPAM, PDN) was introduced into a ... ...

Abstract	We developed two-step thermoresponsive membranes that have two different lower critical solution temperatures. To achieve this, poly(2-dimethylaminoethyl methacrylate)-block-poly(N-isopropylacrylamide) (PDMAEMA-b-PNIPAM, PDN) was introduced into a polyethersulfone (PES) ultrafiltration membrane. The combined Fourier-transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, attenuated total reflection Fourier-transform infrared spectroscopy, and field-emission scanning electron microscopy results showed that PDN was successfully synthesized, and introduced into the PES membrane. The hydration capacity changes showed that the PES membrane with introduced PDN (PES/PDN) was temperature responsive, and that its pore structure changed. Water flux and protein separation experiments showed that the permeation properties of the PES/PDN membrane effectively changed, and protein separation was achieved based on pore structure changes in response to temperature changes. In particular, PES/PDN containing 5% PDN compared to PES separated water and three types of protein with high efficiency via three clear separation steps, at 30, 50, and 70 °C. In addition, the thermoresponsive polymer block in the PES/PDN membrane improved the flux recovery ratio from 29% to 69%.
Keywords	Fourier transform infrared spectroscopy ; artificial membranes ; cleaning ; nuclear magnetic resonance spectroscopy ; polymers ; scanning electron microscopy ; temperature ; ultrafiltration
Language	English
Dates of publication	2018-0515
Size	p. 117-124.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	194516-6
ISSN	0376-7388
ISSN	0376-7388
DOI	10.1016/j.memsci.2018.02.060
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Article ; Online: Clinical guidelines for ovarian cancer: the Korean Society of Gynecologic Oncology guidelines.

Lee, Banghyun / Chang, Suk-Joon / Kwon, Byung Su / Son, Joo-Hyuk / Lim, Myong Cheol / Kim, Yun Hwan / Lee, Shin-Wha / Choi, Chel Hun / Eoh, Kyung Jin / Lee, Jung-Yun / Suh, Dong Hoon / Kim, Yong Beom

Journal of gynecologic oncology

2023 Volume 35, Issue 1, Page(s) e43

Abstract: Since the latest practice guidelines for ovarian cancer were developed by the Korean Society of Gynecologic Oncology (KSGO) in 2021, many studies have examined the efficacy and safety of various treatments for epithelial ovarian cancer (EOC). Therefore, ... ...

Abstract	Since the latest practice guidelines for ovarian cancer were developed by the Korean Society of Gynecologic Oncology (KSGO) in 2021, many studies have examined the efficacy and safety of various treatments for epithelial ovarian cancer (EOC). Therefore, the need to develop recommendations for EOC treatments has been raised. This study searched the literature using 4 key items and the Population, Intervention, Comparison, and Outcome: the efficacy and safety of poly-ADP ribose polymerase inhibitors in newly diagnosed advanced EOC; the efficacy and safety of intraperitoneal plus intravenous chemotherapy in optimally debulked advanced EOC; the efficacy and safety of secondary cytoreductive surgery in platinum-sensitive recurrent ovarian cancer; and the efficacy and safety of the addition of bevacizumab to platinum-based chemotherapy in first platinum-sensitive recurrent EOC patients who received prior bevacizumab. The evidence for these recommendations, according to each key question, was evaluated using a systematic review and meta-analysis. The committee of ovarian cancer of the KSGO developed updated guidelines for treatments of EOC.
MeSH term(s)	Female ; Humans ; Bevacizumab/adverse effects ; Carcinoma, Ovarian Epithelial/drug therapy ; Neoplasm Recurrence, Local/drug therapy ; Ovarian Neoplasms/drug therapy ; Republic of Korea
Chemical Substances	Bevacizumab (2S9ZZM9Q9V)
Language	English
Publishing date	2023-12-27
Publishing country	Korea (South)
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2478405-9
ISSN	2005-0399 ; 2005-0380
ISSN (online)	2005-0399
ISSN	2005-0380
DOI	10.3802/jgo.2024.35.e43
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