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  1. Book ; Online: Chapter Convention versus contemporaneity

    Schifelbein de Menezes, Cristiane / Chatterjee, Abhishek / Dias, Nuno / Branco, Vasco

    The affordances of design-led mediation towards sustaining an ancestral cycle of linen making in Castelões, Portugal

    2023  

    Keywords Product design ; Design Research ; Heritage preservation ; Linen Cycle ; Territory and Identity ; Cultural Sustainability
    Language English
    Size 1 electronic resource (4 pages)
    Publisher Academia Press
    Publishing place Ghent
    Document type Book ; Online
    Note English
    HBZ-ID HT030647190
    ISBN 9789401496476 ; 9401496471
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Exposure of human glioblastoma cells to thimerosal inhibits the thioredoxin system and decreases tumor growth-related factors.

    Bramatti, Isabella / Aschner, Michael / Branco, Vasco / Carvalho, Cristina

    Toxicology and applied pharmacology

    2024  Volume 484, Page(s) 116844

    Abstract: Glioblastoma multiforme (GBM) is the most common, aggressive, and fatal primary malignant brain tumor in adults. The therapeutic efficacy of temozolomide (TMZ) is limited owing to frequent treatment resistance. The latter is in part related to the ... ...

    Abstract Glioblastoma multiforme (GBM) is the most common, aggressive, and fatal primary malignant brain tumor in adults. The therapeutic efficacy of temozolomide (TMZ) is limited owing to frequent treatment resistance. The latter is in part related to the overexpression of redox systems such as the thioredoxin system. This system is fundamental for cell survival and proliferation, regulating hypoxia inducible factor-1alpha (HIF-1α) activity, in turn controlling vascular endothelial growth factor (VEGF), which is indispensable for tumor invasiveness, angiogenesis and microenvironment maintenance. HIF-1α can also be regulated by the signal transducer and activator of transcription 3 (STAT3), an oncogene stimulated by pro-inflammatory cytokines and growth factors. The thioredoxin system has several known inhibitors including mercury compounds such as Thimerosal (TmHg) which readily crosses the blood-brain barrier (BBB) and accumulates in the brain. Though previously used in various applications epidemiological evidence on TmHg's neurotoxicity is lacking. The objective of this study was to verify whether thimerosal is a suitable candidate for hard repurposing to control glioblastoma; therefore, the effects of this molecule were evaluated in human GBM (U87) cells. Our novel results show that TmHg decreased cellular viability (>50%) and migration (up to 90% decrease in wound closure), reduced thioredoxin reductase (TrxR/TXNRD1) and thioredoxin (Trx) activity, and increased reactive oxygen species (ROS) generation. Moreover, TmHg reduced HIF-1α expression (35%) as observed by immunofluorescence. Co-exposure of U87 cells to TmHg and TMZ reduced HIF-1α, VEGF, and phosphorylated STAT3. Consequently, TmHg alone or combined with chemotherapeutic drugs can reduce neoangiogenesis and ameliorate glioblastoma progression and treatment.
    MeSH term(s) Adult ; Humans ; Glioblastoma/drug therapy ; Glioblastoma/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Thimerosal/pharmacology ; Thimerosal/therapeutic use ; Temozolomide/pharmacology ; Temozolomide/therapeutic use ; Thioredoxins ; Cell Line, Tumor ; Hypoxia-Inducible Factor 1, alpha Subunit ; Tumor Microenvironment
    Chemical Substances Vascular Endothelial Growth Factor A ; Thimerosal (2225PI3MOV) ; Temozolomide (YF1K15M17Y) ; Thioredoxins (52500-60-4) ; Hypoxia-Inducible Factor 1, alpha Subunit
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2024.116844
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Nanoplastics activate a TLR4/p38-mediated pro-inflammatory response in human intestinal and mouse microglia cells.

    Antunes, Joana / Sobral, Paula / Martins, Marta / Branco, Vasco

    Environmental toxicology and pharmacology

    2023  Volume 104, Page(s) 104298

    Abstract: The crescent presence of nanoplastics in the environment raises concerns regarding their potential impact on health. This study exposed human colon adenocarcinoma cells (HT29) and microglia cells (N9) to nanoplastics (25 nm, 50 nm, and 100 nm Polystyrene) ...

    Abstract The crescent presence of nanoplastics in the environment raises concerns regarding their potential impact on health. This study exposed human colon adenocarcinoma cells (HT29) and microglia cells (N9) to nanoplastics (25 nm, 50 nm, and 100 nm Polystyrene) to investigate their inflammatory responses, which are vital for body's defence. Although cytotoxicity remained generally low, HT29 cells exhibited a notable upregulation of p50 and p38 expression, concomitant with elevated TLR4 expression, in contrast with N9 cells that showed a less pronounced upregulation of these proteins. Additionally, nanoplastic exposure increased IL-1ß levels, partially attenuated by pre-exposure to TLR4 or p38 inhibitors. Intriguingly, N9 cells exposed to nanoplastics exhibited substantial increases in iNOS mRNA. This effect was entirely prevented by pre-exposure to TLR4 or p38 inhibitors, while TNF-α mRNA levels remained relatively stable. These findings underscore the potential of nanoplastics to activate inflammatory pathways, with response kinetics varying depending on the cell type.
    MeSH term(s) Animals ; Mice ; Humans ; Microglia ; Microplastics ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/metabolism ; Adenocarcinoma/metabolism ; Colonic Neoplasms ; RNA, Messenger/metabolism
    Chemical Substances Microplastics ; Toll-Like Receptor 4 ; RNA, Messenger ; TLR4 protein, human
    Language English
    Publishing date 2023-10-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1318302-3
    ISSN 1872-7077 ; 1382-6689
    ISSN (online) 1872-7077
    ISSN 1382-6689
    DOI 10.1016/j.etap.2023.104298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4490: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Editorial: Redox-signaling in neurodegenerative diseases: biomarkers, targets, and therapies.

    Carvalho, Andreia N / Branco, Vasco / van Horssen, Jack / Saso, Luciano

    Frontiers in cellular neuroscience

    2023  Volume 17, Page(s) 1198669

    Language English
    Publishing date 2023-04-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2023.1198669
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Relationships between emotional processing difficulties and early maladaptive schemas on the regulation of psychological needs.

    Faustino, Bruno / Vasco, António Branco

    Clinical psychology & psychotherapy

    2020  Volume 27, Issue 6, Page(s) 804–813

    Abstract: Emotional processing difficulties may be viewed as dysfunctional emotional states emerging from non-adequately processed emotional experience while early maladaptive schemas are experienced-based dysfunctional mental structures associated with chronic ... ...

    Abstract Emotional processing difficulties may be viewed as dysfunctional emotional states emerging from non-adequately processed emotional experience while early maladaptive schemas are experienced-based dysfunctional mental structures associated with chronic and recurrent psychological disorders. Schemas and emotional difficulties were previously associated with impairments on the regulation of psychological needs. However, clarifications about the relationships between these constructs are lacking. In a cross-sectional study, a clinical sample of 66 participants (M = 46.4, SD = 13.1) completed self-report questionnaires. Emotional processing difficulties correlated positively with schemas and negatively with the regulation of psychological needs. Disconnection and rejection, lack of autonomy and impaired limits schema domains mediated the relationship between emotional processing difficulties and psychological needs. Emotional processing difficulties may be associated with impairments on the regulation of psychological needs, due to activation of early maladaptive schemas, which, in turn, prompts symptomatology. Transtheoretical intervention regarding marker-guided interventions and phase-by-phase schema restructuring may be used to promote the regulation of psychological needs.
    MeSH term(s) Adaptation, Psychological ; Cross-Sectional Studies ; Emotions ; Humans ; Self Report ; Surveys and Questionnaires
    Language English
    Publishing date 2020-06-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1169313-7
    ISSN 1099-0879 ; 1063-3995
    ISSN (online) 1099-0879
    ISSN 1063-3995
    DOI 10.1002/cpp.2464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3950: Show issues Location:
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  6. Article ; Online: N-Acetylcysteine or Sodium Selenite Prevent the p38-Mediated Production of Proinflammatory Cytokines by Microglia during Exposure to Mercury (II).

    Branco, Vasco / Coppo, Lucia / Aschner, Michael / Carvalho, Cristina

    Toxics

    2022  Volume 10, Issue 8

    Abstract: Mercury (Hg) is known for its neurotoxicity and is reported to activate microglia cells at low exposure levels. Since mercury decreases the activity of the glutathione and thioredoxin systems, we hypothesize that Hg would, in turn, disrupt microglia ... ...

    Abstract Mercury (Hg) is known for its neurotoxicity and is reported to activate microglia cells at low exposure levels. Since mercury decreases the activity of the glutathione and thioredoxin systems, we hypothesize that Hg would, in turn, disrupt microglia homeostasis by interfering with redox regulation of signaling pathways. Thus, in this work, we analyzed the effect of exposure to Hg
    Language English
    Publishing date 2022-07-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics10080433
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: An expert-based assessment of global threats and conservation measures for spiders

    Vasco Veiga Branco / Pedro Cardoso

    Global Ecology and Conservation, Vol 24, Iss , Pp e01290- (2020)

    2020  

    Abstract: Despite the prominent role of spiders in most ecosystems, these invertebrates are still notably endangered as well as underrepresented in current conservation efforts. We sent a survey to spider experts and enthusiasts belonging to arachnological ... ...

    Abstract Despite the prominent role of spiders in most ecosystems, these invertebrates are still notably endangered as well as underrepresented in current conservation efforts. We sent a survey to spider experts and enthusiasts belonging to arachnological societies across the globe to determine the general consensus on globally relevant threats to spiders as well as the most relevant conservation measures. We report that respondents found agriculture, livestock farming & forestry, climate change, urbanisation and pollution (including pesticides) to be the most relevant threats to spider species worldwide. Likewise, land protection and education & awareness were considered the most relevant conservation measures to avoid species declines and extinctions. Although these results tend to be consistent across the biogeographic regions of expertise of respondents, there was significant variation between regions. We discuss the support and justification for the patterns found, their regional variations, and the relevance of threats and conservation measures. This is the first global roadmap for spider species conservation action and research. In general, land should be set aside for species protection, agroforestry practices should be carefully considered, climate change should be mitigated, and the general public should be made more aware of spiders, their importance and the threats they face.
    Keywords Araneae ; Endangered species ; Extinctions ; Invertebrate conservation ; Population declines ; Survey ; Ecology ; QH540-549.5
    Subject code 333
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Exploring the impacts of COVID-19 related social distancing on loneliness, psychological needs and symptomatology.

    Faustino, Bruno / Branco Vasco, António / Delgado, João / Farinha-Fernandes, António / Guerreiro, José Carlos

    Research in psychotherapy (Milano)

    2021  Volume 23, Issue 3, Page(s) 492

    Abstract: Loneliness may be a consequence of social distancing, a measure imposed by several governments to try to reduce the contagion ... ...

    Abstract Loneliness may be a consequence of social distancing, a measure imposed by several governments to try to reduce the contagion of
    Language English
    Publishing date 2021-01-14
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2654235-3
    ISSN 2239-8031 ; 2239-8031
    ISSN (online) 2239-8031
    ISSN 2239-8031
    DOI 10.4081/ripppo.2020.492
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Thioredoxin Reductase Inhibitors as Potential Antitumors

    Vanessa Pires / Isabella Bramatti / Michael Aschner / Vasco Branco / Cristina Carvalho

    Frontiers in Molecular Biosciences, Vol

    Mercury Compounds Efficacy in Glioma Cells

    2022  Volume 9

    Abstract: Glioblastoma multiforme (GBM) is the most aggressive and common form of glioma. GBM, like many other tumors, expresses high levels of redox proteins, such as thioredoxin (Trx) and thioredoxin reductase (TrxR), allowing tumor cells to cope with high ... ...

    Abstract Glioblastoma multiforme (GBM) is the most aggressive and common form of glioma. GBM, like many other tumors, expresses high levels of redox proteins, such as thioredoxin (Trx) and thioredoxin reductase (TrxR), allowing tumor cells to cope with high levels of reactive oxygen species (ROS) and resist chemotherapy and radiotherapy. Thus, tackling the activity of these enzymes is a strategy to reduce cell viability and proliferation and most importantly achieve tumor cell death. Mercury (Hg) compounds are among the most effective inhibitors of TrxR and Trx due to their high affinity for binding thiols and selenols. Moreover, organomercurials such as thimerosal, have a history of clinical use in humans. Thimerosal effectively crosses the blood–brain barrier (BBB), thus reaching effective concentrations for the treatment of GBM. Therefore, this study evaluated the effects of thimerosal (TmHg) and its metabolite ethylmercury (EtHg) over the mouse glioma cell line (GL261), namely, the inhibition of the thioredoxin system and the occurrence of oxidative cellular stress. The results showed that both TmHg and EtHg increased oxidative events and triggered cell death primarily by apoptosis, leading to a significant reduction in GL261 cell viability. Moreover, the cytotoxicity of TmHg and ETHg in GL261 was significantly higher when compared to temozolomide (TMZ). These results indicate that EtHg and TmHg have the potential to be used in GBM therapy since they strongly reduce the redox capability of tumor cells at exceedingly low exposure levels.
    Keywords glioblastoma ; thioredoxin reductase ; thioredoxin ; thimerosal (thiomersal) ; ethylmercury ; Biology (General) ; QH301-705.5
    Subject code 500
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Early maladaptive schemas and COVID-19 anxiety: The mediational role of mistrustfulness and vulnerability to harm and illness.

    Faustino, Bruno / Vasco, António Branco / Delgado, João / Farinha-Fernandes, António / Guerreiro, José Carlos

    Clinical psychology & psychotherapy

    2022  Volume 29, Issue 4, Page(s) 1297–1308

    Abstract: Background: Early maladaptive schemas (EMS), as lifelong psychological structures, tend to be associated with psychopathological symptomatology. Previous research has suggested that schemas act as psychological vulnerabilities to stressful life ... ...

    Abstract Background: Early maladaptive schemas (EMS), as lifelong psychological structures, tend to be associated with psychopathological symptomatology. Previous research has suggested that schemas act as psychological vulnerabilities to stressful life situations, such as the present worldwide COVID-19 pandemic. In this context, anxiety and psychological distress have been documented as two of the main psychological symptoms associated with the COVID-19 pandemic. However, the associations between specific EMS and COVID-19 anxiety remain unexplored. Therefore, this study aims to explore the relationships between EMS, COVID-19 anxiety as well as other mental health variables such as psychological well-being, distress and life satisfaction.
    Methods: In a cross-sectional design, 249 individuals (M = 34.2, SD = 12.0) completed several self-report measures.
    Results: EMS from different schematic domains were positively associated with COVID-19 anxiety and psychological distress and negatively associated with psychological well-being and life satisfaction. An EMS hierarchical regression model predicted COVID-19 anxiety. Mistrustfulness and vulnerability to harm and illness mediated the relationships between COVID-19 anxiety, psychological distress and life satisfaction.
    Conclusions: According to these results, mistrustfulness and vulnerability to harm and illness can act as underlying variables for the decrease in mental health associated with the COVID-19 pandemic.
    MeSH term(s) Adaptation, Psychological ; Anxiety/complications ; COVID-19 ; Cross-Sectional Studies ; Depression ; Humans ; Pandemics ; Surveys and Questionnaires
    Language English
    Publishing date 2022-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1169313-7
    ISSN 1099-0879 ; 1063-3995
    ISSN (online) 1099-0879
    ISSN 1063-3995
    DOI 10.1002/cpp.2706
    Database MEDical Literature Analysis and Retrieval System OnLINE

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